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Elsevier

Books in Life sciences

Elsevier's Life Sciences collection helps researchers get comprehensive coverage and up-to-date information on the study of living organisms, their processes, and interrelationships, spanning disciplines like biology, genetics, and biochemistry, and addressing emerging trends such as genomics, biotechnology, and sustainability, essential for advancing knowledge and driving innovation in the field.

  • Advances in Hepatorenal Syndrome Research

    Untangling Pathophysiology, Improving Diagnostic Strategies, and Leveraging Therapeutic Innovations
    • 1st Edition
    • Justin Belcher
    • English
    Advances in Hepatorenal Syndrome Research: Untangling Pathophysiology, Improving Diagnostic Strategies, and Therapeutic Innovations is a comprehensive review of the historical perspectives, prevalence, and prognosis of HRS, offering insights into its evolving clinical recognition and shifting paradigms of pathophysiology. Explore the multifaceted pathophysiology of HRS as experts navigate the complexities of cardiac dysfunction, inflammatory cytokines, and other modern understandings shaping the field. Explore differential diagnosis, uncovering alternative etiologies and current diagnostic criteria, while shedding light on biomarkers and novel diagnostic tests revolutionizing patient assessment. Contents will also guide readers through the utility of point-of-care ultrasound in intravascular volume assessment sets the stage for exploring medical therapy options, including vasoconstrictors and albumin usage. Written by a team of experts, this comprehensive reference highlights the intricate pathophysiology of hepatorenal syndrome while delivering the most up-to-date insights into diagnostic and therapeutic approaches. Historically overshadowed by grim prognoses, hepatorenal syndrome has undergone a renaissance of interest due to recent breakthroughs, revolutionizing treatment paradigms. Whether you're a seasoned practitioner or a burgeoning researcher immersing yourself in this dynamic field, this resource offers a thorough examination, encompassing novel diagnostic criteria, innovative biomarkers, and state-of-the-art treatments.

  • Applications of Microfluidics Device Technology

    • 1st Edition
    • Volume 227
    • English
    Microfluidics is a rapidly expanding field that is recognized as a powerful platform for accelerating biological science research and innovation. It has the potential to reduce the cost and reagent consumption by enabling the precise manipulation of a small amount of fluids through microchannel ranging from ten to hundreds micrometres in size. It is a multidisciplinary domain, which integrates molecular analysis, molecular biology, and microelectronics. It has demonstrated practical applications in the design and fabrication of systems capable of processing low volumes of fluids while enabling multiplexing, automation, and high-throughput screening. Since its emergence in early 1980s, microfluidics has significantly contributed in the development of inkjet printheads, DNA chips, lab-on-a-chip technology, micro-propulsion, and micro-thermal technologies. Microfluidic chips comprise intricate networks of microchannels and chambers designed to manipulate fluids at the microscale. This volume highlights the applications of microfluidics in the detection and analysis of infectious diseases caused by bacteria, viruses, fungi, and protozoa. It also explores the use of microfluidic technologies in the diagnosis and study of non-infectious diseases, including cardiovascular disorders, cancer, metabolic diseases, and neurological conditions. It also covered single-cell analysis, high-throughput drug screening, cell sorting, and both preclinical and clinical applications. It also used in role of microfluidics in organ culture, regenerative medicine, and personalized healthcare. It also addresses ethical and regulatory issues in the development and use of microfluidic devices. This volume is designed to serve as valuable resource for students, researchers, scientists, clinicians, stakeholders, policymakers, and practitioners to understand microfluidics and apply microfluidics technology/devices in various fields. It provides a strong foundation to help the extension of microfluidics knowledge and accelerate research, innovation, technology and practical applications.

  • Electrocardiography of Laboratory Animals

    • 3rd Edition
    • Meg M. Sleeper + 1 more
    • English
    Electrocardiography of Laboratory Animals, Third Edition, provides the latest information on critical topics such as safety electrocardiography, toxicology, safety pharmacology, and telemetry, ensuring that readers are well-equipped with the knowledge required for accurate ECG interpretation in preclinical studies. The book begins with the fundamental principles of electrocardiography and its applications in drug safety evaluation but then covers electrocardiography in a wide range of laboratory animals, including rodents, guinea pigs, rabbits, cats, dogs, and various non-human primates such as marmosets, cynomolgus monkeys, rhesus monkeys, baboons, and chimpanzees.Addition... it reviews the ECG characteristics of minipigs, nanopigs, and micropigs. The text also includes chapters on telemetry and echocardiography in preclinical safety studies, as well as discussions on important parameters like PR (PQ), QRS, and QT intervals. The book concludes with chapters on cardiac assays, biomarkers, stem cells, and cardiovascular medical devices, providing a holistic view of cardiovascular research. It is an essential resource for biological and medical researchers, veterinarians, zoologists, and students.

  • Geostatistical Approaches to Environmental and Public Health Issues

    • 1st Edition
    • Deepak Kumar + 4 more
    • English
    Geostatistical Approaches to Environmental and Public Health Issues discusses how geostatistical techniques can be leveraged to better understand and respond to pressing environmental and public health challenges. The book showcases how techniques like kriging, spatial regression, Bayesian modeling, and space-time analysis offer powerful, nuanced insights into these issues. Emphasizing stochastic, non-deterministic approaches, it highlights the importance of modeling uncertainty in both environmental and health domains. Through case studies and research-driven chapters, sections demonstrate how integrating geospatial and statistical methods can enhance our understanding of where, why, and how events occur—ultimately improving the precision of health interventions and environmental policies.By aligning cutting-edge statistical approaches with the geospatial dimensions of health and environmental data, this book fills a critical gap in the literature and supports more targeted, data-driven decision-making in the face of global uncertainty. It bridges methodological innovation with applied research, making it an essential resource for scientists, policymakers, and public health practitioners.

