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Elsevier

Books in Molecular biology cellular biology and genetics

This collection offers insights into gene expression, cell signalling, and genetic regulation. Supporting researchers, clinicians, and students, it features advanced techniques, genetic engineering, and disease mechanisms, fostering innovations in personalized medicine, regenerative therapies, and molecular diagnostics.

  • Proteomics and Metabolomics in Drug Discovery

    • 1st Edition
    • Volume 155
    • English
    Proteomics and Metabolomics in Drug Discovery explores how large-scale protein and metabolite analysis is transforming the identification, validation, and development of new therapeutic targets. The book highlights emerging technologies, analytical strategies, and real-world applications that support biomarker discovery, mechanism-of-action studies, and precision medicine approaches in modern drug development.

  • Human-AI-Cognitive Intelligence Software, System, and Services for Quality Assurance

    Theories and Methods with Systems Thinking for Behaviour Change in the Medical Decision-Making Pathway
    • 1st Edition
    • Pantea Keikhosrokiani
    • English
    Habit-based Behavior Change Medical Information Support System and Artificial Intelligence: Theories, Methods, and Data Analytics Approach provides a guideline to design and implement Habit-based Behavior Change Support Systems (HBCSS) which can change patient’s unhealthy habits to prevent the development of diseases. It presents theories, methods, management, and data analytics approach required to design, implement, and prescribe the use of HBCSS for several diseases’ management.It discusses topics such as theories of behavior change, ontologies and knowledge management, data mining, privacy and security, descriptive and prescription analytics. In addition, it discusses how to measure habit-change, future directions of the field, and case studies based on real-world examples.It is a valuable resource for clinicians, researchers, students, and member of the biomedical and medical fields who want to learn more about the use of medical systems to improve patients’ health.

  • Protein Folding

    • 1st Edition
    • Timir Tripathi
    • English
    Protein Folding explores the fundamental and applied aspects of protein folding, misfolding, and stability in biological systems. Focusing on the biochemical principles and molecular dynamics that drive folding processes, the book provides readers with a comprehensive understanding of how proteins attain their native structures and what happens when this process goes awry. Covering diverse approaches from structural biology, biophysics, enzymology, and systems biology, the book highlights the molecular basis of folding pathways and the pathological consequences of misfolded proteins in diseases such as Alzheimer's, Parkinson's, and cystic fibrosis. It integrates insights into chaperone function, folding kinetics, and the cellular quality control mechanisms that safeguard proteostasis. Across its chapters, the book addresses key themes including protein folding landscapes, folding intermediates, the role of cellular compartments, aggregation-prone sequences, and the impact of mutations. It also examines current methodologies for studying protein folding, including spectroscopy, calorimetry, and computational simulations, and considers emerging therapeutic strategies that target misfolding and aggregation. This book is a valuable resource for biochemists, molecular biologists, biotechnologists, enzymologists, and researchers in protein science. It supports academic researchers, postgraduate students, and pharmaceutical scientists working to understand protein behavior and develop interventions for protein misfolding diseases.

  • PACAP

    From Discovery to Function
    • 1st Edition
    • David Vaudry + 1 more
    • English
    PACAP: From Discovery to Function in Health and Disease serves as a comprehensive review covering all aspects of PACAP and its receptors, from expression to function in healthy tissues and disease models. The book introduces the biochemical, pharmacological and signaling properties of PACAP before exploring the biological actions of PACAP in normal health and pathological conditions. It considers PACAP in relation to various aspects, including pain, stress, brain injury, tumor cells and neurodegenerative disease. Effect on peripheral organs is also covered, from the gastrointestinal tract and cardiovascular system to immune cells and bones, among others. Therapeutic potential is also explored. This is a volume in the Molecular Mediators in Health and Disease book series, and provides a complete analysis of PACAP and the latest research in the field. Thus it is an ideal guide for researchers interested in PACAP and its impact across health and disease.

  • Methods in Systems Bioinorganic Chemistry

    • 1st Edition
    • Volume 741
    • English
    Methods in Systems Bioinorganic Chemistry, Volume 741 provides understanding of high-level properties involving metals in biology that are founded on molecular or mechanistic level interactions. Currently, there is no established “tool kit” for studying bioinorganic systems, so the methods included in the book span a diverse range of topics and approaches, from imaging to proteomics, from metals-in-mice to mathematical modeling. Specific chapters cover Inductively Coupled Plasma Mass Spectrometry (ICP-MS)-based methods to quantify transition metals in cells and vertebrate models, ICP-MS elemental analysis in tissue samples, and much more.Additional chapters delve into An inductively-coupled-... triple quadrupole method with oxygen for the determination of essential elements and protein concentration, Calculating metal speciation of proteins inside cells, Probing biological copper in the subfemtomolar regime, Using LC-ICP-MS chromatography to detect and characterize Labile Metal Pools, Linking dynamic bioinorganic chemistry processes of toxic metals in the bloodstream to establish their exposure-response relationship in humans, Contextualizing X-ray fluorescent microscopy – high resolution X-rays meet subcellular morphology, Chemoproteomic profiling of transition metal binding sites in bacterial proteomes, Heme Labeling by Proximity (HeLP) to Identify Hemoproteins, and much more.

  • Enzymology in Drug Discovery

    • 1st Edition
    • Volume 740
    • English
    This volume is focused on the application of enzymology to drug discovery, with the overarching objective of introducing the general audience to the important role that enzymology plays in modern, molecular targeted drug discovery. The volume opens with a chapter on the role of enzymes in normal human physiology and the causal role played by aberrant enzyme activity in various disease state. A second chapter provides a comprehensive review of inhibition modalities for therapeutic enzyme inhibitors. From there the volume is composed of chapters that cover two general categories of information: (1) methodologies for studying enzyme-ligand interactions and (2) case studies of molecular targeted drug discovery against specific enzyme targets. Chapters within the first category cover methods such as assay design, the role of structural biology in drug optimization, analysis of slow and tight binding inhibitors, enzyme-inhibitor complex dynamics, and covalent enzyme inactivators. The second category includes case studies of therapeutic inhibitors of various enzyme target classes: proteases, methyltransferases, histone demethylases, helicases, nucleic acid processing enzymes, kinesin motor proteins, and cytochrome P450s. Finally, a chapter is also devoted to therapeutic replacement or repair of defective enzymes.

