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Academic Press

  • Translational Surgery

    • 1st Edition
    • Adam E.M. Eltorai
    • English
    Translational Surgery covers the principles of evidence-based medicine and applies these principles to the design of translational investigations. The reader will come to fully understand important concepts including case-control studies, prospective cohort studies, randomized trials, and reliability studies. Investigators will benefit from greater confidence in their ability to initiate and execute their own investigations, avoid common pitfalls in surgical research, and know what is needed for collaboration. Further, this title is an indispensable tool in grant writing and funding efforts. The practical, straightforward approach helps the translational research navigate challenging considerations in study design and implementation. The book provides valuable discussions of the critical appraisal of published studies in surgery, allowing the reader to learn how to evaluate the quality of such studies. Thus, they will improve at measuring outcomes; making effective use of all types of evidence in patient care. In short, this practical guidebook will be of interest to every surgeon or surgical researcher who has ever had a good clinical idea, but not the knowledge of how to test it.

  • Psychophysics and Experimental Phenomenology of Pattern Cognition

    • 1st Edition
    • Jiro Hamada
    • English
    Psychophysics and Experimental Phenomenology of Pattern Cognition examines the cognitive transformations that underly this cognitive system and the specialized subsystems for processing these transformations. Sections cover symmetry cognition, contour perception and geometric illusion. Weight sensation is also discussed, as are repetitive and dot patterns. By incorporating elements of both psychophysics and experimental phenomenology, pattern cognition is examined from both the physical and mental sensory perspective, thus providing a comprehensive view of this cognitive system.

  • Myeloid-Derived Suppressor Cells

    • 1st Edition
    • Volume 375
    • English
    Myeloid-Derived Suppressor Cells, Volume 375 includes comprehensive and detailed reviews on the current advances in myeloid derived suppressor cells, an immature, heterogenous cell population from the myeloid lineage that has been extensively described in the last decades due to its potent immunosuppressive activity in a variety of pathologies. Chapters in this new release include Cancer-cell-intrinsi... mechanisms regulate myeloid-derived suppressor cells through cytokine networks, Role of myeloid-derived suppressor cells in head and neck cancer, Role of myeloid-derived suppressor cells in breast cancer, Role of myeloid-derived suppressor cells in endometriosis, Role of myeloid-derived suppressor cells in ovarian cancer, Role of myeloid-derived suppressor cells in sarcoma, and more.

  • Essentials of Pharmatoxicology in Drug Research, Volume 1

    Toxicity and Toxicodynamics
    • 1st Edition
    • Rakesh Kumar Tekade + 1 more
    • English
    Toxicity and Toxicodynamics, Volume One in the Essentials of Pharmatoxicology in Drug Research series provides an overview on the essentials of toxicology, risk assessment and the mechanisms. Topics discussed include the types of cellular responses to chemical toxicants, mechanisms of drug toxicity, and their relevance to pharmaceutical product development. The book examines omics and computer-aided technologies for mechanistic and predictive toxicology and covers state-of-art testing in the evaluation of detrimental pathways, dose selection in toxicity studies, as well as the role of regulatory agencies in toxicity studies. In addition, there is also discussion on clinical interventions such as pharmacotherapy and managed care strategies for acute poisoning. This volume is a valuable resource to those learning more about the drug development process related to toxicology and those who want to get an update on newer concepts on the toxicology aspect of drug research.

  • One Health Meets the Exposome

    Human, Wildlife, and Ecosystem Health
    • 1st Edition
    • Mary Ann Ottinger + 1 more
    • English
    One Health Meets the Exposome: Human, Wildlife, and Ecosystem Health brings together the two powerful conceptual frameworks of One Health and the Exposome to comprehensively examine the myriad of biological, environmental, social, and cultural challenges impacting the interrelated health of humans, wildlife, and ecosystems. One Health as an encompassing concept and collaborative framework recognizes the interconnections among humans, wildlife, and our shared environment with the goal of optimizing health outcomes for all. The Exposome is more specifically oriented to human health and considers cumulative environmental exposures affecting individuals, communities, and populations. This book will provide the broadened and integrative view that considers a more holistic approach needed to confront the complex issues facing us today. One Health Meets the Exposome: Human, Wildlife, and Ecosystem Health is a valuable and cutting-edge resource for researchers and practitioners in medicine, public health, animal science, wildlife and field biology, and for any reader looking to better understand the relationships among human health and the environment.