  • Shared Research Resources

    Best Practices in Management and Administration
    • 1st Edition
    • Andrew Vinard + 1 more
    • English
    Shared Research Resources: Best Practices in Management and Administration brings together best practices and case studies from research institutions around the world. Covering all areas of management, with examples and applications specific to the research environment, this is the perfect reference to build managerial skills. The first part is dedicated to introducing Shared Research Resources (SRR) management. The second part covers all aspects of staffing. Part three contains complete coverage of operations, including service development, instrument procurement, marketing, management software, customer support, safety, maintenance and repair. Part four is dedicated to fiscal management, budgeting, and reporting.Part five covers strategic management. Part six is devoted to the sustainability of the core facility. The final part covers assessment, including annual reports, program reviews, and audits. This book is a complete reference targeted at SRR managers and staff who need to keep updated with current best practices and case studies. It is also important reading for research institution managers and function leaders.

  • Multiple Faces of Takotsubo Syndrome

    Clinical Presentations, Mechanisms and Advanced Diagnostic Insights
    • 1st Edition
    • Luca Saba + 1 more
    • English
    Multiple Faces of Takotsubo Syndrome: Clinical Presentations, Mechanisms and Advanced Diagnostic Insights offers a thorough review of Takotsubo syndrome and the role of advanced imaging techniques in improving diagnosis, monitoring, and management of this complex cardiac condition. The book begins with an introduction to Takotsubo syndrome, covering its historical background, prevalence, and key clinical characteristics. Subsequent chapters delve into epidemiology, risk factors, and psychological aspects, including the impact of COVID-19 and other viral infections. Then, clinical manifestations, management, prevention, and treatments are thoroughly discussed, along with complications and prognosis. The basic science section explores the pathophysiological mechanisms, the heart-brain axis, and multi-organ involvement.A significant focus throughout is placed on invasive and non-invasive imaging modalities, including angiography, echocardiography, cardiac MRI, computed tomography, and nuclear imaging. Future directions highlight emerging biomarkers and imaging techniques for personalized medicine, and real-world case studies provide practical insights for clinicians. The book offers invaluable benefits to scientists, researchers, and clinicians alike.

  • Neurogenetic Therapies

    Advancements in Treating Nervous System Disorders
    • 1st Edition
    • Ashutosh Pareek + 4 more
    • English
    Neurogenetic Therapies: Advancements in Treating Nervous System Disorders offers a comprehensive resource on the latest gene therapy techniques and their applications in treating neurological disorders. The book delves into various gene therapy methods, including genomic DNA-based therapies, vector-mediated delivery, and RNA interference-based gene silencing. It explores the use of these techniques in treating conditions such as Alzheimer's disease, Parkinson's disease, spinal muscular atrophy, and Duchenne muscular dystrophy. Key topics include the molecular and genetic basis of nervous system disorders, the role of epigenetics, and the development of stem cell and genome editing therapies.With contributions from leading experts, the book also addresses regulatory and ethical considerations in gene therapy, providing a balanced perspective on the challenges and opportunities in this rapidly evolving field. Case studies and practical examples illustrate successful gene therapy treatments, offering valuable insights into translating research into clinical practice. This book is an essential resource for students, researchers, and scientists in neurogenetics, neurology, and molecular biology, as well as clinicians interested in the mechanisms and treatment of neurodegenerative diseases.

  • Introduction to Tactile Intelligence

    • 1st Edition
    • Shan Luo
    • English
    Introduction to Tactile Intelligence emphasizes the growing importance of tactile intelligence, essential for robots to interact effectively with the physical world. This book explores the science of tactile intelligence, equipping robots and intelligent machines with the ability to touch and feel the world, recognize textures, develop fine motor skills, and even convey emotions through physical contact. It anticipates a future where robots seamlessly integrate with the physical world through tactile intelligence and offers solutions for its development and application in various domains. This book is a good resource for students in robotics to experienced professionals, providing a solid foundation in tactile sensing, tactile-based control, and learning, as well as the integration of tactile data into broader robotic systems. This book provides valuable insights and practical guidance, and it serves as a reference for researchers at all stages of their careers in the dynamic field of tactile development and applications.

  • Protein Misfolding

    • 1st Edition
    • Timir Tripathi
    • English
    Protein Misfolding explores the structural and biochemical foundations of protein misfolding, highlighting its wide-reaching implications for cellular function, disease progression, and biomedical innovation. This book provides a comprehensive understanding of how proteins deviate from their native conformations and the resulting biological consequences. Focusing on both physiological and pathological misfolding, the volume covers essential topics such as folding quality control, molecular chaperones, degradation pathways, and proteostasis. It presents in-depth analyses of protein aggregation mechanisms, amyloid formation, and misfolding-associate... diseases including Alzheimer's, Parkinson's, and prion-related disorders. Additional chapters explore structural approaches to understanding misfolded states, computational modeling of aggregation kinetics, and current efforts to design therapeutics that restore folding homeostasis or prevent toxic accumulation. The book also addresses the cellular response to misfolding stress and the integration of folding dynamics with cellular signaling pathways. This book is a valuable resource for researchers, educators, and professionals in biochemistry, structural biology, molecular medicine, biotechnology, and related disciplines. It supports efforts to understand the fundamental principles of protein structure and function, while offering insight into emerging therapeutic strategies and future research directions in disease-focused protein science.

  • Plant Development

    • 1st Edition
    • Volume 172
    • English
    Plant Development provides an overview of the fundamental processes that govern the growth, differentiation, and organization of plants throughout their life cycle. The book explores key developmental stages, from embryogenesis and seed germination to organ formation, flowering, and senescence, highlighting the genetic, molecular, cellular, and environmental factors that regulate these events. By integrating classical concepts with modern advances in developmental biology, the volume offers valuable insight into how plants establish form, adapt to their surroundings, and coordinate growth in response to internal and external signals. It serves as a useful resource for researchers, students, and professionals interested in plant biology, developmental mechanisms, and related fields.

  • Management of Chronic Kidney Disease and Its Complications

    • 1st Edition
    • Thakur Gurjeet Singh + 4 more
    • English
    Management of Chronic Kidney Disease and Its Complications  presents the latest scientific advances in diagnosing and managing Chronic Kidney Disease (CKD) and its diverse complications. This authoritative text covers molecular mechanisms such as inflammation and oxidative stress, genetic and epigenetic factors, and explores cutting-edge technologies including artificial intelligence and regenerative medicine. With detailed chapters on cardiovascular, metabolic, neurological, and hematological complications, the book offers a holistic approach to understanding CKD’s complexity and evolving treatment strategies.The book’s content is organized to provide a thorough exploration of CKD, beginning with foundational topics like genetic contributions and diagnostic evaluation, progressing through specific complications such as diabetic nephropathy, hypertension, and urologic conditions. Special focus is given to management strategies, nutritional interventions, and unique considerations in pediatric, geriatric, and pregnant populations. Emerging therapies, including precision medicine, gut microbiota modulation, and AI-driven early detection, are also extensively covered to keep readers at the forefront of nephrology research and clinical practice.Management of Chronic Kidney Disease and Its Complications is an essential resource for nephrologists, general practitioners, medical students, nursing professionals, and healthcare providers involved in kidney disease care and research.

