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Elsevier

Academic Press

  • Mononuclear Non-heme Iron Dependent Enzymes

    • 1st Edition
    • Volume 703
    • English
    Mononuclear Non-heme Iron Dependent Enzymes, Volume 703 focuses on methods for studying, characterizing, and leveraging the chemistry of mononuclear non-heme iron dependent enzymes. Chapters in this new release include Photoreduction for Rieske oxygenase chemistry, Insights into the Mechanisms of Rieske Oxygenases from Studying the Unproductive Activation of Dioxygen, Non-heme iron and 2-oxoglutarate enzymes catalyze cyclopropane and azacyclopropane formations, Obtaining precise metrics of substrate positioning in Fe(II)/2OG dependent enzymes using Hyperfine Sublevel Correlation Spectroscopy, Xe-pressurization studies for revealing substrate-entrance tunnels, and much more.Additional chapters cover A tale of two dehydrogenases involved in NADH recycling, Rieske oxygenases and/or their partner reductase proteins, Expression, assay and inhibition of 9-cis-epoxycarotenoi... dioxygenase (NCED) from Solanum lycopersicum and Zea mays, Biocatalysis and non-heme iron enzymes, In vitro analysis of the three-component Rieske oxygenase cumene dioxygenase from Pseudomonas fluorescens IP01, Structure and function of carbazole 1,9a-dioxygenase, Characterization of a Mononuclear Nonheme Iron-dependent Mono-oxygenase OzmD in Oxazinomycin Biosynthesis, and much more.

  • Fundamentals of Soft Interfaces in Colloid and Surface Chemistry

    • 1st Edition
    • Volume 37
    • Hiroyuki Ohshima
    • English
    This book explains and summarizes the fundamentals of soft interfaces and soft particles from a colloid and surface chemistry standpoint, bringing knowledge together into a single resource for the first time. It provides detailed mathematical description of colloidal and interfacial systems, with a particular emphasis on ionic, electrokinetic, and electrostatic phenomena. Hiroyuki Ohshima covers the most recent theoretical advances in the field of electrostatic interactions between soft interfaces, electrophoresis, diffusiophoresis, gel electrophoresis of soft particles including ionic size effects, ion-partitioning effects, and the effects of hydrodynamic slip on hydrophobic surfaces. It will help readers by providing a range of approximate analytic formulas which can be used to interpret various interfacial phenomena of soft interfaces and analyze experimental data in various fields. Fundamentals of Soft Interfaces in Colloid and Surface Chemistry is written for graduate students and researchers chiefly in chemistry but also chemical engineering, physics, and materials science.

  • mRNA Therapeutics

    Foundations, Innovations, and Clinical Applications
    • 1st Edition
    • Anya Hillery
    • English
    mRNA Therapeutics: Foundations, Innovations and Clinical Applications aims to provide a comprehensive text that covers all aspects of mRNA therapeutics, from the foundational science that underpins this disruptive new drug class, through the scientific and technological breakthroughs crucial for therapeutic success, to the current clinical applications and the innovative advances driving future directions. The book begins with foundational knowledge covering mRNA biology, the immune system, and vaccines. The second section addresses the major challenges associated with mRNA as a therapeutic modality, and the molecular engineering innovations and delivery technologies that have allowed these hurdles to be largely overcome. The third section describes the current and future clinical applications of mRNA therapeutics that are transforming, or are poised to transform, medicine and health. This includes the use of mRNA vaccines for COVID-19 and other infectious diseases, as well as mRNA's role in revolutionizing cancer immunotherapy, covering immunostimulants, cancer vaccines including personalized neoantigen vaccines, and CAR T cell technologies. Additional chapters describe the use of mRNA therapeutics for protein replacement therapy and gene-editing, as well as newer mRNA constructs, including self-amplifying mRNA. The final section addresses the safety and regulatory considerations of mRNA therapeutics, along with broader cultural issues including vaccine hesitancy, global vaccine inequality, and pandemic preparedness. Currently, mRNA texts either provide personal accounts from key players involved in COVID-19 vaccine development, with limited scientific depth, or focus on highly specialized, more esoteric applications of mRNA in advanced molecular biology. This book aims to bridge this gap by providing a scientifically rigorous and wide-ranging exploration of mRNA's role in therapeutics. This pioneering textbook serves as a vital addition to the academic canon, providing an essential tool for the current and next generation of students, scientists, researchers and professionals in a wide variety of related disciplines including molecular biology, biomedical engineering, pharmaceutical science, oncology, and the health sciences.

  • Understanding Autism

    Perspectives, Assessment, Interventions, and the Journey Towards Inclusion
    • 1st Edition
    • Neophytos L. Papaneophytou + 1 more
    • English
    Understanding Autism: Perspectives, Assessment, Interventions, and the Journey Toward Inclusion is a compelling book offering a multifaceted examination, providing readers with a comprehensive understanding of autism spectrum disorder from both biological and social perspectives. From the role of bioactive lipids in the pathobiology of autism to the challenges faced by individuals with autism within the criminal justice system, this book explores critical aspects of autism, assessment strategies, and innovative interventions. From a biological perspective, readers will be introduced to the gut-brain connection and the impact of vitamin D on the gut microbiota. Meanwhile, the social perspective sheds light on sensory processing, autonomic regulation, and socio-emotional development in autism, as well as the pressing issue of justice and representation. Through the assessment section, readers will explore the unique challenges faced by parents with autism spectrum disorder and delve into linguistic anomalies in autism. Finally, the interventions section introduces groundbreaking programs and strategies designed to improve the lives of individuals with autism. Whether you’re a healthcare professional, educator, or simply curious about autism, this book is an essential guide that offers diverse insights into this complex condition, ultimately fostering greater awareness, understanding, and support for individuals on the spectrum.