  • Animal Models of Disease Part F

    • 1st Edition
    • Volume 212
    • English
    Animal Models of Disease, Part F, Volume 212 in the Methods in Cell Biology series, presents significant advancements in understanding disease mechanisms through animal models. The book features chapters on timely topics such as characterizing tumor-infiltrating group 1 innate lymphoid cells in PyMT breast tumors and using zebrafish to unravel the molecular mechanisms of Alzheimer’s disease. The book also covers colitis mouse models and appropriate models for studying diabetes pathophysiology, demonstrating its comprehensive approach to current research.Additional sections cover evaluating polyglutamine protein aggregation in transgenic Caenorhabditis elegans models of Huntington's disease and studying tumor responses to radioimmunotherapy in ovarian cancer models. It also highlights the antimicrobial regime for gut microbiota depletion in mice and the biodistribution of metallic nanoparticles for lymphoma studies. This book is an essential resource for researchers seeking to explore disease mechanisms and therapeutic approaches through animal models.

  • Cell Death Part F

    • 1st Edition
    • Volume 211
    • English
    Cell Death: Part F, Volume 211 presents the latest advances and comprehensive reviews in the rapidly evolving field of cell death. This volume explores Methods to Assess BAX Conformation, Activation, Translocation, and Mitochondrial Outer Membrane Permeabilization, Proximity biotin labelling identification of Bcl-2 protein interactions in live cells, Bimolecular fluorescence complementation assays for investigating Bcl-2 family protein interactions, Assessing apoptotic sensitivity in primary mouse B cells by BH3 profiling, Liposome permeabilization assays to monitor pore formation by cell death proteins, Flow Cytometry Assessment of Mitochondrial Membrane Potential, Biomass, and ROS in OXPHOS-Dependent and Glycolytic Cancer Cells during Cell Death Induction, and much more.Additional chapters cover Assessment of Viability Versus Cell Death: What is What?, Flow cytometry-based drug response profiling of primary B-precursor ALL cells in co-culture with bone marrow-derived stromal cells, An in vitro model of efferocytosis in macrophage foam cells to probe lipid-driven dysregulation of dead cell clearance, Measuring tumor cell killing using in vivo bioluminescence imaging, and more.

  • The Metabolon

    • 1st Edition
    • Volume 739
    • English
    Methods in Enzymology series: The Metabolon, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Advanced Technologies for Disease Intervention

    Innovations Across Precision Medicine, Nutrition, and Holistic Therapies
    • 1st Edition
    • Ranbir Chander Sobti + 3 more
    • English
    Advanced Technologies for Disease Intervention: Innovations Across Precision Medicine, Nutrition and Holistic Therapies, Two Volume Set investigates current and emerging advances in disease detection, diagnosis, treatment and prevention, and how molecular medicine and biotechnology have contributed to this changing landscape. Volume One focuses on sustainable health practices through biotechnology, exploring traditional health systems, diagnostic innovations, and integrative therapies. Key topics include: the role of traditional medicine and practices in sustainable health; contemporary and emerging technologies such as aptamer diagnostics, telemedicine, nanomaterials and AI in healthcare, and much more.Volume Two then delves deeper into emerging technologies for disease intervention, focusing on drug development, delivery systems, nutrition, and natural products for health. Themes explored here include: developments and trends in drug discovery; drug repurposing; contemporary drug delivery systems; phototherapeutics; personalized drug delivery; innovations in vaccine development; the role of nutraceuticals in disease prevention; and the use of natural products and herbal interventions for sustainable health.

  • Advances in Applied Microbiology

    • 1st Edition
    • Volume 137
    • English
    Advances in Applied Microbiology presents the latest developments and innovative research in applied microbiology, covering topics such as microbial biotechnology, environmental applications, industrial processes, and medical advancements. It offers valuable insights into the practical uses of microorganisms in solving real-world challenges, making it an essential resource for researchers, professionals, and students in microbiology and related fields.

  • Ecology of Marine Rocky Shores

    • 1st Edition
    • Volume 105
    • English
    Ecology of Marine Rocky Shores, Volume 105 in the Advances in Marine Biology series, highlights new advances in the field, presenting comprehensive chapters written by an international board of authors. This volume explores key ecological processes shaping rocky shore environments, including the impacts of plastic pollution, the dynamics of warm-temperate and subtropical systems, and the roles of foundation species and community interactions.Additio... chapters examine conservation planning, kelp ecology and restoration, fisheries and indigenous knowledge, and the influence of ocean rafting on species distribution. The volume also addresses spatial and network approaches to ecology, coastal marine microbiology, and the ecological impacts of invasive species. Together, these contributions provide an integrated perspective on the structure, function, and resilience of rocky shore ecosystems, offering valuable insights for researchers, marine ecologists, and environmental scientists.

  • Nerve Growth Factor

    From Neuron Development to Neurology
    • 1st Edition
    • Antonino Cattaneo + 1 more
    • English
    Nerve growth factor: From Neuron Development to Neurology, the latest release in the Molecular Mediators in Health and Disease series, offers a complete guide to nerve growth factor (NGF) across health and disease. Sections cover key properties, the latest advances, and biomedical applications of this neuropeptide. The book begins with an introduction and historical overview of the discovery of NGF before exploring its molecular characteristics. It then covers NGF in organ function, with chapters discussing the brain, immune system, blood vessels, heart, reproductive organs, teeth, and lungs. NGF pharmacology is then considered, with a focus on NGF as a therapeutic agent.The final section of the book covers NGF across diseases, including Alzheimer’s disease, cancer, diseases of the eye, chronic pain, and visceral disfunctions. Throughout the book, NGF is considered in the context of both mammalian and non-mammalian biology, making it an ideal reference for researchers working across the fields of cell biology, molecular biology, pharmacology, and other biomedical areas.

  • Structural Biology of Ubiquitination

    From Mechanisms to Interventions
    • 1st Edition
    • Navaneet Chaturvedi + 1 more
    • English
    Structural Biology of Ubiquitination: From Mechanisms to Interventions provides an in-depth exploration of the structural and biophysical principles governing ubiquitination and their implications in diseases such as cancer and neurodegeneration. The book seamlessly integrates experimental insights with advanced computational methods, including AI-driven drug discovery, molecular modeling, and biophysical simulations, offering a comprehensive toolkit for researchers and clinicians. By bridging fundamental science with translational applications, the book empowers readers to design targeted therapeutics, understand disease mechanisms at the molecular level, and accelerate progress toward personalized medicine.

  • The Potential of Extracellular Vesicles from Plant and Animal Sources for Improving Human Beauty and Health

    • 1st Edition
    • Khalid Rehman Hakeem + 2 more
    • English
    The Potential of Extracellular Vesicles from Plant and Animal Sources for Improving Human Beauty and Health is a comprehensive resource that consolidates the latest research on the mechanisms of extracellular vesicles (EVs) and their applications in the cosmetic industry. The book explores a range of topics, including the latest techniques in isolation and characterization of EVs, safety considerations, methods, and challenges associated with large-scale production, and recent advancements in biomedical applications. The therapeutic potential of EVs for age-related neurological conditions and autoimmune skin diseases is investigated, as well as the application of EVs for skincare, hair loss and anti-aging products.The book considers EVs from a variety of sources, including humans, plants, animals and bacteria, highlighting their major differences. It also includes a discussion of market trends and the global impact for EV products in cosmetic and anti-aging industries. With growing interest in the role of extracellular vesicles in enhancing health and beauty, this book provides invaluable insights to researchers working in this field, equipping them with the knowledge to leverage EVs for innovative cosmetic applications and natural solutions.