  • Federated Quantum Convolutional Neural Networks in Healthcare

    Enhancing Privacy and Efficiency
    • 1st Edition
    • Abhishek Kumar + 3 more
    • English
    Federated Quantum Convolutional Neural Networks in Healthcare: Enhancing Privacy and Efficiency explores the innovative intersection of quantum computing and federated learning in the context of healthcare. As medical data grows exponentially and privacy concerns intensify, this book addresses the urgent need for secure, scalable AI solutions that enable collaborative data analysis without compromising patient confidentiality. It offers a detailed examination of the theoretical foundations of quantum machine learning and federated systems, complemented by practical case studies spanning medical imaging, genomics, and disease diagnosis. The content delves into architecture design, security protocols, and optimization techniques, equipping researchers and practitioners with the tools to develop privacy-preserving AI models tailored for medical applications. The book also discusses regulatory considerations, deployment challenges, and future research directions, positioning itself as a vital resource for advancing healthcare AI. Its comprehensive approach bridges fundamental science and real-world implementation, empowering healthcare professionals, data scientists, and policy makers to harness next-generation quantum federated systems for improved patient outcomes and data security. This resource is essential for those seeking to implement cutting-edge AI technologies in healthcare, ensuring secure, efficient, and collaborative medical data analysis.

  • Digital Twins and Predictive Modeling in Robotic Surgery

    • 1st Edition
    • Mudassir Khan + 3 more
    • English
    Digital Twins and Predictive Modeling in Robotic Surgery addresses the transformative convergence of digital twin technology, predictive analytics, and robotic surgery. This reference responds to the critical need for a comprehensive resource that bridges simulation science, artificial intelligence, and real-time robotic execution, facilitating enhanced surgical precision, patient-specific planning, and intraoperative decision-making. The content is organized into four parts covering foundational intelligent surgical systems, predictive modeling and simulation, clinical applications with case studies, and challenges alongside future directions. Topics include AI integration, IoT-enabled sensor networks, digital twin architectures encompassing the entire surgical ecosystem, surgical workflow modeling, risk assessment, human-robot interaction, technology acceptance, ethical and regulatory considerations. Real-world examples from smart hospitals worldwide illustrate practical implementation. This books benefits biomedical engineers, researchers, and healthcare system architects by providing interdisciplinary insights, practical implementation frameworks, and cutting-edge case studies. It supports improved surgical planning, precision, and decision-making, empowering end users to advance the adoption of intelligent, AI-powered robotic surgery systems in clinical practice and research environments.

  • Protein Folding

    • 1st Edition
    • Timir Tripathi
    • English
    Protein Folding explores the fundamental and applied aspects of protein folding, misfolding, and stability in biological systems. Focusing on the biochemical principles and molecular dynamics that drive folding processes, the book provides readers with a comprehensive understanding of how proteins attain their native structures and what happens when this process goes awry. Covering diverse approaches from structural biology, biophysics, enzymology, and systems biology, the book highlights the molecular basis of folding pathways and the pathological consequences of misfolded proteins in diseases such as Alzheimer's, Parkinson's, and cystic fibrosis. It integrates insights into chaperone function, folding kinetics, and the cellular quality control mechanisms that safeguard proteostasis. Across its chapters, the book addresses key themes including protein folding landscapes, folding intermediates, the role of cellular compartments, aggregation-prone sequences, and the impact of mutations. It also examines current methodologies for studying protein folding, including spectroscopy, calorimetry, and computational simulations, and considers emerging therapeutic strategies that target misfolding and aggregation. This book is a valuable resource for biochemists, molecular biologists, biotechnologists, enzymologists, and researchers in protein science. It supports academic researchers, postgraduate students, and pharmaceutical scientists working to understand protein behavior and develop interventions for protein misfolding diseases.

  • Sustainable Digital Medicine

    Green Technology Integration for Inclusive Health Systems
    • 1st Edition
    • Patricia Ordonez de Pablos + 1 more
    • English
    Sustainable Digital Medicine: Green Technology Integration for Inclusive Health Systems explores the transformative potential of digital innovation in healthcare. This edited volume brings together global perspectives on how emerging technologies can modernize health systems while promoting sustainability and inclusivity. The book covers key topics such as AI integration in medicine, digital tools for citizen empowerment, modernization of medical education, and the environmental impact of healthcare technologies. It includes case studies from Asia, Europe, the Gulf Region, and the Americas, offering comparative insights and practical applications. Contributors analyze challenges and opportunities in digital health, with policy recommendations for decision-makers. Designed for researchers, academics, and policymakers, this book provides timely knowledge and actionable strategies. Readers gain a deeper understanding of digital transformation in healthcare, new professional skillsets, and the role of technology in building resilient, equitable health systems aligned with global sustainability goals.

  • Endoscopic/Robotic Thyroidectomy Surgery

    Using the Gasless Unilateral Axillary Approach
    • 1st Edition
    • Chuanming Zheng + 1 more
    • English
    Endoscopic/Robotic Thyroidectomy Surgery: Using the Gasless Unilateral Axillary Approach is a comprehensive and systematic resource on endoscopic/robotic thyroidectomy using the gasless unilateral axillary approach comprehensive and systematically presented resource on the gasless axillary approach to endoscopic/robotic thyroidectomy. It includes a detailed introduction to all aspects of surgical treatment including anesthesia coordination and robotic surgery. The book provides practical guidance on postoperative complication management and postoperative care and describes specific methods for technical simulation training and functional exercises. While many journal papers on specific aspects of this surgical approach have been published, no book is currently available.

