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Books in Life sciences

Elsevier's Life Sciences collection helps researchers get comprehensive coverage and up-to-date information on the study of living organisms, their processes, and interrelationships, spanning disciplines like biology, genetics, and biochemistry, and addressing emerging trends such as genomics, biotechnology, and sustainability, essential for advancing knowledge and driving innovation in the field.

  • Advances in Microbial Physiology

    • 1st Edition
    • Volume 90
    • English
    Advances in Microbial Physiology series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.
  • Functioning Neuroendocrine Tumors and Paraneoplastic Endocrine Syndromes

    • 1st Edition
    • Volume 135
    • English
    Volume 135, Functioning Neuroendocrine Tumors and Paraneoplastic Endocrine Syndromes, provides a comprehensive and contemporary overview of the biology, clinical presentation, diagnosis, and management of hormone-secreting neuroendocrine neoplasms and endocrine paraneoplastic syndromes. Functioning neuroendocrine tumors (NETs) represent a unique group of neoplasms characterized by excessive hormone production, leading to diverse and often complex clinical syndromes that require a multidisciplinary approach. At the same time, paraneoplastic endocrine syndromes, resulting from ectopic hormone secretion by non-endocrine malignancies, remain important diagnostic and therapeutic challenges due to their rarity, heterogeneous manifestations, and significant impact on patient outcomes. This volume integrates recent advances in molecular biology, endocrine physiology, functional imaging, pathology, biomarkers, genetics, and precision medicine to provide an evidence-based approach to these disorders. Chapters cover the epidemiology, pathophysiology, diagnostic algorithms, localization techniques, medical and surgical treatment, peptide receptor radionuclide therapy, targeted therapies, and long-term follow-up of patients with functioning NETs, including insulinomas, gastrinomas, glucagonomas, VIPomas, somatostatinomas, ACTH-producing tumors, and other rare hormone-secreting neoplasms. In addition, the volume comprehensively reviews endocrine paraneoplastic syndromes such as ectopic Cushing syndrome, humoral hypercalcemia of malignancy, SIADH, tumor-induced hypoglycemia, and other ectopic hormone secretion syndromes, emphasizing early recognition and optimal multidisciplinary management.
  • Mitochondria Part B

    • 1st Edition
    • Volume 217
    • English
  • Advances in Agronomy

    • 1st Edition
    • Volume 204
    • English
    Advances in Agronomy, Volume 204, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field, each written by an international board of authors.
  • Aging and Troponin

    Clinical Implications and Uses Beyond Diagnosis
    • 1st Edition
    • Gary Tse + 3 more
    • English
    Aging and Troponin: Clinical Implications and Uses Beyond Diagnosis examines the multifaceted role of troponin in clinical medicine, with a special focus on aging. This comprehensive reference provides essential technical knowledge, diagnostic and prognostic applications, and model development insights from leading experts in clinical biochemistry, pathology, and epidemiology. The book emphasizes the impact of aging on troponin test results and their interpretation, addressing age-related disorders such as renal failure. Sections cover the technical aspects of troponin assays, comparing traditional and high-sensitivity assays and exploring point-of-care testing advancements.The book also examine age-related changes and intra- and inter-individual variability in troponin levels, focuses on diagnostic applications, including troponin as a biomarker for cardiac injury and dysfunction, and the effects of age, sex, and renal impairment on diagnostic sensitivity and specificity, and discusses troponin's prognostic value for mortality in various conditions, including heart disease, sepsis, and COVID-19, and its role as a marker of organ biological age. The final section offers cutting-edge insights into the clinical applicability of troponin testing, highlighting the benefits of incorporating high-sensitivity assays into clinical workflows and providing perspectives and age-related considerations from practicing physicians on implementation and evidence-based practice.
  • Evidence Based Diagnosis and Management of Testicular Tumors

    • 1st Edition
    • Axel Heidenreich
    • English
    Evidence Based Diagnosis and Management of Testicular Tumors is a comprehensive reference that addresses the current needs of urologists, oncologists, and related specialists involved in testicular cancer care. This book synthesizes the latest research, clinical guidelines, and expert insights to facilitate accurate diagnosis, staging, and personalized treatment strategies. It emphasizes a multidisciplinary approach, integrating pathology, molecular genetics, imaging, and surgical techniques, to optimize patient outcomes and minimize long-term toxicity. The contents are organized into key sections covering epidemiology, pathology, staging, diagnostic evaluation, disease management, and follow-up. Each chapter begins with case scenarios and interactive questions, fostering active learning and decision-making skills. The book also dedicates sections to rare tumors and pediatric cases, ensuring broad applicability across age groups and tumor types. Visual content, including figures, flow charts, tables, and videos, enhances comprehension and procedural training. This reference aims to bridge the knowledge gap in current testicular cancer management, providing practitioners with practical, guideline-conforming advice. It supports clinicians in delivering individualized, risk-adapted care, ultimately improving survival rates and quality of life for patients. By combining expert perspectives with evidence-based protocols, this book serves as an essential resource for advancing clinical practice in testicular oncology.
  • Implications of Artificial Intelligence in Next Generation Physiotherapy

    • 1st Edition
    • Manpreet Kaur + 3 more
    • English
    Implications of Artificial Intelligence in Next Generation Physiotherapy explores how artificial intelligence is transforming the future of physiotherapy across the entire continuum of rehabilitation. Covering musculoskeletal, neurological, cardiopulmonary, sports, paediatric, geriatric, women's health, and community-based physiotherapy, the book highlights how AI is reshaping clinical practice through intelligent assessment, precision rehabilitation, personalized treatment planning, predictive analytics, remote monitoring, and data-driven clinical decision-making.The book presents comprehensive coverage of emerging AI technologies, including machine learning, deep learning, computer vision, wearable sensors, robotics, virtual and augmented reality, digital twins, tele-rehabilitation, and intelligent clinical decision support systems. It also discusses workload monitoring, movement analysis, biomechanical assessment, functional outcome prediction, patient engagement, and continuous recovery tracking, supported by current research, real-world applications, and clinical case studies.Designed for researchers, clinicians, educators, students, and healthcare innovators, this book bridges the gap between cutting-edge artificial intelligence and evidence-based physiotherapy practice. By examining both current applications and future directions, it provides readers with the knowledge required to implement AI-driven innovations that enhance diagnostic accuracy, optimize rehabilitation outcomes, improve healthcare accessibility, and advance patient-centred care in the next generation of physiotherapy.
  • Therapeutic Horizons in Non-Small Cell Lung Cancer

