Pediatric Epilepsy Surgery Techniques
Controversies and Evidence
- 1st Edition - November 9, 2024
- Editors: Aria Fallah, George M. Ibrahim, Alexander G. Weil
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 5 9 8 1 - 0
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 5 9 8 2 - 7
Pediatric Epilepsy Surgery Techniques: Controversies and Evidence offers clinicians a roadmap for navigating the complex decision-making process involved in selecting surgical… Read more
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Request a sales quotePediatric Epilepsy Surgery Techniques: Controversies and Evidence offers clinicians a roadmap for navigating the complex decision-making process involved in selecting surgical interventions for children with drug-resistant epilepsy. Over the last decade, the landscape of pediatric epilepsy surgery has undergone substantial transformation, marked by the introduction of several emerging technologies that are now supported by an expanding body of evidence, yet leading to a wide range of treatment practices. This book addresses several decision-making dichotomies in pediatric epilepsy surgery, both in terms of established and novel surgical modalities and techniques. The book explores long-standing debated topics, such as the relative benefits of disconnective compared to resective strategies, the utility of surgical adjuncts like intra-operative electrocorticography, as well as rationales for different surgical approaches, namely selective amygdalo-hippocampectomy versus anteromesial temporal lobectomy. Further, it addresses dichotomies between traditional approaches and contemporary modalities, such as microsurgical resection versus laser interstitial thermal therapy. Chapters also offer comparisons of modern technologies, such as different neuromodulation strategies, including vagus nerve stimulation, deep brain stimulation, and responsive neurostimulation.
This book provides readers with the relevant scientific literature and expert commentary to inform evidence-based approaches to surgical care in pediatric drug-resistant epilepsy.
- Discusses state-of-the-art technology in the surgical treatment of pediatric drug-resistant epilepsy
- Provides an up-to-date overview of current controversies, competing approaches, and their relative evidence, indications, advantages, and disadvantages for pediatric epilepsy surgery
- Outlines evidence-based recommendations to guide decision-making in pediatric epilepsy surgery
- Title of Book
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Foreword
- Preface
- Acknowledgment
- Part 1: Evidence in pediatric epilepsy surgery
- Chapter 1. Evidence in pediatric epilepsy surgery
- Abstract
- Pediatric epilepsy surgery
- Invasive monitoring
- Curative procedures
- Palliative procedures
- Neuromodulation
- References
- Chapter 2. Controversies in the timing of pediatric epilepsy surgery: is earlier better?
- Abstract
- Introduction
- Motivation for early intervention
- Epilepsy surgery in early life
- Surgery prior to completing trials of two medications
- Conclusion
- References
- Part 2: Invasive investigation
- Chapter 3. Electroencephalographic evaluation of epileptogenicity: traditional versus novel biomarkers to guide surgery
- Abstract
- Introduction
- Traditional biomarkers of epileptogenicity
- Novel biomarkers of epileptogenicity
- Exploring the frequency spectrum
- Overlap between spikes, high-frequency oscillation and infra-slow activity
- Biomarkers looking at network changes
- Summary
- References
- Chapter 4. Invasive monitoring: stereoelectroencephalography (sEEG) versus subdural electrode (SDE) versus hybrid evaluation
- Abstract
- Introduction
- Subdural electrode recordings
- Stereoelectroencephalography
- Hybrid approach: subdural and depth electrodes (hybrid)
- Reported outcomes of each technique
- Discussion
- Evidence-based recommendations
- References
- Part 3: Resective or Ablative surgery
- Chapter 5. Intraoperative adjuncts to optimize the surgical treatment of drug-resistant epilepsy: do new tools improve outcome?
