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Elsevier

Books in Life sciences

Elsevier's Life Sciences collection helps researchers get comprehensive coverage and up-to-date information on the study of living organisms, their processes, and interrelationships, spanning disciplines like biology, genetics, and biochemistry, and addressing emerging trends such as genomics, biotechnology, and sustainability, essential for advancing knowledge and driving innovation in the field.

  • Social Determinants of Health in Surgery

    Research Methods and Clinical Review
    • 1st Edition
    • Steven A. Toms + 4 more
    • English
    Social Determinants of Health in Surgery: Research Methods and Clinical Review is a groundbreaking resource dedicated to examining the role of social determinants within surgical care. This book is designed for surgical trainees, healthcare providers, researchers, and policy administrators, offering a thorough exploration of how social factors impact surgical outcomes and practice. Featuring a detailed analysis of eleven key domains, it addresses the challenges and opportunities of integrating social determinants into surgical research and practice. The text provides essential guidance for those seeking to understand and improve patient outcomes through a broader, community-driven lens.In addition to its comprehensive coverage, the book delves into specialized topics such as big data analytics, ethical considerations, global health perspectives, pediatric surgical care, and clinical applications for research. It presents methodological guidance, including valuable tips and common pitfalls useful for readers at any stage of their surgical careers. The book also offers an in-depth review of social determinants research across ten major surgical specialties, highlighting significant trends, key studies, and current gaps in knowledge. Case studies and reflective interviews from experienced clinicians further enrich the reader’s understanding.

  • Alternative Splicing

    Recent Advances in Health and Disease
    • 1st Edition
    • Sayeed ur Rehman A. Kalam + 1 more
    • English
    Alternative Splicing: Recent Advances in Health and Disease offers a comprehensive study of this cellular process, its fundamental characteristics, latest advances, and clinical utilization. Opening with an introduction to alternative splicing and its function in generating transcriptome and protein diversity, the book considers the role of this process across a range of diseases and disorders, including cardiovascular disease, cancer, obesity, and viral infections. Key methods used to study alternative splicing are also investigated, including high-throughput sequencing-based methods, bioinformatics tools, computational methods, single-cell sequencing techniques and mass-spectrometry based proteomics.This is followed with analysis of therapeutic approaches associated with alternative splicing. This is an ideal reference for those involved in investigating alternative splicing and its impact to health and disease, and is therefore relevant to researchers across cell biology, molecular biology, pharmacology and related areas.

  • Shared Research Resources

    Best Practices in Management and Administration
    • 1st Edition
    • Andrew Vinard + 1 more
    • English
    Shared Research Resources: Best Practices in Management and Administration brings together best practices and case studies from research institutions around the world. Covering all areas of management, with examples and applications specific to the research environment, this is the perfect reference to build managerial skills. The first part is dedicated to introducing Shared Research Resources (SRR) management. The second part covers all aspects of staffing. Part three contains complete coverage of operations, including service development, instrument procurement, marketing, management software, customer support, safety, maintenance and repair. Part four is dedicated to fiscal management, budgeting, and reporting.Part five covers strategic management. Part six is devoted to the sustainability of the core facility. The final part covers assessment, including annual reports, program reviews, and audits. This book is a complete reference targeted at SRR managers and staff who need to keep updated with current best practices and case studies. It is also important reading for research institution managers and function leaders.

  • Innovation in Emergency Medicine

    Technology Development and Commercialization Handbook
    • 1st Edition
    • Nancy Patterson + 3 more
    • English
    Innovation in Emergency Medicine: Technology Development and Commercialization Handbook is a step-by-step guide to emergency medicine technology innovation reflecting recent trends of industry globalization and value-conscious healthcare. Written by a team of medical, engineering, and business experts, the authors provide a comprehensive resource that leads engineers, clinicians, students, researchers, and entrepreneurs through a clear process for the identification, invention, and implementation of new solutions. Case studies on innovative products from around the world, successes and failures, practical advice, and end-of-chapter 'Getting Started' sections encourage readers to learn from real projects and apply important lessons to their own work. This new volume in the Clinical and Medical Innovation Series will be of interest to every biomedical engineer and those working in emergency medicine who has ever had a good idea for an invention but does not know where and how to start bringing it to the bedside.

  • Melanin-Concentrating Hormone

    From Metabolism to Sleep Disorders
    • 1st Edition
    • Jackson C. Bittencourt + 1 more
    • English
    Melanin-Concentratin... Hormone: From Metabolism to Sleep Disorders, the latest volume in the Molecular Mediators in Health and Disease series, offers a comprehensive understanding of this multifunctional peptide. The book covers a wide range of topics, including molecular biology of MCH, MCH in organ function, pharmacology, and MCH in disease. Recent developments in MCH imaging and pharmacological modulation are explored, along with the impact of MCH in psychiatric and neurodegenerative disorders and its role in the neuroimmunological modulation of vitiligo. Additionally, MCH is considered in the context of reproductive behavior, sleep, cognition, memory, and peripheral function.The book also explores MCH across various species such as humans, reptiles, non-primate mammals and teleosts. This is an ideal reference for researchers working with MCH across the fields of cell biology, molecular biology, pharmacology, neuroscience, endocrinology, and beyond.

  • A Comprehensive Guide to Dorsal Root Ganglion Stimulation for Pain Management

    • 1st Edition
    • Scott G. Pritzlaff + 4 more
    • English
    A Comprehensive Guide to Dorsal Root Ganglion Stimulation for Pain Management explores the theoretical foundations, clinical applications, and technical nuances of DRG stimulation, providing a robust framework for understanding and implementing this advanced pain management technique. The book consolidates current best practices, novel technical considerations, and emerging research into a single, authoritative volume. Main themes include the anatomical and physiological basis of DRG stimulation, clinical indications, patient selection, surgical techniques, device programming, and long-term patient outcomes. By integrating insights from leading experts in the field, the book provides a comprehensive and practical guide for clinicians, researchers, and students. Distinct from existing titles that merely touch upon the subject, this book offers a detailed and specialized focus on DRG stimulation, including up-to-date evidence, clinical guidelines, and case studies. The book also features pedagogical elements such as learning objectives, review questions, and case studies to enhance understanding and application.

  • Interstitial Lung Diseases

    New Frontiers in Research and Clinical Applications
    • 1st Edition
    • Carlo Vancheri + 1 more
    • English
    Interstitial Lung Diseases: New Frontiers in Research and Clinical Applications is the book professionals working with Interstitial Lung Diseases (ILDs) have been waiting for. This comprehensive, invaluable resource integrates the pathogenic, functional, clinical, and radiological aspects of ILDs, providing clinicians with a practical tool for patient care. It elucidates on the distinguishing features of different ILDs, empowering readers to confidently navigate the diagnostic and therapeutic landscape. Sections offer a practical, step-by-step approach to diagnosing ILDs and understanding their nuances that is structured around the latest scientific evidence.Further, the book covers etiology, epidemiology, pathogenesis, diagnostic processes, and therapeutic options, incorporating diagnostic and treatment algorithms to serve as both a reference and a practical guide for clinical decision-making. By filling gaps in the literature, it equips respiratory professionals with the knowledge and skills necessary to enhance diagnostic accuracy, improve patient management, and foster ongoing innovation in the study of ILDs.