    AI-Driven Innovations in Diagnosis and Treatment
    • 1st Edition
    • Vaishali Aggarwal + 3 more
    • English
    Therapeutic Horizons in NSCLC: AI-Driven Innovations in Diagnosis and Treatment explores how artificial intelligence transforms the diagnosis and management of non-small cell lung cancer (NSCLC). The book offers an interdisciplinary overview of NSCLC biology, diagnostics, and therapeutic strategies, emphasizing AI and machine learning applications. It covers molecular pathogenesis, biomarkers, personalized therapies, and cutting-edge AI-driven tools integrated into clinical workflows. The content provides insights into global clinical practices, emerging precision medicine approaches, and innovative AI techniques such as predictive modeling and genomic data integration. It aims to bridge the gap between technological advances and clinical application, offering practical guidance for implementation. The book also addresses disparities in NSCLC care and promotes equitable, data-driven solutions for improved patient outcomes. This resource benefits clinicians, researchers, and data scientists by enhancing understanding of AI’s role in early detection, targeted therapies, and prognosis. It equips readers with actionable knowledge to translate AI innovations into real-world clinical and research settings, fostering collaboration across disciplines.
  • Metabolic Challenges in Cancer Treatment

    Precision Oncology in Diabetes and Radiotherapy
    • 1st Edition
    • Alok Raghav + 4 more
    • English
    Metabolic Challenges in Cancer Treatment: Precision Oncology in Diabetes and Radiotherapy presents an interdisciplinary academic reference that examines the complex interplay between diabetes mellitus, metabolic dysregulation, and radiotherapy outcomes in cancer patients. The book positions metabolic health as a critical determinant of therapeutic efficacy, toxicity, and survival, offering a timely contribution to precision oncology. The volume integrates endocrinology, radiation oncology, metabolism, and clinical medicine to explore pathophysiological mechanisms, radiotherapy‑induced metabolic alterations, glycemic control strategies, nutritional management, pharmacologic interactions, and personalized radiotherapy approaches. It combines mechanistic insights with clinical trial data, real‑world case discussions, and emerging research directions. For its academic audience, the book provides a unified framework that bridges bench‑to‑bedside translation, supports evidence‑based clinical decision‑making, and advances interdisciplinary research. It serves as a comprehensive resource for improving patient‑oriented outcomes and quality of life in cancer patients with metabolic comorbidities.
  • Biosynthesis

    • 1st Edition
    • Volume 749
    • English
    In this volume on Biosynthesis, we focus on “unusual enzyme reactions in natural products biosynthesis”. We used the broadest possible definition of the scope of mechanistic biology and biosynthesis to bring in contributors from diverse scientific areas. The articles presented here survey a broad range of enzyme reactions in natural product biosynthesis. We appreciate the valuable contributions from all the authors, and hope that readers can enjoy and learn a lot from these articles.
  • Deep Learning Approaches for Healthcare Data Analysis and Decision Making

    • 1st Edition
    • Ashish Bagwari + 5 more
    • English
    Deep Learning Approaches for Healthcare Data Analysis and Decision Making demystifies complex data-driven technologies, providing a clear framework for integrating advanced analytics into healthcare practices. With a focus on practical applications, the authors present a comprehensive digital transformation methodology that empowers readers to tackle the multifaceted challenges of healthcare data management. By leveraging deep learning techniques, readers will learn to analyze vast datasets, identify critical patterns, and develop predictive models that enhance diagnosis and treatment strategies while ensuring compliance with stringent data regulations. The book also addresses the pressing need for ethical AI practices, emphasizing patient privacy and data security.Real-world case studies illustrate how to implement personalized healthcare solutions and foster interdisciplinary collaboration, breaking down silos in knowledge and practice. Moreover, it explores innovative business models for sustainable AI integration, offering actionable insights for healthcare providers. This resource equips professionals with the tools to drive innovation, improve patient outcomes, and navigate the complexities of digital transformation in healthcare, making it a must-read for anyone at the intersection of technology and healthcare.
  • Artificial Intelligence in Point-of-Care Nanobiosensors Technology

    Enhancing Disease Diagnostics and Improved Healthcare Outcomes
    • 1st Edition
    • Tharmaraj Vairaperumal + 2 more
    • English
    Artificial Intelligence in Point-of-Care Nanobiosensors Technology: Enhancing Disease Diagnostics and Improved Healthcare Outcomes delves into the revolutionary integration of artificial intelligence (AI) with nanobiosensors to elevate point-of-care (POC) diagnostics for both communicable and non-communicable diseases. Readers will find insightful chapters covering topics ranging from foundational AI and machine learning techniques to specific applications in cardiovascular disease, diabetes, cancer, chronic respiratory ailments, and infectious diseases. Each chapter not only highlights recent breakthroughs in nanobiosensors but also emphasizes the pivotal role of AI in enhancing diagnostic accuracy and facilitating personalized health interventions. Additional discussions around regulatory considerations and the future landscape of AI in biomedical research make this an essential read for those navigating this rapidly evolving field. This book primarily targets researchers and professionals engaged in the interdisciplinary realms of AI, nanomaterials, and biomedical sciences. By providing a critical understanding of emerging AI-based diagnostic technologies and their applications in POC settings, this book fosters collaboration across diverse scientific domains.
  • Research Methods

    Principles in Practice
    • 1st Edition
    • Samy A. Azer
    • English
    Research Methods: Principles in Practice provides undergraduate research students, novice researchers, and instructors with engaging approaches to understanding research and how to apply and use different research methods. The book helps students develop skills in conducting literature searches, reading literature, designing research projects, selecting research methods, collecting data, interpreting findings, and writing research reports. Topics covered include research philosophy; study design; developing research questions; the use of theories in research; research ethics; qualitative, quantitative, and mixed-methods research; social media research; and writing a research report. The book provides practical activities, model answers at the end of each chapter, and further reading, enabling students to gain a deeper understanding of research methods and to master their application.
  • Modern Bioinformatics

