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Books in Life sciences

Elsevier's Life Sciences collection helps researchers get comprehensive coverage and up-to-date information on the study of living organisms, their processes, and interrelationships, spanning disciplines like biology, genetics, and biochemistry, and addressing emerging trends such as genomics, biotechnology, and sustainability, essential for advancing knowledge and driving innovation in the field.

BooksJournals

    • Nanotechnology and Regenerative Medicine

      • 1st Edition
      • November 24, 2022
      • Maria H. Santana + 2 more
      • English
      • Paperback
        9 7 8 0 3 2 3 9 0 4 7 1 1
      • eBook
        9 7 8 0 3 2 3 9 0 4 3 2 2
      "Cell niches” are present in several human body tissues as a dynamic microenvironment essential to modulate stem cells’ behavior in health, under injury, and in regenerative processes. The interplay between stem cells and their niche is necessary for sustaining tissues. The extracellular matrix (ECM) is the crucial component of the stem cell. It defines the architectural space, physical binding to the cell membrane, and interactions with the neighborhood cells and supports physical stress. Domains with nano or micrometric sizes define the surface and topology of the ECM, mediating cell interactions and macrophage recruitment to injured sites. Over the last two decades, the integration of biomedicine with other engineering and biomaterial sciences promoted the development of nanotechnology and regenerative medicine toward mimicking the specialized stem cell niches to treat diseases with less invasive and efficient therapies. Innovative approaches in nanotechnology, such as targeting the immunological system, transporting drugs across blood–brain/BBB and blood–retinal barriers/BRB, directing active moiety to specific disease location/organs, encapsulation of multiple components, and promoting signalization and pathway-specific surfaces for cell interactions and growth, are indeed promising. On the other side, developments of biomaterial scaffolds to mimic the cell niches for interactions with stem cells in vitro or in vivo have tremendous potential. The three-dimensional printing technology offers a base for a wide array of applications, for example, developing tissue constructs, mimetic organs, organoids, and organ-on-a-chip, thus avoiding the differences between animal model species and humans. Aiming closer to the natural environments, fresh autologous products from the blood, such as platelet-rich plasma (PRP), contain platelets and leukocytes, providing growth factors, cytokines, and proteins for the resident stem cells in the stages of regeneration. PRP also provides pain relief, reducing disabilities in elderly or diseased people. This book brings thought-provoking multidisciplinary topics on the diverse aspects of basic and applied sciences. The prime focus of the compilation is to understand the challenges researchers encounter in combining nanotechnology and regenerative medicine, ultimately integrating both disciplines for the benefit of the patient and offering them a ray of hope to be cured.

    • Inflammasome Biology

      • 1st Edition
      • November 23, 2022
      • Pablo Pelegrin
      • English
      • Paperback
        9 7 8 0 3 2 3 9 1 8 0 2 2
      • eBook
        9 7 8 0 3 2 3 9 7 2 0 6 2
      Inflammasome Biology: Fundamentals, Role in Disease States, and Therapeutic Opportunities is a complete reference on the role of inflammasomes in health and disease. Sections cover the different types of inflammasomes, including cellular signaling, structural and evolutive aspects, overview the role of inflammasomes in key diseases, microbial infections and human body systems conditions, cover the interplay between Inflammasomes and cell death processes, and discuss current therapeutic opportunities driven by inflammasome research, including targeting, blocking and inhibiting the development of inflammasomes through both synthetic and natural compounds. This book is the perfect reference for cell biologists, immunologists and research clinicians to understand the foundations of inflammasomes and explore the therapeutic opportunities they present. Pharma researchers may also find this reference invaluable in devising new approaches to developing anti-inflammatory drugs.

    • Esophageal Disease and the Role of the Microbiome

      • 1st Edition
      • November 23, 2022
      • David A. Johnson
      • English
      • Paperback
        9 7 8 0 3 2 3 9 5 0 7 0 1
      • eBook
        9 7 8 0 3 2 3 9 5 0 7 1 8
      Esophageal Diseases and the Role of the Microbiome provides evidence on biomic influence in esophageal diseases. The book builds on the translational information on H pylori for ulcer disease as well as the explosive focus on biomic influence in virtually all areas of esophageal diseases. This important reference will help translational researchers by providing scientific understanding and hypothesis generation that is needed for furthering this field of study. It will also provide clinicians with disease management options for esophageal diseases (for GERD and PPI options/side effects) and present cutting-edge science to promote provider/patient understanding and options.