  • Human Reproductive and Prenatal Genetics

    • 2nd Edition
    • Peter C.K. Leung + 1 more
    • English
    **Selected for Doody’s Core Titles® 2024 in Clinical Genetics**Human Reproductive and Prenatal Genetics, Second Edition provides application-driven coverage of key topics in human reproductive and prenatal genetics, including genetic control underlying the development of the reproductive tracts and gametogenesis, the genetics of fertilization and implantation, the genetic basis of female and male infertility, as well as genetic and epigenetic aspects of assisted reproduction. Also examined are the genetics and epigenetics of the placenta in normal and abnormal pregnancy, preimplantation genetic diagnosis and screening, and cutting-edge advances in noninvasive prenatal screening, prenatal genetic counseling, and bioethical and medicolegal aspects of relevance in the lab and clinic.This new edition has been fully revised to address new and evolving technologies in human reproductive genetics, with new chapters added on chromatin landscapes and sex determination, genetic alterations of placental development and preeclampsia, metabolism and inflammation in PCOS, pre-implantational genetic testing, maternal genetic disorders, bioethics, and future applications.

  • The Book of Fructans

    • 1st Edition
    • Wim Van den Ende + 1 more
    • English
    After more than 30 years, The Book of Fructans represents the first and most comprehensive coverage of fructans generated by pioneer glycoscientists from the field. It outlines the fundamentals of all fructan types, their terminology, chemical and structural-functiona... features, biosynthetic enzymes that make and break them, their presence and possible roles in nature, their evolutionary aspects and their microbial, enzymatic, and plant-based production. Additional sections cover the applications of fructans, specifically, the agro/chemical and biomedical applications, health, pharmaceutical and cosmetic applications, fructans in food and feed, fructan nanotechnology, the immunomodulatory and antiviral effects of fructans and the perspectives for fructans in circular economies and sustainable societies. Intended for scientists, entrepreneurs, academicians and students working in related fields, this book will be a useful resource for all who wish to learn more about these extraordinary carbohydrates.

  • Mathematical Modeling, Simulations, and AI for Emergent Pandemic Diseases

    Lessons Learned From COVID-19
    • 1st Edition
    • Esteban A. Hernandez-Vargas + 1 more
    • English
    Mathematical Modeling, Simulations, and Artificial Intelligence for Emergent Pandemic Diseases: Lessons Learned from COVID-19 includes new research, models and simulations developed during the COVID-19 pandemic into how mathematical methods and practice can impact future response. Chapters go beyond forecasting COVID-19, bringing different scale angles and mathematical techniques (e.g., ordinary differential and difference equations, agent-based models, artificial intelligence, and complex networks) which could have potential use in modeling other emergent pandemic diseases. A major part of the book focuses on preparing the scientific community for the next pandemic, particularly the application of mathematical modeling in ecology, economics and epidemiology. Readers will benefit from learning how to apply advanced mathematical modeling to a variety of topics of practical interest, including optimal allocations of masks and vaccines but also more theoretical problems such as the evolution of viral variants.

  • Plant RNA Viruses

    Molecular Pathogenesis and Management
    • 1st Edition
    • Rajarshi Kumar Gaur + 2 more
    • English
    Plant RNA Viruses: Molecular Pathogenesis and Management provides wide-ranging coverage on the recognition and signaling events between plants and RNA viruses. The book examines the molecular biology of signaling, host-virus interaction, RNA virus diversity, and how plants and cellular pathogens interact. Sections cover Virus Diversity and Diagnosis, Virus-Host Interactions and Virus Management. Specific chapters discuss classification and nomenclature of viruses, detail the molecular characteristics of viral genomes, highlight the viral manipulation of cellular key regulatory systems for successful virus infection, and discuss the movement of plant viruses into plant cells. Additional topics include RNA plant viruses and host interaction, detection and diversity of plant RNA viruses, and strategies for combating and management of plant viruses. With contributions from an international group of experts, the book is a comprehensive reference for those in research, academia, industry and anybody engaging in the study of plant viruses at the molecular level.

  • Cilia: From Mechanisms to Disease–Part A

    • 1st Edition
    • Volume 175
    • English
    Cilia: From Mechanisms to Disease, Part A, Volume 175 in the Methods in Cell Biology series, offers a range of techniques and protocols that can be used to study aspects of this interesting cellular organelle both in vitro and in vivo. Sections in this new release include Protocols to induce and study ciliogenesis, Flow Cytometry-Based Approach for the study of primary Cilia, Microscopic observation of human airway ciliary movement using wheat germ agglutinin, Time-lapse imaging of primary cilia behavior with physiological expression of fluorescent ciliary proteins, Evaluation of ciliary-GPCR dynamics using a validated organotypic brain slice culture method, and much more. Other sections cover Studying the morphology, composition and function of the photoreceptor primary cilium in zebrafish, Visualizing Multiciliated Cells in the Zebrafish, Isolation of Ciliary Ectosomes and Analysis of Peptide-mediated Chemotaxis in Chlamydomonas, Using Paramecium as a Model for Ciliopathies, Using organoids to study cilia, Using in vivo cerebellar electroporation to study neuronal cell proliferation and differentiation in a Joubert syndrome mouse model, and more.

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