
Cryo-electron Tomography
A Journey from Sample Preparation to Data Mining
- 1st Edition - July 25, 2025
- Imprint: Academic Press
- Editors: Dorit Hanein, Niels Volkmann
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 8 8 2 9 - 9
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 8 8 3 0 - 5
Cryo-Electron Tomography: A Journey from Sample Preparation to Data Mining providing a holistic overview of this rapidly advancing field and equipping researchers with the kn… Read more

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Request a sales quote- Offers a comprehensive overview of cryo-ET sample preparation and data mining protocols, consolidating approaches in a single resource
- Includes foundational knowledge underpinning the field
- Explores the latest methods, techniques and recent developments in cryo-ET
- Offers guidance to researchers for key procedures
- Written by an international range of experts
2. Cryo-FIB Developments to Enable Nanoscale Biopsies
3. Preparing Bacterial Cells for Cryo-electron Tomography
4. Revealing the Hidden World of Microbes in Situ: Sample Preparation Workflows for Cryo-electron Tomography
5. Mastering the Preparation of Eukaryotic Cell Samples for Cryo-ET: Tips and Techniques
6. Interpretation of Cellular Tomograms
7. Denoising
8. Feature Detection in cryo-Electron Tomography Image Analysis
9. Validation
- Edition: 1
- Published: July 25, 2025
- No. of pages (Paperback): 360
- No. of pages (eBook): 360
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780443188299
- eBook ISBN: 9780443188305
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Dorit Hanein
Prof. Dorit Hanein received her doctoral degree from the Weizmann Institute in Israel. She completed her training as a Fulbright postdoctoral fellow at Brandeis University under the mentorship of Professor David DeRosier, a pioneer in three-dimensional image reconstruction techniques via electron microscopy. Prof. Hanein is affiliated with the University of California, Santa Barbara, and serves as a PEW Innovation Fund Investigator. She holds a “Habilitation à Diriger des Recherches” (HDR, Accreditation to Direct Research) from Sorbonne University, France.
Prof. Hanein’s research lies at the intersection of structural biology, cell biology, systems biology, and engineering science. Her work focuses on the quantitative integration of high-resolution imaging technologies, designed to visualize the molecular architecture and dynamic conformational landscape of biological nanomachines in three dimensions within their native environments and under mechanical perturbations. She has made seminal contributions to our understanding of the cytoskeleton and macromolecular assemblies, advanced the field of quantitative electron microscopy, pioneered the use of correlative light and cryo-electron microscopic tomography and functionalized substrates. The strategic employment of these techniques has revolutionized our ability to define the building blocks of large dynamic macromolecular complexes in three dimensions with high fidelity and high resolution, while contextualizing their function within whole cells.
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