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Books in Molecular biology cellular biology and genetics

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Concepts and Techniques in OMICS and System Biology

  • 1st Edition
  • August 13, 2024
  • Asmat Farooq + 5 more
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 2 1 9 2 3 - 8
  • eBook
    9 7 8 - 0 - 4 4 3 - 2 1 9 2 4 - 5
Concepts and Techniques in OMICS and Systems Biology provides a concise and lucid account on the technical aspects of omics, system biology and their application in fields of different life science.With a strong focus on the fundamental principles understanding of metabolomics, ionomics and system biology, the book also gives an updated account on technical aspects of omics and system biology. Since both omics and systems biology fields are fast advancing filed of biological sciences, its significance and applications need to be understood from the baseline.In 10 chapters Concepts and Techniques in OMICS and Systems Biology introduces the reader to both Proteomics, Metabolomics and Ionomics, and System Biology, the technical applications, describes both the software in for proteomics as metabolomic enumeration and preludes Omics technologies and their applications.The chapters are designed in a well-defined chronology such that readers will understand the concepts and techniques involved in omics and system biology. This compilation will be ideal reading material for students, researchers and people working in the industries related to biological sciences.

Fatty Acid-Binding Proteins and Their Roles in Human Health and Disease

  • 1st Edition
  • August 6, 2024
  • Asim K. Duttaroy
  • English
  • Paperback
    9 7 8 - 0 - 3 2 3 - 9 5 7 0 0 - 7
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 5 7 0 1 - 4
Fatty Acid-Binding Proteins and Their Roles in Human Health and Disease: From Basic Science to Clinical Application presents the latest information on the contributions of different FABPs in physiology and pathophysiology, along with their importance in clinical outcomes. The book is divided into six main sections that cover FABP biology and their role in inflammation and diseases, such as cardiovascular, neurological, and liver diseases, to FABPs and their clinical applications.Each chapter thoroughly reviews current literature, primary research data and clinical cases, providing readers with an overview of the latest information in the expanded field of FABPs. This is an invaluable resource for both researchers and clinicians familiar with and those new to the exciting and everchanging world of fatty acid-binding proteins and clinical disorders.

Artificial Intelligence in Microbiology: Scope and Challenges Volume 1

  • 1st Edition
  • Volume 55
  • July 30, 2024
  • Akanksha Srivastava + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 4 4 3 - 2 9 6 2 4 - 6
  • eBook
    9 7 8 - 0 - 4 4 3 - 2 9 6 2 5 - 3
Nowadays, the field of microbiology is undergoing a revolutionary change due to the emergence of Artificial Intelligence (AI). AI is being used to analyze massive data in a predictable form, about the behavior of microorganisms, to solve microbial classification-related problems, exploring the interaction between microorganisms and the surrounding environment. It also helps to extract novel microbial metabolites which have been used in various fields like medical, food and agricultural industries. As the pace of innovation in Microbiology is accelerating, the use of AI in these industries will be beneficial. AI will not only show its extraordinary potential in expanding the market of antibiotics, food, and agriculture but also offer an eco-friendly, safer, and profitable solution to the respective industries. It would be challenging to search out specific features and discuss future research on AI in microbiology with a wide perspective.

Redox Signaling in Wound Healing in Elderly Populations: Theoretical Basis, Part 1

  • 1st Edition
  • Volume 2
  • July 24, 2024
  • Ufuk Cakatay + 2 more
  • English
  • Hardback
    9 7 8 - 0 - 4 4 3 - 2 9 4 5 6 - 3
  • eBook
    9 7 8 - 0 - 4 4 3 - 2 9 4 5 7 - 0
Redox Signaling in Wound Healing in Elderly Populations: Theoretical Basis, Part 1 deals with wounds in different types and locations (diabetic, ischemic, post-operational) in subcellular and macro dimensions, examine their relationship with aging aim to target deteriorating redox signaling cascades, and will also focus on promising therapeutic approaches. Understanding the indication for the use of new therapeutics targeting the illuminated pathways in wound healing will help adjust treatment regimens befitting modern medicine. Ineffective redox adaptation and disseminated oxidative injury are the hallmarks of continuing oxidative stress. However, oxidative stress cannot be simply described as the imbalance between ROS formation and antioxidant defense capacity; it also covers impairment in redox sensing and signaling pathways. The term oxidative stress is an expression that is losing its use in modern redox biology. It is now an accepted fact that ROS cannot be described as an apparent enemy or friend. Its optimum level modulates signal transduction and stress responses by acting as a second messenger for redox-sensitive cascades. Redox-dependent second messengers are generated in subcellular locations according to specific rules and regulations. Their appearance depends on cellular needs in response to external and internal stimuli variations. A good understanding of the wound healing cascades, which deteriorate especially in advancing ages, is critical in developing the most appropriate approach. To understand the redox signaling mechanisms and healing cascades in wound healing, to pioneer new pharmacoactive drugs that can be developed based on these mechanisms, to reveal the deteriorating dynamics in the elderly patient group, and to propose new treatment methods suitable for the advanced age group.

