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Academic Press

  • From DNA to Traditional Chinese Medicine

    • 1st Edition
    • Jesse Li-Ling
    • English
    From DNA to Traditional Chinese Medicine presents how genetic disorders can be explained using concepts of Traditional Chinese Medicine. This book explores the striking correlation between the characteristics of congenital syndromes and fundamental concepts of Traditional Chinese Medicine, such as Jing-Mai (Meridians or Channels) and Zang-Fu (the Yin and Yang internal organs). This correlation appears to be systematic and comprehensive, suggesting that these Chinese concepts have correctly summarized the connections between particular parts of the human body during embryonic development. Should this discovery be correct, it will have an immense impact on the understanding of genomic medicine as well as Chinese medicine. The uncovering of the mechanism of Chinese medicine, may also lead to development of new treatments for various human diseases. This book covers topics including genetic syndromes and fundamental concepts of Traditional Chinese Medicine. Starting with DiGeorge/Velocardiof... syndrome, this book will first introduce the basics of Medical Genetics and congenital syndromes, and then the fundamental concepts of Traditional Chinese Medicine including Jing-Mai and Zang-Fu. It will provide a completely new perspective on genetic syndromes with insights into how they relate to Traditional Chinese Medicine. This book is a valuable resource for graduates, medical undergraduates and researchers as well as professionals from both academia and industry.

  • Lipases

    Foundations, Applications, and Perspectives
    • 1st Edition
    • Eliane Pereira Cipolatti + 2 more
    • English
    Lipases: Foundations, Applications, and Perspectives, a new volume in the Foundations and Frontiers of Enzymology series, offers a practical, in-depth discussion of lipases and instruction in their use across research and industry. Here, global experts in the field introduce readers to basic lipase biology and the history of the field, interfacial activation and lipase lids, evolving analytical techniques and technology for studying lipases, and a range of lipase applications, from health and drug discovery to biofuels, food, cosmetics, and waste treatment. Lipase sources and production methods discussed include mammalian lipases, microbial lipase production, biomass lipase production, immobilized lipases, and tailor-made recombinant lipases, among other approaches.

  • Machine Learning Solutions for Inverse Problems: Part A

    • 1st Edition
    • Volume 26
    • English
    Machine Learning Solutions for Inverse Problems: Part A, Volume 26 in the Handbook of Numerical Analysis, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Data-Driven Approaches for Generalized Lasso Problems, Implicit Regularization of the Deep Inverse Prior via (Inertial) Gradient Flow, Generalized Hardness of Approximation, Hallucinations, and Trustworthiness in Machine Learning for Inverse Problems, Energy-Based Models for Inverse Imaging Problems, Regularization Theory of Stochastic Iterative Methods for Solving Inverse Problems, and more.Other sections cover Advances in Identifying Differential Equations from Noisy Data Observations, The Complete Electrode Model for Electrical Impedance Tomography: A Comparative Study of Deep Learning and Analytical Methods, Learned Iterative Schemes: Neural Network Architectures for Operator Learning, Jacobian-Free Backpropagation for Unfolded Schemes with Convergence Guarantees, and Operator Learning Meets Inverse Problems: A Probabilistic Perspective

  • Future of Internet of Bio-Nano Things in Personalized Healthcare

    Applications and Challenges
    • 1st Edition
    • Jayachitra Sekar + 3 more
    • English
    Future of Internet of Bio-nano Things in Personalized Healthcare: Applications and Challenges explores the core principles of nanomaterials and the sensing paradigms essential for medical devices based on nano-sensors technology, examining the latest theoretical and practical developments in Internet of Bio-nano Things (IoBNT) for health applications. This book explores how IoBNT facilitates the detection and treatment of diseases within the human body through communication between an in-body network of nanodevices and an external control unit. Readers will discover the transformative benefits of IoBNT, which integrates information and communication technologies with medical and nano-bio sensor devices to enhance patient care. The book highlights advances in telemedicine, including highly functional electronic medical devices like implantable and wearable devices engineered through nanotechnology. It details real-time case studies on smart drug delivery, edge computing, and personalized healthcare applications to provide valuable insights into optimizing network performance and utilization in personalized healthcare. The comprehensive exploration of machine learning algorithms and communication protocols further equips readers with the knowledge to design and implement end-to-end IoBNT solutions.

  • Nitrogen Heterocycles in Cancer Therapy

    • 1st Edition
    • Sanjeev Kumar Sahu + 1 more
    • English
    Nitrogen Heterocycles in Cancer Therapy explores the vast array of recently discovered nitrogen-containing heterocyclic compounds utilized in combating cancer. This comprehensive work not only highlights the fundamentals of oncology but also explains the intricacies of designing, synthesizing, and understanding the anticancer mechanisms of these compounds. Spanning across 10 chapters, the book explores the principles underlying the design, synthesis, and anticancer mechanisms of nitrogen-containing heterocyclic compounds, drawing from the latest research findings. Its scope extends beyond molecular targeting to encompass the exploration of newly identified heterocyclic compounds with potential anticancer properties. A significant emphasis is placed on crucial evaluation techniques such as in-vitro cell culture and in-vivo animal models, providing insights into the performance of these compounds in combating cancer. Particularly noteworthy is the inclusion of clinical study reports detailing the efficacy of various drug candidates across different cancer conditions, coupled with an analysis of their global market impact and pharmacoeconomics. Offering profound insights, this book emerges as an indispensable resource for researchers, clinicians, and students alike.

