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Elsevier

Books in Life sciences

Elsevier's Life Sciences collection helps researchers get comprehensive coverage and up-to-date information on the study of living organisms, their processes, and interrelationships, spanning disciplines like biology, genetics, and biochemistry, and addressing emerging trends such as genomics, biotechnology, and sustainability, essential for advancing knowledge and driving innovation in the field.

  • Bioinformatics Essentials II

    From Multi‑omics to AI – Methods, Workflows, and Translational Applications
    • 1st Edition
    • Syed Mudasir Ahmad + 2 more
    • English
    Bioinformatics Essentials II, From Multi‑omics to AI – Methods, Workflows, and Translational Applications offers a comprehensive guide to modern bioinformatics, focusing on best-practice workflows for multi-omics data analysis and AI-assisted discovery. Designed for learners and early-career researchers, it bridges foundational knowledge with cutting-edge applications. The book covers experimental design, sequencing technologies, and core omics workflows including transcriptomics, proteomics, metabolomics, and epigenomics. Advanced chapters explore single-cell and spatial omics, multi-omics integration, AI/ML applications, and environmental bioinformatics.Each chapter includes learning objectives, worked examples, toolbox comparisons, and reproducible code. This resource empowers students, faculty, and applied researchers to confidently analyze complex datasets and translate findings into agriculture, health, and environmental solutions. Its modular structure and companion website enhance usability in both coursework and independent study.

  • Mannose Binding Lectin Associated Serine Proteases

    Structure, Function and Therapeutic Implications
    • 1st Edition
    • Krishnan Hajela
    • English
    Mannose Binding Lectin Associated Serine Proteases: Structure, Function and Therapeutic Implications provides a comprehensive overview of MASP-1, MASP-2, and MASP-3, highlighting their roles in immune defense, disease mechanisms, and therapeutic intervention. This book covers the molecular structure and catalytic mechanisms of these key serine proteases, emphasizing their involvement in the lectin pathway of complement activation as well as their emerging functions in coagulation and bradykinin pathways. Chapters detail the biology of animal lectins and collections, classical and alternative complement pathways, and specific biochemical activities of MASP-1, MASP-2, and MASP-3.Readers will find in-depth discussions on the clinical significance of MASP gene polymorphisms and serum levels, and more. Special focus is given to the application of MASP-2 inhibitors in the management of complications such as hematopoietic stem-cell transplantation-asso... thrombotic microangiopathy (HSCT-TMA). This book is an essential resource for researchers in immunology, biochemistry, and molecular medicine, as well as clinicians seeking to advance their understanding of complement biology and the therapeutic potential of targeting the lectin pathway.

  • Health Geography

    Theories, Methods, and Case Studies
    • 1st Edition
    • Peng Jia
    • English
    Health Geography: Theories, Methods, and Case Studies examines the interdisciplinary domain of health geography, systematically integrating geographical science with public health paradigms. The book provides an in-depth analysis of the theoretical foundations, methodological innovations, and practical implications of health geography. Special emphasis is placed on employing geo-spatial technologies, such as Geographic Information Systems (GIS) and remote sensing to enhance disease prevention, health risk assessments, and healthcare resource allocation.By fostering an integrative dialogue among geography, epidemiology, and advanced technological approaches, the book addresses contemporary public health challenges from local to global scales. The book includes over 50 international case studies addressing infectious and chronic diseases, and health resource allocation.

  • Cold-Adapted Enzymes

    Biochemistry and Biotechnology
    • 1st Edition
    • Diego Gomez-Casati + 1 more
    • English
    Cold-Adapted Enzymes: Biochemistry and Biotechnology, the latest release in the Foundations and Frontiers of Enzymology series, provides a detailed investigation into enzymes that adapt to cold environments. The book covers the catalytic, structural, and regulatory properties of this type of enzyme and the potential advances in their biotechnological applications. Topics covered include the evolution of enzymes in cold environments, enzymes involved in carbohydrate metabolism (such as xylanases, B-galactosidase, and B-glucosidase), cold-adapted enzymes in lipid metabolism (such as esterases and lipases), and redox enzymes. In addition, the book also explores bacterial cold-adapted enzymes and those from organisms in extreme environments like Antarctica.Recombina... expression methods, protein engineering, and computational approaches are also featured. This book offers a complete overview of cold-adapted enzymes, making it a useful reference for researchers across a range of interdisciplinary fields, including biochemistry, enzymology, biotechnology, molecular evolution, structural biology and microbiology.

  • 3D Bioprinting and Bioinks for Regenerative Engineering

    Current Concepts and Future Advances
    • 1st Edition
    • Anthony Atala + 1 more
    • English
    3D Bioprinting and Bioinks for Regenerative Engineering: Current Concepts and Future Advances covers bioinks and their associated materials, design formulations, biological interactions, commercial products, and diverse applications in regenerative engineering of various tissues and organs. Part I lays the foundation for bioink concepts and their significance. Part II delves into various 3D printing technologies that enable the creation of complex biological structures. Part III focuses on the fundamentals of bioinks—critical materials that play a key role in printing viable tissues. In Part IV, attention shifts to the process of printing and the development of tissue and organ constructs.Finally, Part V addresses regulatory considerations and offers insights into future perspectives, emphasizing the challenges and opportunities ahead as the field continues to evolve. As the field is on the verge of a new era in engineering tissues, and tissue/body on a chip technologies will play a central role, bioinks are becoming a multidisciplinary field involving materials science, cell biology, biofabrication, and clinical applications. By combining cutting-edge research, practical applications, and expert contributions, this book will become an indispensable resource for both newcomers and experienced professionals.

  • Diabetic Neuropathy

    • 1st Edition
    • Shahidul Islam
    • English
    "Recent Therapeutic Targets for the Prevention and Management of Diabetic Complications: Neuropathy" covers recent research and therapeutic approaches of this diabetic complication for the management of diabetes. It is a detailed reference to understand the pathogenesis of diabetes to alleviate the overall complications of neuropathy to improve patient care. It is uniquely focused on the different aspects of neuropathy with a focus on the molecular and biological pathways (therapeutic target) to detect an early diagnosis to better manage the disease and improve patient care. The book is useful to anyone in the field particularly those who do research investigations, and day-to-day practice in the area of diabetes.