Targeted Genome Engineering via CRISPR/Cas9 in Plants

  • 1st Edition
  • July 18, 2024
  • Alvina Gul
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 2 6 6 1 4 - 0
  • eBook
    9 7 8 - 0 - 4 4 3 - 2 6 6 1 5 - 7
Targeted Genome Engineering via CRISPR/Cas9 in Plants provides in-depth insights into the use of the emerging “CRISPR/Cas9” technology for precise genome editing. This technology has revolutionized plant science research particularly for crop improvement owing to its simplicity and efficiency. The book provides a wide range of CRISPR/Cas9 gene editing techniques for a variety of plants. Chapters include the latest applications of CRISPR/Cas9 system in connection with abiotic stresses, biotic stresses, biofortification, yield improvement, disease modelling and prognosis and molecular diagnosis. Targeted Genome Engineering via CRISPR/Cas9 in Plants also evaluates various regulatory and ethical aspects that must be considered when implementing the CRISPR/Cas9 approach. This book is a valuable resource for professionals and researchers, as it provides effective CRISPR/Cas9-based strategies for sustainable agriculture and treatment of various diseases.

Personalized Epigenetics

  • 2nd Edition
  • July 17, 2024
  • Trygve Tollefsbol
  • English
  • eBook
    9 7 8 - 0 - 4 4 3 - 2 3 8 0 3 - 1
Personalized Epigenetics, Second Edition discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy. Fully updated and revised, this new edition details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field. It also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug development in personalized epigenetics.Most importantly, the text covers personalized epigenetics from a disease-oriented perspective, presenting chapters that provide advances in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management.

Reverse Vaccinology

  • 1st Edition
  • July 6, 2024
  • Jayashankar Das + 3 more
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 1 3 3 9 5 - 4
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 3 3 9 6 - 1
Reverse Vaccinology: Concept, Methods, and Advancement presents the development strategy of new vaccines through genome sequencing bioinformatics analysis. This book promises to revolutionize vaccine development, especially for pathogens to which the classical applications of Pasteur’s principles have failed, and it is explained in detail in this book.This book is split into three sections: the first, Concept, brings the basis of reverse vaccinology, vaccine antigen discovery, and subunit vaccine; the second, Tools and Methods, describes immunoinformatic, proteomics for epitope-vaccine design, databases, network analysis, machine learning, and NGS-driven antigen screening technology; and the last one, Disease Case Study, discusses real-world examples in the development of new vaccines for diverse diseases.It is a valuable resource for bioinformaticians, researchers, students, and members of the biomedical and medical fields who want to learn more about a new and agile process for the development of new vaccines.

Recent Trends in Fractional Calculus and Its Applications

  • 1st Edition
  • July 2, 2024
  • Praveen Agarwal + 2 more
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 1 8 5 0 5 - 2
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 8 5 0 6 - 9
Recent Trends in Fractional Calculus and Its Applications addresses the answer to this very basic question: "Why is Fractional Calculus important?" Until recent times, Fractional Calculus was considered as a rather esoteric mathematical theory without applications, but in the last few decades there has been an explosion of research activities on the application of Fractional Calculus to very diverse scientific fields ranging from the physics of diffusion and advection phenomena, to control systems to finance and economics. An important part of mathematical modelling of objects and processes is a description of their dynamics.The term Fractional Calculus is more than 300 years old. It is a generalization of the ordinary differentiation and integration to noninteger (arbitrary) order. The subject is as old as the calculus of differentiation and goes back to times when Leibniz, Gauss, and Newton invented this kind of calculation. Several mathematicians contributed to this subject over the years. People like Liouville, Riemann, and Weyl made major contributions to the theory of Fractional Calculus. In recent decades the field of Fractional Calculus has attracted the interest of researchers in several areas, including mathematics, physics, chemistry, engineering, finance, and social sciences.