  • Multiple Faces of Takotsubo Syndrome

    Clinical Presentations, Mechanisms and Advanced Diagnostic Insights
    • 1st Edition
    • Luca Saba + 1 more
    • English
    Multiple Faces of Takotsubo Syndrome: Clinical Presentations, Mechanisms and Advanced Diagnostic Insights offers a thorough review of Takotsubo syndrome and the role of advanced imaging techniques in improving diagnosis, monitoring, and management of this complex cardiac condition. The book begins with an introduction to Takotsubo syndrome, covering its historical background, prevalence, and key clinical characteristics. Subsequent chapters delve into epidemiology, risk factors, and psychological aspects, including the impact of COVID-19 and other viral infections. Then, clinical manifestations, management, prevention, and treatments are thoroughly discussed, along with complications and prognosis. The basic science section explores the pathophysiological mechanisms, the heart-brain axis, and multi-organ involvement.A significant focus throughout is placed on invasive and non-invasive imaging modalities, including angiography, echocardiography, cardiac MRI, computed tomography, and nuclear imaging. Future directions highlight emerging biomarkers and imaging techniques for personalized medicine, and real-world case studies provide practical insights for clinicians. The book offers invaluable benefits to scientists, researchers, and clinicians alike.

  • Microplastics and the Hidden Threat to Human Reproduction

    Plastic Peril
    • 1st Edition
    • Nimra Afzal + 1 more
    • English
    Microplastics and the Hidden Threat to Human Reproduction: Plastic Peril explores the intricate relationship between microplastics and reproductive health, delving into the sources and distribution of microplastics in the environment, human exposure routes, associated risks, the toxicological effects on reproductive health, potential connections to fertility, endocrine disruption, and developmental consequences due to maternal exposure. It includes impacts on both male and female reproductive health, risks during pregnancy, population-level health concerns, strategies for mitigating microplastic exposure, and the policy and regulatory frameworks surrounding this issue. The book also provides insights into the future direction of research and public health initiatives.In essence, it explores how tiny microplastic particles can have significant and far-reaching consequences on human reproductive health, making this a vital and emerging area of concern. This is a comprehensive resource for anyone interested in understanding the various aspects of the microplastics-reprod... health connection and a go-to reference for researchers, healthcare professionals, policymakers, and concerned individuals.

  • Advances in Noncoding RNA Diagnostics and Therapeutics in Immunity and Cancer

    • 1st Edition
    • Afsar Naqvi + 1 more
    • English
    Advances in Noncoding RNA Diagnostics and Therapeutics in Immunity and Cancer explores the critical role of noncoding RNAs in immune-mediated diseases and cancers, providing an essential resource on their diagnostic and therapeutic potential. The book contributes valuable insights into the pathobiology of noncoding RNAs and their application in various diseases, delving into the latest research on noncoding RNAs, including their mechanisms, interactions, and roles in disease. In addition, it examines how noncoding RNAs influence immune responses, inflammation, and cancer progression. With a focus on both diagnostic and therapeutic applications, this book highlights the potential of noncoding RNAs as biomarkers and therapeutic targets. Across comprehensive chapters, the book covers a wide range of topics, including the role of virus-encoded microRNAs in immune evasion, the therapeutic aspects of non-coding RNA in hepatocellular carcinoma, the impact of microRNAs in periodontal inflammation, and the involvement of miRNAs and lncRNAs in regulating the tumor microenvironment in HCC. Other chapters explore the functions and clinical value of tumor-derived exosomes and miRNAs in cancer immune response, the interaction of noncoding RNA in cancer metastasis, and a panorama of non‐coding RNA in prostate cancer. This book is an invaluable resource for basic science researchers in the noncoding RNA field, cancer biologists, immunologists and RNA biologists interested in the latest advancements in noncoding RNA research.

  • Introduction to Structural Bioinformatics

    • 1st Edition
    • Yang Zhang + 2 more
    • English
    Introduction to Structural Bioinformatics offers a complete overview on the fundamental concepts and methodologies of structural bioinformatics and computational structural biology. The book is divided into three sections, beginning with a discussion of the key principles of bioinformatics and fundamental aspects, including bioinformatics databases, multiple sequence alignment, and machine learning. Section two then moves on to structural bioinformatics, where topics include Monte Carlo simulation, protein structure prediction, RNA structure prediction, and protein design. The final section of the book focuses on experimental structural determination, where chapters focus on techniques including X-ray crystallography, nuclear magnetic resonance and cryo-electron microscopy. This is an ideal guide on key principles, methods, and the most up-to-date developments across structural bioinformatics and computational structural biology. It will be a comprehensive reference for postgraduate students, instructors, and researchers working in these and adjacent subjects.

  • Hypoxia-induced Tumor Heterogeneity and Immune Evasion

    Clinical Interventions
    • 1st Edition
    • Benjamin Bonavida + 1 more
    • English
    Hypoxia-induced Tumor Heterogeneity and Immune Evasion: Clinical Interventions explores how hypoxic stress within the tumor microenvironment drives cancer progression, immune escape, and resistance to therapy. The volume integrates foundational and cutting-edge insights into tumor biology, immunology, and therapeutic innovation. It is structured into five parts, covering tumor heterogeneity, hypoxia-driven mechanisms, immune evasion, clinical diagnostics, and future directions. Topics include metabolic reprogramming, angiogenesis, immune suppression, and hypoxia-targeted therapies, with emphasis on translational relevance.By bringing together global experts to examine how hypoxia shapes tumor evolution, alters immune responses, and influences treatment outcomes, this resource benefits researchers, clinicians, and advanced students by offering a comprehensive, up-to-date synthesis of a rapidly evolving field. It supports deeper understanding of tumor complexity and equips readers with knowledge to inform experimental design, clinical strategies, and therapeutic development in oncology.

  • Federated Intelligence in Medicine

    AI-Driven Robotics for Secure and Intelligent Healthcare Systems
    • 1st Edition
    • Manisha Guduri + 3 more
    • English
    Federated Intelligence in Medicine: AI-Driven Robotics for Secure and Intelligent Healthcare Systems explores the rapidly evolving field where medical robotics intersects with cutting-edge artificial intelligence and secure data-sharing technologies. Covering a comprehensive range of topics, the book begins with foundational knowledge in medical robotics and Generative AI, progressing to advanced concepts such as federated learning and architectural modeling tailored for AI-driven robotic systems. Readers will explore algorithms enhancing surgical robotics, remote robotic surgeries, and human-robot interaction. The text also tackles AI-driven diagnostic robots, privacy preservation through homomorphic encryption, and differential privacy and emerging medical imaging techniques integrated with robotics.Later chapters examine the synergy of large language models, agent AI, and edge AI with robotic technologies, providing both theoretical frameworks and practical case studies that illuminate real-world applications and challenges. This book is an invaluable resource for researchers and academicians engaged in artificial intelligence, robotics, and medical technology. It also serves undergraduate and graduate students in Biomedical Engineering, Electronics and Electrical Engineering, and Computer Science and Engineering.