  • Advances in Applied Microbiology

    • 1st Edition
    • Volume 136
    • English
    Advances in Applied Microbiology provides a comprehensive overview of the latest research, innovations, and practical applications in the field of microbiology. Covering a broad spectrum of topics, this book explores recent advances in microbial biotechnology, environmental and industrial microbiology, medical and food microbiology, and emerging technologies. Each chapter highlights significant developments, challenges, and future directions, making it an invaluable resource for researchers, students, and professionals seeking to stay updated on the dynamic landscape of applied microbiology. With contributions from leading experts, this volume offers insights into the vital roles microorganisms play in various sectors, including health, agriculture, industry, and the environment.

  • Enzyme Microfluidics

    • 1st Edition
    • Volume 737
    • English
    Enzyme Microfluidics, Volume 737 in the Methods in Enzymology series, presents detailed methodological descriptions and protocols that cover a wide range of microfluidics-based approaches for mechanistic enzymology, high-throughput screening, and enzyme engineering campaigns. The volume includes both established methods as well as advances in the field. Sections in this new release cover four unique sections, including Chips and Reagents, Enzyme Characterization, Enzyme Engineering, and Moving Beyond Microfluidics (from micro to nanoscale). Specific chapters delve into Joint Methods for Fabricating Microfluidic Chips, A liquid handling robotic workflow for quantifying the activity of antibiotic resistance genes (ARGs) in cell-free protein synthesis, and much more.Additional chapters cover Preparation of uniform microcrystals by droplet microfluidics for time-resolved serial crystallography, Droplet microfluidic HDX for investigating highly dynamic proteins, An Accessible, Low-Cost Platform for High-Throughput Microfluidic Enzyme Kinetics, High-Throughput Data Processing, DA-MEK, Mass Spectrometry of Droplets, Digital Bioassay Using a Femtoliter Reactor Array Device, Confocal absorbance droplet sorting, Sequence-Function Data Analysis from Microfluidics Screening, and much more.

  • Arginase: Structure, Function, and Therapeutic Targeting

    • 1st Edition
    • Volume 738
    • English
    Arginase: Structure, Function, and Therapeutic Targeting, Volume 740 in the Methods in Enzymology series, provides a comprehensive, methodology-driven perspective on arginase research spanning molecular, biochemical, and translational domains. Chapters in this new release include Expression, Purification, and Structural Characterization of Human and Leishmania Arginase with Comparative Analysis of Structures from the Protein Data Bank, Synthesis of First-Generation Arginase Inhibitors, Computational and Structure-Guided Design of Arginase Inhibitors, Metal Substitution in Arginase: Experimental Approaches to Study Metal-Dependent Catalysis, Therapeutic Arginase Formulations: PEGylation, Stability, and Advanced Delivery Systems, and much more.Additional chapters cover Dual ARG1/ARG2 Inhibition: Experimental and Structural Strategies for Inhibitor Design and Optimization, Synthesis of Second-Generation Arginase Inhibitors, Cryo-EM Workflow and Structural Characterization of Arginase–Antibody Complexes, Development and Validation of an Electrochemical Assay for Arginase Activity, Experimental and Structural Analysis of H. pylori Arginase in Gastric Immune Evasion, Agmatinase and Alternative Arginine Utilization Pathways in Bacteria: Biochemical and Functional Perspectives, Catalytic Diversification of the Arginase Fold: Structural and Mechanistic Insights from DcsB, Beyond Arginase: Structural Biology of the Extended Guanidinase Family, Plant Arginase: Structural and Functional Roles in Nitrogen Metabolism, and much more.

  • Advances in Genomics and Neurosciences for Neurologic and Behavioral Disorders

    • 1st Edition
    • Moyra Smith
    • English
    Advances in Genomics and Neurosciences for Neurologic and Behavioral Disorders explores the latest breakthroughs in genomics and neurosciences, providing essential insights for understanding, diagnosing, and managing neurodevelopmental, psychiatric, and neurodegenerative disorders. The book highlights the intersection of genetic and genomic diagnostic techniques with brain function and structure analysis to enhance therapeutic strategies. Sections cover a wide range of topics, including the analysis of brain circuits, synapses, and neural activity, as well as the role of ion channels and neurotrophins in brain function. It examines advanced genetic and genomic diagnostic methods such as chromosome studies, gene sequencing, RNA analysis, and metabolite profiling.The book also addresses neurodevelopmental disorders like cerebral palsy, epilepsy, and autism, psychiatric disorders such as schizophrenia and thought disorders, and the molecular biology of memory and age-related cognitive decline. Organized into five sections, the book includes chapters on the latest techniques for brain analysis, genetic diagnostics, neurodevelopmental and psychiatric disorders, aging-related impairments, and new therapeutic approaches. Key topics include brain regions and circuits, new methods for studying these areas, and the relevance of this information for accurate diagnosis and patient care.

  • Molecular and Cellular Biology Approaches and Applications in Modern Drug Discovery

    • 1st Edition
    • Mithun Rudrapal + 1 more
    • English
    Molecular and Cellular Biology Approaches and Applications in Modern Drug Discovery is an essential guide that bridges the latest advances in molecular and cellular biology to revolutionize drug discovery. The book explores a wide range of tools and techniques and their applications in drug discovery, including genetic engineering, gene therapy, regenerative medicine, developmental biology, molecular diagnostics, biomarkers, RNA therapeutics, molecular immunology, and vaccine development. The book also considers multi-omics approaches, biophysical methods, epigenetics and epigenomics, biomedical engineering, nanotechnology, artificial intelligence, bioinformatics, structural and computational approaches, and more.This comprehensive volume covers critical domains such as transcriptomics, proteomics, genomics, genetics, and cell signaling pathways, providing an in-depth understanding of their pivotal roles in drug development. It is an invaluable reference for researchers and advanced students working in these areas across molecular biology, biochemistry, pharmacology, biotechnology, and related fields.