    • Advances in Biomembranes and Lipid Self-Assembly

      • 1st Edition
      • Volume 36
      • November 23, 2022
      • Aleš Iglič︎ + 2 more
      • English
      • Hardback
        9 7 8 0 3 2 3 9 8 5 9 6 3
      • eBook
        9 7 8 0 3 2 3 9 8 6 0 6 9
      Advances in Biomembranes and Lipid Self-Assembly, Volume 36 serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

    • Bidirectional Gene Promoters

      • 1st Edition
      • November 23, 2022
      • Fumiaki Uchiumi
      • English
      • Paperback
        9 7 8 0 1 2 8 1 8 7 8 7 6
      • eBook
        9 7 8 0 1 2 8 1 9 4 6 1 4
      • eBook
        9 7 8 0 1 2 8 1 9 0 6 8 5
      Recent studies in human genetics and in silico analyses have revealed that a number of genes are head-head orientated with other genes or non-coding RNAs. The expression of regulatory element-containing 5’-upstream regions of gene pairs are referred to as bi-directional promoters and are thought to have a key role in biological regulatory mechanisms. For example, tumor suppressor protein-encoding TP53 and BRCA1 genes are head-head bound with WRAP53 and NBR2, respectively. DNA-repair factor-encoding ATM and PRKDC (DNA-PKcs) genes have bidirectional partner NPAT and MCM4, respectively. Surveillance of the human DNA database has revealed that the numbers of DNA repair/mitochondrial function/immune response-associated genes are bound with other genes that are transcribed to opposite direction. The observations may encourage us to investigate in the molecular mechanisms how DNA repair/mitochondrial function/immune response-associated genes are regulated by bidirectional promoters. Not only protein-coding genes, but also quite a few ncRNAs, which play important roles in various cellular events, are transcribed under the regulation of the bidirectional promoters. More importantly, we know that dysregulation in the promoter activity and transcription initiation of genes might cause human diseases.

    • RNA Methodologies

      • 6th Edition
      • November 22, 2022
      • Robert E. Farrell Jr.
      • English
      • Paperback
        9 7 8 0 3 2 3 9 0 2 2 1 2
      • eBook
        9 7 8 0 3 2 3 9 1 6 5 6 1
      RNA Methodologies: A Laboratory Guide for Isolation and Characterization, Sixth Edition provides the most up-to-date ribonucleic acid lab techniques for seasoned scientists and graduate students alike. This edition features new material on RNA sequencing, RNA in Situ Hybridization, non-coding RNAs, computational RNA biology, transcriptomes and bioinformatics, along with the latest advances in methods and protocols across the field of RNA investigation. As a leader in the field, Dr. Farrell provides a wealth of knowledge on the topic of RNA biology while also giving readers helpful hints and troubleshooting techniques from his own personal experience in this subject area. This book presents the essential knowledge and techniques to use when working with RNA for the experienced practitioner, while also aiding the beginner in fully understanding this important branch of molecular biology.

    • Mathematical Approaches to Molecular Structural Biology

      • 1st Edition
      • November 19, 2022
      • Subrata Pal
      • English
      • Paperback
        9 7 8 0 3 2 3 9 0 3 9 7 4
      • eBook
        9 7 8 0 3 2 3 9 0 6 6 3 0
      Mathematical Approaches to Molecular Structural Biology offers a comprehensive overview of the mathematical foundations behind the study of biomolecular structure. Initial chapters provide an introduction to the mathematics associated with the study of molecular structure, such as vector spaces and matrices, linear systems, matrix decomposition, vector calculus, probability and statistics. The book then moves on to more advanced areas of molecular structural biology based on the mathematical concepts discussed in earlier chapters. Here, key methods such as X-ray crystallography and cryo-electron microscopy are explored, in addition to biomolecular structure dynamics within the context of mathematics and physics. This book equips readers with an understanding of the fundamental principles behind structural biology, providing researchers with a strong groundwork for further investigation in both this and related fields.

    • Immediately Sequential Bilateral Cataract Surgery (ISBCS)

      • 1st Edition
      • November 18, 2022
      • Steve A. Arshinoff + 6 more
      • English
      • Paperback
        9 7 8 0 3 2 3 9 5 3 0 9 2
      • eBook
        9 7 8 0 3 2 3 9 5 3 1 0 8
      Immediately Sequential Bilateral Cataract Surgery (ISBCS): Global History and Methodology is a comprehensive guide for the safe and efficient performance of ISBCS. It provides an overview of the history, recommended protocols, necessary precautions, exclusion criteria, benefits and risks associated with this procedure, organizational standards, and more. Written by the most prominent ISBCS surgeons in the world, chapters recount the arguments for and against bilateral surgery that have been made throughout the ages, up to the present, and deliver achieved and proposed resolutions to all problems discussed. Topics such as ethics and medico-legal issues surrounding ISBCS are also discussed, and a chapter on the global evolution of bilateral cataract surgery provides readers with a complete overview of the development of ISBCS practices in countries from all continents.

    • DNA Damage and Double Strand Breaks Part B

      • 1st Edition
      • Volume 52
      • November 17, 2022
      • English
      • Hardback
        9 7 8 0 3 2 3 9 9 3 9 8 2
      • eBook
        9 7 8 0 3 2 3 9 9 4 0 6 4
      Intersection of Iron and Lipid Metabolism, Volume 52 in the Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics relating to enzymes research.

    • Advances in Clinical Chemistry

      • 1st Edition
      • Volume 111
      • November 17, 2022
      • Gregory S. Makowski
      • English
      • Hardback
        9 7 8 0 3 2 3 9 8 5 9 0 1
      • eBook
        9 7 8 0 3 2 3 9 8 6 0 0 7
      Advances in Clinical Chemistry, Volume 111, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists.

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