  • Complications in Spinal Surgery

    A Comprehensive Guide
    • 1st Edition
    • Rafael De la Garza Ramos + 2 more
    • English
    Complications in Spinal Surgery: A Comprehensive Guide is a comprehensive reference for before and after surgery, covering common complications and rare complexities. The book is divided into major sections, including safety in spine surgery, general complications, complications by region (cervical, thoracic, lumbar, and sacral), complications related to pediatrics, and predictive analytics. Although some complications can happen irrespective of the spinal region, dividing into anatomical sections make the most sense for the reader. Designed to benefit both surgeons-in-training... and fellows—and seasoned professionals in orthopedic and neurosurgical spine practice, this book provides critical insights into the prevention, recognition, and management of complications.Unique to this book are the other implications of complications, such as how to approach patients and families, the medicolegal aspects of complications, and how to deal with these situations at a personal level. With its evidence-based approach, real-world case discussions, and expert perspectives, it equips readers with the knowledge and confidence to navigate the complexities of spine surgery and improve patient outcomes.

  • Implications of Artificial Intelligence in Next Generation Physiotherapy

    • 1st Edition
    • Manpreet Kaur + 3 more
    • English
    Implications of Artificial Intelligence in Next Generation Physiotherapy explores how artificial intelligence is transforming the future of physiotherapy across the entire continuum of rehabilitation. Covering musculoskeletal, neurological, cardiopulmonary, sports, paediatric, geriatric, women's health, and community-based physiotherapy, the book highlights how AI is reshaping clinical practice through intelligent assessment, precision rehabilitation, personalized treatment planning, predictive analytics, remote monitoring, and data-driven clinical decision-making.The book presents comprehensive coverage of emerging AI technologies, including machine learning, deep learning, computer vision, wearable sensors, robotics, virtual and augmented reality, digital twins, tele-rehabilitation, and intelligent clinical decision support systems. It also discusses workload monitoring, movement analysis, biomechanical assessment, functional outcome prediction, patient engagement, and continuous recovery tracking, supported by current research, real-world applications, and clinical case studies.Designed for researchers, clinicians, educators, students, and healthcare innovators, this book bridges the gap between cutting-edge artificial intelligence and evidence-based physiotherapy practice. By examining both current applications and future directions, it provides readers with the knowledge required to implement AI-driven innovations that enhance diagnostic accuracy, optimize rehabilitation outcomes, improve healthcare accessibility, and advance patient-centred care in the next generation of physiotherapy.

  • Endoscopic/Robotic Thyroidectomy Surgery

    Using the Gasless Unilateral Axillary Approach
    • 1st Edition
    • Chuanming Zheng + 1 more
    • English
    Endoscopic/Robotic Thyroidectomy Surgery: Using the Gasless Unilateral Axillary Approach is a comprehensive and systematic resource on endoscopic/robotic thyroidectomy using the gasless unilateral axillary approach comprehensive and systematically presented resource on the gasless axillary approach to endoscopic/robotic thyroidectomy. It includes a detailed introduction to all aspects of surgical treatment including anesthesia coordination and robotic surgery. The book provides practical guidance on postoperative complication management and postoperative care and describes specific methods for technical simulation training and functional exercises. While many journal papers on specific aspects of this surgical approach have been published, no book is currently available.

  • LGBTQ+ Access to Inflammatory Bowel Disease Healthcare

    Current Trends and Considerations
    • 1st Edition
    • Lesley Dibley + 1 more
    • English
    LGBTQIA+ Access to Inflammatory Bowel Disease Healthcare: Current Trends and Considerations illuminates the unique medical, surgical, and mental health issues faced by LGBTQIA+ patients, providing clinicians with the knowledge to understand why these issues arise and how they can be effectively addressed. This crucial resource aims to elevate awareness among healthcare providers and commissioners about the need for gender- and identity-affirming care. As societal recognition of LGBTQIA+ rights grows, this book steps into the unexplored terrain of LGBTQIA+ healthcare and IBD, addressing both medical complexities and the social and political dimensions of care. The book opens with an introduction to the significance of LGBTQIA+ access to healthcare and the necessity for clinician awareness. It includes contributions from leading experts and a comprehensive glossary of relevant LGBTQIA+ terms. Key topics covered are the socio-cultural and political history influencing healthcare access, the impact of stigma on healthcare utilization and adherence, and specific medical, surgical, and mental health considerations for transgender patients with IBD. The text also covers gender- and identity-affirming practices, advocating for effective patient-provider communication and supportive healthcare environments, even in challenging settings. The concluding chapters assess the progress made and the journey ahead in LGBTQIA+ IBD care. Designed for clinicians and healthcare providers, this book serves as an indispensable reference, consolidating essential contemporary evidence into a single, accessible resource. Whether you are a gastroenterologist, surgeon, mental health professional, or healthcare researcher, this book offers the insights and tools necessary to deliver inclusive and effective care, keeping pace with the evolving healthcare advocacy and equality landscape.

  • Advances in Hepatorenal Syndrome Research

    Untangling Pathophysiology, Improving Diagnostic Strategies, and Leveraging Therapeutic Innovations
    • 1st Edition
    • Justin Belcher
    • English
    Advances in Hepatorenal Syndrome Research: Untangling Pathophysiology, Improving Diagnostic Strategies, and Therapeutic Innovations is a comprehensive review of the historical perspectives, prevalence, and prognosis of HRS, offering insights into its evolving clinical recognition and shifting paradigms of pathophysiology. Explore the multifaceted pathophysiology of HRS as experts navigate the complexities of cardiac dysfunction, inflammatory cytokines, and other modern understandings shaping the field. Explore differential diagnosis, uncovering alternative etiologies and current diagnostic criteria, while shedding light on biomarkers and novel diagnostic tests revolutionizing patient assessment. Contents will also guide readers through the utility of point-of-care ultrasound in intravascular volume assessment sets the stage for exploring medical therapy options, including vasoconstrictors and albumin usage. Written by a team of experts, this comprehensive reference highlights the intricate pathophysiology of hepatorenal syndrome while delivering the most up-to-date insights into diagnostic and therapeutic approaches. Historically overshadowed by grim prognoses, hepatorenal syndrome has undergone a renaissance of interest due to recent breakthroughs, revolutionizing treatment paradigms. Whether you're a seasoned practitioner or a burgeoning researcher immersing yourself in this dynamic field, this resource offers a thorough examination, encompassing novel diagnostic criteria, innovative biomarkers, and state-of-the-art treatments.

  • Digital Twins and Predictive Modeling in Robotic Surgery

    • 1st Edition
    • Mudassir Khan + 3 more
    • English
    Digital Twins and Predictive Modeling in Robotic Surgery addresses the transformative convergence of digital twin technology, predictive analytics, and robotic surgery. This reference responds to the critical need for a comprehensive resource that bridges simulation science, artificial intelligence, and real-time robotic execution, facilitating enhanced surgical precision, patient-specific planning, and intraoperative decision-making. The content is organized into four parts covering foundational intelligent surgical systems, predictive modeling and simulation, clinical applications with case studies, and challenges alongside future directions. Topics include AI integration, IoT-enabled sensor networks, digital twin architectures encompassing the entire surgical ecosystem, surgical workflow modeling, risk assessment, human-robot interaction, technology acceptance, ethical and regulatory considerations. Real-world examples from smart hospitals worldwide illustrate practical implementation. This books benefits biomedical engineers, researchers, and healthcare system architects by providing interdisciplinary insights, practical implementation frameworks, and cutting-edge case studies. It supports improved surgical planning, precision, and decision-making, empowering end users to advance the adoption of intelligent, AI-powered robotic surgery systems in clinical practice and research environments.