  • Combinatorial Biotechnology

    Methods for Synthesis of Peptide, Oligonucleotide and Oligosaccharide Libraries and Applications
    • 1st Edition
    • Preeti Srivastava
    • English
    Combinatorial Biotechnology: Methods for Synthesis of Peptide, Oligonucleotide and Oligosaccharide Libraries and Applications covers methods used for synthesizing peptide, oligonucleotide, and oligosaccharide libraries. It presents the concepts of combinatorial biotechnology, detailing both solid phase and solution phase synthesis techniques, including modern biological methods such as in vitro and in vivo display libraries. Key topics include solid phase synthesis, parallel peptide synthesis, encoding technologies, deconvolution methods, and chemical and biological ligations. With chapters covering the chemical and biological synthesis of recombinant peptides and proteins, as well as the genetic reprogramming of the genetic code, this book offers a rich source of practical guidance.The inclusion of advanced methods and illustrative examples makes it a unique and essential reference in the field. This book is an essential resource for undergraduate and postgraduate students in biochemical engineering, biotechnology, and biosciences, as well as industry professionals in R&D divisions. It equips readers with the latest techniques and applications in combinatorial biotechnology, addressing current challenges and advancing their research and development efforts.

  • Advances in Applied Microbiology

    • 1st Edition
    • Volume 135
    • English
    Advances in Applied Microbiology, Volume 133 presents a comprehensive exploration of the latest innovations in applied microbiology. The book delves into the diverse applications of microbiology across various industries, including agriculture, food production, biotechnology, environmental science, and healthcare. Chapters in this new release include Advances in production related petroleum microbiology, Degradation of Steroid Four-Ring Structures by Comamonas testosteroni: Similar Mechanisms Observed in Various Bacteria Including Mycobacterium tuberculosis, Detoxification of mycotoxins by microorganisms, Use of Deep Eutectic Solvents in Microbial Technology, and more.Through a collection of insightful chapters authored by experts in the field, readers are offered in-depth analyses of cutting-edge research, emerging trends, and practical applications of microbiological principles. From novel microbial technologies to the impact of microbiomes on human health and beyond, this book serves as a valuable resource for researchers, professionals, and students seeking to stay informed and inspired by the exciting advancements.

  • Advances in Applied Mechanics: Letters

    • 1st Edition
    • Volume 63
    • English
    Advances in Applied Mechanics, Volume 63 highlights new advances, with this volume presenting interesting chapters written by an international board of authors. Chapters in this release cover higher order discontinuous Galerkin finite element methods for the contact problems, Anisotropic Recovery-Based Error Estimators and Mesh Adaptation Tailored for Real-Life Engineering Innovation, Adaptive mesh refinement on Cartesian meshes applied to the mixed finite element discretization of the multigroup neutron diffusion equations, and more. Other sections cover a posteriori error analysis for Finite Element approximation of some groundwater models Part I: Linear models, a posteriori error estimates for low frequency electromagnetic computations, and more.

  • Microbial Biofilms and Cancer - Part B

    • 1st Edition
    • Volume 225
    • English
    Biofilms in Cancer: Molecular Mechanisms, Host Reprogramming and Tumor Progression presents a focused and multidisciplinary examination of the emerging role of microbial biofilms in cancer biology. The volume challenges the conventional view of biofilms as merely persistent microbial communities and highlights their potential contribution to chronic inflammation, host-cell reprogramming, tumor development, cancer progression, and invasion.The book begins by establishing biofilms as an underestimated threat in cancer, providing a foundation for understanding the complex interactions between microbial communities and malignant tissues. It subsequently explores the molecular mechanisms through which quorum sensing and biofilm-associated signals can influence host-cell behavior, together with the mechanisms underlying biofilm formation and microbial interaction with host cells.A major focus of the volume is the biofilm-mediated modulation of the tumor microenvironment. The chapters examine how biofilm components can dysregulate cytokines and chemokines, sustain chronic inflammatory responses, and create conditions that may favor tumorigenesis. Particular attention is given to the transition from persistent microbial colonization and inflammation to malignant transformation and tumor progression.The book also provides organism- and cancer-specific perspectives, with detailed discussions of the contribution of Porphyromonas gingivalis and Candida biofilms to oral squamous cell carcinoma, as well as the involvement of Helicobacter pylori, Fusobacterium nucleatum, P. gingivalis, Escherichia coli, and Candida across specific cancer contexts. These chapters highlight the diversity of microbial strategies and host responses associated with biofilm-linked malignancies.The concluding perspective addresses the emerging role of biofilms in cancer invasion, bringing together microbial persistence, host-cell interaction, inflammatory signaling, and tumor progression into an integrated framework. Collectively, the volume provides a comprehensive overview of the biofilm–host–inflamm... axis, emphasizing how microbial communities may influence different stages of cancer biology.This book will be valuable to microbiologists, cancer biologists, oncologists, molecular biologists, immunologists, oral health researchers, infectious-disease specialists, biotechnologists, clinicians, and postgraduate researchers seeking to understand the increasingly important intersection of microbial biofilms and cancer. It also provides a foundation for identifying new research questions, biomarkers, preventive strategies, and potential therapeutic targets at the interface of infection and malignancy.

  • Clinical Genomics

    A Guide to Clinical Next Generation Sequencing
    • 2nd Edition
    • Shashikant Kulkarni + 1 more
    • English
    Clinical Genomics, Second Edition is a comprehensive, practical reference [AN1] designed specifically for laboratory directors, clinical medical directors, and genomic medicine professionals. Edited by renowned genomic pathology leaders Kulkarni and Roy, this updated edition offers clear guidance on the current technical, bioinformatic, clinical, regulatory, and reimbursement considerations involved in implementing next-generation sequencing technologies within clinical molecular diagnostic laboratories.Structu... for ease of reference, this book covers targeted gene sequencing methods, whole exome/genome approaches, emerging technologies such as long-read sequencing, and critical considerations for assay validation. Detailed sections address bioinformatics workflows, variant detection and interpretation methodologies, integration with clinical informatics systems, and essential IT infrastructure, including cloud-based solutions.This book also thoroughly addresses practical topics essential to laboratory management, such as regulatory compliance, ethical frameworks, billing strategies, and reimbursement paradigms, helping directors navigate the evolving landscape of genomic diagnostics.

  • Lifestyle Epigenomics

    • 1st Edition
    • Ana B Crujeiras
    • English
    Lifestyle Epigenomics, a new volume in the Translational Epigenetics series, comprehensively details the interplay between lifestyle factors and epigenetic modifications associated with the onset of noncommunicable diseases and aging, shedding light on potential preventive and therapeutic strategies for disease from an epigenomics perspective. Here, more than 35 international experts in the field consider how lifestyle choices or habits can condition or prevent disease, along with tools for new research, from bioinformatics methodology to non-invasive sampling.Early, foundational chapters are followed by all-inclusive sections on epigenetic machinery in health and disease; dietary factors and epigenetics; adiposity and physical activity and epigenetics; psychological stress, social environment, toxins and contaminants exposure effects on epigenetics; and transgenerational and childhood epigenetics. To support understanding, each chapter includes a summary and key points lists, terms and definition, as well as research case studies outlining core components of recent studies, detailing their conditions, research techniques involved, and outcomes.