  • Correlative Light and Electron Microscopy VI

    • 1st Edition
    • Volume 213
    • English
    Correlative Light and Electron Microscopy VI presents current methods and applications in combining light microscopy and electron microscopy to study biological structures and processes with high spatial and temporal resolution. The volume highlights practical approaches for linking dynamic imaging with ultrastructural analysis, enabling researchers to investigate cells, tissues, and subcellular components in greater detail. Covering both established and emerging techniques, this book serves as a useful resource for scientists working in cell biology, structural biology, imaging, and related biomedical fields.

  • RNA-Binding Proteins Part A

    • 1st Edition
    • Volume 743
    • English
    Overall, this volume serves as a comprehensive methodological resource that integrates RNA-binding proteins, RNA metabolism, phase separation, and neurodegenerative disease mechanisms. As Volume 743 of the Methods in Enzymology series, RNA-Binding Proteins highlights recent advances in the field through chapters covering topics such as RNA-Binding Proteins: Structure, Function, and RNA Interactions; RNA Granules, Phase Separation, and Biomolecular Condensates; RNA Regulation in Cellular Physiology; RNA-Binding Proteins in Neurobiology and Neurodegeneration; RNA Processing, Editing, Splicing, and Decay; Non-Coding RNAs, Small RNAs, and RNA Therapeutics; and Experimental and Computational Methods for RNA–Protein Interaction Analysis. Collectively, these contributions provide valuable methodological and conceptual insights, making the volume highly relevant to researchers in molecular biology, neuroscience, RNA biology, and translational medicine.

  • Implications of Artificial Intelligence in Next Generation Physiotherapy

    • 1st Edition
    • Manpreet Kaur + 3 more
    • English
    Implications of Artificial Intelligence in Next Generation Physiotherapy explores the transformative integration of artificial intelligence into physiotherapy, a vital component of rehabilitation for musculoskeletal conditions, including chronic issues and sports injuries. Traditionally reliant on in-person sessions or passive guidance, physiotherapy is set for a revolution through AI technologies that enhance diagnostics, treatment planning, and personalized care, making therapy more accessible. The book covers topics such as workload monitoring, movement pattern detection, muscle imbalance identification, and recovery tracking, alongside next-generation methods and wearable technology. It provides a comprehensive resource for researchers, practitioners, and students, consolidating current research, case studies, and practical applications. By offering insights into how AI can tailor treatment plans and improve public health outcomes, this book equips the audience with essential knowledge to navigate the future of physiotherapy, ensuring they remain informed about advancements that can significantly enhance clinical outcomes and patient care.

  • The Pancreatic Tumor Microenvironment

    Systems Biology of Stroma–Microbiome Interactions for Precision Therapy
    • 1st Edition
    • Ganji Purnachandra Nagaraju + 1 more
    • English
    The Pancreatic Tumor Microenvironment: Systems Biology of Stroma–Microbiome Interactions for Precision Therapy unites leading experts to integrate stromal biology and microbiome science into a single, translational roadmap for pancreatic cancer. It frames tumor progression and treatment resistance as emergent properties of an ecosystem, not isolated cells. The book surveys the composition and heterogeneity of the tumor microenvironment; cancer associated fibroblast plasticity; extracellular matrix and signaling dynamics; immune suppression; metabolic and hypoxic reprogramming; and gut/tumor associated microbiomes. Methodological chapters highlight single cell, spatial and multi omics approaches, experimental models, biomarkers, and clinical trial design, culminating in combination strategies and future directions. Readers gain a mechanistic, systems level synthesis that clarifies conflicting literature, prioritizes targets, and bridges basic, translational, and clinical domains—accelerating precision oncology and informing study design, patient stratification, and therapeutic combinations.

  • Wound Microenvironment Responsive Smart Dressing for Effective Healing

    • 1st Edition
    • Mohit Kumar + 4 more
    • English
    Wound Microenvironment Responsive Smart Dressing for Effective Healing presents a cutting-edge scientific exploration of phytoconstituent-bas... smart wound dressings engineered to accelerate and improve tissue repair. Bridging the therapeutic wisdom of traditional herbal medicine with advanced biomaterials, nanotechnology, polymer science, and bioengineering, this volume highlights how natural bioactive compounds can be transformed into clinically viable wound therapies. The book provides an integrated understanding of the molecular and cellular mechanisms governing wound healing, and demonstrates how stimuli-responsive delivery platforms—sensitive to pH, temperature, enzymes, ROS, or glucose—can enable precise, controlled release of phytochemicals directly at the wound site. These innovative systems overcome limitations of conventional formulations, such as instability, poor solubility, low bioavailability, and lack of targeted action. With contributions spanning smart hydrogels, nanocarriers, microneedles, 3D/4D printing, and AI-assisted wound monitoring, this multidisciplinary reference offers both foundational principles and translational guidance. Case studies and globally inclusive perspectives ensure broad relevance for researchers, clinicians, and formulation scientists working toward next-generation wound management solutions.

  • Bioinformatics, Computational Biology, and Multi-Omics–Driven Probiotic Design for Gut Microbiome Engineering

    • 1st Edition
    • Naheed Mojgani + 3 more
    • English
    Bioinformatics, Computational Biology, and Multi Omics–Driven Probiotic Design for Gut Microbiome Engineering presents an interdisciplinary framework for applying artificial intelligence to microbiome science, probiotic development, and personalized nutrition. The book integrates bioinformatics, computational biology, and clinical insight to address current challenges in gut microbiome research and translation. The volume covers AI driven microbiome profiling, multi omics integration, computational modeling of host–microbe interactions, and predictive analytics. It progresses from foundational concepts to advanced applications, including AI assisted probiotic design, gut–brain axis research, regulatory considerations, and real world case studies supporting translational and clinical relevance. The book equips bioinformaticians, translational microbiome researchers, and clinician scientists with actionable methodologies, conceptual clarity, and validated examples. It supports evidence based decision making, accelerates translational research, and bridges discovery science with implementation in personalized nutrition and probiotic innovation.