  • Artificial Intelligence in Point-of-Care Nanobiosensors Technology

    Enhancing Disease Diagnostics and Improved Healthcare Outcomes
    • 1st Edition
    • Tharmaraj Vairaperumal + 2 more
    • English
    Artificial Intelligence in Point-of-Care Nanobiosensors Technology: Enhancing Disease Diagnostics and Improved Healthcare Outcomes delves into the revolutionary integration of artificial intelligence (AI) with nanobiosensors to elevate point-of-care (POC) diagnostics for both communicable and non-communicable diseases. Readers will find insightful chapters covering topics ranging from foundational AI and machine learning techniques to specific applications in cardiovascular disease, diabetes, cancer, chronic respiratory ailments, and infectious diseases. Each chapter not only highlights recent breakthroughs in nanobiosensors but also emphasizes the pivotal role of AI in enhancing diagnostic accuracy and facilitating personalized health interventions. Additional discussions around regulatory considerations and the future landscape of AI in biomedical research make this an essential read for those navigating this rapidly evolving field. This book primarily targets researchers and professionals engaged in the interdisciplinary realms of AI, nanomaterials, and biomedical sciences. By providing a critical understanding of emerging AI-based diagnostic technologies and their applications in POC settings, this book fosters collaboration across diverse scientific domains.

  • Neurogenetic Therapies

    Advancements in Treating Nervous System Disorders
    • 1st Edition
    • Ashutosh Pareek + 4 more
    • English
    Neurogenetic Therapies: Advancements in Treating Nervous System Disorders offers a comprehensive resource on the latest gene therapy techniques and their applications in treating neurological disorders. The book delves into various gene therapy methods, including genomic DNA-based therapies, vector-mediated delivery, and RNA interference-based gene silencing. It explores the use of these techniques in treating conditions such as Alzheimer's disease, Parkinson's disease, spinal muscular atrophy, and Duchenne muscular dystrophy. Key topics include the molecular and genetic basis of nervous system disorders, the role of epigenetics, and the development of stem cell and genome editing therapies.With contributions from leading experts, the book also addresses regulatory and ethical considerations in gene therapy, providing a balanced perspective on the challenges and opportunities in this rapidly evolving field. Case studies and practical examples illustrate successful gene therapy treatments, offering valuable insights into translating research into clinical practice. This book is an essential resource for students, researchers, and scientists in neurogenetics, neurology, and molecular biology, as well as clinicians interested in the mechanisms and treatment of neurodegenerative diseases.

  • Anorectal Malformations

    • 1st Edition
    • Ivo de Blaauw + 2 more
    • English
    Anorectal Malformations is an essential resource for pediatric surgical specialists and caregivers, providing a comprehensive approach to the diagnosis, treatment, and follow-up of patients with anorectal malformations. This book not only covers the latest surgical techniques but also delves into the intricacies of the condition, offering structured advice from a trusted organization, ERN eUROGEN, and addressing the significant gaps in literature related to this rare disease. The handbook is meticulously organized, beginning with an introduction to the ERN eUROGEN and ARMnet networks, followed by an exploration of key topics such as anatomy, embryology, genetics, and epidemiology of anorectal malformations. It details surgical procedures, including colostomy and reconstruction techniques, as well as non-surgical treatments for common complications like constipation and incontinence. The book also emphasizes long-term outcomes, global care networks, and patient perspectives, ensuring a holistic understanding of the patient journey.Anorectal Malformations is invaluable for clinicians, researchers, and healthcare professionals, providing the necessary insights to make accurate diagnoses, perform effective surgeries, and ensure proper follow-up care. It serves as a critical reference guide for anyone involved in the care of patients with anorectal malformations, ultimately improving clinical outcomes and enhancing the quality of life for affected individuals and their families.

  • Correlative Light and Electron Microscopy VI

    • 1st Edition
    • Volume 213
    • English
    Correlative Light and Electron Microscopy VI presents current methods and applications in combining light microscopy and electron microscopy to study biological structures and processes with high spatial and temporal resolution. The volume highlights practical approaches for linking dynamic imaging with ultrastructural analysis, enabling researchers to investigate cells, tissues, and subcellular components in greater detail. Covering both established and emerging techniques, this book serves as a useful resource for scientists working in cell biology, structural biology, imaging, and related biomedical fields.

  • 3D Bioprinting and Bio-Regenerative Medicine for Personalized Oncology

    Innovations for Personalized Oncology
    • 1st Edition
    • Ashok Kumar + 2 more
    • English
    3D Bioprinting and Bio-Regenerative Medicine for Personalized Oncology: Innovations for Personalized Oncology presents a comprehensive exploration of the transformative role of 3-D bioprinting and bio-generative engineering in modern medicine, with a specific focus on precision oncology. By examining innovative applications of these technologies, the book aims to bridge the gap between emerging scientific advancements and their practical implications in clinical settings. It delves into how patient-specific models of human tissues and organs can revolutionize drug testing, disease diagnostics, and personalized treatment plans, ultimately enhancing the quality of cancer care.Addressing critical challenges in oncology, this book highlights how 3-D bioprinting and bio-generative engineering can improve the accuracy of drug efficacy evaluations, reduce reliance on animal testing, and tackle the pressing issue of organ shortages for transplantation. Furthermore, it emphasizes the ethical considerations and regulatory challenges associated with integrating these technologies into everyday oncology practice, ensuring a balanced perspective on their adoption.

  • Pheochromocytoma, Paraganglioma and Adrenocortical Carcinoma: Physiopathology and Diagnosis

    • 1st Edition
    • Volume 133
    • English
    Volume 133 provides a comprehensive and up-to-date overview of three of the most challenging endocrine neoplasms—pheochromo... paraganglioma, and adrenocortical carcinoma. Bringing together contributions from internationally recognized experts, this volume explores the latest advances in tumor biology, genetics, molecular mechanisms, and endocrine pathophysiology, while offering a practical approach to modern diagnostic strategies. Readers will find detailed discussions on hereditary syndromes, genotype–phenotype correlations, biochemical testing, imaging modalities, histopathological assessment, molecular profiling, and emerging biomarkers that are reshaping the diagnosis and risk stratification of adrenal tumors. Integrating cutting-edge scientific discoveries with clinical practice, this volume serves as an essential resource for endocrinologists, oncologists, endocrine surgeons, pathologists, radiologists, nuclear medicine specialists, geneticists, researchers, and trainees seeking to improve the diagnosis and understanding of these rare but clinically significant endocrine malignancies. With its multidisciplinary perspective and strong translational focus, Volume 133 is an indispensable reference for clinicians and scientists dedicated to advancing adrenal tumor care and research.