    From Molecular Insights to Biomedical Innovation
    • 1st Edition
    • Kolla Bhanu Prakash + 2 more
    • English
    Modern Bioinformatics: From Molecular Insights to Biomedical Innovation explores the rapidly advancing field of bioinformatics, addressing a critical gap in current literature by integrating quantum biology and quantum biosensors with computational bioinformatics. The book offers a thorough exploration of bioinformatics from foundational concepts to translational applications. It begins with molecular structures of proteins, DNA, and RNA, advancing through nano-molecular visualization and structural domain analysis. Readers gain insights into deep learning techniques like AlphaFold for protein structure prediction, AI applications in genomics, and molecular interactions critical to function. The text further covers computational methods in drug discovery, forensic bioinformatics, and molecular evolution.A unique emphasis is placed on the convergence of nanotechnology and quantum innovations in molecular diagnostics and biosensing, including quantum biosensors and quantum computing applications. The final sections focus on computational strategies for drug target identification, biomarker discovery, and clinical trial analysis, providing a holistic view of modern bioinformatics workflows. This book is an indispensable reference for advanced researchers, graduate students, and professionals in bioinformatics, molecular biology, and biomedical engineering seeking to integrate quantum computing and nanotechnology into their work.
  • Bioinformatics, Computational Biology, and Multi-Omics–Driven Probiotic Design for Gut Microbiome Engineering

    • 1st Edition
    • Naheed Mojgani + 3 more
    • English
    Bioinformatics, Computational Biology, and Multi Omics–Driven Probiotic Design for Gut Microbiome Engineering presents an interdisciplinary framework for applying artificial intelligence to microbiome science, probiotic development, and personalized nutrition. The book integrates bioinformatics, computational biology, and clinical insight to address current challenges in gut microbiome research and translation. The volume covers AI driven microbiome profiling, multi omics integration, computational modeling of host–microbe interactions, and predictive analytics. It progresses from foundational concepts to advanced applications, including AI assisted probiotic design, gut–brain axis research, regulatory considerations, and real world case studies supporting translational and clinical relevance. The book equips bioinformaticians, translational microbiome researchers, and clinician scientists with actionable methodologies, conceptual clarity, and validated examples. It supports evidence based decision making, accelerates translational research, and bridges discovery science with implementation in personalized nutrition and probiotic innovation.
  • Wearable Sensors for Healthcare Monitoring

    Smart Tools for Real-time Applications
    • 1st Edition
    • Pushpesh Ranjan + 1 more
    • English
    Wearable Sensors for Healthcare Monitoring: Smart Tools for Real-time Applications addresses the growing need for advanced diagnostic tools amid increasing global health challenges. The reference explores state-of-the-art wearable biosensors that enable non-invasive, continuous, and real-time monitoring of disease biomarkers in biofluids such as sweat, saliva, and tears. This technology offers promising solutions to overcome limitations of conventional diagnostics, providing sensitive, portable, and user-friendly healthcare management tools. The contents cover fundamental to advanced topics including nanoengineered materials, design and fabrication methods, classifications of biosensors, and detection techniques for various biomarkers. Additional chapters focus on applications in diabetic care, inflammatory biomarker monitoring, wound healing, infectious disease detection, personalized nutrition, and integration with intelligent wireless technologies.The book also addresses self-powered wearable devices and market commercialization prospects, offering a holistic view of the wearable biosensor landscape. This books benefits researchers, academicians, clinicians, diagnostic laboratories, and industry professionals by delivering comprehensive insights into the design, development, and application of wearable biosensors. It serves as a valuable platform for innovation, enabling the creation of high-performance, affordable, and smart diagnostic tools that can transform personalized healthcare and point-of-care monitoring.
  • Contemporary Practice in Clinical Chemistry

    • 5th Edition
    • William Clarke + 1 more
    • English
    Contemporary Practice in Clinical Chemistry, Fifth Edition is a comprehensive, updated reference and teaching resource focused on Laboratory Medicine, specifically tailored for clinical chemistry faculty, trainees, clinical laboratory scientists, clinical pathologists, and laboratory managers. Edited by renowned experts, the book integrates cutting-edge developments in clinical chemistry with practical applications for professional practice. This new edition covers foundational and advanced topics in clinical chemistry and laboratory medicine, emphasizing the integration of new technologies and methodologies. It addresses precision medicine, medical biotechnology, and artificial intelligence applications within the clinical laboratory setting. The content is designed to support both learning and board exam preparation, providing a deep understanding of the field alongside practical insights.
  • Microbiome-Modulating Strategies in Diabetic Wound Healing

    • 1st Edition
    • Jeena Gupta + 2 more
    • English
    Microbiome-Modulatin... Strategies in Diabetic Wound Healing provides researchers with an in-depth analysis of the wound microbiome’s role in diabetic foot ulcers and chronic wound pathology. This reference elucidates microbial dysbiosis, biofilm formation, and host–microbe interactions that exacerbate impaired healing in diabetic patients. It critically evaluates emerging microbiome-targeted interventions—includ... probiotics, bacteriophages, antimicrobial peptides, and nanotechnology-enabl... drug delivery—supported by the latest molecular, microbiological, and clinical research. The book integrates advanced diagnostic methodologies such as next-generation sequencing and bioinformatics to facilitate precise microbial profiling and personalized therapeutic design. By bridging mechanistic insights with translational and clinical evidence, this resource equips diabetic researchers with comprehensive knowledge to innovate and optimize microbiome-based strategies, ultimately aiming to reduce infection rates, combat antibiotic resistance, and improve regenerative outcomes in diabetic wound management.
  • Intelligent Gait Assistive Technologies

    Gait Biomechanics and Machine Learning Applications in Rehabilitation and Injury Prevention
    • 1st Edition
    • Rezaul Begg + 1 more
    • English
    Intelligent Gait Assistive Technologies: Gait Biomechanics and Machine Learning Applications in Rehabilitation and Injury Prevention brings together contemporary research and applications to show how gait biomechanics combined with machine learning can be used to develop techniques to provide safer, more mechanically efficient locomotion to individuals with significant visual, musculoskeletal, or neurological deficits. Developments in gait rehabilitation and injury prevention outlined in this book will contribute to improved quality of life for individuals with gait-related impairments, with a major contribution to medical cost savings due to reduction in falls.Researchers, engineers, and students in biomedical engineering and biomechanics will find this a welcomed reference in better understanding the role of machine learning and intelligent technologies in the advancement of gait rehabilitation and injury reduction to both impaired and healthy individuals.
  • Basics of Sleep Technology