  • Cold-Adapted Enzymes

    Biochemistry and Biotechnology
    • 1st Edition
    • Diego Gomez-Casati + 1 more
    • English
    Cold-Adapted Enzymes: Biochemistry and Biotechnology, the latest release in the Foundations and Frontiers of Enzymology series, provides a detailed investigation into enzymes that adapt to cold environments. The book covers the catalytic, structural, and regulatory properties of this type of enzyme and the potential advances in their biotechnological applications. Topics covered include the evolution of enzymes in cold environments, enzymes involved in carbohydrate metabolism (such as xylanases, B-galactosidase, and B-glucosidase), cold-adapted enzymes in lipid metabolism (such as esterases and lipases), and redox enzymes. In addition, the book also explores bacterial cold-adapted enzymes and those from organisms in extreme environments like Antarctica.Recombina... expression methods, protein engineering, and computational approaches are also featured. This book offers a complete overview of cold-adapted enzymes, making it a useful reference for researchers across a range of interdisciplinary fields, including biochemistry, enzymology, biotechnology, molecular evolution, structural biology and microbiology.

  • Tissue Organization in Development

    • 1st Edition
    • Volume 171
    • English
    Tissue Organization in Development explores how cells coordinate, communicate, and arrange themselves to build functional tissues during embryonic and postnatal development. The book brings together current perspectives on the molecular, cellular, and mechanical principles that govern tissue patterning, morphogenesis, and structural organization across developing systems. Covering key topics such as cell fate specification, cell–cell interactions, extracellular matrix dynamics, polarity, migration, and tissue remodeling, it highlights how complex biological form emerges from coordinated developmental processes. This volume provides a valuable resource for researchers, students, and professionals interested in developmental biology, cell biology, and tissue formation.

  • Self-Learning AI in Healthcare

    Agentic Systems for Smarter Medicine
    • 1st Edition
    • Rajesh Kumar Dhanaraj + 4 more
    • English
    Self-Learning AI in Healthcare: Agentic Systems for Smarter Medicine covers the transformative potential of advanced artificial intelligence within modern medicine. The book addresses the critical need for self-learning and agentic AI systems that autonomously adapt, refine decision-making, and navigate complex clinical environments with minimal intervention. Chapters provide foundational insights into the rise of self-learning AI and neural networks tailored for adaptive medical systems. Subsequent chapters delve into unsupervised, semi-supervised, and reinforcement learning for autonomous healthcare decision-making, alongside decentralized edge AI approaches. Specialized sections cover personalized medicine, hospital workflow optimization, remote patient monitoring, early disease detection, federated learning for privacy preservation, and more.Further, this book explores AI applications in drug discovery, mental health support, radiology, digital twins, and medical robotics, culminating with an examination of future challenges, ethics, and regulatory frameworks shaping self-learning AI’s trajectory in healthcare. It is tailored to serve a diverse yet specialized audience spanning academic, professional, and research sectors. Healthcare IT professionals and clinical informatics specialists will gain practical guidance for implementing adaptive AI solutions within complex healthcare environments. AI researchers and data scientists focused on developing self-learning models will find cutting-edge methodologies and case studies that advance medical applications.

  • Omics Approaches in Rhizosphere Microbiology: Part A

    • 1st Edition
    • Volume 60
    • English
    Omics Approaches in Rhizosphere Microbiology: Part A series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Machine Learning in Enzymology

    • 1st Edition
    • Volume 742
    • English
    This volume surveys cutting-edge machine learning–based approaches for the study of enzyme catalysis, dynamics, and design. It brings together computational and experimental approaches that integrate molecular simulation, machine learning, and high-throughput data to interrogate enzymatic catalysis at multiple scales. The chapters in the volume highlight how data-driven frameworks complement physics-based models to advance mechanistic understanding and enable rational enzyme engineering.

  • Glial Mechanisms in Sleep and Circadian Biology

    • 1st Edition
    • Marcos G. Frank
    • English
    Glial Mechanisms in Sleep and Circadian Biology presents a comprehensive and up-to-date discussion of the role of glial cells in numerous, often unexpected, aspects of sleep. It seamlessly links glial cell activity to the multi-system processes that affect sleep. Experts in the field discuss how glial cells influence the sleep-wake cycle, the accumulation and discharge of sleep drive, the timing of sleep and wake across the 24-hour day, and how glial cells may govern important sleep functions (e.g., brain plasticity and metabolism). This is a book that could well change scientists’ and practitioners’ traditional beliefs about the factors underlying sleep.Users will find the book's content at the forefront of one of the hottest topics in basic sleep research. Over the last decade, scientists have made breakthrough discoveries revealing that sleep is not only a product of neurons, but of neuronal-glial interactions.

  • Essentials of Stem Cell Biology

    • 4th Edition
    • Robert Lanza + 1 more
    • English
    Essentials of Stem Cell Biology, Fourth Edition is designed for the growing community of scientists, researchers, practitioners, and students embracing the latest advancements in stem cells. This comprehensive book, a collaboration of 7 editors and over 200 pioneering scholars and scientists, provides a thorough understanding of adult and embryonic stem cells. It combines fundamental concepts with cutting-edge research in specific organ systems, ensuring a robust foundation for anyone entering the field. Beyond the basics, the book delves into early development and the differentiation of ectoderm, mesoderm, and endoderm.It covers methods, applications to human diseases, regulation, ethics, and patient perspectives, leaving no stone unturned in the stem cell domain.

  • Congenital Adrenal Hyperplasia

    A Comprehensive Guide
    • 2nd Edition
    • Peter C. Hindmarsh + 1 more
    • English
    Congenital Adrenal Hyperplasia: A Comprehensive Guide, Second Edition provides a fully-illustrated edition that outlines the basics of CAH and its interrelation with hormones and bodily function, including updated content on the latest clinical research. A new chapter dedicated to gene therapy covers principles, current status, the latest research developments, and potential treatments for congenital adrenal hyperplasia. In addition, this new release updates patient profiles due to several new clinical studies in CAH for improved condition management, with practical information on how to deal with emergencies, medic alert emergency kits, emergency injection needles, handling illness, surgery, and more.In addition, new assays are incorporated for the analysis of pituitary and adrenal hormones for the determination of the disease. This new edition continues to be a vital reference to pediatric endocrinologists as well as primary care providers to help affected patients with an updated model of care and appropriate treatment. Patients and family members will continue to benefit from the new trend-forward information presented and will be empowered to approach their health care providers with the expectation of receiving individualized care and treatment of the disorder.

