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    • The DNA Replication-Repair Interface

      • 1st Edition
      • Volume 661
      • November 12, 2021
      • English
      • Hardback
        9 7 8 0 3 2 3 9 0 7 3 3 0
      • eBook
        9 7 8 0 3 2 3 9 0 7 3 4 7
      Replication-Coupled Repair, Volume 661 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including the Repair of replication-born DNA breaks by sister chromatid recombination, High resolution and high throughput DNA cyclization measurements to interrogate DNA bendability, A programmable detection method for genomic signatures: from disease diagnosis to genome editing, Characterization of the telomerase modulating activities of yeast DNA helicases, Eukaryotic DNA replication with purified budding yeast proteins, Single molecule studies of yeast Rad51 paralogs, Light activation and deactivation of Cas9 for DNA repair studies, and more. Other chapters explore MIDAS: Direct sequencing to map mitotic DNA synthesis and common fragile sites at high precision, Studying the DNA damage response in embryonic systems, GLASS-ChIP to map Mre11 cleavage sites in the human genome, New chemical biology approaches to trap reaction intermediates in living cells, Single-molecule imaging approaches for monitoring replication fork conflicts at genomic DNA G4 structures and R-loops in human cells, Monitoring the replication of structured DNA through heritable epigenetic change, Visualizing replication fork encounters with DNA interstrand crosslinks, and much more.

    • Safety Risk Management for Medical Devices

      • 2nd Edition
      • November 11, 2021
      • Bijan Elahi
      • English
      • Paperback
        9 7 8 0 3 2 3 8 5 7 5 5 0
      • eBook
        9 7 8 0 3 2 3 9 1 8 2 3 7
      Safety Risk Management for Medical Devices, Second Edition teaches the essential safety risk management methodologies for medical devices compliant with the requirements of ISO 14971:2019. Focusing exclusively on safety risk assessment practices required in the MedTech sector, the book outlines sensible, easily comprehensible, state-of the-art methodologies that are rooted in current industry best practices, addressing safety risk management of medical devices, thus making it useful for those in the MedTech sector who are responsible for safety risk management or need to understand risk management, including design engineers, product engineers, development engineers, software engineers, Quality assurance and regulatory affairs. Graduate-level engineering students with an interest in medical devices will also benefit from this book. The new edition has been fully updated to reflect the state-of-the-art in this fast changing field. It offers guidance on developing and commercializing medical devices in line with the most current international standards and regulations.

    • Adapting Cognitive Behavioral Therapy for Insomnia

      • 1st Edition
      • November 11, 2021
      • Sara Nowakowski + 3 more
      • English
      • Paperback
        9 7 8 0 1 2 8 2 2 8 7 2 2
      • eBook
        9 7 8 0 1 2 8 2 2 8 7 3 9
      Cognitive behavioral therapy for insomnia (CBT-I) has emerged as the standard first-line treatment for insomnia. The number of patients receiving non-medication treatments is increasing, and there is a growing need to address a wide range of patient backgrounds, characteristics, and medical and psychiatric comorbidities. Adapting Cognitive Behavioral Therapy for Insomnia identifies for clinicians how best to deliver and/or modify CBT-I based on the needs of their patients. The book recommends treatment modifications based on patient age, comorbid conditions, and for various special populations.

    • Current Progress in iPSC Disease Modeling

      • 1st Edition
      • November 11, 2021
      • Alexander Birbrair
      • English
      • Paperback
        9 7 8 0 3 2 3 8 5 7 6 5 9
      • eBook
        9 7 8 0 3 2 3 8 5 6 4 3 0
      Current Progress in iPSC Disease Modeling, Volume Fourteen in the Advances in Stem Cell Biology series, is a timely and expansive collection of information and new discoveries in the field. This new volume addresses advances in research on how induced pluripotent stem cells are used for the creation of new tissues and organs. The creation of iPSC technology allowed the development of disease-specific human pluripotent stem cells. These cells allow researchers to study questions once impossible for some human diseases. This volume addresses iPSCs for vascular tissue engineering, bioprinting, derived lung organoids for pulmonary disorders, skeletal muscle engineering, human kidney organoids, and more. It is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation, and is contributed by world-renowned authors in the field.

    • Foundations of Sleep Health

      • 1st Edition
      • November 11, 2021
      • F. Javier Nieto + 1 more
      • English
      • Paperback
        9 7 8 0 1 2 8 1 5 5 0 1 1
      • eBook
        9 7 8 0 1 2 8 1 5 5 0 2 8
      Foundations of Sleep Health presents sleep health as a critical element of overall individual and population health. Sleep disorders are an increasing problem plaguing more than 40 million Americans. Sleep impacts numerous biological functions and plays a critical role in brain development, including learning and memory consolidation, cognitive functioning, and emotion regulation. This book provides an historic and current overview of the state of sleep health with an emphasis on the interplay between several levels of determinants and factors that influence sleep health. The text provides students in the health professions with in-depth discussion on the theory, research, and practice of sleep health, while also detailing mechanisms, hypotheses, and determinants of sleep and ways to improve sleep health.

