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Retinoids in Development and Disease
- 1st Edition, Volume 161 - March 1, 2025
- Editors: Norbert Ghyselinck, Gregg Duester
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 9 1 7 0 0 - 1
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 1 7 0 1 - 8
Retinoids in Development and Disease, Volume 161 in the Current Topics in Developmental Biology series focuses on the role of retinoids during development and disease. Topi… Read more
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Request a sales quoteAdditional sections cover Retinoic acid homeostasis and disease, Redefining the roles of endogenously produced retinoic acid in heart development and regeneration: lessons from genetic models, The Multifaceted Roles of Retinoids in Vision, Eye Development, and Retinal Degenerative Diseases, Essential roles for retinoid signaling in craniofacial development, and much more.
- Teaches about the role of retinoids from the germ cell to the adult organism
- Helps readers discover the normal functions of retinoic acid during embryonic development
- Provides knowledge on how retinoids continue to function in the adult
Gregg Duester and Norbert Ghyselinck
1. Retinoids, Retinol-Binding Protein 2 (RBP2), Retinol-Binding Protein 4 (RBP4): Obesity and Metabolic Disease
William S. Blaner
2. Early Retinoic Acid Signaling Organizes the Body Axis and Defines Domains for the Forelimb and Eye
Gregg Duester
3. Rethinking Retinoic Acid Self-Regulation: A Signaling Robustness Network Approach
Abraham Fainsod and Rajanikanth Vadigepalli
4. Meiotic initiation in the fetal ovary without retinoic acid receptors: an unforeseen twist
Norbert Ghyselinck
5. Action of retinoic acid on progenitor cells in the testis
Michael David Griswold
6. Role of Cellular retinoic acid binding proteins (CRABPs) in regulating retinoic acid metabolism and signaling
Nina Isoherranen
7. Retinoic acid homeostasis and disease
Maureen A. Kane
8. Redefining the roles of endogenously produced retinoic acid in heart development and regeneration: lessons from genetic models
Alexander R. Moise
9. The Multifaceted Roles of Retinoids in Vision, Eye Development, and Retinal Degenerative Diseases
Krzysztof Palczewski
10. Essential roles for retinoid signaling in craniofacial development
Lisa L. Sandell
11. Retinoic acid signaling in pancreas development, islet function, and pancreatic diseases
Lori Sussel and David Lorberbaum
12. Vitamin A supply in the eye and establishment of the visual cycle
Johannes von Lintig
- No. of pages: 362
- Language: English
- Edition: 1
- Volume: 161
- Published: March 1, 2025
- Imprint: Academic Press
- Hardback ISBN: 9780323917001
- eBook ISBN: 9780323917018
NG
Norbert Ghyselinck
GD
Gregg Duester
The goal of my research is to understand the function of retinoic acid (RA) during development. Early in my career I gained a broad background in developmental biology with expertise in the area of RA signaling that directed my research direction. As a postdoctoral fellow I cloned one of the first genes known to encode an enzyme for RA synthesis. As an Assistant Professor my research led to the discovery and characterization of one of the first RA response elements to be described. As a Professor at the Sanford Burnham Prebys (SBP) Medical Discovery Institute, I expanded my research into the function of RA by generating mouse knockouts of enzymes controlling RA synthesis. As a PI on several NIH-funded grants, I laid the groundwork for understanding RA function by providing genetic loss-of-function evidence implicating RA in major developmental pathways including eye development, body axis formation, somitogenesis, limb formation, and neurogenesis. I was an author on several reviews including a 2008 article in Cell summarizing what is known about embryonic RA synthesis and signaling, and a Cell SnapShot on Retinoic Acid Signaling in 2011. In 2015, my laboratory published a review in Nature Reviews Molecular Cell Biology summarizing the developmental pathways and genes directly controlled by RA during organogenesis. In 2017, I published a Letter in Science describing how challenges in the RA signaling field can be solved with more reliance on knockout studies which can now be performed more easily with CRISPR/Cas9 gene editing. In 2019, I published a Development at A Glance review on RA signaling in Development along with Dr. Ghyselinck who is a co-Editor in this volume of Current Topics in Development and Disease. My goal now is to bring knowledge of how RA normally functions to as wide an audience as possible.