Books in Molecular biology cellular biology and genetics

Targeted Protein Degradation Technologies

1st Edition
August 6, 2025
Jiangjiang Qin + 2 more
English
Paperback
9 7 8 0 4 4 3 2 1 8 1 6 3
eBook
9 7 8 0 4 4 3 2 1 8 1 7 0

Targeted Protein Degradation Technologies provides a thorough overview of targeted protein degradation from the latest developments in the field to potential therapeutic applications. The book begins with an introduction to the mechanisms of protein degradation followed by a section covering both protease-mediate degradation and lysosome-mediate degradation. A range of cutting-edge technologies are covered, including PROTAC, AbTAC, molecular glues, hydrophobic tagging, LYTAC, GlueTAC and AUTAC. Degraders of specific proteins are then investigated, including signal transduction receptors, membrane proteins, and transcription factor degraders.The book closes with a section on the clinical applications of targeted protein degradation and a look at future perspectives. It is a useful resource to those in the fields of molecular biology, cell biology, and related areas working with protein degradation and the development of therapeutic technologies in this arena.

Metagenomics for Microbiology

2nd Edition
August 4, 2025
Jacques Izard + 1 more
English
Paperback
9 7 8 0 4 4 3 2 2 3 7 6 1
eBook
9 7 8 0 4 4 3 2 2 3 7 7 8

Metagenomics for Microbiology, Second Edition unveils the intricate and diverse world of microbial communities, emphasizing their critical roles in health, disease, and ecosystem functionality. This updated edition addresses the significant challenges in the field and introduces promising approaches to make metagenomics research more feasible. Through comprehensive revisions and over five new chapters, readers are equipped with the latest research data and analyses, advancing their understanding of microbial principles. Notably, this edition provides a robust foundation for the design and analysis of omics studies, focusing on technological underpinnings and practical applications. It remains an essential resource for characterizing microbial consortia.

Methods in Biomolecular Modelling

1st Edition
August 3, 2025
Thomas W. Keal
English
eBook
9 7 8 0 4 4 3 2 2 0 4 0 1

Methods in Biomolecular Modelling, Volume Two in the series, considers modeling methods with relevance to the study of biomolecular systems, including the workhorse of classical molecular dynamics and related techniques, areas where electronic structure methods find use, the higher length scales achievable through coarse grained and mesoscale methods, and combinations of scales. Applicability of methods is then illustrated with a wide range of biomolecular modeling research topics drawn from current research. Throughout the text, practical considerations of research are emphasized, including sourcing of structural data, scalability of methods on HPC systems, and linking of computation to experiment.Part I introduces a range of modeling techniques used for biomolecular simulation, explaining the fundamental principles of each and the research areas to which they are applicable. The strengths and weaknesses of each method are outlined, along with their real-world performance on current computing resources and future trends. Part II looks at a range of application areas, with case studies illustrating the methods that can be used to investigate biomolecular systems in these areas.

The Emerging Genomic Landscape of Complex Immune-Mediated Traits

1st Edition
Volume 114
August 1, 2025
Juliana Miranda Cerqueira
English
Hardback
9 7 8 0 4 4 3 2 2 4 1 5 7
eBook
9 7 8 0 4 4 3 2 2 4 1 6 4

The Emerging Genomic Landscape of Complex Immune-Mediated Traits, Volume 114 in the Advances in Genetics series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Unraveling the Interplay of Genetic Variants and Epigenetic Signatures in Complex traits, Crosstalk between T Cell Gene Regulation and Intestinal Epithelial Cells: Insights into Mucosal Immunity, Understanding the link between regulatory RNA regions and genomic variation with coeliac disease, Interplay Between the Host Genome, Autoimmune Disease and Infection, and Organoids and gut-on-chip as powerful tools to model the genetics of intestinal mucosal inflammation.

Immuno-oncology and Immunotherapy Part D

1st Edition
Volume 196
August 1, 2025
Lorenzo Galluzzi + 2 more
English
Hardback
9 7 8 0 4 4 3 2 9 6 1 8 5
eBook
9 7 8 0 4 4 3 2 9 6 1 9 2

Immuno-oncology and immunotherapy, Part D, Volume 196 in the Methods in Cell Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Investigating the endothelial-immune axis in cancer, Establishing Tyro3, Axl, and Mertk Chinese Hamster Ovary (CHO) Reporter Cell Lines for Cancer Immunology and Therapeutic Applications, Amino acid analog-based labelling of the immunomodulatory cancer secretome, Human and mouse iNKT cell expansion and engineering with viral vectors, Next-generation deconvolution of the tumor microenvironment with omnideconv, and much more.Additional sections cover Comprehensive prediction of tumor neoantigens with NextNEOpi, Ex vivo profiling of organotypic tumor spheroids in 3D microfluidic culture, A flow cytometry-based assay for evaluation of T cell activation and degranulation in coculture systems, An adenosine production assay suitable for 2D and 3D cancer cell culture, Determination of lactate in the tumor interstitial fluid, Combined in vitro differentiation and cell sorting-based isolation of highly pure mouse bone marrow-derived basophils, Organ-on-Chip immunostaining method for three-dimensional identification and study of immune cells responding to drug-treated tumor cells, and much more.