    Fundamentals of Sleep Technology
    • 1st Edition
    • Ravi Gupta + 2 more
    • English
    Basics of Sleep Technology: Fundamentals of Sleep Technology covers the critical elements of sleep and sleep technologies. The book gives a thorough understanding of sleep physiology, neurophysiological concepts, the principles of operation of the numerous equipment types used to diagnosis sleep disorders, and contemporary methodologies for diagnosing sleep disorders. As sleep professionals must understand the fundamentals of signal creation, acquisition principles, and data grading from a sleep diary, actigraphy, and polysomnography, this book provides all of this and more to anyone wishing to develop a comprehensive understanding of sleep.The book underscores that sleep medicine and technology are dynamic and rapidly growing medical specialties, and that one must stay up with the newest innovations in the area, but not at the price of the fundamentals. Users will find a solid background on cutting-edge advances in sleep medicine, diagnostics, monitoring, and therapeutics.
  • Shared Research Resources

    Best Practices in Management and Administration
    • 1st Edition
    • Joshua Z. Rappoport + 1 more
    • English
    Shared Research Resources: Best Practices in Management and Administration brings together best practices and case studies from research institutions around the world. Covering all areas of management, with examples and applications specific to the research environment, this is the perfect reference to build managerial skills. The first part is dedicated to introducing Shared Research Resources (SRR) management. The second part covers all aspects of staffing. Part three contains complete coverage of operations, including service development, instrument procurement, marketing, management software, customer support, safety, maintenance and repair. Part four is dedicated to fiscal management, budgeting, and reporting.Part five covers strategic management. Part six is devoted to the sustainability of the core facility. The final part covers assessment, including annual reports, program reviews, and audits. This book is a complete reference targeted at SRR managers and staff who need to keep updated with current best practices and case studies. It is also important reading for research institution managers and function leaders.
  • The AI Biotech Breakthrough

    Innovating Life with Intelligent Machines
    • 1st Edition
    • Dibyajit Lahiri + 4 more
    • English
    The AI Biotech Breakthrough: Innovating Life with Intelligent Machines explores how artificial intelligence is revolutionizing the fields of genomics, biochemistry, and biotechnology. With an emphasis on practical implementation and cross-disciplinary integration, this book provides researchers with a forward-looking roadmap for applying AI tools in biological research and life science innovation. Chapters cover foundational AI concepts tailored for biologists and explore their applications across key biotechnology domains. Readers will find detailed analysis of how machine learning and computational methods accelerate drug discovery, optimize genomic and proteomic data interpretation, and enable novel approaches in metabolic engineering and synthetic biology. Additional topics include AI-driven diagnostics, personalized medicine, bioprocess optimization, and the use of AI in agricultural biotechnology and microbial systems. Each chapter includes real-world case studies, method summaries, and discussions of emerging trends, providing a high-value guide for researchers at the interface of biology and data science. This book is a valuable resource for geneticists, biotechnologists, computational biologists, systems biologists, bioinformaticians, and graduate students seeking to harness the power of AI for transformative impact across the life sciences.
  • Cancer Progression and the Immune System

    Mechanisms, Microenvironment, and Immunotherapy
    • 1st Edition
    • Pranav Kumar Prabhakar + 3 more
    • English
    Cancer Progression and the Immune System: Mechanisms, Microenvironment, and Immunotherapy examines the dynamic interplay between cancer and immunity, highlighting how immune responses shape tumor growth and therapeutic outcomes. The book explores immune surveillance, tumor immunoediting, and evasion strategies, alongside the role of the tumor microenvironment, chronic inflammation, and immunosuppressive factors. It provides detailed coverage of cutting-edge immunotherapies, including checkpoint inhibitors, CAR-T cell therapy, cancer vaccines, and NK cell-based approaches, as well as molecular and cellular insights into immune regulation. Designed for oncologists, immunologists, and researchers, this resource bridges foundational immunology with translational applications. It equips readers with knowledge of emerging therapies, biomarkers, and systems-level approaches, offering a roadmap for innovative cancer treatment strategies.
  • Algal Bioprospecting and Bioprocessing

    Current Trends and Future Perspectives
    • 1st Edition
    • Nitin Trivedi + 1 more
    • English
    Algal Bioprospecting and Bioprocessing: Current Trends and Future Perspectives explores the rapidly evolving field of algal biotechnology and emphasizes the increasing importance of marine and freshwater algae as sustainable sources of bioproducts. By highlighting recent advancements and industrial applications, it aims to promote translational research and promote a circular bioeconomy within the blue economy framework. The book covers a wide array of topics, including algal biomass processing, bioactive metabolites, proteins, pigments, and biorefinery strategies. Key chapters look into advanced extraction techniques, genetic engineering, and the development of high-value products such as omega-3 fatty acids, oligosaccharides, and biopolymers. The book also explores the role of algae in sustainable agriculture, aquaculture, biofuel production, and space missions, providing a holistic view of current research and future prospects. Algal Bioprospecting and Bioprocessing: Current Trends and Future Perspectives is primarily for university students, academics, researchers, and professionals interested in applied phycology and marine biotechnology. This book also appeals to aspiring algapreneurs, industry experts, and policymakers. It encourages a scientific approach to harnessing algae’s societal benefits and promotes understanding of innovative technologies transforming micro- and macroalgae into valuable industrial products within a sustainable, circular economy.
  • Accurate Results in the Clinical Laboratory

    A Guide to Error Detection and Correction
    • 3rd Edition
    • Amitava Dasgupta + 1 more
    • English
    Accurate Results in the Clinical Laboratory:A Guide to Error Detection and Correction, 3rd Edition continues to be an in-depth resource of common sources of errors in clinical laboratories. It provides strategies to avoid pre-analytical errors, including patient preparation, specimen collection, and anticoagulant use and Insights into major sources of pre-analytical errors such as sample processing and specimen misidentification. This book is an essential reference for professionals and students aiming to enhance accuracy and reliability in clinical laboratory testing. This new edition has fully updated chapters and new information on how to eliminate lab errors including avoiding post analytic phase of reporting results through laboratory informatics system. This is a guide for laboratory professionals and clinicians regarding sources of errors and misinterpretation in the clinical laboratory and how to resolve such errors and identify discordant specimens. Accurate laboratory result interpretation is essential for patient safety. This book is intended as a practical guide to laboratory professionals and clinicians who deal with erroneous results on a regular basis.
  • Coronary Physiology in the Cardiac Cath Lab

