iPSC Derived Progenitors
- 1st Edition - November 10, 2021
- Editor: Alexander Birbrair
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 8 5 5 4 5 - 7
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 0 0 7 3 - 7
iPSC Derived Progenitors, Volume Thirteen in the Advances in Stem Cell Biology series is a timely collection of information and new discoveries in the field of stem cell biolog… Read more
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Request a sales quoteiPSC Derived Progenitors, Volume Thirteen in the Advances in Stem Cell Biology series is a timely collection of information and new discoveries in the field of stem cell biology. The book addresses the importance of induced pluripotent stems cells and how can they be differentiated into different progenitors. Progenitors cells are often the first-step to making more differentiating cell types. This volume addresses iPSCs derived from bone, dental pulp, craniofacial, neural stem cells, otic, cardiac, and much more. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine, organ transplantation, and is contributed by world-renowned authors.
- Provides an overview of the fast-moving field of stem cell biology and function, regenerative medicine and therapeutics
- Covers how iPSCs can be differentiated into different progenitors
- Contributed by world renowned experts in the field
Researchers and scientists in stem cell therapy, cell biology, regenerative medicine, and organ transplantation. Graduate and undergraduate students in the above fields
- Cover image
- Title page
- Table of Contents
- Advances in Stem Cell Biology
- Copyright
- Dedication
- Contributors
- About the editor
- Preface
- Chapter 1. Induced pluripotent stem cell–derived neural stem cells
- Introduction
- Development of the nervous system in vivo
- Extracellular matrix
- In vitro models for neural stem cells and their progeny
- Examples for the use of in vitro models
- Ethical aspects
- Future trends
- Chapter 2. Induced pluripotent stem cells-derived craniofacial mesenchymal progenitor cells
- Introduction
- The neural crest and craniofacial development
- Craniofacial pathologies
- iPSC-derived craniofacial mesenchymal progenitors
- Derivation of NCC-MPCs from iPSCs
- Characterization of iPSC-derived NCC-MPCs
- Potential applications of NCC-MPCs
- Conclusions and perspectives
- Chapter 3. Human induced pluripotent stem cell–derived astrocytes progenitors as discovery platforms: opportunities and challenges
- Introduction
- Human induced pluripotent stem cell–derived astrocytes
- Challenges for in vitro modeling
- Alternative techniques and new approaches
- Modeling normal astrocyte biology with hiPSC-A
- Functional characterization of human induced pluripotent stem cells into astrocytes
- Modeling astrocyte roles in neurological disorders with human induced pluripotent stem cells into astrocytes
- Alexander disease
- Transplantation of glial progenitor cells and astrocytes
- Conclusion
- Chapter 4. Induced pluripotent stem cells-derived mesothelial progenitors; implications in cell-based regenerative medicine
- Introduction
- The origin of mesothelial cells
- Functions of mesothelial cells
- Physiological dysfunctions of mesothelial cells
- Delivery methods for mesothelial cell therapy
- Future trends or directions
- Chapter 5. Human induced pluripotent stem cell–derived keratinocyte progenitors
- Introduction
- Differentiation of keratinocytes from embryonic stem cells
- Differentiation of keratinocytes from induced pluripotent stem cells
- Alternative methods of keratinocyte differentiation
- Direct reprogramming into keratinocytes
- Current use of hiPSC-derived keratinocytes and future trends
- Chapter 6. Induced pluripotent stem cell–derived bone progenitors
- Introduction
- Bone-forming cells
- Summary
- Chapter 7. Induced pluripotent stem cells–derived chondrocyte progenitors
- Introduction
- New cell sources for cartilage regeneration
- Future trends
- Conclusions
- Chapter 8. Induced pluripotent stem cells–derived dental pulp stem cells: Future application in regenerative medicine
- Introduction
- Characteristics of dental pulp stem cells
- Regenerative potential of SHED/DPSCs-derived iPSCs
- Regenerative potential of iPSCs-derived SHED/DPSCs