  • Introduction to Bioinformatics and Machine Learning

    • 1st Edition
    • Milana Frenkel-Morgenstern
    • English
    Introduction to Bioinformatics and Machine Learning 1st Edition bridges the gap between biological data analysis and machine learning techniques, offering a foundational understanding of bioinformatics concepts and practical applications of machine learning in biological research. It covers key topics such as sequence analysis, omics data integration, predictive modelling, RNA and DNA sequencing, and algorithm development, with real-world examples and case studies. The need for this book arises from the rapid growth of biological data and the increasing demand for tools to analyze and interpret it effectively. Unlike existing resources, this textbook provides a balanced approach to both theoretical concepts and hands-on problem-solving, making it suitable for readers with diverse backgrounds in biology, computer science, and data science. The scope includes introductory material, advanced applications, and emerging trends, ensuring depth and relevance for learners and practitioners alike, and is a comprehensive resource for undergraduate and graduate students, as well as professionals transitioning into these fields.

  • Emerging Technologies in Bioengineering for Oncology

    Fundamentals, Research, and Future Prospects
    • 1st Edition
    • Saikat Das + 2 more
    • English
    Emerging Technologies in Bioengineering for Oncology: Fundamentals, Research, and Future Prospects explores the integration of engineering, biology, and medicine to tackle challenges in developing innovative tools for cancer diagnosis and treatment. This comprehensive resource addresses the evolving landscape of bioengineering in oncology, highlighting the intersection of various disciplines to drive advancements in diagnostic and therapeutic approaches. The book explores a range of cutting-edge technologies such as lab-on-chip devices, wearable biosensors, 3D bioprinting, and targeted nanomedicine, offering promising avenues for enhanced diagnostic precision, treatment effectiveness, and personalized healthcare.Geared towards medical students and professionals, the book provides detailed insights into the latest developments, practical applications, and future research directions in the field. By offering a deep dive into the realm of bioengineering for oncology, it serves as a valuable asset for those seeking to advance cancer care through interdisciplinary collaboration and innovation.

  • The Kidney

    • 1st Edition
    • Volume 7
    • Ahmed El-Hashash + 1 more
    • English
    The Kidney, Volume Seven in the Stem Cell Innovation in Health and Disease series, explores the emerging potential of stem cell therapies in treating kidney diseases. With their natural regenerative and anti-inflammatory properties, stem cells offer a promising approach to restoring essential kidney functions and mitigating damage. This volume highlights how stem cell therapies may modulate immune responses, promote tissue repair, and replace damaged kidney cells, offering hope for chronic and acute renal conditions. Key developments include the injection of mesenchymal stem cells (MSCs) into damaged kidneys where they can differentiate into kidney cell types and aid in healing.In addition, urine-derived stem cells have also shown significant potential in improving kidney function in preclinical studies. Additionally, innovative techniques like incorporating MSCs into compact dialysis machines are explored, enabling delivery of pro-repair factors directly to the kidneys during blood filtration. While there are currently no FDA-approved stem cell treatments for kidney diseases, ongoing clinical trials aim to evaluate their safety and efficacy. This volume compiles cutting-edge research, discussing various cell sources, underlying mechanisms, observed therapeutic outcomes, and the practical challenges of clinical translation. By presenting a clear picture of current advances and future directions, this book serves as a vital resource for scientists, clinicians, and health innovators seeking to harness stem cell technology in nephrology.

  • Geostatistical Approaches to Environmental and Public Health Issues

    • 1st Edition
    • Deepak Kumar + 4 more
    • English
    Geostatistical Approaches to Environmental and Public Health Issues discusses how geostatistical techniques can be leveraged to better understand and respond to pressing environmental and public health challenges. The book showcases how techniques like kriging, spatial regression, Bayesian modeling, and space-time analysis offer powerful, nuanced insights into these issues. Emphasizing stochastic, non-deterministic approaches, it highlights the importance of modeling uncertainty in both environmental and health domains. Through case studies and research-driven chapters, sections demonstrate how integrating geospatial and statistical methods can enhance our understanding of where, why, and how events occur—ultimately improving the precision of health interventions and environmental policies.By aligning cutting-edge statistical approaches with the geospatial dimensions of health and environmental data, this book fills a critical gap in the literature and supports more targeted, data-driven decision-making in the face of global uncertainty. It bridges methodological innovation with applied research, making it an essential resource for scientists, policymakers, and public health practitioners.

  • Therapeutic Potentials of Tenofovir Alafenamide in Hepatitis B

    • 1st Edition
    • Lung-Yi Loey Mak + 1 more
    • English
    Therapeutic Potentials of Tenofovir Alafenamide in Hepatitis B offers a comprehensive examination of the therapeutic potentials of Tenofovir Alafenamide (TAF) in hepatitis B, providing a succinct and up-to-date summary of all relevant evidence for this first-line oral antiviral agent. The text delves into key topics such as the pharmacological profile of TAF, its comparative efficacy against traditional antiviral agents, safety and tolerability, and the impact of TAF on drug resistance. Additionally, it explores the use of TAF in special populations, including pediatrics, the elderly, and individuals with renal impairment, as well as future directions in hepatitis B treatment strategies.Readers will discover the diverse potential applications of TAF in chronic hepatitis B, informed by valuable lessons learned from HIV treatment while also gaining insights into future therapeutic possibilities. Authored by leading experts in the field, each chapter presents focused and insightful perspectives, making this book an indispensable resource for practitioners and researchers alike. Serving as a critical resource for physicians, researchers, pharmacologists, and biomedical scientists, this book highlights the core knowledge necessary for understanding TAF and its clinical applications.

  • Nanomaterials for Stem Cell Modulation

    Innovation and Clinical Applications
    • 1st Edition
    • Syed Mahmood + 3 more
    • English
    Nanomaterials for Stem Cell Modulation: Innovation and Clinical Applications provides a comprehensive exploration of how nanotechnology is transforming stem cell science and regenerative medicine. This authoritative volume examines the physicochemical properties of nanomaterials, their interactions with stem cells, and their capacity to direct stem cell behaviors such as proliferation, differentiation, and therapeutic delivery. By blending foundational principles with cutting-edge innovations, the book bridges the gap between basic laboratory discoveries and clinical translation. Written by experts in the field, the book addresses the critical need for an integrated resource that unifies current knowledge with emerging research and practical applications.While interest in nanotechnology and stem cells continues to grow, the literature remains fragmented. This book fills that gap by offering structured insights, case studies, and guidance on selecting nanomaterial systems tailored to specific therapeutic goals, while also navigating regulatory and translational challenges. Designed for researchers, graduate students, and professionals, the text serves as both a practical guide and an academic reference across disciplines including nanotechnology, stem cell biology, regenerative medicine, tissue engineering, biomedical engineering, and pharmaceutical sciences.