    • 1st Edition
    • William F. Fearon
    • English
    Coronary Physiology in the Cardiac Cath Lab provides the foundational knowledge required to understand the concepts behind a variety of coronary physiologic assessments performed and required to apply them effectively when evaluating cardiac patients. Written to bring a practical and evidence-based approach, this book is a valuable resource for interventional and general cardiologists, cardiology researchers, physicians, cardiac catheterization laboratory staff, and anyone interested in understanding the theory and current practice surrounding assessing coronary physiology in the cardiac cath lab.Over the past decade, there has been an explosion of data validating the importance of assessing coronary physiology at the time of coronary angiography. This has led to the development of numerous new techniques and metrics for performing these assessments and also resulted in the inclusion of these indices into practice guidelines.
  • Integrating AI in Psychological and Mental Health Care

    Techniques, Applications, and Ethical Considerations
    • 1st Edition
    • Sandeep Kautish + 4 more
    • English
    Integrating AI in Psychological and Mental Health Care: Techniques, Applications, and Ethical Considerations introduces key concepts and the historical evolution of AI, providing a foundation for understanding its applications in mental health. The content delves into various aspects of AI, including diagnostic tools, machine learning algorithms, and natural language processing, highlighting their roles in enhancing therapeutic outcomes and improving patient care. The discussion encompasses significant mental health conditions such as anxiety, depression, and severe psychological disorders, showcasing how AI technologies can assist in diagnosis, treatment planning, and monitoring. Ethical considerations and privacy issues are critically examined, ensuring a balanced perspective on the benefits and challenges associated with AI-driven interventions. Practical applications, such as virtual psychotherapists and AI-enhanced cognitive behavioral therapy illustrate real-world implementations and their impact on patient care. Additionally, case studies provide insights into successful AI applications in mental health settings, thus enhancing our understanding of potential advantages and obstacles.
  • Advances in Pancreatic Cancer Immunotherapy

    • 1st Edition
    • Vivek P. Chavda + 2 more
    • English
    Advances in Pancreatic Cancer Immunotherapy explores cutting-edge strategies to combat one of the most lethal malignancies. This book provides a focused, comprehensive resource on immunotherapy innovations for pancreatic cancer. It examines the tumor microenvironment, mechanisms of immune evasion, and the latest therapeutic modalities, including immune checkpoint inhibitors, cancer vaccines, and adoptive cell therapies. Chapters cover clinical and preclinical studies, combination strategies, biomarker-driven personalization, and regulatory considerations, offering a deep dive into both foundational science and translational applications. For researchers, clinicians, and graduate students, this book delivers actionable insights into overcoming treatment resistance, integrating immunotherapy into clinical practice, and shaping future research directions. It serves as an essential reference for understanding and applying immunotherapeutic advances to improve patient outcomes.
  • Nanocarriers for Targeted Therapy and Management of Liver Cancer

    • 1st Edition
    • Devesh U. Kapoor + 2 more
    • English
    Nanocarriers for Targeted Therapy and Management of Liver Cancer presents a comprehensive academic overview of nanocarrier‑based strategies for addressing the biological, pharmacological, and translational challenges of liver cancer. The book positions nanomedicine as a critical enabler of targeted, safer, and more effective therapies for hepatocellular carcinoma and related malignancies. The volume systematically covers major nanocarrier platforms alongside emerging approaches such as AI‑assisted design, pharmacokinetic modeling, nanotoxicology, clinical translation, and regulatory considerations. Each chapter integrates foundational concepts with current research, clinical trial insights, and future outlooks to ensure coherence and academic rigor. For researchers and graduate‑level learners, the book provides an authoritative reference that bridges nanocarrier design, liver‑specific biology, and translational feasibility. It supports advanced study, interdisciplinary research, and informed innovation in precision nanomedicine for liver cancer.
  • Smart Microscopy, AI, and Robotics

    Automated Future Disease Detection
    • 1st Edition
    • Priyadarshini Pattanaik + 2 more
    • English
    Smart Microscopy, AI, and Robotics: Automated Future Disease Detection addresses the need to combine automated microscopy with artificial intelligence and robotics to improve accuracy, throughput, and safety in disease detection. It surveys methods for image acquisition, processing, segmentation, and interpretation across sample types, including blood smears, tissue biopsies, cytology, and cytopathology, equipping researchers, clinicians, and technologists with actionable knowledge for deploying AI-powered diagnostic pipelines.The book covers foundational principles and advanced applications, beginning with microscopy and contrast-enhanced imaging, followed by automated microscope–robotics integration, image acquisition and analysis pipelines, and AI methods for disease detection. It then explores applications such as blood disorders, infectious diseases, and cancer diagnostics, including AI-based analysis of neurological and cellular imaging, advanced deep-learning architectures, and foundation models for smart microscopy. System-level considerations address performance metrics, explainability, bias mitigation, ethics, clinical governance, regulation, safety, and human–AI interaction and interoperability. The book also examines AI-enabled drug discovery, therapeutic target identification, smart laboratories, automated diagnostics, and global health impact.Readers will gain practical guidance on building high-throughput, AI-assisted diagnostic systems that are robust, interpretable, and scalable, with insights into data annotation, model validation, and integrating AI with robotic microscopy in clinical and research settings. The work anticipates developments such as self-calibrating instruments, autonomous laboratory workflows, and digital pathology ecosystems.
  • Understanding PCR

    A Practical Bench-Top Guide
    • 2nd Edition
    • Rowena Jenkins + 1 more
    • English
    Understanding PCR: A Practical Bench-Top Guide delivers a comprehensive resource offering researchers the information they need to plan their polymerase chain reactions, from reagents and conditions to analysis and beyond. This updated edition covers a broad spectrum of topics including laboratory preparation, primer design, DNA analysis, quantitative PCR, cloning, protein expression, and the latest applications. The book equips researchers with the knowledge to confidently design and execute PCR experiments, enhancing reproducibility and efficiency. By integrating updated techniques and practical insights, this revised reference supports researchers, laboratory professionals, and students working across molecular biology and related fields.
  • Antimicrobial Resistance in the 21st Century

