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Academic Press

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 116
    • Gregory S. Makowski
    • English
    Advances in Clinical Chemistry, Volume 116, the latest release in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists.
  • Glycolysis

    Tissue-Specific Metabolic Regulation in Physio-pathological Conditions
    • 1st Edition
    • Rita Ferreira + 2 more
    • English
    Glycolysis: Tissue-Specific Metabolic Regulation in Physio-Pathological Conditions provides an integrated overview of glycolysis, spanning basic biochemistry, patho-physiology and therapeutic applications. The book also instructs in methods available to study the involvement of the glycolytic events in healthy biology and disease pathology. It begins with an overview of fundamental glycobiology followed by chapters dedicated to glycolysis physiology in organs and systems, pathologic conditions related to glycolytic alterations, glycolysis as a therapeutic target and in drug discovery efforts, and methodological approaches to advance new glycolysis research. Disease areas considered range from cancer to heart failure, diabetes, inborn glycolytic pathway defects, hematologic malignancies, osteoporosis, neurodegenerative diseases and viral Infections. Omics and computational modeling, interactive study methods, and glycolysis flux measurement are described in detail, with step-by-step descriptions of experimental protocols, set-up and analysis.
  • Snow Leopards

    • 2nd Edition
    • English
    Snow Leopards, Second Edition provides a foundational, comprehensive overview of the biology, ecology and conservation of this iconic species. This updated edition incorporates all the recent information from range-wide surveys and conservation projects, the results of technical and advances particularly in genetics, camera trapping and satellite tracking, and evaluates emerging threats. New chapters synthesize the novel scientific methods and statistical analyses used to develop density and population estimates and how they inform conservation and management estimates. Sections cover historical information, the main biogeographic patterns, evolutionary trends, conservational efforts, and cultural significance. Status and distribution are fully updated for all 12 countries where snow leopards occur. Other sections describe established and emerging threats, including human-wildlife conflict, illegal trade, infrastructure development, and climate change along with conservation solutions used to address these threats. The book concludes with a final section on global snow leopard initiatives and future potentials.
  • The Biology of Ageing: From Hallmarks to Drugs

    • 1st Edition
    • Volume 1
    • Richard Faragher
    • English
    The Biology of Ageing: From Hallmarks to Drugs provides a series of reviews covering multiple aspects of the translational pipeline as interventions in the biology of ageing itself become a clinical reality. New chapters cover Cellular senescence and NAD+: what are the links?, Biomarker for ageing: potential and pitfalls, What chemists offer to ageing research, You are what you eat – or are you? Exploring dietary versus topical anti-oxidants in skin ageing, Clinical trials: A simple guide for gerontologists, Towards an ethical framework for geroscience, and more. The book explores links between known ageing mechanisms and new interventions, agents and actions at the nutraceutical-drug divide, the challenges and opportunities provided by biomarkers and chemistry- biology interface and lastly the ethical and operational challenges of clinical trials in the age of translational geroscience.
  • Social and Communicative Functioning in Populations with Intellectual Disability: Rethinking Measurement

    • 1st Edition
    • Volume 64
    • English
    Social and Communicative Functioning in Populations with Intellectual Disability: A Developmental Perspective, Volume 65 in the International Review of Research in Developmental Disabilities series, focuses on social and communicative functioning with a particular emphasis on people with intellectual disability. The volume brings together international researchers across disciplines to highlight innovative approaches to holistically describe social and communicative abilities in this population including teleassessment, self-report, and community-engaged research designs. Through a lifespan approach, key issues are raised related to social and communicative functioning across a range of communication modalities from infancy through adulthood.Additional chapters cover Adaptation of in-person tools for remote assessment of infants and toddlers with social communication concerns in community-based settings, Measuring social communication in people with ID who use minimal speech: Differences across the lifespan, and Social Inclusion of Adults with IDD: Toward Belonging, Building a Life: Examining the advocacy and social experiences of students with IDD in inclusive postsecondary education.
  • Advances in Virus Research

    • 1st Edition
    • Volume 117
    • English
    Advances in Virus Research, Volume 117, the latest release in a series that highlights new advances in the field, includes invaluable updates written by an international board of authors. Chapters in this new release include Pathogenesis of neuroinvasive flaviviruses, Cellular entry and egress of astroviruses, Rift Valley Fever virus entry and infection, and more.
  • Nanowired Delivery of Drugs and Antibodies for Neuroprotection in Brain Diseases with Co-Morbidity Factors Part B