- Abstract
- Introduction
- The Past: Intraoperative Electrophysiology
- High-Frequency Oscillations
- The Present: Neuronavigation and Intraoperative Neuroimaging
- The Future: Intraoperative Dedicated Epileptogenic Zone Border Sampling and Indirect Histopathology Assessment
- Optical Spectroscopy
- Conclusion
- References
- Chapter 6. Medial temporal lobe epilepsy: selective amygdalohippocampectomy versus anterior temporal lobectomy
- Abstract
- Introduction
- Anterior temporal lobectomy
- Selective amygdalohippocampectomy
- Discussion
- Evidence-based recommendations (agreed upon by majority of experts)
- References
- Chapter 7. Epilepsy in eloquent cortex: resection versus responsive neurostimulation
- Abstract
- Introduction
- Language
- Sensorimotor
- Memory and cognition
- Conclusions
- References
- Chapter 8. Lesional epilepsy: lesionectomy versus ECoG-guided resection
- Abstract
- Advantages of intraoperative electrocorticography
- Disadvantages of intraoperative electrocorticography
- Conclusions
- References
- Chapter 9. Insular/perisylvian epilepsy: Open resection versus stereotactic ablation (MR-guided laser ablation/radiofrequency thermocoagulation) versus responsive neurostimulation
- Abstract
- Introduction
- Anatomy
- Open microsurgical resective surgery for insular epilepsy
- Minimally invasive stereotactic ablative procedure
- Responsive neurostimulation
- Surgery for insular epilepsy—the evidence
- Evidence-based recommendations
- References
- Chapter 10. Hypothalamic hamartoma: open surgery versus endoscopic surgery versus stereotactic radiosurgery versus stereotactic ablation (MR-guided laser ablation/Radiofrequency ablation) versus MRFUS
- Abstract
- Introduction
- Classification
- Disease course and secondary epileptogenesis
- Surgical treatment
- Discussion
- Evidence-based recommendations
- References
- Chapter 11. Resective surgery in tuberous sclerosis complex-related epilepsy: tuberectomy and tuberectomy plus
- Abstract
- Introduction: tuberous sclerosis complex and epilepsy
- Rationality and clinical basis of resective surgery in tuberous sclerosis complex-related epilepsy
- Classification of epileptogenic tubers and approaches to resective surgery
- Relationship between the epileptogenic zone and epileptogenic tuber
- Seizure control after tuberectomy and tuberectomy plus
- IQ and quality of life changes after tuberectomy and tuberectomy plus
- Complications of tuberectomy and tuberectomy plus
- Conclusions
- References
- Part 4: Disconnective procedures
- Chapter 12. Functional hemispheric surgery: vertical versus lateral approach
- Abstract
- Introduction
- Vertical hemispherotomy
- Lateral hemispherotomy
- Discussion
- Evidence-based recommendations
- References
- Chapter 13. Minimally invasive hemispherotomy: endoscopic, radiofrequency and robotic techniques
- Abstract
- Introduction
- Historical perspective
- Summary with important points to note
- References
- Chapter 14. Lobar/multilobar epilepsy: resection versus disconnection
- Abstract
- Introduction
- Lobar epilepsy surgery
- Multilobar epilepsy
- Conclusion
- References
- Further reading
- Chapter 15. Corpus callosotomy: anterior two-thirds (two-stage) versus complete (one-stage)
- Abstract
- Introduction
- Surgical indications
- Surgical outcomes
- Surgical techniques
- References
- Part 5: Neuromodulation
- Chapter 16. Temporal lobe epilepsy with preserved function: multiple hippocampal transection versus neuromodulation (deep brain stimulation, responsive neurostimulation)
- Abstract
- Multiple hippocampal transection
- Neuromodulation—deep brain stimulation and responsive neurostimulation
- Discussion
- References
- Chapter 17. Neuromodulation: comparison of vagus nerve stimulation, deep brain stimulation, and responsive neurostimulation
- Abstract
- Introduction
- Vagus nerve stimulation
- Deep brain stimulation
- Responsive neurostimulation
- Conclusions and recommendations
- References
- Index
- No. of pages: 396
- Language: English
- Edition: 1
- Published: November 9, 2024
- Imprint: Academic Press
- Paperback ISBN: 9780323959810
- eBook ISBN: 9780323959827
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Aria Fallah
Dr. Aria Fallah is a paediatric and adult epilepsy neurosurgeon at the Ronald Reagan UCLA Medical Center and UCLA Mattel Children’s Hospital. He serves as the Director of Epilepsy Surgery and Pediatric Neurosurgery at UCLA. He holds the Alfonsina Q. Davies Chair in Epilepsy Research. Dr. Fallah is an Associate Professor of Neurosurgery and Pediatrics at the David Geffen School of Medicine at UCLA, as well as an Associate Professor in Health Policy & Management at the UCLA Fielding School of Public Health. He is also a member of the Brain Research Institute at UCLA. In addition to his medical qualifications, he has obtained his Executive MBA from the UCLA Anderson School of Management. His clinical practice focuses on the surgical management of children with medically intractable epilepsy.
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George M. Ibrahim
Dr. George Ibrahim is the Abe Bresver Chair in Functional Neurosurgery at the Hospital for Sick Children and Associate Professor in Surgery, Biomedical Engineering and Medical Science at the University of Toronto. He is a Scientist in the Program in Neuroscience and Mental Health at the Hospital for Sick Children Research Institute. He is the Surgical Director of the pediatric DBS program.
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Alexander G. Weil
Dr. Weil is a pediatric and epilepsy neurosurgeon at Sainte-Justine University Hospital and the University of Montreal Hospital Center (CHUM). He serves as an Associate Professor in the Departments of Surgery and Neuroscience at the University of Montreal. Additionally, he is a Surgeon-Scientist in the Brain and Child Development Axis at the CHU Sainte-Justine Research Institute. Dr. Weil is the Director of the University of Montreal Pediatric Neurosurgery Fellowship and the research representative for the University of Montreal Division of Neurosurgery. His clinical practice and expertise focus on the investigation and treatment of drug-resistant epilepsy in both pediatric and adult populations.