  • Foundation of Microfluidics Device Technology

    • 1st Edition
    • Volume 226
    • English
    Foundation of Microfluidics Device Technology, Volume 225 presents the fundamentals of microfluidics and microfluidics devices, including computational design and fabrication, artificial intelligence and internet of things for microfluidics devices, materials, surface modifications and functionalization of microfluidics, fabrication of paper based microfluidics. Additional topics include microfluidics for generation of biomaterials, microfluidics for multi-omics analysis, lab-on-the-chip, microfluidics for 2D and 3D cell culture systems, microfluidics for drug and gene delivery, biomimetic models, and the economic considerations associated with microfluidics devices development.Specific chapters in this new release include An introduction to microfluidics and devices, Computational design and modeling of microfluidics devices, Artificial intelligence and IoT for microfluidics devices, Fabrication techniques for design of microfluidics devices, Materials, surface modification and functionalization of microfluidic devices, Fabrication of paper based microfluidics, Microfluidics in biomaterials generation and formulation, Microfluidics for chemical and biological analysis, and more.

  • SGLT2 Inhibitors in Cardiovascular Diseases

    Mechanisms, Clinical Impact, and Future Directions
    • 1st Edition
    • Tong Liu
    • English
    SGLT2 Inhibitors in Cardiovascular Diseases: Mechanisms, Clinical Impact, and Future Directions reviews the impact of SGLT2 inhibitors on cardiovascular health in individuals with type 2 diabetes, chronic kidney disease, heart failure, and atherosclerosis. The book synthesizes preclinical and clinical evidence to highlight the cardiovascular benefits of these drugs, initially developed for hyperglycemia management. It details recent studies on SGLT2 inhibitors' effects on cognitive dysfunction, sudden death, ventricular arrhythmias, heart remodeling, and cancer risks in diabetic patients.In addition, it compares SGLT2 inhibitors with DPP4 inhibitors, emphasizing the efficacy of empagliflozin and dapagliflozin in reducing syncope and cardiovascular mortality, supported by trials like EMPA-REG OUTCOME and DECLARE-TIMI 58. Addressing a gap in literature, the book provides a comprehensive overview of SGLT2 inhibitors' cardiovascular benefits in high-risk populations, including atrial fibrillation and syncope. It offers valuable insights and recommendations for clinicians, researchers, and policymakers managing cardiovascular risk.

  • Dissolvable Microneedles (DMNS) For Cancer Diagnosis and Treatment

    • 1st Edition
    • Neetu Talreja + 3 more
    • English
    Dissolvable Microneedles (DMNS) For Cancer Diagnosis and Treatment presents a comprehensive, lab‑to‑clinic overview of dissolving microneedles (DMNs) for cancer diagnosis and therapy, emphasizing painless, minimally invasive delivery and localized treatment. The book details DMN materials, design, and fabrication—includin... AI‑enabled and 3D‑printed approaches—then advances to theranostic applications such as immunotherapy, photodynamic therapy, exosome‑loaded systems, and stimulus‑responsive platforms. Translation topics cover regulation, scale‑up, and CMC, alongside supportive strategies during chemotherapy.Academi... readers gain a structured synthesis of recent advances, practical methods, and clinical outlooks, positioning DMNs as patient‑friendly, cost‑effective tools with significant potential to revolutionize cancer care.

  • Value-Based Healthcare in the Digital Age

    Economic Efficiency and Transformation
    • 1st Edition
    • Miltiadis Lytras + 2 more
    • English
    Value-Based Healthcare in the Digital Age: Economic Efficiency and Transformation addresses the transformation in global healthcare that has been driven by digital innovation, economic efficiency, and value-based care. The book provides comprehensive frameworks that integrate health economics, digital transformation, and patient-centered value delivery. Facing rising costs, aging populations, and chronic diseases, the healthcare sector also sees opportunities in AI, machine learning, blockchain, and IoT for smarter, more efficient delivery. Users will find an exploration of the economic implications of these technologies, offering strategies to align them with value-based care principles, optimize resources, and improve patient outcomes.For academics, policymakers, and healthcare professionals, this book bridges theory and practice with cutting-edge research and real-world case studies. It equips readers with the knowledge and frameworks to navigate the evolving healthcare landscape, emphasizing global perspectives and diverse technological applications, ultimately driving innovation and economic sustainability in healthcare delivery.

  • Gut Health in Diabetes and Gastrointestinal Wellness

    Mechanisms and Clinical Applications
    • 1st Edition
    • Sushil Kumar Dubey + 2 more
    • English
    Gut Health in Diabetes and Gastrointestinal Wellness delves into the intricate relationship between gut microbiota and diabetes, emphasizing their significant impact on gastrointestinal health. This book bridges the gap between cutting-edge research and practical applications, offering a comprehensive exploration on how the gut microbiome affects both metabolic and gastrointestinal health. By examining current scientific findings, the book elucidates the mechanisms through which gut bacteria impact insulin sensitivity, glucose metabolism, and inflammatory responses. Additionally, practical strategies for optimizing gut health are provided, encompassing dietary recommendations, lifestyle modifications, and targeted interventions.The gut microbiome plays a crucial role in metabolic and gastrointestinal functions, and recent research has illuminated the mechanisms by which gut bacteria influence conditions such as diabetes, irritable bowel syndrome (IBS), and inflammatory bowel disease (IBD). Dysbiosis, or the imbalance of gut microorganisms, can disrupt glucose metabolism, lead to insulin insensitivity, and promote chronic inflammation, all of which contribute to the progression and development of metabolic diseases like diabetes. Furthermore, gut dysbiosis is linked to various gastrointestinal disorders, often worsening symptoms and complicating treatment efforts.