  • Mitochondrial Intoxication

    • 2nd Edition
    • Marcos Roberto de Oliveira
    • English
    Mitochondrial Intoxication, Second Edition, offers a comprehensive and fully updated exploration of the impact of toxic molecules on mitochondrial physiology and the diseases that result from their dysfunction. Divided into three sections, the book opens with a detailed overview of mitochondrial physiology, molecular markers of mitochondrial intoxication, and challenges of mitochondrial profiling during pre-clinical studies. The book then focuses on endogenous toxicants and their impact on mitochondria, including new chapters on lipids, glucose and microbiota-derived toxicants. Amyloid-β peptide and its impact on mitochondrial dysfunction is also a new addition to this book, as well as inflammation-induced mitochondrial intoxication.The final section explores exogenous toxicants, such as pollutants, food additives, illicit and pharmaceutical drugs, pesticides, and heavy metals. The effects of micro- and nanoplastics on mitochondrial function are newly covered. Furthermore, the latest computational tools in mitochondrial toxicity research are investigated. Incorporating the latest advances in the field, this new release offers cutting-edge insights on mitochondrial toxicity, serving as an invaluable resource for researchers and advanced students in cell biology, molecular biology, toxicology, biochemistry, pharmacology, and related fields.

  • Computational and Experimental Approaches in Protein Engineering and Design

    • 1st Edition
    • Aditya Kumar Padhi + 1 more
    • English
    Computational and Experimental Approaches in Protein Engineering and Design offers a one-stop resource for students, researchers, and practitioners. Cutting-edge techniques in AI and machine learning applications are expertly covered in the book, empowering readers with the tools they need to tackle modern challenges in biotechnology and therapeutics. Step-by-step protocols provide readers with actionable guidance to transition smoothly from computational modelling to laboratory implementation. The inclusion of real-world case studies makes the theoretical concepts relatable and actionable and immediately applicable to solving complex problems, such as producing protein-based vaccines for immunotherapy.The book’s focus on synthetic biology positions it at the forefront of innovation, appealing to a broad audience, from those involved in tissue engineering to those exploring next-generation therapeutics. With its forward-looking approach, emphasizing machine-learning-dri... protein design and nanobody engineering, this book is an indispensable resource for researchers preparing to navigate the future of biotechnology.

  • miRNA in Human Disease

    From Biomarkers to Therapeutics
    • 1st Edition
    • Parul Gupta + 6 more
    • English
    miRNA in Human Disease: From Biomarkers to Therapeutics explores the critical role of microRNAs (miRNAs) in the development and progression of various diseases, emphasizing their significance as biomarkers and therapeutic targets. Sections provide a comprehensive overview of the biogenesis, function, and regulation of miRNAs, offering insights into how these small noncoding RNA molecules influence gene expression and contribute to disease development and progression. The book covers traditional and advanced methods for miRNA extraction, the role of miRNAs in infectious diseases, cancer, neurological disorders, cardiovascular disease, hemoglobinopathies, pregnancy complications, and metabolic disorders.Sections also discuss the latest research on miRNA-based therapies, including the design and delivery of miRNA mimics and inhibitors and their potential applications in personalized medicine. With a strong focus on practical implementation, the book includes detailed case studies and real-world examples that demonstrate the clinical relevance of miRNA research. It addresses the challenges and future directions in the field, providing a roadmap for researchers, clinicians, and industry professionals to harness the potential of miRNAs for disease diagnosis, treatment, and prevention.

  • Cryo-EM Methods and Management

    • 1st Edition
    • Edward T. Eng + 2 more
    • English
    Cryo-EM Methods and Management provides a detailed introduction to the latest advances of cryo-EM, from technical innovations to the logistical challenges of maintaining a modern cryo-EM facility. The book consists of four parts, beginning with an overview of cryo-EM. It then moves on to discuss Cryo-EM workflows, with chapters focusing on sample handling and preparation, data collection and hardware, and data procession and visualization. The third part centers on aspects of cryo-EM infrastructure and community building, considering facility set-up and management, monitoring facility performance, instrumentation monitoring , data sharing and standards, and training and development standards. The book then closes with a section looking towards future prospects for cryo-EM. This is an ideal reference for cryo-EM facility and lab managers, providing guidance to the often-overlooked aspect of facility building and management. Additionally researchers working with cryo-EM across molecular biology, structural biology, cell biology and biochemistry will benefit from this book.

  • Radiation Biology

    Molecular Foundations and Clinical Applications
    • 1st Edition
    • Barry S. Rosenstein + 1 more
    • English
    Radiation Biology: Molecular Foundations and Clinical Applications is a comprehensive exploration of the effects of radiation on living organisms, delving into the molecular mechanisms underlying cellular responses. This book examines critical topics such as radiation-induced DNA damage, repair processes, and molecular signaling pathways. It provides a detailed look at how cells respond to radiation, addressing cell cycle control, apoptosis, and the effects of radiation on immune system functionality. As a resource for researchers, it bridges the gap between molecular biology and clinical oncology, offering insights into radiation's role in both therapeutic contexts and its broader impact on human biology.In addition to its focus on molecular responses, the book covers topics like tumor microenvironment and metabolism, the role of epigenetics in radiation biology, and the hallmarks of cancer relevant to radiation therapy. It also provides discussions on chemotherapeutic agents, radiation carcinogenesis, and the complex interplay between radiation and cancer biology. The later sections extend the scope to tissue, organ, and systemic effects of radiation, making it an invaluable reference for professionals in molecular biology, oncology, and related fields striving to push the boundaries of radiation research.

  • Microscopy in the Life Sciences from 1650 to the Present

    • 1st Edition
    • Joel B. Sheffield
    • English
    Microscopy in the Life Sciences from 1650 to the Present explores the transformation of the microscope and its applications and techniques over the course of history, illustrating how progress in optics and microscope design has informed our growing knowledge of cellular life. Beginning with early observations of cellular structure, the book tracks the movement towards understanding of cell biology and pathology, considering the changing landscape of microscopy, lens development, and limitations and challenges tackled. Users will also find content on recent advances, including fluorescence studies and the use of computational procedures to assemble images of individual molecules. This book traces the evolution of understanding that scientists have had regarding cellular life and how comprehension of this has been supported by the development of the microscope. It considers a range of experts central to its progression over the years, including Schleiden, Schwann, Abbe, Schott and Zeiss, and is a useful reference for researchers working with microscopy techniques across the biological sciences.

