Current Progress in iPSC Disease Modeling
- 1st Edition - November 11, 2021
- Editor: Alexander Birbrair
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 8 5 7 6 5 - 9
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 5 6 4 3 - 0
Current Progress in iPSC Disease Modeling, Volume Fourteen in the Advances in Stem Cell Biology series, is a timely and expansive collection of information and new discoveries in t… Read more
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Request a sales quoteCurrent Progress in iPSC Disease Modeling, Volume Fourteen in the Advances in Stem Cell Biology series, is a timely and expansive collection of information and new discoveries in the field. This new volume addresses advances in research on how induced pluripotent stem cells are used for the creation of new tissues and organs. The creation of iPSC technology allowed the development of disease-specific human pluripotent stem cells. These cells allow researchers to study questions once impossible for some human diseases. This volume addresses iPSCs for vascular tissue engineering, bioprinting, derived lung organoids for pulmonary disorders, skeletal muscle engineering, human kidney organoids, and more.
It is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation, and is contributed by world-renowned authors in the field.
- Provides an overview of the fast-moving field of stem cell biology and function, regenerative medicine and therapeutics
- Covers advances in research on how induced pluripotent stem cells are used to create new tissues/organs
- Contributed by world-renowned experts in the field
Researchers and scientists in stem cell therapy, cell biology, regenerative medicine, and organ transplantation. Graduate and undergraduate students in the above fields
- Cover image
- Title page
- Table of Contents
- Advances in Stem Cell Biology
- Copyright
- Dedication
- Contributors
- About the editor
- Preface
- Chapter 1. Human induced pluripotent stem cell modeling of neurofibromatosis type 1
- Introduction
- Brain development and function
- Nervous system tumors
- Other NF1 clinical features
- Future directions
- Chapter 2. Use of induced pluripotent stem cells to model inflammatory neurodegeneration and repair in multiple sclerosis
- Introduction
- Multiple sclerosis background
- Utility of animal models to study stem cells in multiple sclerosis
- Modeling neurological diseases using stem cells
- Modeling multiple sclerosis with human-derived induced pluripotent stem cells
- Challenges in the field
- Future Directions
- Conclusions
- Chapter 3. Induced pluripotent stem cell technology to model chronic mountain sickness
- Introduction
- Induced pluripotent stem cell–derived in-vitro erythroid system to study hypoxia-induced excessive erythropoiesis in chronic mountain sickness patients
- Induced pluripotent stem cell-derived neural cells to study neuropathology in chronic mountain sickness
- Induced pluripotent stem cell–derived neural cells to study ionic homeostasis in chronic mountain sickness
- Summary and future directions
- Chapter 4. Induced pluripotent stem cells for modeling Noonan, Noonan Syndrome with Multiple Lentigines, and Costello Syndromes
- Glossary of terms
- Preface
- Induced pluripotent stem cells and CRISPR-Cas9
- RASopathies and signaling
- Noonan syndrome
- Disease modeling of Noonan syndrome
- Delineating Noonan syndrome–associated cardiac hypertrophy using induced pluripotent stem cell technology
- Understanding cancer causing Noonan syndrome mutations using induced pluripotent stem cells
- Noonan Syndrome with Multiple Lentigines
- Disease modeling of Noonan Syndrome with Multiple Lentigines
- Delineating Noonan Syndrome with Multiple Lentigines–associated cardiac hypertrophy using induced pluripotent stem cell technology
- Costello Syndrome
- Costello Syndrome and HRAS
- Disease modeling of Costello Syndrome
- Costello Syndrome and induced pluripotent stem cells
- Limitations and future direction of induced pluripotent stem cell model systems
- RASopathies and induced pluripotent stem cells: where do we go from here?
- Conclusions
- Chapter 5. Modeling mitochondrial encephalopathy due to MELAS/Leigh overlap syndrome using induced pluripotent stem cells
- Mitochondrial disease
- Mitochondrial dysfunction and induced pluripotent stem cells
- Future trends
- Chapter 6. How induced pluripotent stem cells changed the research status of polycystic ovary syndrome
- Introduction to stem cells and embryonic stem cells
- The development of somatic reprogramming
- Pathological features of polycystic ovary syndrome
- Progress in polycystic ovary syndrome treatment and research
- Application of induced pluripotent stem cells in polycystic ovary syndrome disease research
- Chapter 7. Modeling inherited retinal dystrophies using induced pluripotent stem cells
- Introduction
- Stem cells
- Disease modeling
- Neural retina: photoreceptors
- Induced pluripotent stem cell disease models of inherited retinal dystrophies
- Conclusion and caveats
- Chapter 8. Modeling hereditary spastic paraplegias using induced pluripotent stem cells
- Introduction
- Cellular pathogenic themes in hereditary spastic paraplegia
- Modeling different types of hereditary spastic paraplegia using induced pluripotent stem cells
- Challenges and future directions
- Chapter 9. Induced pluripotent stem cells for modeling Smith–Magenis syndrome
- Introduction
- The genetics of Smith–Magenis syndrome
- Concluding remarks
- Chapter 10. Induced pluripotent stem cells for modeling of cardiac arrhythmias
- Introduction
- The use of human induced pluripotent stem cells–derived cardiomyocytes to investigate inherited arrhythmias
- Application of human induced pluripotent stem cells–derived cardiomyocytes to investigate acquired arrhythmias
- Limitations
- Conclusion and perspective
- Funding
- Chapter 11. Modeling heritable kidney disease using human kidney iPSC-derived organoids
- Introduction
- Kidney organoids are accurate models of the developing kidney
- Genetic diseases of the glomerulus
- Kidney organoids for the study of glomerular disease
- Inherited diseases of the renal tubule
- Kidney organoids and the study of tubular disease
- Strengths and limitations of kidney organoids as models of inherited kidney disease compared to existing animal and two-dimensional cell culture platforms
- Conclusions
- Index
- No. of pages: 324
- Language: English
- Edition: 1
- Published: November 11, 2021
- Imprint: Academic Press
- Paperback ISBN: 9780323857659
- eBook ISBN: 9780323856430
AB
Alexander Birbrair
Dr. Alexander Birbrair received his bachelor’s biomedical degree from Santa Cruz State University in Brazil. He completed his PhD in Neuroscience, in the field of stem cell biology, at the Wake Forest School of Medicine under the mentorship of Osvaldo Delbono. Then, he joined as a postdoc in stem cell biology at Paul Frenette’s laboratory at Albert Einstein School of Medicine in New York. In 2016, he was appointed faculty at Federal University of Minas Gerais in Brazil, where he started his own lab. His laboratory is interested in understanding how the cellular components of different tissues function and control disease progression. His group explores the roles of specific cell populations in the tissue microenvironment by using state-of-the-art techniques. His research is funded by the Serrapilheira Institute, CNPq, CAPES, and FAPEMIG. In 2018, Alexander was elected affiliate member of the Brazilian Academy of Sciences (ABC), and, in 2019, he was elected member of the Global Young Academy (GYA), and in 2021, he was elected affiliate member of The World Academy of Sciences (TWAS). He is the Founding Editor and Editor-in-Chief of Current Tissue Microenvironment Reports, and Associate Editor of Molecular Biotechnology. Alexander also serves in the editorial board of several other international journals: Stem Cell Reviews and Reports, Stem Cell Research, Stem Cells and Development, and Histology and Histopathology.
Affiliations and expertise
Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
Department of Radiology, Columbia University Medical Center, Medical Center, USARead Current Progress in iPSC Disease Modeling on ScienceDirect