  • Cellular Senescence

    Mechanisms, Disease Links, and Therapeutic Opportunities
    • 1st Edition
    • Kishor Pant + 1 more
    • English
    Cellular Senescence: Mechanisms, Disease Links, and Therapeutic Opportunities provides a comprehensive resource on cellular senescence and its significance as a fundamental driver of various diseases. This reference consolidates mechanistic insights and clinical relevance, bridging the gap between basic science and translational relevance to explore both the molecular underpinnings of senescence, and its implications for therapeutic innovation, highlighting how targeting senescent cells may reshape the future of medicine. The book systematically covers foundational concepts including senescence triggers, molecular pathways, and detection methods, progressing through disease-specific chapters on cancer, metabolic disorders, liver diseases, fibrosis, cardiovascular disease, neurodegenerative conditions and chronic inflammation. It highlights the paradoxical roles of senescent cells alongside emerging therapeutic strategies such as senolytics and senomorphics. Each chapter integrates current research, clinical insights, and translational applications. Step-by-step procedures, case studies, and learning objectives are also included throughout to aid understanding.Cellul... Senescence: Mechanisms, Disease Links, and Therapeutic Opportunities enhances understanding of the complex biology underlying this key cellular process. It is an ideal resource for cell biologists, biomedical researchers, clinicians, and graduate students in related areas who are looking to advance their understanding of cellular senescence and how it may be harnessed to treat a variety of diseases.

  • Digital Medical Twins for Personalized Healthcare

    Generative AI and Multi-Modal Approaches for Predictive Diagnostics and Precision Medicine
    • 1st Edition
    • Yogesh Kumar + 3 more
    • English
    Digital Medical Twins for Personalized Healthcare: Generative AI and Multi-Modal Approaches for Predictive Diagnostics and Precision Medicine presents a rigorous, evidence-based framework for building patient-specific digital replicas that support clinical decision-making and research innovation. The field integrates electronic health records, imaging, genomics, and continuous wearable data into dynamic models that simulate disease trajectories and treatment responses. Readers confront a evolving landscape of AI methods, privacy requirements, and regulatory expectations; this book offers a coherent, practical reference designed for scientists, and health-system professionals seeking to translate digital twins from concept to care delivery.

  • Electrocardiography of Laboratory Animals

    • 3rd Edition
    • Meg M. Sleeper + 1 more
    • English
    Electrocardiography of Laboratory Animals, Third Edition, provides the latest information on critical topics such as safety electrocardiography, toxicology, safety pharmacology, and telemetry, ensuring that readers are well-equipped with the knowledge required for accurate ECG interpretation in preclinical studies. The book begins with the fundamental principles of electrocardiography and its applications in drug safety evaluation but then covers electrocardiography in a wide range of laboratory animals, including rodents, guinea pigs, rabbits, cats, dogs, and various non-human primates such as marmosets, cynomolgus monkeys, rhesus monkeys, baboons, and chimpanzees.Addition... it reviews the ECG characteristics of minipigs, nanopigs, and micropigs. The text also includes chapters on telemetry and echocardiography in preclinical safety studies, as well as discussions on important parameters like PR (PQ), QRS, and QT intervals. The book concludes with chapters on cardiac assays, biomarkers, stem cells, and cardiovascular medical devices, providing a holistic view of cardiovascular research. It is an essential resource for biological and medical researchers, veterinarians, zoologists, and students.

  • Sustainable Digital Medicine

    Green Technology Integration for Inclusive Health Systems
    • 1st Edition
    • Patricia Ordonez de Pablos + 1 more
    • English
    Sustainable Digital Medicine: Green Technology Integration for Inclusive Health Systems explores the transformative potential of digital innovation in healthcare. This edited volume brings together global perspectives on how emerging technologies can modernize health systems while promoting sustainability and inclusivity. The book covers key topics such as AI integration in medicine, digital tools for citizen empowerment, modernization of medical education, and the environmental impact of healthcare technologies. It includes case studies from Asia, Europe, the Gulf Region, and the Americas, offering comparative insights and practical applications. Contributors analyze challenges and opportunities in digital health, with policy recommendations for decision-makers. Designed for researchers, academics, and policymakers, this book provides timely knowledge and actionable strategies. Readers gain a deeper understanding of digital transformation in healthcare, new professional skillsets, and the role of technology in building resilient, equitable health systems aligned with global sustainability goals.

  • Mycorrhizal Symbiosis

    • 1st Edition
    • Volume 121
    • English
    Mycorrhizal Symbiosis, Volume 120 highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Molecular regulation and host-control of Arbuscular Mycorrhizal Symbiosis, Plant-AM fungus communication: key role of nutrition in cry for help signals, Nutrient exchange in mycorrhizal symbiosis, Biotechnological solutions based on mycorrhizae for the improvement of plants against abiotic stress, Mycorrhizae and plant responses to salinity, Mycorrhizal symbiosis regulating plant-biotic interactions, Nutritional quality of mycorrhizal crops: current and future challenges from a One Health perspective, The Role of Arbuscular Mycorrhizal Fungi in Fruit Trees and the Challenges of Their Application, and much more.Additional sections cover Mycorrhizal fungi: key to the functionality and conservation of native forests in southern Chile and Applications of mycorrhizae in ecological restoration.

  • Protein Misfolding

    • 1st Edition
    • Timir Tripathi
    • English
    Protein Misfolding explores the structural and biochemical foundations of protein misfolding, highlighting its wide-reaching implications for cellular function, disease progression, and biomedical innovation. This book provides a comprehensive understanding of how proteins deviate from their native conformations and the resulting biological consequences. Focusing on both physiological and pathological misfolding, the volume covers essential topics such as folding quality control, molecular chaperones, degradation pathways, and proteostasis. It presents in-depth analyses of protein aggregation mechanisms, amyloid formation, and misfolding-associate... diseases including Alzheimer's, Parkinson's, and prion-related disorders. Additional chapters explore structural approaches to understanding misfolded states, computational modeling of aggregation kinetics, and current efforts to design therapeutics that restore folding homeostasis or prevent toxic accumulation. The book also addresses the cellular response to misfolding stress and the integration of folding dynamics with cellular signaling pathways. This book is a valuable resource for researchers, educators, and professionals in biochemistry, structural biology, molecular medicine, biotechnology, and related disciplines. It supports efforts to understand the fundamental principles of protein structure and function, while offering insight into emerging therapeutic strategies and future research directions in disease-focused protein science.

  • RNA-Binding Proteins Part A

    • 1st Edition
    • Volume 743
    • English
    Overall, this volume serves as a comprehensive methodological resource that integrates RNA-binding proteins, RNA metabolism, phase separation, and neurodegenerative disease mechanisms. As Volume 743 of the Methods in Enzymology series, RNA-Binding Proteins highlights recent advances in the field through chapters covering topics such as RNA-Binding Proteins: Structure, Function, and RNA Interactions; RNA Granules, Phase Separation, and Biomolecular Condensates; RNA Regulation in Cellular Physiology; RNA-Binding Proteins in Neurobiology and Neurodegeneration; RNA Processing, Editing, Splicing, and Decay; Non-Coding RNAs, Small RNAs, and RNA Therapeutics; and Experimental and Computational Methods for RNA–Protein Interaction Analysis. Collectively, these contributions provide valuable methodological and conceptual insights, making the volume highly relevant to researchers in molecular biology, neuroscience, RNA biology, and translational medicine.