  • Thiamine, Thiamine Pyrophosphate and Thiamine Pyrophosphate-Dependent Enzymes Part B

    • 1st Edition
    • Volume 736
    • English
    Thiamine Pyrophosphate (TPP)-Dependent Enzymes, Volume 736 in the Methods in Enzymology series covers this diverse group of ubiquitous enzymes with timely chapters on Methods for Studying ThDP-dependent Mycobacterial MenDs (SEPHCHC Synthases), Mammalian 2-hydroxyacyl-CoA lyases, discovery and assays, Anti-infective target 1-deoxy-d-xylulose-5... synthase (DXS) and drug design for enzyme inhibition, Expression, Purification, and Mechanistic Studies of DXP synthases from Deinococcus radiodurans, Plasmodium falciparum, and Plasmodium vivax, Comparison of the catalysis of ThPP-dependent enzymes AHAS, ALS, and DXS, and much more.Additional sections cover Plant and fungal acetohydroxyacid synthases (AHAS): Methods for heterologous expression, kinetic characterization, and structural analysis, Biochemical and Structural characterization of novel ‘split-gene’ archeal transketolases, 4-Hydroxybenzoylform... decarboxylase enzymes from Rhodococcus jostii RHA1 and Pseudomonas fluorescens Pf-5: characterization and involvement in bacterial lignin degradation, Engineering of phosphoketolase from Bifidobacterium adolescentis for increased activity on non-phosphorylated substrates and application in a cell-free reaction system for ATP regeneration, Repurposing TPP-dependent enzymes with anodic oxidation for the conversion of aldehydes to enantioenriched carboxylic acids, and much more.

  • Fundamentals of Absorption Spectroscopy

    • 1st Edition
    • Imtaiyaz Hassan
    • English
    Fundamentals of Absorption Spectroscopy offers a clear and comprehensive introduction to the principles, instrumentation, and applications of absorption spectroscopy across UV-Visible, IR, and other spectral regions. Designed for students, researchers, and industry professionals, this book bridges theory and practice with practical illustrations and real-world case studies, providing a solid foundation in both fundamental concepts and contemporary applications in chemistry, biology, medicine, environmental monitoring, and materials science. It fills the gap between overly advanced and overly simplified texts by combining fundamental theory with practical insights, particularly from biological perspectives. This book addresses the need for an updated, student-friendly, and application-oriented resource in absorption spectroscopy. Readers will benefit from structured guidance that connects theoretical principles with experimental data, explains instrumentation and its limitations, and demonstrates applications across diverse fields such as pharmaceuticals, environmental analysis, and biomolecular sciences. The inclusion of case studies and recent advances in spectroscopic technology ensures relevance for both academic study and professional practice.

  • Advances in Marine Biology

    • 1st Edition
    • Volume 104
    • English
    Advances in Marine Biology, Volume 104, the latest release in this serial that highlights new advances in the field, includes comprehensive chapters written by an international board of authors. Chapters in this new release explore Integrative Fish Biomechanics and Advancing marine invertebrate biodiversity in South Africa: Addressing gaps in taxonomy and genetic knowledge.

  • Microbial Biofilms and Cancer - Part A

    • 1st Edition
    • Volume 224
    • English
    Microbial Biofilms and Cancer - Part A provides a comprehensive and multidisciplinary exploration of the emerging biological connection between microbial biofilms, chronic infection, genetic instability, and cancer development and progression. Moving beyond the traditional perception of biofilms as merely microbial communities associated with antimicrobial resistance, the book examines biofilms as dynamic biological ecosystems capable of influencing host signaling, immune responses, genome stability, epigenetic regulation, cellular metabolism, and oncogenic processes.The opening chapters establish the molecular and genetic foundations of biofilm-associated carcinogenesis. The role of horizontal gene transfer within biofilms and its potential oncogenic consequences is examined alongside genetic profiling of biofilm-associated cancers. Particular emphasis is placed on the signaling pathways that may be hijacked by biofilms and the epigenetic mechanisms governing biofilm biology and host–microbe interactions. The book further explores how biofilms can modulate antitumor immunity and contribute to cancer progression, while genetic instability and biofilm-driven mutations are considered as potential mechanisms linking persistent microbial colonization with malignant transformation.A further dimension of the book focuses on the therapeutic and translational potential of biofilm biology. Bacterial metabolites are examined as emerging sources of anticancer molecules and as potential tools for developing innovative cancer chemotherapeutics. At the same time, the book critically addresses the dual nature of biofilms, considering their potential applications alongside associated biological risks, environmental consequences, biosafety concerns, and legal challenges.The latter part of the book introduces an emerging AI- and nanotechnology-enabl... paradigm for infection–cancer surveillance and diagnostics. Advanced nanostructured biosensors, AI-assisted multiplexed platforms, metaheuristic optimization, and integrated surveillance technologies are presented as approaches for simultaneous detection and monitoring of infectious and cancer-associated biomarkers. The application of AI to wastewater surveillance further expands the discussion toward a One Health framework, connecting environmental pathogen monitoring with potential cancer-risk assessment.The final contribution integrates genomics, metagenomics, and artificial intelligence to investigate infection-associated genomic signatures in Bacteroides fragilis, demonstrating how multi-omics and computational approaches can facilitate biomarker discovery and improve understanding of infection–cancer relationships.Collec... the book brings together microbiology, molecular oncology, genomics, epigenetics, immunology, metabolomics, nanotechnology, biosensing, artificial intelligence, environmental surveillance, and One Health. It provides an integrated perspective on the emerging biofilm–infection–ca... axis, highlighting both fundamental mechanisms and opportunities for diagnosis, prevention and therapeutic intervention.The book is intended for researchers, academicians, clinicians, biotechnologists, microbiologists, cancer biologists, bioinformaticians, nanotechnologists, environmental scientists, and advanced postgraduate students interested in the rapidly evolving interface between microbial biology and cancer.

  • Autophagy – Part C

    • 1st Edition
    • Volume 406
    • English
    Autophagy, Part C, Volume 406 dives cellular housekeeping, weaving together the mechanistic precision of modern biology with the larger questions of health, aging, and resilience. Building on the foundations laid in Parts A and B, this book takes the reader from the microscopic machinery inside a single cell to the sweeping implications for organisms, ecosystems, and medicine. Chapters cover Lysosomal Function and Homeostasis: From Cellular Adaptation to Disease Pathogenesis, Autophagy Meets Plant Virology: From Molecular Crosstalk to Outstanding Challenges, Impact of mitophagy on obesity-affected tissues, Autophagy in Endothelial Cells: a gatekeeper of immune cell trafficking and function, and much more.Additional sections cover Viral Trafficking: The Role of Autophagy in the Release of Virus-Loaded Extracellular Vesicles and Sex matters in macroautophagy: sex-driven differences in autophagic function in aging and aging related-diseases.