  • AI and Global Health

    Unlocking Transformative Potential
    • 1st Edition
    • Adil Haider
    • English
    AI and Global Health: Unlocking Transformative Potential provides a roadmap for practitioners to apply and leverage artificial intelligence to strengthen health systems using the World Health Organization's health systems approach. The book's combination of case studies and secondary research inspires the possibility of what can happen using AI in healthcare, ensuring the use of robust, scientific evidence to draw conclusions. Additionally, readers will learn from others in settings where AI has been a tool for change, providing healthcare practitioners and policymakers with what they need to think through how it can be applied in resource limited settings.The book provides a strong call to action for policymakers and healthcare leaders of governments, international organizations, and healthcare institutions to take the lead in AI implementation as a key lever for advancing global health goals through a systems approach. As AI is a rapidly evolving field with significant investment made in this industry in recent years from government and the private sector, this book articulates how this growth can be harnessed for countries that need a different approach to addressing global health problems.

  • Artificial Intelligence and Clinical Cognition in Pediatric and Neonatal Medicine

    • 1st Edition
    • Anthony Chang + 1 more
    • English
    Artificial Intelligence and Clinical Cognition in Pediatric and Neonatal Medicine is an essential guide with an introduction to data science and artificial intelligence to provide the reader with a quick orientation and education on AI in healthcare. This book vastly improves the speed of adoption of AI in pediatric and neonatal healthcare by providing a framework of AI deployment in children and healthcare. In addition to a large section on the principles and theories of artificial intelligence as well as its application in a number of pediatric subspecialties, the book will have about 50 commentaries that all have the same structure The book is presented in a systematic manner for all clinicians to understand the in-depth thinking of the leaders in the pediatric AI domain from an international perspective. Artificial Intelligence and Clinical Cognition in Pediatric and Neonatal Medicine is an essential guide with an introduction to data science and artificial intelligence to provide the reader with a quick orientation and education on AI in healthcare. It also offers a framework for success in planning, deployment, implementation, and evaluation of AI models in healthcare. In addition, current state of the art of pediatric subspecialties will be presented with future directions to guide the pediatric and neonatal clinicians. Finally, a colorful collection of commentaries by leaders of AI use in children’s health is inserted throughout the book.

  • Fluid Dynamics of Viral Transmission

    • 1st Edition
    • Mehrzad Shams + 1 more
    • English
    Fluid Dynamics of Viral Transmission is an essential exploration into the transmission dynamics of COVID-19, focusing specifically on the airborne spread of respiratory aerosols carrying infectious viruses. In light of the recent global pandemic, it offers crucial insights into the complex interaction between fluid dynamics and viral transmission and provides practical solutions for minimizing risks in indoor environments. The book delves into CFD simulations, optimizing ventilation systems, air filtration strategies, and spatial layout modifications. It evaluates mitigation measures such as mask-wearing, physical distancing, and occupancy limits, aiming to equip readers with the knowledge to create safer indoor spaces. This book is ideal for public health officials, policymakers, healthcare professionals, engineers, researchers, and academics in fluid mechanics, computational fluid dynamics, epidemiology, and virology.

  • Human Reproduction

    From basics to Biotechnology
    • 1st Edition
    • Marc yeste
    • English
    Human Reproduction: From Basics to Biotechnology is a complete reference for anyone in the field of life, health, and biomedical sciences. The book provides an overview of basics in human reproduction to advanced knowledge of the field, including some evidence from other mammalian species that complement our current knowledge on the anatomy and physiology of the male and female reproductive tract and gametes. This resource covers the most used assisted reproductive techniques and technical advances, human reproduction and infertility disorders, their diagnosis and available treatment options.

  • Biology of Aging Accelerators

    Fundamentals, Hallmarks and Therapeutic Interventions
    • 1st Edition
    • Sandeep Kumar Singh + 1 more
    • English
    Biology of Aging Accelerators: Fundamentals, Hallmarks and Therapeutic Interventions explores how biological, genetic, and environmental factors affect cellular and systemic homeostasis and lead to accelerated aging. The book begins with a historical perspectives, highlighting the growth in immune system deterioration, chronic illness, and social issues. It then examines the hallmarks of aging, including primary, antagonistic, and integrative characteristics that may or may not be contributors. Subsequent chapters explore basic concepts and key accelerators in human biology, the role of biological clocks, and mechanisms of aging accelerators such as cellular senescence, DNA damage, and mitochondrial dysfunction.The book also addresses how different organs age at different rates and the brain's role as the body's aging integrator and provides actionable insights into innovative therapies aimed at reducing or stopping the signs and symptoms of aging, including developments in medications, lifestyle adjustments, regenerative medicine, and cutting-edge technologies like stem cell therapy and CRISPR. By integrating scientific research and practical insights, this book offers a realistic perspective on anti-aging research and stimulates novel ideas for improving quality of life.

  • Geographic Atrophy in Age-related Macular Degeneration

    • 1st Edition
    • Jay Chhablani + 1 more
    • English
    Geographic Atrophy in Age-related Macular Degeneration provides a comprehensive resource on this flourishing discipline, focusing on accurate diagnosis, imaging features, clinical trials, differential diagnoses, and both established and emerging treatment options. The book details diagnostic processes using techniques such as visual acuity tests, dilated eye exams, fundus photography, optical coherence tomography (OCT), and fluorescein angiography, emphasizing the importance of early detection. It also differentiates geographic atrophy from other retinal conditions with similar symptoms, such as dystrophies, equipping practitioners with the knowledge for accurate diagnosis.Additional... it explores traditional management approaches like antioxidant supplements, lifestyle changes, and low vision aids, alongside novel treatments such as complement inhibitors, cell-based therapies, and gene therapy, to inform clinicians about the latest advancements and research in patient care. With the recent FDA approval for GA treatment, there has been significant interest in the retina community. This rapidly growing field necessitates a new book on geographic atrophy in age-related macular degeneration to address gaps in existing literature and provide up-to-date, comprehensive information.