  • Artificial Intelligence in Immunoengineering

    Methods, Models, and Translational Applications
    • 1st Edition
    • Steven Zanganeh + 1 more
    • English
    Artificial Intelligence in Immunoengineering: Methods, Models, and Translational Applications examines how AI reshapes immunoengineering to design immune-modulating biomaterials, imaging systems, and diagnostic tools. The book presents an integrated view of data-driven approaches that accelerate discovery and translation in biomedicine. It surveys biological data from single-cell to spatial omics and proteogenomics and offers practical machine learning frameworks, generative and mechanistic models, and multimodal integration strategies. Sections address bench-to-bedside translation, validation pipelines, and regulatory considerations for AI-enabled immunoengineering tools.The book highlights the rapid progress of multidisciplinary research within immunotherapy and immunoengineering. Looking forward, the prospects of immunoengineering appear promising, with further advancements in disease prevention, diagnostics, and treatment on the horizon. Graduate students, academic researchers, clinician-scientists... and computational biologists will gain standardized workflows, mechanism-aware modeling, and reproducible pipelines that advance immunotherapies and diagnostics from concept to clinical impact.

  • Principles and Practice of Nephrocardiology

    • 1st Edition
    • Parta Hatamizadeh
    • English
    Principles and Practice of Nephrocardiology provides a comprehensive introduction to the interdisciplinary subspecialty of Nephrocardiology. The book includes detailed descriptions, along with an in-depth exploration of its primary elements and topics. Coverage spans pathophysiology, epidemiology, prevention, diagnosis, prognosis, monitoring, therapy, risk factors, and the systemic diseases that involve both nephrology-related conditions and cardiovascular diseases. The book guides clinicians and general practitioners in multiple interdisciplinary specialties through diagnostic, preventive, and therapeutic approaches to a wide variety of patient populations. It also opens a myriad of new avenues for future research and guidance for approaching multiple medical topics.

  • Spaceflight Ophthalmology and Medicine

    A Comprehensive Guide to Ocular Health and Related Systemic Health Risks in Astronauts and Space Travelers
    • 1st Edition
    • Ryung Lee + 4 more
    • English
    Spaceflight Ophthalmology and Medicine: A Comprehensive Guide to Ocular Health and Related Systemic Health Risks in Astronauts and Space Travelers provides a comprehensive exploration of ocular health issues faced by astronauts during space missions. The book brings together contributions from leading experts in various fields, addressing the multifaceted risk factors associated with spaceflight and their implications for vision and overall health. Sections examine risk factors for ophthalmic diseases, including the effects of microgravity, space radiation, and oxidative stress, and explore innovative approaches in spaceflight ophthalmology, such as advanced diagnostic techniques and potential treatments for ocular conditions specific to the space environment. This book serves as an essential resource for researchers, clinicians, and space medicine professionals. By offering insights into the latest research and practical applications, it enhances understanding of ocular health in space and promotes the development of effective strategies to ensure astronaut safety and mission success.

  • Antimicrobial Resistance in the 21st Century

    Understanding and Combating the Rising Threat
    • 1st Edition
    • Dipayan Das + 3 more
    • English
    Antimicrobial Resistance in the 21st Century: Understanding and Combating the Rising Threat addresses one of the greatest public health challenges of our time, antibiotic resistance. This book explores the science, history, and global impact of this crisis, providing readers with the knowledge they need to understand the problem and take necessary action. It meticulously unpacks the genetic, biochemical, and evolutionary mechanisms behind antibiotic resistance, while examining how human behaviors—from healthcare practices to agricultural methods—fuel its spread. It highlights the critical roles of environmental factors, misuse of antibiotics, and gaps in diagnosis and stewardship that exacerbate resistance across both clinical and community settings. It also examines innovative solutions, including next-generation antibiotics, alternative therapies, vaccines, and advances in infection control, alongside the global policy strategies necessary to combat this threat. By addressing the scientific, medical, economic, and sociocultural dimensions of antimicrobial resistance, this book provides a roadmap for coordinated, multidisciplinary efforts to preserve antibiotic efficacy and safeguard public health for future generations. It is written by global experts for researchers and scientists in microbiology, infectious diseases, public health, and pharmacology. It is also of interest to healthcare professionals such as clinicians, pharmacists, and nurses, as well as policymakers, public health officials, students, and industry professionals.

  • The Role of Machine Learning and Artificial Intelligence in Revolutionizing Healthcare

    • 1st Edition
    • Prashant Kesharwani + 1 more
    • English
    Revolutionizing Healthcare: The Role of Machine Learning and Artificial Intelligence describes the complexity of healthcare data that necessitates the expanding use of artificial intelligence (AI). This book offers an explicit accounting of vital aspects on artificial intelligence in healthcare, discussing perspectives of the technologies explored based on findings outlined in highly organized tables, illustrative figures, and flow charts. It brings together novel applications of artificial intelligence in healthcare and helps readers define major gaps in knowledge that can lead to significant scientific discoveries.In addition, the book covers computational drug design, genomic data mining, nanomedicines, medical devices, cosmeceuticals, biosensors, genome counseling, quality control, clinical trials, and cybersecurity. Researchers, students, and scientists will find the book provides foundational and practical knowledge, along with the most advanced AI applications in healthcare.

  • Innovative Theranostic Strategies Targeting Cancer

    • 1st Edition
    • Ranjita Shegokar + 1 more
    • English
    Innovative Theranostic Strategies Targeting Cancer focuses on the latest advances in cancer theranostics, emphasizing clinical and preclinical applications. The volume provides in-depth analyses of various cancer types, covering diagnostics, targeted therapies, and innovative strategies like AI and biomarker-based treatments. It combines fundamental knowledge with practical insights, making it a comprehensive resource for researchers and clinicians involved in oncology research and treatment. The book highlights emerging trends, market developments, and cutting-edge technologies, offering a multidisciplinary perspective to support personalized cancer care.By addressing critical challenges and opportunities in theranostics, it aims to facilitate knowledge exchange and foster new approaches for better patient outcomes. This volume serves as an essential guide for academia seeking to stay current with the rapidly evolving field of cancer theranostics.

  • Hyperspectral Imaging

    • 2nd Edition
    • Jose Manuel Amigo + 1 more
    • English
    Hyperspectral Imaging, Second Edition builds on the foundational insights of the first edition, covering core analytical frameworks and introducing new algorithms, hardware technologies, and cutting-edge applications. By incorporating the latest research findings and case studies, sections provide readers with enhanced tools and techniques for effective hyperspectral and multispectral image analysis across diverse scientific, industrial, and field domains. The book also addresses evolving challenges and fresh opportunities in the field, ensuring that users are equipped with the most current knowledge and practices. It underscores the continued relevance and transformative potential of hyperspectral and multispectral imaging in contemporary research and industry.Graduate students, academics, early researchers, and industry scientists across various disciplines working with hyperspectral and multispectral images, including analytical chemistry, remote sensing, vegetation and crops, food and feed production, forensic sciences, biochemistry, medical imaging, pharmaceutical production, art studies, cultural heritage, and more will find this update extremely useful.