  • Protein Folding

    • 1st Edition
    • Timir Tripathi
    • English
    Protein Folding explores the fundamental and applied aspects of protein folding, misfolding, and stability in biological systems. Focusing on the biochemical principles and molecular dynamics that drive folding processes, the book provides readers with a comprehensive understanding of how proteins attain their native structures and what happens when this process goes awry. Covering diverse approaches from structural biology, biophysics, enzymology, and systems biology, the book highlights the molecular basis of folding pathways and the pathological consequences of misfolded proteins in diseases such as Alzheimer's, Parkinson's, and cystic fibrosis. It integrates insights into chaperone function, folding kinetics, and the cellular quality control mechanisms that safeguard proteostasis. Across its chapters, the book addresses key themes including protein folding landscapes, folding intermediates, the role of cellular compartments, aggregation-prone sequences, and the impact of mutations. It also examines current methodologies for studying protein folding, including spectroscopy, calorimetry, and computational simulations, and considers emerging therapeutic strategies that target misfolding and aggregation. This book is a valuable resource for biochemists, molecular biologists, biotechnologists, enzymologists, and researchers in protein science. It supports academic researchers, postgraduate students, and pharmaceutical scientists working to understand protein behavior and develop interventions for protein misfolding diseases.

  • Advanced Ultrasound with Imaging Correlations of Diffuse Liver Diseases

    • 1st Edition
    • Riccardo De Robertis
    • English
    Advanced Ultrasound with Imaging Correlations of Diffuse Liver Diseases addresses the critical need for detailed comparisons between advanced ultrasound (US) techniques and CT/MRI findings in the evaluation of liver diseases. While many books exist, few provide the in-depth analysis and practical guidelines necessary for accurate diagnosis and effective treatment planning. This book fills that gap, offering a multiparametric approach to the assessment of fibrotic and steatotic liver diseases. Inside, readers will find essential topics such as indications for liver US in diffuse liver diseases, advanced Ultrasound techniques for assessing liver fibrosis and steatosis, and the correlation between US, CT, and MRI findings.Key chapters cover the basics of liver ultrasound, conventional Doppler and microvascular flow imaging, ultrasound elastography, and the quantification of liver steatosis. Additionally, the book explores cutting-edge topics like artificial intelligence in liver ultrasound and the application of US in pediatric patients. Contributions from leading experts in the field ensure that each chapter provides valuable insights and practical advice. This is an indispensable resource for scientists, researchers, and clinicians alike. It offers clear guidelines on performing liver ultrasounds, understanding and interpreting results, and making informed comparisons with CT and MRI findings.

  • Practice-Based Physiology in Allied Health Sciences

    From Evidence to Clinical Application
    • 1st Edition
    • Satyajit Tripathy + 3 more
    • English
    Practice-Based Physiology in Allied Health Sciences: From Evidence to Clinical Application provides a comprehensive, systems-based exploration of human physiology specifically designed for applied health sciences. It moves beyond conventional textbook knowledge to integrate cardiovascular, respiratory, neurological, endocrine, and musculoskeletal systems within the context of real-world clinical and functional applications. By emphasizing translational physiology, the text helps readers understand how cellular and systemic mechanisms directly inform therapeutic assessment, intervention planning, and patient-centered care. The book’s multidisciplinary perspective supports students and practitioners in physiotherapy, occupational therapy, nursing, sports medicine, and behavioral science—highlighting physiology as a common language that unites diverse healthcare disciplines. Through detailed explanations, case studies, and applied scenarios, readers learn to interpret physiological data, identify dysfunctions, and design interventions grounded in scientific evidence. Ultimately, this resource bridges the gap between science and practice by linking physiological understanding to outcomes such as recovery, mobility, pain management, fatigue reduction, and overall well-being. It encourages critical thinking, clinical reasoning, and interprofessional collaboration—ensuri... that learners not only grasp how the human body functions but also how that knowledge can meaningfully improve health, performance, and quality of life.

  • Wound Microenvironment Responsive Smart Dressing for Effective Healing

    • 1st Edition
    • Mohit Kumar + 4 more
    • English
    Wound Microenvironment Responsive Smart Dressing for Effective Healing presents a cutting-edge scientific exploration of phytoconstituent-bas... smart wound dressings engineered to accelerate and improve tissue repair. Bridging the therapeutic wisdom of traditional herbal medicine with advanced biomaterials, nanotechnology, polymer science, and bioengineering, this volume highlights how natural bioactive compounds can be transformed into clinically viable wound therapies. The book provides an integrated understanding of the molecular and cellular mechanisms governing wound healing, and demonstrates how stimuli-responsive delivery platforms—sensitive to pH, temperature, enzymes, ROS, or glucose—can enable precise, controlled release of phytochemicals directly at the wound site. These innovative systems overcome limitations of conventional formulations, such as instability, poor solubility, low bioavailability, and lack of targeted action. With contributions spanning smart hydrogels, nanocarriers, microneedles, 3D/4D printing, and AI-assisted wound monitoring, this multidisciplinary reference offers both foundational principles and translational guidance. Case studies and globally inclusive perspectives ensure broad relevance for researchers, clinicians, and formulation scientists working toward next-generation wound management solutions.

  • The Pancreatic Tumor Microenvironment

    Systems Biology of Stroma–Microbiome Interactions for Precision Therapy
    • 1st Edition
    • Ganji Purnachandra Nagaraju + 1 more
    • English
    The Pancreatic Tumor Microenvironment: Systems Biology of Stroma–Microbiome Interactions for Precision Therapy unites leading experts to integrate stromal biology and microbiome science into a single, translational roadmap for pancreatic cancer. It frames tumor progression and treatment resistance as emergent properties of an ecosystem, not isolated cells. The book surveys the composition and heterogeneity of the tumor microenvironment; cancer associated fibroblast plasticity; extracellular matrix and signaling dynamics; immune suppression; metabolic and hypoxic reprogramming; and gut/tumor associated microbiomes. Methodological chapters highlight single cell, spatial and multi omics approaches, experimental models, biomarkers, and clinical trial design, culminating in combination strategies and future directions. Readers gain a mechanistic, systems level synthesis that clarifies conflicting literature, prioritizes targets, and bridges basic, translational, and clinical domains—accelerating precision oncology and informing study design, patient stratification, and therapeutic combinations.

  • The Complete Book of Coronary Artery Disease

    Anatomy, Physiology, Pathology, and Management
    • 1st Edition
    • Robert "Jay" Widmer
    • English
    The Complete Book of Coronary Artery Disease: Anatomy, Physiology, Pathology, and Management covers various essential aspects related to the anatomy, embryology, anomalies, physiology, pathology, imaging, and disease management of the coronary system. The book highlights both invasive and non-invasive imaging techniques, with a focus on coronary CTA and CT-guided PCI. Intravascular imaging methods such as IVUS and OCT are elaborated on in assessing coronary health, along with a section on coronary anomalies and their incidence, diagnosis, and clinical implications. Meanwhile, information on coronary physiology explores non-pathological functions and adaptations to stressors.Coronary ischemia assessment using physiological parameters and unresolved questions regarding symptoms are also fundamental to this volume. Further, this book details coronary atherosclerosis, including pathological processes and treatment options. A non-atherosclerotic coronary anatomy section addresses pathologies impacting coronary arteries in other ways. For professionals seeking consolidated information on an oft-overlooked topic, they need look no further than this book.