Revealing Uncharted Biology with Single Cell Multiplex Proteomic Technologies

  • 1st Edition
  • June 25, 2024
  • Wendy Fantl
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 2 2 2 0 9 - 6
  • eBook
    9 7 8 - 0 - 1 2 - 8 2 2 2 1 0 - 2
Revealing Uncharted Biology with Single Cell Multiplex Proteomic Technologies: Platforms. Understanding the intricate coordination of highly diverse cell types within healthy tissues and organs is essential for grasping their functionality. This coordination, often disrupted in disease, hinges on proteins—the primary drivers of cellular function. By examining protein abundance and activation states in single cells, researchers can identify key cell populations involved in both healthy and diseased states, including those influencing disease initiation, progression, and therapeutic responses. Single-cell multiplex proteomic platforms have recently emerged as powerful tools for biomedical research. Their strengths lie in revealing cell types that are rare or subtly different and would otherwise go undetected in bulk cellular analyses. This unique capability enables deeper insights into cellular behavior and disease mechanisms.This book offers comprehensive overviews of technologies developed for multiplex single-cell proteomic analyses. It begins with the pioneering work from Professors Scott Tanner, Mitchell Winnick and Garry Nolan resulting in the development and early application of the mass cytometer, (CyTOF). The instrument merges flow cytometry with time-of-flight mass spectrometry and analyzes cells labelled with metal tagged antibodies. These components work together to enable CyTOF to perform highly multiplexed protein analysis at the single-cell level, offering a powerful tool for understanding complex cellular behaviors and interactions.Recognizing that cellular organization is critical for tissue function, subsequent chapters explore advanced multiplex imaging platforms including Imaging Mass Cytometry (IMC), Multiplexed Ion Beam Imaging (MIBI), CODetection by InDExing, and Chip Cytometry. Later chapters present recent advances in these imaging platforms and data analysis approaches - Combined Nucleic Acid and Protein Quantification in situ, Tissue Schematics, and High-definition CODEX for 3D Multiplex Spatial Cell Phenotyping. These techniques integrate deep phenotyping with spatial mapping to provide unprecedented insights into cellular interactions within tissues. The book also highlights computational approaches essential for managing and interpreting the vast datasets generated by these technologies. Revealing Uncharted Biology with Single Cell Multiplex Proteomic Technologies: Platforms help researchers in many fields, including developmental biology, cancer biology, immunology, neuroscience, and drug discovery gain an understanding about the theories and detailed methodologies behind these technologies. Integrating proteomics with genetic, epigenetic, and transcriptomic platforms, this book aims to inspire new research opportunities, ultimately advancing the development of reliable biomarkers and improving patient outcomes.

Revealing Uncharted Biology with Single Cell Multiplex Proteomic Technologies

  • 1st Edition
  • June 25, 2024
  • Wendy Fantl
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 2 2 2 1 3 - 3
  • eBook
    9 7 8 - 0 - 1 2 - 8 2 2 2 1 4 - 0
Revealing Uncharted Biology with Single Cell Multiplex Proteomic Technologies: ApplicationsHealthy tissues and organs rely on the precise coordination of diverse cell types, each responding to external and internal signals. Disease disrupts this coordination. Since proteins drive cellular function, analyzing their abundance and activation states in single cells helps identify key cell populations in health and disease. Bulk protein analyses mask critical differences between individual cells. Additionally, the arrangement of cells into neighborhoods through cell-cell interactions is essential for tissue function. Over the last decade, single-cell proteomic phenotyping combined with positional information has become crucial for understanding biology in health and disease. This has led to the development of multiple technology platforms, profoundly impacting fields including developmental biology, cancer biology, immunology, neuroscience, and drug discovery. This book focuses on the application of single-cell multiplex proteomic platforms to various biological systems. These platforms have proved to be essential in biomedical research, advancing our understanding of complex biological systems at the cellular level. Compelling studies where authors use these technologies to answer previously unanswerable questions are featured. Exploring this "Uncharted Biology" opens new avenues for scientific inquiry and clinical translation, covering areas including oncology, immunology, metabolomics, stem cell research, preclinical models, and translational research. The initial chapters discuss incorporating these technologies into core facilities and consortia, providing access for multiple users and integrating datasets from other omics technologies. The following chapters cover applications in diverse areas such as muscle stem cell function in skeletal muscle regeneration, metabolic regulome profiling, translational studies, developing predictive biomarkers for patients receiving immune checkpoint inhibitors, and pre-clinical studies of lung cancer. These applications demonstrate how advanced single cell proteomic technologies are reshaping our understanding of complex biological systems and enhancing clinical translation. Revealing Uncharted Biology with Single Cell Multiplex Proteomic Technologies: Applications highlights the transformative benefits of single-cell proteomics, offering insights into cellular mechanisms underlying health and disease and inspiring further exploration into "Uncharted Biology." It is an essential resource for researchers, clinicians, and students aiming to advance biomedical science and improve therapeutic outcomes.

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