- Advantages in generation of iPSCs from SHED
- Other major concerns in tissue engineering and tissue regeneration
- Conclusion
- Chapter 9. Nephron progenitors in induced pluripotent stem cell–derived kidney organoids
- Introduction
- Overview of mammalian kidney development
- Generation of nephron progenitors from human induced pluripotent stem cells
- Disease modeling using induced pluripotent stem cell–derived nephron progenitors
- Selective induction of glomerular podocytes from induced pluripotent stem cell–derived nephron progenitors
- Propagation of induced pluripotent stem cell–derived nephron progenitors
- Combination of nephron progenitors and ureteric buds toward higher-order kidney structures
- Challenges ahead
- Conclusions
- Chapter 10. Interaction of iPSC-derived MSCs with the gastrointestinal tract and microbiome in the management of inflammatory bowel disease
- Introduction
- Immune mechanisms of gastrointestinal tract inflammation in inflammatory bowel disease
- Role of microbiome alterations in inflammatory bowel disease
- Need for new approaches
- Rationale for use of cellular therapy in managing inflammatory bowel disease
- Evidence of MSC and induced pluripotent stem cell–derived MSC efficacy in animal models of inflammatory bowel disease
- Impact of induced pluripotent stem cell–derived MSC on the gastrointestinal tract microbiome and role in regulating inflammatory bowel disease severity
- Utility of induced pluripotent stem cell–derived MSC for therapeutic use
- Properties of induced pluripotent stem cell–derived MSC
- Use of induced pluripotent stem cell–derived MSC for treatment of inflammatory bowel disease
- Concluding remarks
- Chapter 11. Induced pluripotent stem cells–derived hematopoietic progenitors for cellular immunotherapies
- Introduction
- Induced pluripotent stem cells as a potential source of hematopoietic stem cells and immune cells for immunotherapies
- Concluding remarks and future directions
- Chapter 12. Induced pluripotent stem cells as the source of cancer stem cells providing novel concepts of cancer: gaps between in vitro and in vivo in induced pluripotent stem cells modeling
- Current recognition of cancer disease
- Cancer stem cell
- Gaps between in vitro and in vivo
- Induced cancer stem cells with tissue specificity
- Induced cancer stem cells and metastasis
- Novel concepts of cancer in conclusion
- Index
- No. of pages: 318
- Language: English
- Edition: 1
- Published: November 10, 2021
- Imprint: Academic Press
- Paperback ISBN: 9780323855457
- eBook ISBN: 9780323900737
AB
Alexander Birbrair
Dr. Alexander Birbrair received his bachelor’s biomedical degree from Santa Cruz State University in Brazil. He completed his PhD in Neuroscience, in the field of stem cell biology, at the Wake Forest School of Medicine under the mentorship of Osvaldo Delbono. Then, he joined as a postdoc in stem cell biology at Paul Frenette’s laboratory at Albert Einstein School of Medicine in New York. In 2016, he was appointed faculty at Federal University of Minas Gerais in Brazil, where he started his own lab. His laboratory is interested in understanding how the cellular components of different tissues function and control disease progression. His group explores the roles of specific cell populations in the tissue microenvironment by using state-of-the-art techniques. His research is funded by the Serrapilheira Institute, CNPq, CAPES, and FAPEMIG. In 2018, Alexander was elected affiliate member of the Brazilian Academy of Sciences (ABC), and, in 2019, he was elected member of the Global Young Academy (GYA), and in 2021, he was elected affiliate member of The World Academy of Sciences (TWAS). He is the Founding Editor and Editor-in-Chief of Current Tissue Microenvironment Reports, and Associate Editor of Molecular Biotechnology. Alexander also serves in the editorial board of several other international journals: Stem Cell Reviews and Reports, Stem Cell Research, Stem Cells and Development, and Histology and Histopathology.
Affiliations and expertise
Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
Department of Radiology, Columbia University Medical Center, Medical Center, USARead iPSC Derived Progenitors on ScienceDirect