    Equity, Technology, and One Health Approaches
    • 1st Edition
    • Ajmer Singh Grewal + 4 more
    • English
    Antimicrobial Resistance in the 21st Century: Equity, Technology, and One Health Approaches offers a timely, interdisciplinary exploration of one of the most pressing global health challenges. Moving beyond traditional clinical and microbiological perspectives, this volume integrates equity, digital innovation, and One Health principles into a cohesive framework for understanding and addressing antimicrobial resistance (AMR). It examines how social determinants, economic pressures, and policy environments intersect with biological drivers to shape resistance patterns and outcomes worldwide. Drawing on expertise across pharmacy, medicine, public health, veterinary science, and data science, the book combines foundational knowledge with advanced insights. Real-world case studies and applied examples highlight antimicrobial use in human and animal health, stewardship strategies, infection prevention, and surveillance of both common and neglected diseases. Special attention is given to vulnerable populations, including neonates, children, and marginalized communities, alongside critical discussions of ethics, gender, and global inequities. The integration of artificial intelligence, data analytics, and digital surveillance tools demonstrates how emerging technologies can enhance prediction, monitoring, and decision-making in AMR. By bridging theory, practice, and policy, this book equips readers with the tools to design sustainable, evidence-based interventions. It is an essential resource for researchers, students, and professionals seeking to navigate and address the complex, interconnected dimensions of AMR in a rapidly evolving global landscape.
  • Decoding Cancer

    Precision Oncology through AI, Machine Learning, and Multi-Omics Analytics
    • 1st Edition
    • Pawan Kumar Maurya + 1 more
    • English
    Decoding Cancer: Precision Oncology through AI, Machine Learning, and Multi-Omics Analytics offers an integrated perspective on how computational technologies are transforming cancer research and care. It bridges cancer biology with advanced data-driven approaches to enable precision oncology. The book covers fundamentals of cancer biology alongside applications of artificial intelligence, machine learning, and big data analytics in biomarker discovery, early detection, and personalized treatment. Chapters explore multi-omics integration, predictive modeling, radiomics, surgical robotics, and ethical considerations, supported by diagrams, case studies, and annotated workflows. For academics and professionals, this resource provides actionable insights into cutting-edge tools and methodologies, helping readers understand how computational oncology accelerates translational research and clinical decision-making. It serves as a comprehensive guide for students, researchers, and clinicians navigating the future of data-driven cancer care.
  • Interstitial Lung Diseases

    New Frontiers in Research and Clinical Applications
    • 1st Edition
    • Carlo Vancheri + 1 more
    • English
    Interstitial Lung Diseases: New Frontiers in Research and Clinical Applications is the book that professionals working with Interstitial Lung Diseases (ILDs) have been waiting for. ILDs encompass a complex group of diseases, characterized by varying degrees of inflammation and fibrosis in the lungs, leading to diverse clinical presentations and subtle differences in imaging findings. This complexity makes diagnosis challenging for pulmonologists, radiologists, and researchers, who must stay updated on evolving pathophysiology, diagnostic innovations, and new classification systems. This comprehensive, invaluable resource integrates the pathogenic, functional, clinical, and radiological aspects of ILDs, providing clinicians with a practical tool for patient care. This book elucidates the distinguishing features of different ILDs, empowering readers to navigate the diagnostic and therapeutic landscape confidently. It offers a practical, step-by-step approach to diagnosing ILDs and understanding their nuances, structured around the latest scientific evidence. Further, it covers etiology, epidemiology, pathogenesis, diagnostic processes, and therapeutic options, incorporating diagnostic and treatment algorithms to serve as both a reference and a practical guide for clinical decision-making. By filling gaps in the literature, “Interstitial Lung Diseases: New Frontiers in Research and Clinical Applications” equips respiratory professionals with the knowledge and skills necessary to enhance diagnostic accuracy, improve patient management, and foster ongoing innovation in the study of ILDs.
  • Microbiome Profiling, Techniques, and Therapeutic Management

    • 1st Edition
    • Sanjana Mehrotra + 1 more
    • English
    Microbiome and Tumorigenesis: Microbiome Profiling, Techniques, and Therapeutic Management, vol. 2 offers a comprehensive exploration of cutting-edge methodologies and clinical applications in microbiome research. This book focuses on the intersection of microbiome science with cancer therapy, bioinformatics, and environmental influences, making it a valuable resource for researchers, clinicians, and graduate students in biomedical and life sciences. The book is structured into three parts: tools and techniques for microbiome analysis, the role of the microbiome in cancer therapy, and the impact of diet, environment, and epigenetics on microbiome–tumor interactions. Topics include sampling strategies, AI-driven data analysis, microbiome-based biomarkers, and therapeutic interventions, with contributions from experts across academia and industry. This book equips the academic audience with both foundational and advanced insights into microbiome research. It supports interdisciplinary learning, fosters translational thinking, and provides practical knowledge for designing experiments, interpreting data, and developing novel therapeutic strategies.
  • Artificial Intelligence and Clinical Cognition in Pediatric and Neonatal Medicine

    • 1st Edition
    • Anthony Chang + 1 more
    • English
    Artificial Intelligence and Clinical Cognition in Pediatric and Neonatal Medicine is an essential guide with an introduction to data science and artificial intelligence to provide the reader with a quick orientation and education on AI in healthcare. This book vastly improves the speed of adoption of AI in pediatric and neonatal healthcare by providing a framework of AI deployment in children and healthcare. In addition to a large section on the principles and theories of artificial intelligence as well as its application in a number of pediatric subspecialties, the book will have about 50 commentaries that all have the same structure The book is presented in a systematic manner for all clinicians to understand the in-depth thinking of the leaders in the pediatric AI domain from an international perspective. Artificial Intelligence and Clinical Cognition in Pediatric and Neonatal Medicine is an essential guide with an introduction to data science and artificial intelligence to provide the reader with a quick orientation and education on AI in healthcare. It also offers a framework for success in planning, deployment, implementation, and evaluation of AI models in healthcare. In addition, current state of the art of pediatric subspecialties will be presented with future directions to guide the pediatric and neonatal clinicians. Finally, a colorful collection of commentaries by leaders of AI use in children’s health is inserted throughout the book.
  • The Biomechanics of Osseointegration