  • Empowering Health through Lifestyle Medicine

    The Essential Guide for Preventing and Managing Chronic Disease
    • 1st Edition
    • John Anthony Stevens
    • English
    Empowering Health through Lifestyle Medicine: The Essential Guide for Preventing and Managing Chronic Disease combines the most updated and available research with personal insights and experience, using the Lifestyle Medicine 6 pillar framework. The book engages readers not only in the description and efficacy of LM but also in its knowledge and discussions on concepts and behaviors for managing nutrition, physical activity, stress, mental health, and how our interactions with the environment can create a healthier, happier life. It will encourage clinicians to engage their patients more often, and more practically, with lifestyle medicine, while also helping consumers engage with their clinicians.With a goal of helping clinicians and healthcare related professionals prevent and manage lifestyle-related illnesses for life, this evidenced-based book can be used by anyone in healthcare. It is also ideal for those researching illness prevention and chronic disease management to improve health research practice and patient outcomes.

  • Methods in Systems Bioinorganic Chemistry

    • 1st Edition
    • Volume 741
    • English
    Methods in Systems Bioinorganic Chemistry, Volume 741 provides understanding of high-level properties involving metals in biology that are founded on molecular or mechanistic level interactions. Currently, there is no established “tool kit” for studying bioinorganic systems, so the methods included in the book span a diverse range of topics and approaches, from imaging to proteomics, from metals-in-mice to mathematical modeling. Specific chapters cover Inductively Coupled Plasma Mass Spectrometry (ICP-MS)-based methods to quantify transition metals in cells and vertebrate models, ICP-MS elemental analysis in tissue samples, and much more.Additional chapters delve into An inductively-coupled-... triple quadrupole method with oxygen for the determination of essential elements and protein concentration, Calculating metal speciation of proteins inside cells, Probing biological copper in the subfemtomolar regime, Using LC-ICP-MS chromatography to detect and characterize Labile Metal Pools, Linking dynamic bioinorganic chemistry processes of toxic metals in the bloodstream to establish their exposure-response relationship in humans, Contextualizing X-ray fluorescent microscopy – high resolution X-rays meet subcellular morphology, Chemoproteomic profiling of transition metal binding sites in bacterial proteomes, Heme Labeling by Proximity (HeLP) to Identify Hemoproteins, and much more.

  • Arginase: Structure, Function, and Therapeutic Targeting

    • 1st Edition
    • Volume 740
    • English
    Arginase: Structure, Function, and Therapeutic Targeting, Volume 740 in the Methods in Enzymology series, provides a comprehensive, methodology-driven perspective on arginase research spanning molecular, biochemical, and translational domains. Chapters in this new release include Expression, Purification, and Structural Characterization of Human and Leishmania Arginase with Comparative Analysis of Structures from the Protein Data Bank, Synthesis of First-Generation Arginase Inhibitors, Computational and Structure-Guided Design of Arginase Inhibitors, Metal Substitution in Arginase: Experimental Approaches to Study Metal-Dependent Catalysis, Therapeutic Arginase Formulations: PEGylation, Stability, and Advanced Delivery Systems, and much more.Additional chapters cover Dual ARG1/ARG2 Inhibition: Experimental and Structural Strategies for Inhibitor Design and Optimization, Synthesis of Second-Generation Arginase Inhibitors, Cryo-EM Workflow and Structural Characterization of Arginase–Antibody Complexes, Development and Validation of an Electrochemical Assay for Arginase Activity, Experimental and Structural Analysis of H. pylori Arginase in Gastric Immune Evasion, Agmatinase and Alternative Arginine Utilization Pathways in Bacteria: Biochemical and Functional Perspectives, Catalytic Diversification of the Arginase Fold: Structural and Mechanistic Insights from DcsB, Beyond Arginase: Structural Biology of the Extended Guanidinase Family, Plant Arginase: Structural and Functional Roles in Nitrogen Metabolism, and much more.

  • Thiamine Pyrophosphate (TPP)-Dependent Enzymes

    • 1st Edition
    • Volume 736
    • English
    Thiamine Pyrophosphate (TPP)-Dependent Enzymes, Volume 736 in the Methods in Enzymology series covers this diverse group of ubiquitous enzymes with timely chapters on Methods for Studying ThDP-dependent Mycobacterial MenDs (SEPHCHC Synthases), Mammalian 2-hydroxyacyl-CoA lyases, discovery and assays, Anti-infective target 1-deoxy-d-xylulose-5... synthase (DXS) and drug design for enzyme inhibition, Expression, Purification, and Mechanistic Studies of DXP synthases from Deinococcus radiodurans, Plasmodium falciparum, and Plasmodium vivax, Comparison of the catalysis of ThPP-dependent enzymes AHAS, ALS, and DXS, and much more.Additional sections cover Plant and fungal acetohydroxyacid synthases (AHAS): Methods for heterologous expression, kinetic characterization, and structural analysis, Biochemical and Structural characterization of novel ‘split-gene’ archeal transketolases, 4-Hydroxybenzoylform... decarboxylase enzymes from Rhodococcus jostii RHA1 and Pseudomonas fluorescens Pf-5: characterization and involvement in bacterial lignin degradation, Engineering of phosphoketolase from Bifidobacterium adolescentis for increased activity on non-phosphorylated substrates and application in a cell-free reaction system for ATP regeneration, Repurposing TPP-dependent enzymes with anodic oxidation for the conversion of aldehydes to enantioenriched carboxylic acids, and much more.

  • Biology

    A Human Health Perspective
    • 1st Edition
    • Harry E. Peery + 2 more
    • English
    Biology: A Human Health Perspective offers important medical case histories and complex color illustrations, interacts with the reader, and asks questions throughout. Sections cover the basic chemistry of biology and cell origins, and energy and protein processing before discussing cell reproduction, genetics, evolution, and their place in public healthcare. Clinical applications and medical terminology are also included across chapters, and pioneering medical developments such as holographic surgery, robotic neurosurgery, and tractography are featured.This textbook, along with supporting ancillary materials such as PowerPoint slides, solution manuals and quiz banks is a vital resource for all undergraduate students studying biology or for those looking to develop a career in a health profession who need a basic understanding of the field.