    • AI, Edge and IoT-based Smart Agriculture

      • 1st Edition
      • November 10, 2021
      • Ajith Abraham + 4 more
      • English
      • Paperback
        9 7 8 0 1 2 8 2 3 6 9 4 9
      • eBook
        9 7 8 0 1 2 8 2 3 6 9 5 6
      AI, Edge, and IoT Smart Agriculture integrates applications of IoT, edge computing, and data analytics for sustainable agricultural development and introduces Edge of Thing-based data analytics and IoT for predictability of crop, soil, and plant disease occurrence for improved sustainability and increased profitability. The book also addresses precision irrigation, precision horticulture, greenhouse IoT, livestock monitoring, IoT ecosystem for agriculture, mobile robot for precision agriculture, energy monitoring, storage management, and smart farming. The book provides an overarching focus on sustainable environment and sustainable economic development through smart and e-agriculture. Providing a medium for the exchange of expertise and inspiration, contributions from both smart agriculture and data mining researchers around the world provide foundational insights. The book provides practical application opportunities for the resolution of real-world problems, including contributions from the data mining, data analytics, Edge of Things, and cloud research communities working in the farming production sector. The book offers broad coverage of the concepts, themes, and instruments of this important and evolving area of IOT-based agriculture, Edge of Things and cloud-based farming, Greenhouse IOT, mobile agriculture, sustainable agriculture, and big data analytics in agriculture toward smart farming.

    • Mechanisms of Cell Death and Approaches to Neuroprotection/Disease Modification in Parkinson’s Disease

      • 1st Edition
      • Volume 2
      • November 10, 2021
      • English
      • Hardback
        9 7 8 0 3 2 3 8 9 9 4 3 7
      • eBook
        9 7 8 0 3 2 3 8 9 9 4 4 4
      Mechanisms of Cell Death and Approaches to Neuroprotection/Dise... Modification in Parkinson’s Disease explores the results of numerous studies surrounding in vitro and animal model evidence that looks at the impact of α-synucleinopathy on neuronal dysfunction and behavioral impairments, (ii) how research in animal models supports the development of therapeutic strategies, and (iii) how findings in animal models might relate to the disease process in humans. In this book, the author's shed light upon the complex scenario of the mechanisms of cell death and approaches to neuroprotection/dise... modification in PD, both in vitro to in vivo. Along with degeneration, the pathological hallmark of PD is the presence of intraneuronal proteinaceous cytoplasmic inclusions, named Lewy Bodies (LB) that invade the whole nervous system as the disease progresses. Several fundamental discoveries have shed light upon the implication of the α-syn protein in the pathogenesis of familial and sporadic forms of PD. Other proteins also accumulate in LB, but α-syn is a major protein component of the pathological landmarks.

    • iPSC Derived Progenitors

      • 1st Edition
      • November 10, 2021
      • Alexander Birbrair
      • English
      • Paperback
        9 7 8 0 3 2 3 8 5 5 4 5 7
      • eBook
        9 7 8 0 3 2 3 9 0 0 7 3 7
      iPSC Derived Progenitors, Volume Thirteen in the Advances in Stem Cell Biology series is a timely collection of information and new discoveries in the field of stem cell biology. The book addresses the importance of induced pluripotent stems cells and how can they be differentiated into different progenitors. Progenitors cells are often the first-step to making more differentiating cell types. This volume addresses iPSCs derived from bone, dental pulp, craniofacial, neural stem cells, otic, cardiac, and much more. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine, organ transplantation, and is contributed by world-renowned authors.

    • Cybersecurity for Connected Medical Devices

      • 1st Edition
      • November 9, 2021
      • Arnab Ray
      • English
      • Paperback
        9 7 8 0 1 2 8 1 8 2 6 2 8
      • eBook
        9 7 8 0 1 2 8 1 8 2 6 3 5
      The cybersecurity of connected medical devices is one of the biggest challenges facing healthcare today. The compromise of a medical device can result in severe consequences for both patient health and patient data.　Cybersecurity for Connected Medical Devices covers all aspects of medical device cybersecurity, with a focus on cybersecurity capability development and maintenance, system and software threat modeling, secure design of medical devices, vulnerability management, and integrating cybersecurity design aspects into a medical device manufacturer's Quality Management Systems (QMS). This book is geared towards engineers interested in the medical device cybersecurity space, regulatory, quality, and human resources specialists, and organizational leaders interested in building a medical device cybersecurity program.　

    • Healthcare Strategies and Planning for Social Inclusion and Development

      • 1st Edition
      • November 9, 2021
      • Basanta Kumara Behera + 2 more
      • English
      • Paperback
        9 7 8 0 3 2 3 9 0 4 4 6 9
      • eBook
        9 7 8 0 3 2 3 9 0 4 1 8 6
      Healthcare Strategies and Planning for Social Inclusion and Development: Volume One: Health for All - Challenges and Opportunities in Healthcare Management examines health care management, particularly in developing countries, along with the key aspects of universal health required to address current global health issues. This new volume begins with an overview of the concept and definition of “Health for All.” The book covers how international organizations like the WHO support national health authorities in managing their core healthcare systems, support healthcare workforces, utilize technologies like health information systems, ensure health coverage and funding, and provide primary healthcare education. This volume is a useful resource to graduate students in public health and health care policy, public health professionals, health and social work researchers, and health policy makers interested in global health and primary healthcare services, particularly in developing countries.

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