  • Advances in Child Development and Behavior

    • 1st Edition
    • Volume 67
    • English
    Advances in Child Development and Behavior, Volume 67, the latest release in this classic resource on the field of developmental psychology, includes a variety of timely updates, with this new volume presenting interesting chapters on topics such as Conceptual and Empirical Advances in Afterschool Research, Unraveling the Transracial Adoption Paradox: Construction race and racism in adoptive families, Risk and Resilience Models in Child Development, The Dual Journey: The Development of Twins’ Relationships Throughout Childhood, A sociocultural perspective of multimodal learning by infants and young children, and Defining the Role of Executive Function in Children's Sociomoral Reasoning.

  • Training Human Service Staff

    Evidence-Based Strategies for Promoting Effectiveness, Efficiency, and Trainee Acceptance
    • 1st Edition
    • Dennis H. Reid + 1 more
    • English
    Training Human Service Staff: Evidence-Based Strategies for Promoting Effectiveness, Efficiency, and Trainee Acceptance is a comprehensive guide that equips professionals with the tools and techniques to optimize the training of human service staff. In Section I, readers are introduced to staff training, understanding its importance and the critical criteria for success. The book delves into the gold standard of Behavioral Skills Training and explores in-person training methodologies in Section II, which encompass both group and individual staff training.Section III reviews technology-based training, including video modeling, computer-based training, and distance training via telehealth, offering readers innovative approaches to meet modern training demands. Special topics in staff training, such as maintaining staff skills, professional workshops, and the evolving gold standard, are explored in Section IV, rounding out a comprehensive resource.

  • Metabolomics of Bladder Cancer

    An Emerging Application
    • 1st Edition
    • Vishwajeet Singh + 1 more
    • English
    Metabolomics of Bladder Cancer: An Emerging Application offers insights into the latest research methodologies and potential therapeutic applications. The book examines how applied research on the discovery of metabolomic biomarkers with prognostic and predictive value is needed to stratify patients into different risk groups, minimizing overtreatment and the risk of drug resistance development. In eight chapters, the book gives an in-depth analysis of recent findings in both fundamental and applied research, with a focus on the metabolomics approach and its potential for identifying major metabolic pathways that characterize various diseases and physiological states.It intuitively leads from the discovery of biomarkers for bladder cancer, to the metabolisms of glutamine and fatty acids and finalizes with a chapter on the metabolic effect of cancer therapy. Overall, this book is a comprehensive and insightful resource for researchers, clinicians, and academic professionals interested in the latest developments in bladder cancer research.

  • Earth-Abundant Transition Metal Catalyzed Reactions

    • 1st Edition
    • Volume 74
    • English
    Earth-Abundant Transition Metal Catalyzed Reactions, Volume 74 in the Advances in Catalysis series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Chapters in this new release include in Chiral Iron Complexes for Asymmetric Catalysis, Recent advances in Ni-catalyzed Functionalization of Strong C-O and C-H Bonds, Low-valent Molecular Cobalt Complexes for Reductive Chemistry, Iron-catalyzed group-transfer reactions with hypervalent iodine reagents, and Iron Porphyrins for Mediating Atom Efficient C–C Bond Formations.

  • Artificial Intelligence for Drug Product Lifecycle Applications

    • 1st Edition
    • Alberto Pais + 3 more
    • English
    Artificial Intelligence for Drug Product Lifecycle Applications explains the use of artificial intelligence (AI) in drug discovery and development paths, including the clinical and postapproval phases. This book gives methods for each of the drug development steps, from the fundamentals to postapproval drug product. AI is a synergistic assembly of enhanced optimization strategies with particular applications in pharmaceutical development and advanced tools for promoting cost-effectiveness throughout the drug lifecycle. Specifically, AI brings together the potential to improve drug approval rates, reduce development costs, get medications to patients faster, and help patients comply with their treatments.Accelerat... pharmaceutical development and drug product approval rates will enable larger profits from patent-protected market exclusivity. This book offers the tools and knowledge to create the right AI strategy to extend the landscape of AI applications across the drug lifecycle. It is especially useful for pharmaceutical scientists, health care professionals, and regulatory scientists, as well as advanced students and postgraduates actively involved in pharmaceutical product and process development involving the use of artificial intelligence in drug delivery applications.

  • Pilot Scale Microalgae Cultivation

    Challenges and Practical Solutions to Pond Crash
    • 1st Edition
    • Faiz Ahmad Ansari + 3 more
    • English
    Pilot Scale Microalgae Cultivation: Challenges and Practical Solutions to Pond Crash brings together the latest research on microalgae cultivation for biofuels and proposes methods for tackling the critical issue of sudden pond crash in both pilot and demonstration scale cultivation. Engaging the challenges in both academic research and industrial applications, this book provides routes to identify signs of imminent pond crash, control damage where possible, and prevent future crashes through environmental control and early detection. Chapters outline microalgae cultivation at pilot scale, showing methods for upstream and down-stream processing of microalgae and outlining different applications for microalgae biomass, along with potential challenges.

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