  • Isothermal Titration Calorimetry in Enzymology

    Techniques and Applications
    • 1st Edition
    • Anthony Mittermaier + 1 more
    • English
    Isothermal Titration Calorimetry in Enzymology: Techniques and Applications provides a thorough, practical overview of ITC as a productive and powerful tool for quantifying enzyme catalysis and interactions with substrates, products, cofactors, and inhibitors. Here, global experts in the methodology discuss the full capabilities of ITC and how it may be applied in research, medicine, and industry and offer a basis to continue leveraging ITC as its uses expand and evolve. This book bridges the gap between research and application by giving extensive technical details on cutting edge ITC techniques across a wide swath of both ITC kinetics measurements and ITC thermodynamic measurements, alongside case studies illustrating the depth of knowledge that can be obtained. Applications discussed include measuring binding kinetics by ITC, analyzing ITC kinetic data, in vivo enzyme kinetics by ITC, analyzing enzyme kinetics in crowded solutions, studying catalysis of biological substrates, interpreting ITC binding curves, ITC in drug discovery, ITC in the development of cancer therapeutics, ITC analysis of aminoglycoside resistance enzymes, studying enzyme interactions with toxic metals, using ITC to study ubiquitination, and ITC studies of glycoside hydrolases, among others.

  • Maternal-Fetal and Neonatal Endocrinology

    Physiology, Pathophysiology, and Clinical Management
    • 2nd Edition
    • Christopher S. Kovács + 1 more
    • English
    Maternal-Fetal and Neonatal Endocrinology: Physiology, Pathophysiology, and Clinical Management, Second Edition continues to systematically examine the normal and abnormal endocrinology of the pregnant and lactating female and of the fetus and neonate. This new edition expands coverage of specific disorders and diseases beyond the current endocrinology content on the market making it the go-to reference for translational and clinical research scientists to appreciate the research gaps that require further investigation. It’s comprehensive coverage of pathophysiology, diagnosis, and treatments, will help readers better understand how various diseases present differently in pregnancy and lactation and how to respond to related complications.

  • Polyamines-Phytohormones-Nutrients Network

    Nexus in Plant Responses to Abiotic Stresses
    • 1st Edition
    • Asim Masood + 3 more
    • English
    Polyamine-Phytohormo... Network: Nexus in Plant Responses to Abiotic Stresses presents the latest global research on key tools for improving physiological and biochemical mechanisms that enhance plant health and productivity.Exposur... of plants to abiotic stresses is inevitable, often leading to impaired growth, metabolism, and productivity. However, plants are naturally equipped with endogenous chemicals including intracellular messengers and signalling molecules that counteract potential stress impacts, protect cellular functions, and promote healthy growth and production. Polyamines (PAs) are low-molecular-weight... nitrogen-containing compounds with aliphatic polycationic properties. Beyond their role in growth and development, PAs enhance plant tolerance to abiotic stresses. Given their connection with phytohormones and mineral nutrients, understanding their interactions—whether synergistic or antagonistic—could shed light on their potential to mitigate these stresses.Written by a team of expert contributors, this volume in the Plant Biology, Sustainability, and Climate Change series focuses on the interactions among PAs, phytohormones, and mineral nutrients that are crucial for regulating nutrient assimilation, carbon fixation, and secondary metabolic pathways.

  • Handbook of Melatonin-Based Therapy and its Applications

    • 1st Edition
    • Alejandro Romero Martínez + 2 more
    • English
    Handbook of Melatonin-Based Therapy and its Applications provides pharmaceutical researchers and health professionals with a comprehensive reference on the applications of melatonin in the therapeutic setting. Succinct, meticulously organized, and expertly written, this book addresses all essential aspects. It starts with an overview of safe use of melatonin, translational aspects, and its prospection. The next section of the book covers a variety of clinical applications, including dosage, pharmacokinetics and pharmacodynamic profiles, toxicity, and principles of action. The chapters in this section cover applications to both adults and pediatric patients suffering from conditions like skin cancers, GI issues, psychiatric, hepatic and ocular conditions.This is a comprehensive resource for pharmaceutical scientists and health professionals involved in developing therapies and applying them to patients. Researchers in the fields of medicine, biology, neuroscience, and pharmacology conducting studies related to melatonin-based will benefit from insights into the latest research findings, clinical trials, and therapeutic approaches.

  • Medical Robotics and Intelligent Healthcare Technologies

    AI Applications to Improve Healthcare in Developing Countries
    • 1st Edition
    • Jacky Baltes + 3 more
    • English
    Medical Robotics and Intelligent Healthcare Technologies: AI Applications to Improve Healthcare in Developing Countries is an essential reference for professionals and researchers in fields such as biomedical engineering, health informatics, bioelectronics, medical electronics, physiology, and robotics. This book presents the latest advancements in AI and machine learning-based robotics applications, enabling readers to quickly grasp effective methods and compare various approaches. Addressing critical research areas that directly impact human life and health fills a significant market gap, providing valuable insights into AI, deep learning, machine learning, and big data analytics methods as they relate to emerging robotics research models in the biomedical and healthcare domains.It offers a comprehensive understanding of the concepts, themes, and tools in medical robotics, IoT-based applications, edge computing, and artificial intelligence. With a specific focus on developing countries, this book catalyzes healthcare progress by showcasing the potential of medical robotics and intelligent healthcare technologies. It aims to empower researchers and practitioners to harness these state-of-the-art technologies to improve healthcare systems worldwide.

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