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Genome Chaos
Rethinking Genetics, Evolution, and Molecular Medicine
- 2nd Edition - July 1, 2025
- Author: Henry H. Heng
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 5 4 2 8 - 7
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 5 4 2 7 - 0
Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine, Second Edition transports readers from Mendelian genetics to 4D genomics, building a case for genes and genome… Read more
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Request a sales quoteGenome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine, Second Edition transports readers from Mendelian genetics to 4D genomics, building a case for genes and genomes as distinct biological entities where the genome, rather than individual genes, defines system-level inheritance and represents a clear unit of selection for macroevolution. In this thought-provoking text, Dr. Henry Heng invigorates fresh discussions in Genome Architecture Theory and helps readers reevaluate their current understanding of human genetics, evolution, and new pathways for advancing molecular and precision medicine.
In this timely new edition, Dr. Heng fully embraces the integration of system information with genome-mediated evolutionary mechanisms, and supports this framework with recent findings and growing, interdisciplinary research. Ten evidence-based chapters discuss 4D genomics, genes and genomes as distinct biological entities, genome chaos and cellular macroevolution, karyotype coding and fuzzy inheritance, as well as an entirely novel model of evolution driven by information flow, and more. Brand-new chapters consider the creation and maintenance of system information for complexity and biodiversity, as well as modes of analyzing information-based and historically contingent evolutionary framework. This synthesis offers a revolutionary paradigm of evolutionary theory. It also hypothesizes about how information flow, matter arrangement, and energy interact.
In this timely new edition, Dr. Heng fully embraces the integration of system information with genome-mediated evolutionary mechanisms, and supports this framework with recent findings and growing, interdisciplinary research. Ten evidence-based chapters discuss 4D genomics, genes and genomes as distinct biological entities, genome chaos and cellular macroevolution, karyotype coding and fuzzy inheritance, as well as an entirely novel model of evolution driven by information flow, and more. Brand-new chapters consider the creation and maintenance of system information for complexity and biodiversity, as well as modes of analyzing information-based and historically contingent evolutionary framework. This synthesis offers a revolutionary paradigm of evolutionary theory. It also hypothesizes about how information flow, matter arrangement, and energy interact.
- Bridges basic research and clinical applications, providing a foundation for re-examining the results of large-scale -omics studies and precision medicine
- Gathers the most pressing questions in genomics, cytogenomics, and evolution
- Proposes a novel genome and information-based evolutionary theory that unites the study of physical, chemical, and biological mechanisms within organismal systems
- Contains ten evidence-based chapters that discuss karyotype coding, function of sex, natural information self-creation, and evolution as platform for both innovation and conservation
Active researchers, basic and translational scientists in the areas of human genetics, genomics, molecular biology, computational biology, evolutionary biology, information science, scientific philosophy, history of science, and cancer research, Students and clinicians
1. From Mendelian Genetics to 4D Genomics
2. Genes and Genomes Represent Different Biological Entities
3. Genome Chaos and Cellular Macroevolution: How Evolutionary Cytogenetics Unravels the Mystery of Cancer.
4. Karyotype Coding and Fuzzy Inheritance: The Genomic Basis of Bio-information and Heterogeneity
5. Why Sex? Genome Reinterpretation Dethrones the Queen
6. Breaking the Genome Constraint: The Mechanism of Macroevolution
7. The Creation and Maintenance of System Information for Complexity and Biodiversity
8. Searching for an Information-Based and Historically Contingent Evolutionary Theory
9. The Genome Architecture Theory: A New Framework
10. The Rationale and Challenges for Molecular Medicine
2. Genes and Genomes Represent Different Biological Entities
3. Genome Chaos and Cellular Macroevolution: How Evolutionary Cytogenetics Unravels the Mystery of Cancer.
4. Karyotype Coding and Fuzzy Inheritance: The Genomic Basis of Bio-information and Heterogeneity
5. Why Sex? Genome Reinterpretation Dethrones the Queen
6. Breaking the Genome Constraint: The Mechanism of Macroevolution
7. The Creation and Maintenance of System Information for Complexity and Biodiversity
8. Searching for an Information-Based and Historically Contingent Evolutionary Theory
9. The Genome Architecture Theory: A New Framework
10. The Rationale and Challenges for Molecular Medicine
- No. of pages: 580
- Language: English
- Edition: 2
- Published: July 1, 2025
- Imprint: Academic Press
- Paperback ISBN: 9780443154287
- eBook ISBN: 9780443154270
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Henry H. Heng
Dr. Henry H. Heng has coauthored over 200 publications and serves on the editorial boards of seven international, peer-reviewed journals. Using single-cell analysis of in vitro and in vivo models, Dr. Heng’s group has illustrated the evolutionary dynamics of cancer progression by directly observing evolution in action. Such experiments revealed that cancer evolution involves two phases: punctuated genome alteration-mediated macroevolution (which creates a new system), followed by stepwise gene and epigenetic-mediated microevolution (which leads to population growth). By applying this concept to organismal evolution, he discovered that the main function of sex is to reduce genetic diversity at the genome level in order to preserve genome-defined species identity information. Heng introduced the Genome Architecture Theory, a new genome-based conceptual framework of genomics and evolution.
Affiliations and expertise
Professor, Center for Molecular Medicine and Genetics, Pathology Department, Wayne State University School of Medicine, Wayne State University, Detroit, MI, USA