    • 1st Edition
    • Volume 172
    • English
    Nanowired Delivery of Drugs and Antibodies for Neuroprotection in Brain Diseases with Co-morbidity Factors, Part B, Volume 172 in the International Review of Neurobiology series, includes chapters on Spinal cord injury induced exacerbation of Alzheimer's disease pathophysiology in the cord is reduced by topical application of nanowired cerebrolysin and antibodies to tumor necrosis factor alpha, Nanodelivery of histamine H3 receptor inverse agonist BF-2549 with clobenpropit a H3 receptor antagonist and H4 receptor agonist induced neuroprotection in spinal cord injury is potentiated by antioxidant compound H-290/51, and Neuromodulation and quality of life for patient with spasticity after spinal cord injury, and more.Other sections cover Efficacy of invasive and non-invasive methods for the treatment of Parkinson´s disease: nanodelivery and enriched environment, Co-administration of DL-3-n-butylphthalid... and neprilysin is neuroprotective in Alzheimer disease associated with brain injury, Nicotine Neurotoxicity Exacerbation following Engineered Ag and Cu (50-60 nm) nanoparticles intoxication, and Neuroprotection with nanowired delivery of antioxidant compound H-290/51 together with serotonin 5-HT3 receptor antagonist ondansetron.
  • Encyclopedia of Food Safety

    • 2nd Edition
    • Geoffrey W Smithers
    • English
    Encyclopedia of Food Safety, Second Edition, Four Volume Set provides an authoritative one-stop reference work covering all aspects of the field. Specific focus lies in the book's coverage of key industry developments over the last ten years, including: (i) detailed understanding of infectious agents and toxins and their route into the food chain; (ii) sophisticated detection and identification methods; (iii) effective control mechanisms, like heat treatment, refrigeration and sanitizers; (iv) education of food processors, handlers and consumers about safe food handling practices; (v) sanctioned food production, processing, storage and transport control protocols, like HACCP; and (vi) a strong policy and regulatory environment. With approximately 270 outstandingly written chapters from the world’s leading experts in food science, the book covers all aspects of food safety along the entire food chain and in one complete work, thus providing the ideal reference tool for professionals working across the multiple scientific disciplines and technologies that constitute modern food safety.
  • Artificial Intelligence in the Age of Neural Networks and Brain Computing

    • 2nd Edition
    • Robert Kozma + 3 more
    • English
    Artificial Intelligence in the Age of Neural Networks and Brain Computing, Second Edition demonstrates that present disruptive implications and applications of AI is a development of the unique attributes of neural networks, mainly machine learning, distributed architectures, massive parallel processing, black-box inference, intrinsic nonlinearity, and smart autonomous search engines. The book covers the major basic ideas of "brain-like computing" behind AI, provides a framework to deep learning, and launches novel and intriguing paradigms as possible future alternatives. The present success of AI-based commercial products proposed by top industry leaders, such as Google, IBM, Microsoft, Intel, and Amazon, can be interpreted using the perspective presented in this book by viewing the co-existence of a successful synergism among what is referred to as computational intelligence, natural intelligence, brain computing, and neural engineering. The new edition has been updated to include major new advances in the field, including many new chapters.
  • Epigenetics in Human Disease

    • 3rd Edition
    • Trygve O. Tollefsbol
    • English
    Epigenetics in Human Disease, Third Edition examines the diseases and conditions on which we have advanced knowledge of epigenetic mechanisms, such as cancer, autoimmune disorders, aging, metabolic disorders, neurobiological disorders and cardiovascular disease. From molecular mechanisms and epigenetic technology to clinical translation of recent research, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics to therapeutic interventions for epigenetic-based disorders, with an emphasis throughout on understanding and application of key concepts in new research and clinical practice. Fully revised and up-to-date, this Third Edition discusses topics of current interest in epigenetic disease research, including stem cell epigenetic therapy, bioinformatic analysis of NGS data, epigenetic mechanisms of imprinting disorders, microRNA in cancer, epigenetic approaches to control obesity, epigenetics and airway disease, and epigenetics in cardiovascular disease. Further sections explore online epigenetic tools and datasets; early-life programming of epigenetics in age-related diseases; the epigenetics of addiction and suicide, and epigenetic approaches to regulating and preventing diabetes, cardiac disease, allergic disorders, Alzheimer’s disease, respiratory diseases, and many other human maladies. In addition, each chapter now includes chapter summaries, definitions, and vibrant imagery and figures to reinforce understanding, as well as step-by-step methods and disease research case studies.