  • Dry Eye Disease

    A Clinical Handbook
    • 1st Edition
    • James Stuart William Wolffsohn + 2 more
    • English
    Dry Eye Disease: A Clinical Handbook illuminates the translation of cutting-edge research on dry eye disease into practical situations, allowing clinical diagnosis and management of the condition using the latest evidence-based methods. It first presents research on the core pathophysiological features of dry eye disease, including tear film instability, hyperosmolarity, inflammation, and ocular surface damage. Thereafter, it champions a patient-centered approach to dry eye management, emphasizing the necessity of classifying the ocular surface disease(s) most relevant to each case. It discusses global disease distribution and the role of non-modifiable risk factors like age, sex, and ethnicity. Additionally, the book describes tools for monitoring symptoms over time and assessing subtle signs of the disease. Readers will find practical methods for improving patient outcomes both in clinical settings and at home.

  • Animal Models of Disease Part F

    • 1st Edition
    • Volume 212
    • English
    Animal Models of Disease, Part F, Volume 212 in the Methods in Cell Biology series, presents significant advancements in understanding disease mechanisms through animal models. The book features chapters on timely topics such as characterizing tumor-infiltrating group 1 innate lymphoid cells in PyMT breast tumors and using zebrafish to unravel the molecular mechanisms of Alzheimer’s disease. The book also covers colitis mouse models and appropriate models for studying diabetes pathophysiology, demonstrating its comprehensive approach to current research.Additional sections cover evaluating polyglutamine protein aggregation in transgenic Caenorhabditis elegans models of Huntington's disease and studying tumor responses to radioimmunotherapy in ovarian cancer models. It also highlights the antimicrobial regime for gut microbiota depletion in mice and the biodistribution of metallic nanoparticles for lymphoma studies. This book is an essential resource for researchers seeking to explore disease mechanisms and therapeutic approaches through animal models.

  • The Metabolon

    • 1st Edition
    • Volume 739
    • English
    Methods in Enzymology series: The Metabolon, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Cell Death Part F

    • 1st Edition
    • Volume 211
    • English
    Cell Death: Part F, Volume 211 presents the latest advances and comprehensive reviews in the rapidly evolving field of cell death. This volume explores Methods to Assess BAX Conformation, Activation, Translocation, and Mitochondrial Outer Membrane Permeabilization, Proximity biotin labelling identification of Bcl-2 protein interactions in live cells, Bimolecular fluorescence complementation assays for investigating Bcl-2 family protein interactions, Assessing apoptotic sensitivity in primary mouse B cells by BH3 profiling, Liposome permeabilization assays to monitor pore formation by cell death proteins, Flow Cytometry Assessment of Mitochondrial Membrane Potential, Biomass, and ROS in OXPHOS-Dependent and Glycolytic Cancer Cells during Cell Death Induction, and much more.Additional chapters cover Assessment of Viability Versus Cell Death: What is What?, Flow cytometry-based drug response profiling of primary B-precursor ALL cells in co-culture with bone marrow-derived stromal cells, An in vitro model of efferocytosis in macrophage foam cells to probe lipid-driven dysregulation of dead cell clearance, Measuring tumor cell killing using in vivo bioluminescence imaging, and more.

  • Morbidity Prevention in Aging

    The Role of Salutogenesis Amidst Crises
    • 1st Edition
    • Nestor Asiamah + 3 more
    • English
    Morbidity Prevention in Aging: The Role of Salutogenesis Amidst Crises addresses the urgent need to rethink disease prevention strategies for an aging population. The book begins by exploring how age-friendly environments support health-seeking behaviors. The next section focuses on developing personal skills such as resilience and self-efficacy for maintaining health during crises. Section III examines the reorientation of health services to support preventive care, including community care and diet promotion, while Section IV addresses the creation of policies that facilitate health-promoting interventions and integrate prevention strategies. Community engagement and empowerment in promoting health is emphasized in the fifth section.The book concludes by providing a framework for understanding disease prevention amidst crises, focusing on diverse racial, cultural, and socioeconomic experiences and ensuring equitable opportunities for lifelong disease prevention. This groundbreaking book emphasizes a salutogenic approach that focuses on factors promoting health rather than merely treating diseases. It provides a comprehensive framework for understanding how to maintain health and prevent diseases across the lifespan, even amidst challenges such as wars, climate change, and industrial hazards.

  • Lightweight, Real-time Deep Learning Models for Healthcare Applications

    • 1st Edition
    • Tina Babu + 2 more
    • English
    Lightweight, Real-time Deep Learning Models for Healthcare Applications addresses the pressing need for deploying efficient artificial intelligence models in clinical environments constrained by limited computational resources. As AI adoption accelerates in healthcare, this reference targets the gap between advanced deep learning research and practical real-time applications, emphasizing model optimization, privacy, and regulatory compliance. The content comprehensively covers model compression techniques such as pruning, quantization, knowledge distillation, and neural architecture search, alongside federated learning frameworks and real-time inference optimization. Detailed chapters present hardware-aware strategies, security considerations, continuous learning, and regulatory validation. The book also provides extensive case studies and implementation blueprints demonstrating practical deployment on devices like Raspberry Pi, NVIDIA Jetson, and mobile health platforms. This book benefits researchers, clinicians, and healthcare technology professionals by offering practical solutions to develop, validate, and implement AI models that maintain diagnostic accuracy while meeting clinical constraints. It equips students and educators with theoretical foundations and hands-on examples to foster innovation in biomedical AI, ultimately enhancing diagnostic capabilities and patient care in diverse healthcare settings.

  • Advances in Applied Microbiology

    • 1st Edition
    • Volume 137
    • English
    Advances in Applied Microbiology presents the latest developments and innovative research in applied microbiology, covering topics such as microbial biotechnology, environmental applications, industrial processes, and medical advancements. It offers valuable insights into the practical uses of microorganisms in solving real-world challenges, making it an essential resource for researchers, professionals, and students in microbiology and related fields.