  • Management of Chronic Kidney Disease and Its Complications

    • 1st Edition
    • Thakur Gurjeet Singh + 4 more
    • English
    Management of Chronic Kidney Disease and Its Complications  presents the latest scientific advances in diagnosing and managing Chronic Kidney Disease (CKD) and its diverse complications. This authoritative text covers molecular mechanisms such as inflammation and oxidative stress, genetic and epigenetic factors, and explores cutting-edge technologies including artificial intelligence and regenerative medicine. With detailed chapters on cardiovascular, metabolic, neurological, and hematological complications, the book offers a holistic approach to understanding CKD’s complexity and evolving treatment strategies.The book’s content is organized to provide a thorough exploration of CKD, beginning with foundational topics like genetic contributions and diagnostic evaluation, progressing through specific complications such as diabetic nephropathy, hypertension, and urologic conditions. Special focus is given to management strategies, nutritional interventions, and unique considerations in pediatric, geriatric, and pregnant populations. Emerging therapies, including precision medicine, gut microbiota modulation, and AI-driven early detection, are also extensively covered to keep readers at the forefront of nephrology research and clinical practice.Management of Chronic Kidney Disease and Its Complications is an essential resource for nephrologists, general practitioners, medical students, nursing professionals, and healthcare providers involved in kidney disease care and research.

  • Applications of Microfluidics Device Technology

    • 1st Edition
    • Volume 227
    • English
    Microfluidics is a rapidly expanding field that is recognized as a powerful platform for accelerating biological science research and innovation. It has the potential to reduce the cost and reagent consumption by enabling the precise manipulation of a small amount of fluids through microchannel ranging from ten to hundreds micrometres in size. It is a multidisciplinary domain, which integrates molecular analysis, molecular biology, and microelectronics. It has demonstrated practical applications in the design and fabrication of systems capable of processing low volumes of fluids while enabling multiplexing, automation, and high-throughput screening. Since its emergence in early 1980s, microfluidics has significantly contributed in the development of inkjet printheads, DNA chips, lab-on-a-chip technology, micro-propulsion, and micro-thermal technologies. Microfluidic chips comprise intricate networks of microchannels and chambers designed to manipulate fluids at the microscale. This volume highlights the applications of microfluidics in the detection and analysis of infectious diseases caused by bacteria, viruses, fungi, and protozoa. It also explores the use of microfluidic technologies in the diagnosis and study of non-infectious diseases, including cardiovascular disorders, cancer, metabolic diseases, and neurological conditions. It also covered single-cell analysis, high-throughput drug screening, cell sorting, and both preclinical and clinical applications. It also used in role of microfluidics in organ culture, regenerative medicine, and personalized healthcare. It also addresses ethical and regulatory issues in the development and use of microfluidic devices. This volume is designed to serve as valuable resource for students, researchers, scientists, clinicians, stakeholders, policymakers, and practitioners to understand microfluidics and apply microfluidics technology/devices in various fields. It provides a strong foundation to help the extension of microfluidics knowledge and accelerate research, innovation, technology and practical applications.

  • Federated Quantum Convolutional Neural Networks in Healthcare

    Enhancing Privacy and Efficiency
    • 1st Edition
    • Abhishek Kumar + 3 more
    • English
    Federated Quantum Convolutional Neural Networks in Healthcare: Enhancing Privacy and Efficiency explores the innovative intersection of quantum computing and federated learning in the context of healthcare. As medical data grows exponentially and privacy concerns intensify, this book addresses the urgent need for secure, scalable AI solutions that enable collaborative data analysis without compromising patient confidentiality. It offers a detailed examination of the theoretical foundations of quantum machine learning and federated systems, complemented by practical case studies spanning medical imaging, genomics, and disease diagnosis. The content delves into architecture design, security protocols, and optimization techniques, equipping researchers and practitioners with the tools to develop privacy-preserving AI models tailored for medical applications. The book also discusses regulatory considerations, deployment challenges, and future research directions, positioning itself as a vital resource for advancing healthcare AI. Its comprehensive approach bridges fundamental science and real-world implementation, empowering healthcare professionals, data scientists, and policy makers to harness next-generation quantum federated systems for improved patient outcomes and data security. This resource is essential for those seeking to implement cutting-edge AI technologies in healthcare, ensuring secure, efficient, and collaborative medical data analysis.

  • Understanding Molecular Processes using Electrochemical Methods

    • 1st Edition
    • Ashis Kumar Satpati + 1 more
    • English
    Understanding Molecular Processes using Electrochemical Methods offers a detailed compendium of techniques for molecular analysis. The book considers step and sweep techniques, scanning electrochemical microscopy, spectroelectrochemic... techniques, electrochemiluminesc... and scanning probe techniques while also exploring COSMOL multiphysics simulation, electroanalysis in biomedical and clinical applications, and future prospects for electrochemical techniques. Chapters focus on evaluating redox reactions, biological interactions, kinetics, quorum sensing, biofilm formation, surface modification and more molecular aspects. This volume offers a deep-dive into the fundamental principles behind the latest electrochemical techniques, equipping researchers with practical guidance for their own experiments.Users will find this to be an ideal reference for researchers working across a range of disciplines including molecular biology, bioanalytical chemistry, biomedical science, and translational medicine.

  • Tissue Organization in Development

    • 1st Edition
    • Volume 171
    • English
    Tissue Organization in Development explores how cells coordinate, communicate, and arrange themselves to build functional tissues during embryonic and postnatal development. The book brings together current perspectives on the molecular, cellular, and mechanical principles that govern tissue patterning, morphogenesis, and structural organization across developing systems. Covering key topics such as cell fate specification, cell–cell interactions, extracellular matrix dynamics, polarity, migration, and tissue remodeling, it highlights how complex biological form emerges from coordinated developmental processes. This volume provides a valuable resource for researchers, students, and professionals interested in developmental biology, cell biology, and tissue formation.

  • Self-Learning AI in Healthcare

    Agentic Systems for Smarter Medicine
    • 1st Edition
    • Rajesh Kumar Dhanaraj + 4 more
    • English
    Self-Learning AI in Healthcare: Agentic Systems for Smarter Medicine covers the transformative potential of advanced artificial intelligence within modern medicine. The book addresses the critical need for self-learning and agentic AI systems that autonomously adapt, refine decision-making, and navigate complex clinical environments with minimal intervention. Chapters provide foundational insights into the rise of self-learning AI and neural networks tailored for adaptive medical systems. Subsequent chapters delve into unsupervised, semi-supervised, and reinforcement learning for autonomous healthcare decision-making, alongside decentralized edge AI approaches. Specialized sections cover personalized medicine, hospital workflow optimization, remote patient monitoring, early disease detection, federated learning for privacy preservation, and more.Further, this book explores AI applications in drug discovery, mental health support, radiology, digital twins, and medical robotics, culminating with an examination of future challenges, ethics, and regulatory frameworks shaping self-learning AI’s trajectory in healthcare. It is tailored to serve a diverse yet specialized audience spanning academic, professional, and research sectors. Healthcare IT professionals and clinical informatics specialists will gain practical guidance for implementing adaptive AI solutions within complex healthcare environments. AI researchers and data scientists focused on developing self-learning models will find cutting-edge methodologies and case studies that advance medical applications.

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