  • Thiamine and Thiamine-Pyrophosphate (TPP) Riboswitches

    • 1st Edition
    • Volume 735
    • English
    Thiamine and Thiamine-Pyrophospha... (TPP) Riboswitches is devoted to the cofactor thiamine, also known as vitamin B1, and its phosphorylated derivatives. The biosynthesis of thiamine is discussed in terms of key enzymes and their regulation, the evolution of metabolic pathways, and its importance in plant and yeast metabolism. The importance of quantifying and distinguishing between phosphorylated and unphosphorylated thiamine in animal and human tissues using chromatographic, enzymatic, and nanopore methods is also discussed. In addition to these methods, thiamine riboswitches are a major focus of this book, covering everything from their identification in plants and the elucidation of their structure to their application in detection.This book presents state-of-the-art methods and detailed protocols intended for all researchers interested in thiamine metabolism or its detection.

  • Molecular Insights into Proteinopathies

    Increased Scope from Neurodegeneration to other Pathologies of the Brain
    • 1st Edition
    • Eva Žerovnik + 1 more
    • English
    Molecular Insights into Proteinopathies: Increased Scope from Neurodegeneration to other Pathologies of the Brain investigates the molecular events that lead to various diseases. The book is divided into four parts, the first of which delves into protein aggregation across a range of diseases, including Alzheimer’s disease, Parkinson’s disease, schizophrenia, and neuropsychiatric diseases. It then moves on to discuss signaling pathways and biomarkers of disease, including oxidative stress, mitochondrial decline, and dysregulated molecular pathways. The third part explores small molecules as modulators of key processes in the pathogenesis of proteinopathies, including antioxidants, polyphenol compounds, metal chelators, and repurposed drugs that modulate proteinopathies.The final section considers biophysical methods, molecular dynamics, and machine learning approaches in the study of these aspects. The book provides a detailed overview of protein dysfunction and its implications for health and disease, aiding understanding of protein condensates and aggregates, protein misfolding, co-chaperoning and toxicity of pre-amyloid aggregates. By understanding the fundamental properties underlying these, the book paves the way for investigating how proteinopathies could be treated.

  • Alternative Proteins

    • 1st Edition
    • Volume 154
    • English
    Alternative Proteins, Volume 154 provides a comprehensive overview of alternative proteins, exploring their sources, production technologies, nutritional profiles, and potential to transform the global food system. Covering plant-based, microbial, insect, and cultured (cell-based) proteins, the book examines the scientific advances, market trends, regulatory challenges, and sustainability implications of these innovative protein sources. Chapters in this new release include Introduction to Alternative Proteins, Molecular Properties of Plant-Based Proteins for Alternative Proteins, The Science of Alternative Proteins: Comparing Animal and Plant-Based Sources, Blue Proteins: Marine-Derived Alternatives for Sustainable Nutrition and Climate-Resilient Food Systems, and much more. Additional sections cover Insect Proteins for Alternative Proteins: Sustainable Solutions with Molecular Efficiency, Plant-Based Proteins: Key Sources and Production Methods, Fungal proteins as Eco-friendly Alternate Proteins, Algae and Microbial Proteins for Alternative Proteins: Untapped Molecular Resources, Integrating Siddha Dietary Principles with Alternative Protein Systems: A Pathway Toward Sustainable and Functional Nutrition, Alternative Proteins: Structure and Functional Properties, and a variety of extensive and timely topics.

  • Erythropoiesis/Hematopoiesis

    • 1st Edition
    • Volume 170
    • English
    Erythropoiesis/Hemat... Volume 170 provides a comprehensive overview of erythropoiesis and hematopoiesis—the processes by which blood cells are formed, developed, and maintained in the body. The book covers the molecular, cellular, and physiological mechanisms that regulate the formation of red blood cells (erythropoiesis) and all other blood cell lineages (hematopoiesis), including stem cell biology, signaling pathways, and genetic regulation. Timely chapters in this new release include Ribosomal RNA transcription in normal and leukemic hematopoiesis, Regulation of erythroid development by iron metabolism, Mediator at the Helm: Coordinating Transcription and Biomolecular Condensates in Hematopoiesis, and much more.Additional chapters explore Cell fate decision and lineage specification mechanisms in hematopoiesis, Hijacking the Host: Red Blood Cell Remodeling and Extracellular Vesicle Release During Babesia Infection, How advances in chromosome conformation capture methods are reshaping our understanding of gene regulation in haematopoiesis, Post-transcriptional regulation in erythropoiesis, Erythropoiesis resolved through spatial omics, and Transcription elongation mechanisms that control gene expression in erythropoiesis.

  • Advances in Cancer Research

    • 1st Edition
    • Volume 172
    • English
    Advances in Cancer Research, Volume 172 in this ongoing series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Memantine and its Analogs: Potential Applications in Cancer Therapy, The role of epigenetic modifications in mediating cancer health disparities, Tumor Associated Macrophages: Ontogeny, Plasticity, Spatial Ecosystems, and Therapeutic Targeting, Recognizing the significance of cancer-nerve crosstalk in advanced prostate cancer, and much more.

  • Advances in Structural Biology

    Applications in Protein Structure, Function, and Disease
    • 1st Edition
    • Anas Shamsi + 3 more
    • English
    Advances in Structural Biology: Applications in Protein Structure, Function, and Disease offers a comprehensive, practical resource that bridges the latest experimental and computational approaches in structural biology. Backed by real-world case studies, it demonstrates how these technologies can be utilized to serve a range of biological needs. The content spans foundational principles of protein structure and bioinformatics tools, cutting-edge methodologies such as cryogenic electron microscopy, and the transformative role of artificial intelligence (AI) and big data analytics in structural biology. It also considers applications including drug discovery, vaccine development, antiviral therapy, personalized medicine, and the structural basis of aging and neurodegenerative diseases. This book also explores systems integration approaches, combining structural and omics data to advance immunotherapy and cancer treatment, concluding with a look toward future trends in the field.Advances in Structural Biology: Applications in Protein Structure, Function, and Disease provides a detailed investigation into the latest developments in structural and computational biology, sharing insights into integrative methodologies that combine both traditional and emerging technologies. This resource is invaluable for advanced students, researchers, and professionals aiming to harness structural biology for innovative solutions in precision medicine and translational research.