  • Perianal Crohn’s Disease

    Diagnosis and Treatment
    • 1st Edition
    • Bolin Yang + 2 more
    • English
    Perianal Crohn’s Disease: Diagnosis and Treatment includes the latest knowledge, concepts, first-hand theoretical views, and clinical experience of clinical frontline experts in the field of inflammatory bowel disease. The book systematically describes disease phenotypes, clinical features, examination methods, diagnoses, and treatments. It takes a scientific, practical, and systematic account of both common and rare conditions associated with Perianal Crohn’s Disease, offering informative content, clinical case information, cutting-edge viewpoints, and current, authoritative research findings. The book contains a depth of current clinical experience, including the use of photographs to support examples of conditions, methods, and techniques. In addition, it provides clear ideas and a wealth of clinical information for the clinical diagnosis and management of perianal Crohn's disease.

  • Organic Semiconducting Systems for Applications in Biomedical Engineering

    • 1st Edition
    • Neha Rani Kumar + 1 more
    • English
    Organic Semiconducting Systems for Applications in Biomedical Engineering explores the properties and applications of organic semiconductors, which are conjugated systems made from small organic molecules or polymers that exhibit semiconductor characteristics. These materials offer flexibility, lightweight construction, low cost, and large-area production capabilities. Their tunable electronic and optical properties, along with biocompatibility, such as biosensors, smart drug delivery systems, medical diagnostics, and implantable devices.The book targets professionals and students in the fields of organic electronics, biomedical engineering, biomaterials, and environmental science. It provides a comprehensive understanding of organic conjugated systems and their principles, aiding readers in designing innovative solutions for challenges in medical sectors. Additionally, it delves into the latest research findings and practical applications of organic semiconductors, helping readers stay informed and identify new research opportunities. This book clarifies complex concepts, making it suitable for beginners. It also offers a forward-looking perspective on the potential of organic semiconductors to revolutionize biotechnology, inspiring readers to pursue research and innovation for sustainable development.Overall, this book serves as an essential resource for understanding organic semiconductors in biotechnology, biomedical engineering, and bioelectronic applications.

  • Understanding Molecular Processes using Electrochemical Methods

    • 1st Edition
    • Ashis Kumar Satpati + 1 more
    • English
    Understanding Molecular Processes using Electrochemical Methods offers a detailed compendium of techniques for molecular analysis. The book considers step and sweep techniques, scanning electrochemical microscopy, spectroelectrochemic... techniques, electrochemiluminesc... and scanning probe techniques while also exploring COSMOL multiphysics simulation, electroanalysis in biomedical and clinical applications, and future prospects for electrochemical techniques. Chapters focus on evaluating redox reactions, biological interactions, kinetics, quorum sensing, biofilm formation, surface modification and more molecular aspects. This volume offers a deep-dive into the fundamental principles behind the latest electrochemical techniques, equipping researchers with practical guidance for their own experiments.Users will find this to be an ideal reference for researchers working across a range of disciplines including molecular biology, bioanalytical chemistry, biomedical science, and translational medicine.

  • Structural Biology of Ubiquitination

    From Mechanisms to Interventions
    • 1st Edition
    • Navaneet Chaturvedi + 1 more
    • English
    Structural Biology of Ubiquitination: From Mechanisms to Interventions provides an in-depth exploration of the structural and biophysical principles governing ubiquitination and their implications in diseases such as cancer and neurodegeneration. The book seamlessly integrates experimental insights with advanced computational methods, including AI-driven drug discovery, molecular modeling, and biophysical simulations, offering a comprehensive toolkit for researchers and clinicians. By bridging fundamental science with translational applications, the book empowers readers to design targeted therapeutics, understand disease mechanisms at the molecular level, and accelerate progress toward personalized medicine.

  • The Potential of Extracellular Vesicles from Plant and Animal Sources for Improving Human Beauty and Health

    • 1st Edition
    • Khalid Rehman Hakeem + 2 more
    • English
    The Potential of Extracellular Vesicles from Plant and Animal Sources for Improving Human Beauty and Health is a comprehensive resource that consolidates the latest research on the mechanisms of extracellular vesicles (EVs) and their applications in the cosmetic industry. The book explores a range of topics, including the latest techniques in isolation and characterization of EVs, safety considerations, methods, and challenges associated with large-scale production, and recent advancements in biomedical applications. The therapeutic potential of EVs for age-related neurological conditions and autoimmune skin diseases is investigated, as well as the application of EVs for skincare, hair loss and anti-aging products.The book considers EVs from a variety of sources, including humans, plants, animals and bacteria, highlighting their major differences. It also includes a discussion of market trends and the global impact for EV products in cosmetic and anti-aging industries. With growing interest in the role of extracellular vesicles in enhancing health and beauty, this book provides invaluable insights to researchers working in this field, equipping them with the knowledge to leverage EVs for innovative cosmetic applications and natural solutions.

  • Nerve Growth Factor

    From Neuron Development to Neurology
    • 1st Edition
    • Antonino Cattaneo + 1 more
    • English
    Nerve growth factor: From Neuron Development to Neurology, the latest release in the Molecular Mediators in Health and Disease series, offers a complete guide to nerve growth factor (NGF) across health and disease. Sections cover key properties, the latest advances, and biomedical applications of this neuropeptide. The book begins with an introduction and historical overview of the discovery of NGF before exploring its molecular characteristics. It then covers NGF in organ function, with chapters discussing the brain, immune system, blood vessels, heart, reproductive organs, teeth, and lungs. NGF pharmacology is then considered, with a focus on NGF as a therapeutic agent.The final section of the book covers NGF across diseases, including Alzheimer’s disease, cancer, diseases of the eye, chronic pain, and visceral disfunctions. Throughout the book, NGF is considered in the context of both mammalian and non-mammalian biology, making it an ideal reference for researchers working across the fields of cell biology, molecular biology, pharmacology, and other biomedical areas.