  • Molecular Insights for Harnessing Urine Biomarkers in Precision Medicine

    • 1st Edition
    • Cheng Xue + 3 more
    • English
    Molecular Insights for Harnessing Urine Biomarkers in Precision Medicine provides a comprehensive exploration into the molecular signatures and clinical implications of urine biomarkers, providing invaluable insights for clinicians, researchers, and healthcare professionals. From historical perspectives to cutting-edge technologies, this reference presents an updated understanding of urine biomarkers' role across diverse bodily systems. With sections devoted to fundamental concepts, molecular signatures, and clinical applications, readers gain a deep understanding of urine biomarkers' significance in disease diagnosis and personalized medicine.Each chapter explores specific body systems, including renal, urological, cardiovascular, and respiratory, uncovering the diagnostic potential of urine biomarkers in various conditions like cancer, cardiovascular diseases, and neurological disorders. Highlighted are the latest advances in technology, challenges, and future directions, keeping readers abreast of the rapidly evolving landscape of urine biomarker research. Real-world case studies illustrate practical applications, enhancing comprehension and facilitating knowledge transfer to clinical practice.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 136
    • English
    Advances in Clinical Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Biomechanics of the Heart

    From Model to Patient
    • 1st Edition
    • Peter Bovendeerd + 3 more
    • English
    Biomechanics of the Heart: From Model to Patient provides readers with a comprehensive overview of the modeling and assessment of the heart’s biomechanics. The book addresses topics such as the physiology of normal and diseased hearts, cardiovascular imaging, modeling of myocardial tissue in the passive and active states, as well as state-of-the-art approaches for patient specific modeling of the heart’s mechanical function. This is all augmented by case studies and examples of exploitation of models for computer-aided diagnosis, treatment, and monitoring of heart diseases. Readers are introduced to modeling of the heart’s anatomical and muscular structure, a review of imaging techniques to analyze the geometry, content and dynamics of the heart, as well as an in-depth look at the biomechanical properties of normal and diseased hearts. Finally, chapters cover modeling cardiac passive and contractile mechanics, biomechanical finite element simulations of the heart, patient-specific modeling of the heart and circulatory system, as well as the exploitation of models for computer-aided diagnosis, treatment, and monitoring of heart diseases.

  • Health Impacts of Climate Change

    A Global Perspective
    • 1st Edition
    • Mohammad Hadi Dehghani + 2 more
    • English
    Health Impacts of Climate Change: A Global Perspective confronts the most urgent reality of our time: the climate crisis is, at its core, a health crisis. Drawing from the latest research in climate science, public health, and policy, this book offers a comprehensive, interdisciplinary look at how global warming is already endangering lives—and what can be done to protect them. Readers will gain a deep understanding of direct health threats like heatstroke, air pollution, and disaster-related trauma, as well as the less visible dangers: rising zoonotic diseases, crop failures leading to malnutrition, and mental health challenges driven by climate-induced displacement.What sets this book apart is its unwavering focus on equity. It explores how climate change disproportionately impacts the most vulnerable—low-incom... communities, people in the Global South, and marginalized groups—who contribute the least to global emissions but bear the brunt of the damage. Through case studies, personal narratives, and policy analysis, the book amplifies frontline experiences and calls for climate justice as an essential part of any effective health response. From practical strategies for healthcare professionals to frameworks for policymakers, this book empowers a wide range of readers—from students and researchers to community leaders and concerned citizens.

  • Translational Medicine in Dry Eye Disease

    A Comprehensive Clinical and Scientific Strategy
    • 1st Edition
    • Marco Zeppieri + 2 more
    • English
    Translational Medicine in Dry Eye Disease: A Comprehensive Clinical and Scientific Strategy offers clinicians, researchers, and healthcare professionals a comprehensive, multidisciplinary resource that translates the latest scientific advances into practical strategies for diagnosing, managing, and treating dry eye disease. By bridging laboratory research and clinical application, this book equips end users with up-to-date insights, innovative diagnostic tools, and evidence-based therapies to improve patient outcomes in the rapidly evolving field of ocular surface health.

  • Mannose Binding Lectin Associated Serine Proteases

    Structure, Function and Therapeutic Implications
    • 1st Edition
    • Krishnan Hajela
    • English
    Mannose Binding Lectin Associated Serine Proteases: Structure, Function and Therapeutic Implications provides a comprehensive overview of MASP-1, MASP-2, and MASP-3, highlighting their roles in immune defense, disease mechanisms, and therapeutic intervention. This book covers the molecular structure and catalytic mechanisms of these key serine proteases, emphasizing their involvement in the lectin pathway of complement activation as well as their emerging functions in coagulation and bradykinin pathways. Chapters detail the biology of animal lectins and collections, classical and alternative complement pathways, and specific biochemical activities of MASP-1, MASP-2, and MASP-3.Readers will find in-depth discussions on the clinical significance of MASP gene polymorphisms and serum levels, and more. Special focus is given to the application of MASP-2 inhibitors in the management of complications such as hematopoietic stem-cell transplantation-asso... thrombotic microangiopathy (HSCT-TMA). This book is an essential resource for researchers in immunology, biochemistry, and molecular medicine, as well as clinicians seeking to advance their understanding of complement biology and the therapeutic potential of targeting the lectin pathway.

  • Health Geography

    Theories, Methods, and Case Studies
    • 1st Edition
    • Peng Jia
    • English
    Health Geography: Theories, Methods, and Case Studies examines the interdisciplinary domain of health geography, systematically integrating geographical science with public health paradigms. The book provides an in-depth analysis of the theoretical foundations, methodological innovations, and practical implications of health geography. Special emphasis is placed on employing geo-spatial technologies, such as Geographic Information Systems (GIS) and remote sensing to enhance disease prevention, health risk assessments, and healthcare resource allocation.By fostering an integrative dialogue among geography, epidemiology, and advanced technological approaches, the book addresses contemporary public health challenges from local to global scales. The book includes over 50 international case studies addressing infectious and chronic diseases, and health resource allocation.

  • 3D Bioprinting and Bioinks for Regenerative Engineering

    Current Concepts and Future Advances
    • 1st Edition
    • Anthony Atala + 1 more
    • English
    3D Bioprinting and Bioinks for Regenerative Engineering: Current Concepts and Future Advances covers bioinks and their associated materials, design formulations, biological interactions, commercial products, and diverse applications in regenerative engineering of various tissues and organs. Part I lays the foundation for bioink concepts and their significance. Part II delves into various 3D printing technologies that enable the creation of complex biological structures. Part III focuses on the fundamentals of bioinks—critical materials that play a key role in printing viable tissues. In Part IV, attention shifts to the process of printing and the development of tissue and organ constructs.Finally, Part V addresses regulatory considerations and offers insights into future perspectives, emphasizing the challenges and opportunities ahead as the field continues to evolve. As the field is on the verge of a new era in engineering tissues, and tissue/body on a chip technologies will play a central role, bioinks are becoming a multidisciplinary field involving materials science, cell biology, biofabrication, and clinical applications. By combining cutting-edge research, practical applications, and expert contributions, this book will become an indispensable resource for both newcomers and experienced professionals.