  • Gene Therapy in Neurodegenerative Disorders

    From Bench to Bedside
    • 1st Edition
    • Vahid Mansouri + 1 more
    • English
    Gene Therapy in Neurodegenerative Disorders: From Bench to Bedside offers a comprehensive review of gene therapy modalities and their applications in treating neurodegenerative disorders. Initial chapters focus on the fundamentals of gene therapy strategies, including gene delivery methods and CNS-targeted gene delivery. Subsequent chapters delve into specific neurodegenerative disorders such as Spinal Muscular Atrophy (SMA), Amyotrophic Lateral Sclerosis (ALS), Duchenne Muscular Dystrophy (DMD), and Alzheimer's Disease (AD), highlighting the latest gene therapy approaches for each condition. Each chapter provides a detailed introduction to the relevant field before exploring specific tools and applications.With contributions from leading experts, the book addresses current and ongoing clinical trials, potential challenges, and promising advances in gene therapy for neurodegenerative disorders. It also discusses regulatory and ethical considerations in translating research from bench to bedside. This book is an essential resource for basic science researchers in gene therapy, geneticists, biotechnologists, and clinical researchers seeking new and effective treatments for neurodegenerative diseases. It equips readers with the knowledge and tools needed to advance their work and drive innovation in gene therapy.

  • Advances in Applied Microbiology

    • 1st Edition
    • Volume 134
    • English
    Advances in Applied Microbiology, Volume 134 presents a comprehensive exploration of the latest innovations in applied microbiology. The book delves into the diverse applications of microbiology across various industries, including agriculture, food production, biotechnology, environmental science, and healthcare. Through a collection of insightful chapters authored by experts in the field, readers are offered in-depth analyses of cutting-edge research, emerging trends, and practical applications of microbiological principles. From novel microbial technologies to the impact of microbiomes on human health and beyond, this book serves as a valuable resource for researchers, professionals, and students seeking to stay informed and inspired by the exciting advancements.

  • RNases in Health and Diseases

    From Housekeeping Enzymes to Moonlight Proteins
    • 1st Edition
    • Ester Boix
    • English
    RNases in Health and Diseases: From Housekeeping Enzymes to Moonlight Proteins provides coverage of the structural and functional properties of RNases, introducing new concepts such as their recently discovered multifaceted properties, their involvement in the generation of non-coding signaling RNAs, and their proposed uses as diagnostic and therapeutic tools. This book's sections cover the structure of RNases, present research methods and tools to study RNases, and delve into RNases and diseases. Users will find a wider perspective on the topics discussed that will serve researchers and students engaged in the study of RNases who are interested in acquiring a better understanding.

  • Cell Death Part E

    • 1st Edition
    • Volume 210
    • English
    Cell Death Part E, Volume 210 presents the latest advances and comprehensive reviews in the rapidly evolving field of cell death. This volume explores the molecular mechanisms, regulatory pathways, and biological consequences of various forms of cell death—including apoptosis, necrosis, autophagy, and other non-canonical processes. Chapters in this new release include Flow cytometry analysis of mitochondrial apoptotic priming with BH3 profiling on senescent cells, Methods to study PIDDOsome and caspase 2 signaling, Isolation, characterization, and experimental applications of apoptotic bodies in vitro, Lipid ROS Measurement by Spectral Flow Cytometry based on the ratiometric dye BODIPYTM C11 581/591, and much more.Additional chapters cover CRISPR-Cas9 Screen to Identify Genes Regulating Cell Death, Flow cytometry-assisted discrimination of early apoptotic, late apoptotic and primary necrotic morphological markers in Saccharomyces cerevisiae, Cytofluorometric analysis of cell death in primary human neutrophils, Real-time tracking of cell death in human intestinal organoids: a quantitative imaging approach, and more.

  • Histone Deacetylases in Neurodegenerative Disease Part B

    • 1st Edition
    • Volume 734
    • English
    Histone Deacetylases in Neurodegenerative Disease Part B, Volume 734 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on timely topics surrounding the Interaction of HDAC6 ZnF UBP with Tau affects its stability by NMR and Simulation studies, Protocols for In Vitro Analysis of Liquid-Liquid Phase Separation of Proteins, Histone deacetylases in NS, Histone Deacetylase 6 ZnF UBP domain enhances podosome formation in neuronal cells studied by high-resolution confocal microscopy, Methodological approach to Investigate Peroxiredoxin 1 Deacetylation by Histone Deacetylase 6, Critical structural features of HDAC11 inhibitors, and much more.Additional chapters in this release include Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration, Elucidation of Site-Specific Ubiquitination on Chaperones in Response to Mutant Huntingtin, Protein acetylation dynamics (histone and non-histone) and role protein deacetylases in disease, Epigenetic Clues: Predicting Maternal Depression Through DNA Methylation, A short guide on in vivo transfection of flag-HDAC4 in dentate gyrus for study of adult neurogenesis in brain trauma, Decoding the Acetylation Journey from Neural Crest to Melanocyte, and more.

  • Microbial Technologies for Sustainable Waste Management

    • 1st Edition
    • Rajneesh Kumar + 2 more
    • English
    Microbial Technologies for Sustainable Waste Management explores advanced waste management through microbial processes. The book investigates the current limitations of traditional waste treatment and the potential for microbial cell factories in bringing innovative solutions to this field. Beginning with an introduction to the role of microbes in waste management, it examines global case studies demonstrating success stories in microbial waste treatment and microbial innovations for biotechnological applications in waste conversion. Concluding chapters focus on microbial pathways for anaerobic digestion, hydrolysis, and fermentation, and microbial technologies for industrial applications such as wastewater treatment and the biofuel industry.Additionall... the book considers microbial remediation of hazardous and toxic waste, microbial fuel cells, and strategies for plastic waste degradation. Emerging technologies, such as AI integration, microbial nanotechnology, and engineered microbes are discussed, along with their environmental impacts and potential for scaling up to commercial applications.

  • Genome Damage

    Repair and Adaptation Across Life
    • 1st Edition
    • Vinod K. Kannaujiya + 2 more
    • English
    Genome Damage: Repair and Adaptation Across Life explores the significance of nucleic acid damage from environmental pollutants, UV radiation, and other stressors that can lead to mutations, genetic instability, and various diseases, including cancer. This book delves into the mechanisms of DNA and RNA repair, which are crucial for maintaining cellular health and enabling evolutionary adaptations. It examines these intricate processes across microbes, plants, and animals, providing a comprehensive understanding of how genetic materials are regulated and repaired under diverse environmental conditions.Other sections cover a wide range of topics, including advanced molecular mechanisms of nucleotide repair, UV-induced damage, apoptosis cell death and autophagy, genetic instability in crops, and the role of post-translational modifications in DNA repair, the detection and quantification of DNA damage, the impact of synthetic chemicals and climate change on nucleic acids, and the therapeutic significance of DNA repair mechanisms. The book closes with a look towards future perspectives.

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