    • 1st Edition
    • Adriano Piattelli + 1 more
    • English
    The Biomechanics of Osseointegration offers a comprehensive, evidence-based exploration of the biomechanical, anatomical, and biological principles essential to safe and effective use of dental implants. By integrating core sciences with clinical applications, it equips both current and future practitioners with the tools to deliver long-term success in implant therapy. From fundamental concepts such as bone biology and stress-strain relationships to advanced topics like finite element modeling, fatigue testing, and real-world clinical implications, this work bridges the divide between theory and practice. Readers gain deep insight into the biomechanics of standard, short, pterygoid, and zygomatic implants across varying bone types, loading conditions, and anatomical challenges. Examined are long-term histological findings from retrieved human implants, unpacking the reasons behind the success of design elements such as the Cone Morse connection. Grounded in both research and practical examples—including case studies and data spanning three decades—the importance of connecting basic science with clinical expertise is highlighted. Designed primarily for dentists considering the integration of implantology into their practice, as well as postgraduate students in Periodontology, Prosthodontics, Oral Surgery, and Biomedical Engineering, The Biomechanics of Osseointegration also serves as a valuable resource for undergraduate dental and biomechanical engineering students who are entering the field with limited formal education in implant science. With an interdisciplinary approach and emphasis on biomechanics and biology, it provides a critical foundation for anyone committed to advancing in the field of dental implants—ensuring their work is not only innovative but also grounded in safe and effective treatment principles.
  • Cold-Adapted Enzymes

    Biochemistry and Biotechnology
    • 1st Edition
    • Diego Gomez-Casati + 1 more
    • English
    Cold-Adapted Enzymes: Biochemistry and Biotechnology provides a cutting-edge investigation into the molecular mechanisms, structural dynamics, and regulatory pathways of enzymes adapted to cold environments.Beyond classical microbiology, the book explores cold adaptation from psychrophilic bacteria and Antarctic fungi to microalgae, plants, and mammalian cell physiology. It provides biochemistry insights into carbohydrate (amylases, glucoamylases) and lipid metabolism, proteases, and redox enzymes, alongside the roles of molecular chaperones and prokaryotic proteomics. A key highlight is its focus on next-generation biotechnology, featuring AI-driven protein design, advanced computational modeling, and structural bioinformatics. Bridging foundational science with market reality, the volume explores applications from organic waste valorization to industrial biocatalysis, analyzing the global patent landscape and commercial players.As the latest volume in the Foundations and Frontiers of Enzymology series, this book is an indispensable reference for researchers across biochemistry, biotechnology, structural biology, and microbiology.
  • Biofabrication Technologies for Tissue and Organ Engineering and Manufacturing

    • 1st Edition
    • Lorenzo Moroni + 1 more
    • English
    Biofabrication Technologies for Tissue and Organ Engineering and Manufacturing is the fourth volume in the Regenerative and Transplant Medicine Series. The book offers a range of benefits tailored to its diverse audience. For students in biomedical engineering and related fields it provides a comprehensive understanding of biofabrication technologies in tissue and organ engineering and preparing them for future careers. Researchers and scientists in tissue engineering benefit from staying current with the latest advancements, fostering interdisciplinary collaboration, and offering practical insights for experimental design. Clinicians and healthcare professionals gain a deeper understanding of biofabrication applications, improving patient care and staying informed about emerging technologies. Industry professionals in medical devices and biofabrication find valuable insights for product development and market opportunities, while educators use the textbook to enrich curricula and provide real-world applications for students. Regulatory affairs specialists benefit from updates on ethical considerations and compliance in biofabrication, and government officials gain insights into shaping policies for responsible innovation.The authorship is intentionally diverse, encompassing professionals from various backgrounds, including gender, ethnicity, and geographical location. The authors explore applications of biofabrication technologies across different cultural and medical contexts, including voices from underrepresented groups in the fields of biomedical engineering and biofabrication.
  • Redefining the MicroRNA Functionality in Cancer Diagnostics and Therapeutics

    • 1st Edition
    • Vivek Kumar + 2 more
    • English
    Redefining the MicroRNA Functionality in Cancer Diagnostics and Therapeutics is an authoritative volume that explores the pivotal role of microRNAs (miRNAs) in precision oncology. The book integrates fundamental biology, cutting-edge bioinformatics, and translational research, providing a comprehensive overview of miRNA mechanisms, regulation, and clinical applications. It emphasizes technological advances such as single-cell profiling, CRISPR engineering, and AI-driven diagnostics. The content covers miRNA biology, multi-omics integration, innovative therapeutic strategies, and clinical translation, including liquid biopsies and biosensors.In addition, it also addresses industry and regulatory aspects, offering practical insights for translating research into clinical and commercial settings. Rich with case studies and visual aids, the book bridges the gap between bench research and bedside implementation. For the academic audience, this book offers a multidisciplinary resource that enhances understanding of miRNA-based diagnostics and therapeutics, fostering innovation and accelerating clinical adoption in cancer care.
  • Statistics in Medicine

    • 5th Edition
    • Robert H. Riffenburgh + 1 more
    • English
    Statistics in Medicine, 5th Edition serves as an essential resource for health care students, professionals and researchers seeking to understand the application of statistical methods in medical research. This comprehensive text encompasses a wide range of topics, from foundational concepts to advanced techniques, ensuring that readers are well-equipped to design, analyse, and interpret health-related studies. The book includes updated chapters on critical subjects such as missing data, regression models for discrete outcomes, polytomous response regression, classification and regression trees, and the integration of machine learning and AI with statistical methodologies. Each chapter provides practical examples and step-by-step methods, helping readers understand complex concepts while reinforcing learning through exercises and real-world applications. For the academic audience, this book offers a user-friendly approach to medical statistics, making it accessible even to those with limited statistical training. By bridging the gap between theory and practice, it empowers health care professionals to conduct rigorous research, interpret findings accurately, and contribute meaningfully to advancements in medical science.
  • Avian Models of Development

    • 1st Edition
    • Volume 173
    • English
    Avian Models of Development provides practical and experimental approaches for using avian systems to study developmental processes. It covers key methods, model applications, and emerging techniques that support research in embryogenesis, tissue formation, gene function, and developmental mechanisms.
  • Protein-Based Hydrogels