  • Principles and Practice of Nephrocardiology

    • 1st Edition
    • Parta Hatamizadeh
    • English
    Principles and Practice of Nephrocardiology provides a comprehensive introduction to the interdisciplinary subspecialty of Nephrocardiology. The book includes detailed descriptions, along with an in-depth exploration of its primary elements and topics. Coverage spans pathophysiology, epidemiology, prevention, diagnosis, prognosis, monitoring, therapy, risk factors, and the systemic diseases that involve both nephrology-related conditions and cardiovascular diseases. The book guides clinicians and general practitioners in multiple interdisciplinary specialties through diagnostic, preventive, and therapeutic approaches to a wide variety of patient populations. It also opens a myriad of new avenues for future research and guidance for approaching multiple medical topics.

  • Hyperspectral Imaging

    • 2nd Edition
    • Jose Manuel Amigo + 1 more
    • English
    Hyperspectral Imaging, Second Edition builds on the foundational insights of the first edition, covering core analytical frameworks and introducing new algorithms, hardware technologies, and cutting-edge applications. By incorporating the latest research findings and case studies, sections provide readers with enhanced tools and techniques for effective hyperspectral and multispectral image analysis across diverse scientific, industrial, and field domains. The book also addresses evolving challenges and fresh opportunities in the field, ensuring that users are equipped with the most current knowledge and practices. It underscores the continued relevance and transformative potential of hyperspectral and multispectral imaging in contemporary research and industry.Graduate students, academics, early researchers, and industry scientists across various disciplines working with hyperspectral and multispectral images, including analytical chemistry, remote sensing, vegetation and crops, food and feed production, forensic sciences, biochemistry, medical imaging, pharmaceutical production, art studies, cultural heritage, and more will find this update extremely useful.

  • Empowering Health through Lifestyle Medicine

    The Essential Guide for Preventing and Managing Chronic Disease
    • 1st Edition
    • John Anthony Stevens
    • English
    Empowering Health through Lifestyle Medicine: The Essential Guide for Preventing and Managing Chronic Disease combines the most updated and available research with personal insights and experience, using the Lifestyle Medicine 6 pillar framework. The book engages readers not only in the description and efficacy of LM but also in its knowledge and discussions on concepts and behaviors for managing nutrition, physical activity, stress, mental health, and how our interactions with the environment can create a healthier, happier life. It will encourage clinicians to engage their patients more often, and more practically, with lifestyle medicine, while also helping consumers engage with their clinicians.With a goal of helping clinicians and healthcare related professionals prevent and manage lifestyle-related illnesses for life, this evidenced-based book can be used by anyone in healthcare. It is also ideal for those researching illness prevention and chronic disease management to improve health research practice and patient outcomes.

  • Diabetic Neuropathy

    • 1st Edition
    • Shahidul Islam
    • English
    "Recent Therapeutic Targets for the Prevention and Management of Diabetic Complications: Neuropathy" covers recent research and therapeutic approaches of this diabetic complication for the management of diabetes. It is a detailed reference to understand the pathogenesis of diabetes to alleviate the overall complications of neuropathy to improve patient care. It is uniquely focused on the different aspects of neuropathy with a focus on the molecular and biological pathways (therapeutic target) to detect an early diagnosis to better manage the disease and improve patient care. The book is useful to anyone in the field particularly those who do research investigations, and day-to-day practice in the area of diabetes.

  • Foundation of Microfluidics Device Technology

    • 1st Edition
    • Volume 226
    • English
    Foundation of Microfluidics Device Technology, Volume 225 presents the fundamentals of microfluidics and microfluidics devices, including computational design and fabrication, artificial intelligence and internet of things for microfluidics devices, materials, surface modifications and functionalization of microfluidics, fabrication of paper based microfluidics. Additional topics include microfluidics for generation of biomaterials, microfluidics for multi-omics analysis, lab-on-the-chip, microfluidics for 2D and 3D cell culture systems, microfluidics for drug and gene delivery, biomimetic models, and the economic considerations associated with microfluidics devices development.Specific chapters in this new release include An introduction to microfluidics and devices, Computational design and modeling of microfluidics devices, Artificial intelligence and IoT for microfluidics devices, Fabrication techniques for design of microfluidics devices, Materials, surface modification and functionalization of microfluidic devices, Fabrication of paper based microfluidics, Microfluidics in biomaterials generation and formulation, Microfluidics for chemical and biological analysis, and more.

  • SGLT2 Inhibitors in Cardiovascular Diseases

    Mechanisms, Clinical Impact, and Future Directions
    • 1st Edition
    • Tong Liu
    • English
    SGLT2 Inhibitors in Cardiovascular Diseases: Mechanisms, Clinical Impact, and Future Directions reviews the impact of SGLT2 inhibitors on cardiovascular health in individuals with type 2 diabetes, chronic kidney disease, heart failure, and atherosclerosis. The book synthesizes preclinical and clinical evidence to highlight the cardiovascular benefits of these drugs, initially developed for hyperglycemia management. It details recent studies on SGLT2 inhibitors' effects on cognitive dysfunction, sudden death, ventricular arrhythmias, heart remodeling, and cancer risks in diabetic patients.In addition, it compares SGLT2 inhibitors with DPP4 inhibitors, emphasizing the efficacy of empagliflozin and dapagliflozin in reducing syncope and cardiovascular mortality, supported by trials like EMPA-REG OUTCOME and DECLARE-TIMI 58. Addressing a gap in literature, the book provides a comprehensive overview of SGLT2 inhibitors' cardiovascular benefits in high-risk populations, including atrial fibrillation and syncope. It offers valuable insights and recommendations for clinicians, researchers, and policymakers managing cardiovascular risk.

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