Healthcare Applications of Neuro-Symbolic Artificial Intelligence

1st Edition
August 1, 2025
Boris Galitsky
English
Paperback
9 7 8 0 4 4 3 3 0 0 4 6 2
eBook
9 7 8 0 4 4 3 3 0 0 4 7 9

Healthcare Applications of Neuro-Symbolic Artificial Intelligence provides a comprehensive introduction to the field of neuro-symbolic (NS) artificial intelligence (AI), presenting the most recent advances in deep learning and integration of NS systems and large language models (LLMs). This book evaluates traditional approaches, current approaches, as well as the author’s own approach to NS, to create hybrid architectures and reasoning techniques to overcome the limitations of most existing AI systems such as deep learning, neural networks, and symbolic AI.This book will be a welcome resource for researchers and graduate students in AI, natural language processing, and biomedical informatics, as well as professionals in software development looking to redesign current systems to leverage LLMs through the health application of NS architecture.

The Microbiome in Cancer and Autoimmunity - Part B

1st Edition
Volume 395
August 1, 2025
Manisha Singh
English
Hardback
9 7 8 0 4 4 3 3 1 7 0 8 8
eBook
9 7 8 0 4 4 3 3 1 7 0 9 5

Microbiome in Cancer and Autoimmunity - Part B, Volume 395 offers a comprehensive exploration of the intricate relationship between the human microbiome and the development of cancer and autoimmune diseases. Delving into cutting-edge research and clinical insights, this groundbreaking work elucidates the role of microbial communities in influencing immune responses, disease pathways, and therapeutic outcomes. Specific chapters cover the Effect of Microbial Dysbiosis on Autoimmune-Associate... Inflammation, Gut Microbiota and Systemic Immune Responses in Cancer, The role of microbiome in gastrointestinal cancer, Cancer and Microbiome-Targeted Therapies, Autoimmune disease and Microbiome Targeted Therapies, and the Effect of Diet and Lifestyle on Microbiome Composition.

Protein Termini

1st Edition
Volume 718
August 1, 2025
Thomas Arnesen
English
Hardback
9 7 8 0 4 4 3 4 1 4 8 3 1
eBook
9 7 8 0 4 4 3 4 1 4 8 4 8

Protein termini represent a major route to protein regulation. From the moment the very first amino acid of a polypeptide chain exits the ribosome there is potential for steering from the cellular environment. This volume of Methods in Enzymology Modifications and Targeting of Protein Termini focuses on Protein N-termini and C-termini and their modifications which include acetylation, arginylation, myristoylation and oxidation. Also, the impact of terminal modifications is covered, in particular the impact on protein turnover and the ubiquitin E3 ligases which specifically recognize protein N-termini (N-degrons) and C-termini (C-degrons). In addition to the detailed methods and laboratory protocols, the chapters include informative overviews and reviews of the different subfields.

Cell Physiology Source Book

5th Edition
July 31, 2025
F. Javier Alvarez-Leefmans + 2 more
English
Hardback
9 7 8 0 1 2 8 1 1 1 1 4 7
eBook
9 7 8 0 1 2 8 1 1 1 1 5 4

Cell Physiology Source Book, Fifth Edition covers a broad range of topics in cell physiology. The book discusses research areas that have become active since the last edition (e.g., aquaporins, apicoplast and other organelles) and broadens its scope to include chronobiology, expansion of receptor/sensory physiology, endocrinology, and other topics such as quorum sensing and taxis. As methods or approaches on performing experiments appear to be very valuable parts of books to which readers tend to frequently refer, expansion of these types of chapters and/or appendices are included in this edition. Applicable to scientists, researchers, postdocs and graduate students across physiological, biochemical, biological and biomedical backgrounds, cell physiology is important for understanding larger organisms and potential advances in biomedicine.

Novel Genetic Pathways Associated to Energy Homeostasis Impairments

1st Edition
Volume 113
July 1, 2025
Marc Schneeberger
English
Hardback
9 7 8 0 4 4 3 2 3 7 4 4 7
eBook
9 7 8 0 4 4 3 2 3 7 4 5 4

Novel Genetic Pathways Associated to Energy Homeostasis Impairments, Volume 113 in the Advances in Genetics series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Advances in Metabolism: Energy Balance Circuitry, Advances in Metabolism: Diabetic Retinopathy, From Metabolomics to Energy Balance Physiology, Advances in Metabolism: Prader-Willi Syndrome, Neural Mechanisms and Health Implications of Food Cravings During Pregnancy, Advances in Metabolism: Diabetes, Advances in Metabolism: Cachexi, and Parkinson’s Disease and Metabolic Disorders: Understanding Their Shared Co-Morbidity Through the Autonomic Nervous System.

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