    Exploring the Roles of Protein Hydrogels in Membrane-less Organelles, Disease Mechanisms, and Therapeutic Applications
    • 1st Edition
    • Vladimir N. Uversky + 1 more
    • English
    Protein-Based Hydrogels: Exploring the Roles of Protein Hydrogels in Membrane-less Organelles, Disease Mechanisms, and Therapeutic Applications presents a comprehensive overview of natural and engineered protein hydrogels, examining their critical roles in cellular organization, disease pathology, and therapeutic innovation. This book contributes unique value by integrating fundamental biology, cutting-edge biotechnology, and translational biomedical science to address emerging questions about protein phase separation and gelation. Structured into three sections, the book begins by exploring the physiological functions of protein hydrogels in phase-separated organelles, cellular stress sensing, memory formation, and compartmentalization... It then investigates the pathological consequences of hydrogel dysregulation, including their roles in neurodegenerative diseases, cancer, and viral infections. Finally, it examines biomedical applications such as controlled drug delivery, regenerative medicine, biosensing, and the design of synthetic organelles. Each chapter is contributed by a leading expert, offering multidisciplinary perspectives from biochemistry, molecular biology, bioengineering, and medical research. This book is a valuable resource for academic researchers, graduate students, and professionals working in protein engineering, structural biology, molecular medicine, and pharmaceutical sciences. It supports readers in understanding the full spectrum of protein hydrogel biology—from cell physiology to disease mechanisms and therapeutic design—making it especially relevant for those interested in neurodegeneration, cancer biology, and translational bioengineering.
  • The Human Electroretinogram

    A Diagnostic Guide
    • 1st Edition
    • Benedetto Falsini
    • English
    The Human Electroretinogram: A Diagnostic Guide describes the physiological basis and clinical applications of the human electroretinogram (ERG). Several sub-types of ERGs are evoked by Full-Field stimuli, with characteristics that depend critically on the properties of the stimulus. This book discusses the human retina’s high sensitivity to light and its ability to respond robustly to even single quanta of light. Specifically, it clarifies that the major components of flash ERG, the a-wave and b-wave, are generated by photoreceptors and bipolar cells, respectively. This book explores how changes in light intensity, adaptation, and temporal frequency can alter the contributions of different retinal generators (e.g., rods, cones, and bipolar cell subtypes). In addition to Full Field ERG, other important diagnostic electroretinograms including focal, multifocal, and pattern ERGs are clarified. This book uniquely illustrates the combined use of these ERG tools, allowing clinicians to perform a functional dissection of the retina and achieve a layer-by-layer analysis.The approach of The Human Electroretinogram: A Diagnostic Guide correlates with retinal layer evaluations performed using modern multimodal imaging techniques, such as optical coherence tomography (OCT). ERG analysis exemplifies a critically important tool for early diagnosis, follow-up, and treatment monitoring of retinal diseases involving different retinal layers. This book is essential in providing ophthalmological professionals with the know-how to manage the interplay between these numerous elements.
  • Advancements in Digital Cytopathology and Artificial Intelligence

    • 1st Edition
    • Keluo Yao + 2 more
    • English
    Advancements in Digital Cytopathology and Artificial Intelligence offers an extensive and reliable resource for those intrigued by the opportunities for employing artificial intelligence in cytopathology, within both clinical and research settings. The book provides advances in research and commercial technologies, regulatory and business environment updates and special considerations in cytopathology that impacts AI applications in the medical field. It describes the current state of cytopathology digitization and AI technologies, the current cytopathology practice environment, including laws and compliance issues in the context of digitization and AI technologies. This an essential reference for cytologists and trainees who are interested in AI and digital pathology and AI researchers and industry partners who are interested in developing applications for cytopathology.
  • Gallin and Ognibene's Principles and Practice of Clinical Research

    • 5th Edition
    • John I. Gallin + 2 more
    • English
    Gallin and Ognibene’s Principles and Practice of Clinical Research, 5th Edition is the definitive text on clinical research, written by internationally recognized experts in their field, from the US National Institutes of Health, the US Food and Drug Administration, academia, and global researchers. The new edition contains fully updated chapters, with more than 50 new authors and 15 new chapters. The book continues a strong emphasis on study design and biostatistics in clinical research, with new chapters containing fresh information on a variety of topics, including chapters on how to engage a full range of research participants and research opportunities for people involved in patient care including surgeons, pharmacists, and other clinical researchers. For the international researcher, two new chapters detail international clinical research experiences in South Africa and India. As with the 4th edition, the new edition provides readers with summary questions and answers after select chapters.
  • Innovation in Emergency Medicine

    Technology Development and Commercialization Handbook
    • 1st Edition
    • Nancy Patterson + 3 more
    • English
    Innovation in Emergency Medicine: Technology Development and Commercialization Handbook is a step-by-step guide to emergency medicine technology innovation reflecting recent trends of industry globalization and value-conscious healthcare. Written by a team of medical, engineering, and business experts, the authors provide a comprehensive resource that leads engineers, clinicians, students, researchers, and entrepreneurs through a clear process for the identification, invention, and implementation of new solutions. Case studies on innovative products from around the world, successes and failures, practical advice, and end-of-chapter 'Getting Started' sections encourage readers to learn from real projects and apply important lessons to their own work. This new volume in the Clinical and Medical Innovation Series will be of interest to every biomedical engineer and those working in emergency medicine who has ever had a good idea for an invention but does not know where and how to start bringing it to the bedside.
  • Advances in Applied Microbiology

    • 1st Edition
    • Volume 138
    • English
  • 3D Bioprinting and Bio-Regenerative Medicine for Personalized Oncology

    Innovations for Personalized Oncology
    • 1st Edition
    • Ashok Kumar + 2 more
    • English
    3D Bioprinting and Bio-Regenerative Medicine for Personalized Oncology: Innovations for Personalized Oncology presents a comprehensive exploration of the transformative role of 3-D bioprinting and bio-generative engineering in modern medicine, with a specific focus on precision oncology. By examining innovative applications of these technologies, the book aims to bridge the gap between emerging scientific advancements and their practical implications in clinical settings. It delves into how patient-specific models of human tissues and organs can revolutionize drug testing, disease diagnostics, and personalized treatment plans, ultimately enhancing the quality of cancer care.Addressing critical challenges in oncology, this book highlights how 3-D bioprinting and bio-generative engineering can improve the accuracy of drug efficacy evaluations, reduce reliance on animal testing, and tackle the pressing issue of organ shortages for transplantation. Furthermore, it emphasizes the ethical considerations and regulatory challenges associated with integrating these technologies into everyday oncology practice, ensuring a balanced perspective on their adoption.
  • Advances in Agronomy

    • 1st Edition
    • Volume 203
    • English
    Advances in Agronomy, Volume 203, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field, each written by an international board of authors.