  • Flavoproteins and Flavoenzymes

    • 1st Edition
    • Volume 738
    • English
    Flavoproteins and Flavoenzymes, Volume 738 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Kirisu2 and KiPaD: global analysis of rapid flavoprotein redox kinetics from stopped-flow multi, ilagros Mendina, A Generic First Approach to Dissecting Flavoenzyme Catalytic Cycles, Removing Covalent Constraints of Protein Loops and Lids by a Split-Gene Strategy, Designing Oxygen Reaction Sites in Flavoprotein Dehydrogenases, Converting Noncovalent Flavoproteins into Covalently Flavinylated Proteins, Complexities of Riboflavin Biosynthesis, Reactions of Riboflavin Catabolism, and much more.Additional sections cover Ferredoxin-dependent thioredoxin reductase, Thermophilic Methylenetetrahydrof... Reductases, Ion-Pumping NADH:Quinone Oxidoreductase, Loading E. coli Dihydroorotate Dehydrogenase with Coenzyme Q, and Single-Component Halogenases.

  • Super-Resolution Nanoscopy for Protein Imaging

    • 1st Edition
    • Varun Vyas
    • English
    Super-Resolution Nanoscopy for Protein Imaging decodes the intricate world of protein visualization using cutting-edge nanoscopic techniques. This comprehensive guide is crafted to equip master students, PhD candidates, and early-stage researchers with essential knowledge and practical insights into advanced protein imaging technologies. The book covers foundational principles, innovative methodologies, and real-world applications, providing a complete resource for mastering the complexities of protein imaging. This book offers a unique compilation of diverse nanoscopic methods, overcoming the limitation of technique-specific texts currently available.By collecting scattered information into a single volume, it delivers an in-depth exploration of imaging techniques, from Atomic Force Microscopy (AFM) to Electron Microscopy (EM), and Single Molecule Fluorescence Imaging. Each section delves into instrumentation, sample preparation, data analysis, and the latest developments, making it an indispensable reference for understanding how to visualize proteins in their natural environments.

  • PACAP

    From Discovery to Function
    • 1st Edition
    • David Vaudry + 1 more
    • English
    PACAP: From Discovery to Function in Health and Disease serves as a comprehensive review covering all aspects of PACAP and its receptors, from expression to function in healthy tissues and disease models. The book introduces the biochemical, pharmacological and signaling properties of PACAP before exploring the biological actions of PACAP in normal health and pathological conditions. It considers PACAP in relation to various aspects, including pain, stress, brain injury, tumor cells and neurodegenerative disease. Effect on peripheral organs is also covered, from the gastrointestinal tract and cardiovascular system to immune cells and bones, among others. Therapeutic potential is also explored. This is a volume in the Molecular Mediators in Health and Disease book series, and provides a complete analysis of PACAP and the latest research in the field. Thus it is an ideal guide for researchers interested in PACAP and its impact across health and disease.

  • Advances in Applied Microbiology

    • 1st Edition
    • Volume 136
    • English
    Advances in Applied Microbiology provides a comprehensive overview of the latest research, innovations, and practical applications in the field of microbiology. Covering a broad spectrum of topics, this book explores recent advances in microbial biotechnology, environmental and industrial microbiology, medical and food microbiology, and emerging technologies. Each chapter highlights significant developments, challenges, and future directions, making it an invaluable resource for researchers, students, and professionals seeking to stay updated on the dynamic landscape of applied microbiology. With contributions from leading experts, this volume offers insights into the vital roles microorganisms play in various sectors, including health, agriculture, industry, and the environment.

  • Molecular and Cellular Biology Approaches and Applications in Modern Drug Discovery

    • 1st Edition
    • Mithun Rudrapal + 1 more
    • English
    Molecular and Cellular Biology Approaches and Applications in Modern Drug Discovery is an essential guide that bridges the latest advances in molecular and cellular biology to revolutionize drug discovery. The book explores a wide range of tools and techniques and their applications in drug discovery, including genetic engineering, gene therapy, regenerative medicine, developmental biology, molecular diagnostics, biomarkers, RNA therapeutics, molecular immunology, and vaccine development. The book also considers multi-omics approaches, biophysical methods, epigenetics and epigenomics, biomedical engineering, nanotechnology, artificial intelligence, bioinformatics, structural and computational approaches, and more.This comprehensive volume covers critical domains such as transcriptomics, proteomics, genomics, genetics, and cell signaling pathways, providing an in-depth understanding of their pivotal roles in drug development. It is an invaluable reference for researchers and advanced students working in these areas across molecular biology, biochemistry, pharmacology, biotechnology, and related fields.

  • Bio-Click Chemistry

    Expanding Horizons Beyond the Click
    • 1st Edition
    • Flavia Zacconi + 2 more
    • English
    Bio-Click Chemistry: Expanding Horizons Beyond the Click delves into the dynamic intersection of biocatalysis and click chemistry, providing a comprehensive exploration of these rapidly evolving fields. This book offers in-depth insights into both historical perspectives and the latest advancements, ensuring readers gain a thorough understanding of fundamental principles, practical applications, and future directions. Readers will discover the versatile applications of biocatalysis and click chemistry in pharmaceuticals, biotechnology, biology, biomedicine, nanomedicine, and materials science, equipping researchers, educators, and industry professionals with the tools and techniques needed to foster innovation and real-world impact. Furthermore, the book investigates the emerging trends, challenges, and opportunities in biocatalysis and click chemistry, empowering readers to stay ahead of the curve and drive transformative developments in chemical synthesis and enzymatic engineering. This indispensable guide is designed for researchers, educators, and industry professionals dedicated to advancing their work and exploring new frontiers in chemical synthesis and biocatalytic processes.

  • Computational and Experimental Approaches in Protein Engineering and Design

    • 1st Edition
    • Aditya Kumar Padhi + 1 more
    • English
    Computational and Experimental Approaches in Protein Engineering and Design offers a one-stop resource for students, researchers, and practitioners. Cutting-edge techniques in AI and machine learning applications are expertly covered in the book, empowering readers with the tools they need to tackle modern challenges in biotechnology and therapeutics. Step-by-step protocols provide readers with actionable guidance to transition smoothly from computational modelling to laboratory implementation. The inclusion of real-world case studies makes the theoretical concepts relatable and actionable and immediately applicable to solving complex problems, such as producing protein-based vaccines for immunotherapy.The book’s focus on synthetic biology positions it at the forefront of innovation, appealing to a broad audience, from those involved in tissue engineering to those exploring next-generation therapeutics. With its forward-looking approach, emphasizing machine-learning-dri... protein design and nanobody engineering, this book is an indispensable resource for researchers preparing to navigate the future of biotechnology.

  • Nano Meets Micro

    Revolutionizing Medicine through Microfluidic Devices
    • 1st Edition
    • Fatemeh Hataminia + 1 more
    • English
    Nano Meets Micro: Revolutionizing Medicine through Microfluidic Devices explores the transformative potential of integrating nanotechnology with microfluidics to revolutionize medical diagnostics, treatment, and personalized medicine. The book provides a detailed examination of how these cutting-edge technologies are making healthcare more precise, efficient, and personalized. Sections highlight nanomedicine and microfluidics, highlighting their importance in healthcare and their intersection with advanced healthcare solutions. It covers traditional and emerging fabrication techniques for microfluidic devices, the design and synthesis of nanoparticles, and the integration of nanomedicine into microfluidic systems. Examples and case studies illustrate how these technologies are used in drug delivery, disease diagnosis, and rapid diagnostics.With a strong focus on future implications, the book discusses emerging trends and potential advances in microfluidics and nanotechnology, including the integration of artificial intelligence and data analytics. It addresses the challenges and future directions in the commercialization of nanomedicine and microfluidic devices, providing a roadmap for translating laboratory innovations into clinical applications.

  • Capsule Endoscopy in Pediatric Patients from Theory to Practice

    • 1st Edition
    • Thomas M. Attard
    • English
    Capsule Endoscopy in Pediatric Patients from Theory to Practice is a practical and authoritative guide that empowers pediatric gastroenterologists, physicians, and trainees to navigate the complexities of Video Capsule Endoscopy (VCE) in children. With a focus on bridging knowledge gaps and providing practical insights, this book offers updated information on understanding and utilizing VCE in the pediatric population. The book covers the background and technical aspects of VCE, including guidance on setting up a pediatric VCE service and an overview of indications and limitations. It delves into practical aspects such as preprocedural preparation, artifact reduction techniques, and management of capsule retention. By exploring VCE in various disease conditions such as inflammatory bowel disease, gastrointestinal bleeding, hereditary polyposis syndromes, and chronic abdominal pain, readers gain a comprehensive understanding of diagnosis, surveillance, and management. Special content elements, including key terms, case studies, and a timeline of recent advances, enhance the learning experience. This essential resource empowers readers to optimize patient care, make informed decisions, and confidently navigate the realm of VCE in children.

  • Acute Myocardial Infarction in Young Women

    Understanding its Mechanisms and Management
    • 1st Edition
    • Stéphane Peggy Manzo-Silberman
    • English
    Acute Myocardial Infarction in Young Women: Understanding its Mechanisms and Management serves as a seminal reference for understanding the current landscape of cardiovascular health in young women, highlighting clinical areas that require focused attention. By customizing the information to their unique physiological and clinical differences, more precise and effective interventions will lead to improved outcomes. The information is meticulously updated to address the specific cardiovascular health issues encountered by young women with myocardial infarction. This ensures that each stage of care—from cardiovascular risk assessment and symptom-recognition to the acute myocardial infarction (AMI) pathway, and rehabilitation follow-up—is optimized.Ultimately... this book equips health professionals with the most current and evidence-based information, enabling them to deliver the highest standard of care for young women with myocardial infarction. It will enhance quality of care, and contribute to improved health outcomes for young women across all stages of the cardiovascular healthcare continuum.

  • Pediatric Substance Exposure

    • 1st Edition
    • Ju Lee Oei
    • English
    Pediatric Substance Exposure is a crucial resource for medical practitioners focusing on the long-term management of children exposed to addictive substances during pregnancy. It provides guidance on supporting families affected by substance abuse, starting with a comprehensive overview of epidemiology and global policy. The book examines various substances and their impact on children, discussing fetal management, infant and child care, and addressing family needs as the child grows. Beyond the basics, the book reviews social aspects, future research, and policy needs. Clinicians and researchers will find it invaluable for evidence-based decision-making and optimal treatment strategies.

  • Modern Bioinformatics

    From Molecular Insights to Biomedical Innovation
    • 1st Edition
    • Kolla Bhanu Prakash + 2 more
    • English
    Modern Bioinformatics: From Molecular Insights to Biomedical Innovation explores the rapidly advancing field of bioinformatics, addressing a critical gap in current literature by integrating quantum biology and quantum biosensors with computational bioinformatics. The book offers a thorough exploration of bioinformatics from foundational concepts to translational applications. It begins with molecular structures of proteins, DNA, and RNA, advancing through nano-molecular visualization and structural domain analysis. Readers gain insights into deep learning techniques like AlphaFold for protein structure prediction, AI applications in genomics, and molecular interactions critical to function. The text further covers computational methods in drug discovery, forensic bioinformatics, and molecular evolution.A unique emphasis is placed on the convergence of nanotechnology and quantum innovations in molecular diagnostics and biosensing, including quantum biosensors and quantum computing applications. The final sections focus on computational strategies for drug target identification, biomarker discovery, and clinical trial analysis, providing a holistic view of modern bioinformatics workflows. This book is an indispensable reference for advanced researchers, graduate students, and professionals in bioinformatics, molecular biology, and biomedical engineering seeking to integrate quantum computing and nanotechnology into their work.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 135
    • English
    Advances in Clinical Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Ecology of Marine Rocky Shores

    • 1st Edition
    • Volume 105
    • English
    Ecology of Marine Rocky Shores, Volume 105 in the Advances in Marine Biology series, highlights new advances in the field, presenting comprehensive chapters written by an international board of authors. This volume explores key ecological processes shaping rocky shore environments, including the impacts of plastic pollution, the dynamics of warm-temperate and subtropical systems, and the roles of foundation species and community interactions.Additio... chapters examine conservation planning, kelp ecology and restoration, fisheries and indigenous knowledge, and the influence of ocean rafting on species distribution. The volume also addresses spatial and network approaches to ecology, coastal marine microbiology, and the ecological impacts of invasive species. Together, these contributions provide an integrated perspective on the structure, function, and resilience of rocky shore ecosystems, offering valuable insights for researchers, marine ecologists, and environmental scientists.

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