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Elsevier

Academic Press

  • Diagnostic Molecular Pathology

    A Guide to Applied Molecular Testing
    • 2nd Edition
    • William B. Coleman + 1 more
    • English
    Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing, Second Edition assembles a group of experts to discuss the molecular basis and mechanisms of major human diseases and disease processes and how the molecular features of disease can be harnessed to develop practical molecular tests for disease detection, diagnosis and prognosis. The book explains how molecular tests are utilized in the treatment of patients in personalized medicine, highlights new technologies and approaches of applied molecular pathology, and discusses how this discovery-based research yields new and useful biomarkers and tests. As it is essential to stay up-to-date on new molecular diagnostics in this changing field, this book covers critically important areas in the practice of personalized medicine and reflects our understanding of the pathology, pathogenesis and pathophysiology of human disease.

  • Modern Methods of Drug Design and Development

    • 1st Edition
    • Volume 690
    • English
    Modern Methods of Drug Design and Development, a volume in the Methods in Enzymology series highlights new advances in the field with this new volume presenting interesting chapters on a variety of topics, including Recombinant protein purification for structural and kinetic studies, Steady-state kinetic analysis of reversible enzyme inhibitors, Steady-State Enzyme Kinetics, Analysis of enzyme kinetic data using ICEKAT, NMR techniques in drug discovery, Dynamic simulations and pre-steady state kinetics to guide drug discovery, Design and assay of substrate-product analogues for racemases and epimerases, Sensitive high throughput methods to screen for P450 inhibition: A- MI complex forming drugs, and more. Other chapters cover Sensitive high throughput methods to screen for P450 inhibition: B-Heme loss causing drugs, Discovery and development of inhibitors of acetyltransferase Eis to combat Mycobacterium tuberculosis, Crystallographic fragment screening in academic cancer drug discovery, Fast fragment- and compound-screening pipeline at the Swiss Light Source, Chemical biology, enzymology and drug discovery, PROTACs, Proximity-Induced Pharmacology (PROTACs), and much more.

  • Advances in Physical Organic Chemistry

    • 1st Edition
    • Volume 57
    • English
    Advances in Physical Organic Chemistry, Volume 57 presents the latest reviews of recent work in physical organic chemistry, providing a valuable source of information that is ideal not only for physical organic chemists applying their expertise to both novel and traditional problems, but also for non-specialists across diverse areas who identify a physical organic component in their approach to research. The book's hallmark is its quantitative, molecular level understanding of phenomena across a diverse range of disciplines.

  • Clinician’s Guide to Sexuality and Autism

    A Guide to Sex Education for Individuals with Autism Spectrum Disorders
    • 1st Edition
    • Jessica Cauchi + 3 more
    • English
    Clinician’s Guide to Sexuality and Autism: A Guide to Sex Education for Individuals with Autism Spectrum Disorders is the first book to provide clinicians with comprehensive curriculum of sexuality education skills for people with Autism Spectrum Disorders (ASD). Starting with the importance of teaching sexuality skills to people with autism, this book provides an outline and overview of the recommended teaching strategies (e.g., Behavioral Skills Training, Cool vs. Not Cool, video modeling). This book also reviews the fourteen skill domains directly related to sexuality, including the key skills one should acquire in each domain. A timeline focusing on what skills should be targeted at what age and what skills to teach across the lifespan are also discussed. The curriculum covers domains that are often neglected in sex education for people with different disabilities in general (e.g. values, types of relationships, gender identity, or preferences). Additionally, this curriculum addresses component skills of sexuality in a way that allows early teaching to build upon areas of learning systematically over time, thus likely to have an improvement in teaching over time.

  • Microbiome Drivers of Ecosystem Function

    • 1st Edition
    • Javid A. Parray + 2 more
    • English
    Microbiome Drivers of Ecosystem Function, the latest release in the Microbiome Research in Plants and Soil series, focuses on advancements in microbial technologies towards harnessing the microbiome for improved crop productivity and health. The book provides insights into the diversity of endophytic microbiomes and their potential utility in agricultural production. As increased crop yield through chemical interventions have limit thresholds and alternative, natural, and/or integrated approaches are increasingly needed, this book serves as an ideal reference for researchers and students in the fields of agricultural biotechnology, biochemistry, environmental science, plant biology, agricultural sciences, and agricultural engineering.Microbia... inoculants provide ways in which food production efficiency can be improved. Plant growth-promoting soil organisms increase net crop uptake of soil nutrients, resulting in larger crops and higher yields of harvested food. These and other symbiotic associations between plants and microbes can ultimately be exploited for the increased food production necessary to feed the world, in addition to creating safer farming techniques that minimize ecological disruption.

  • Nanowired Delivery of Drugs and Antibodies for Neuroprotection in Brain Diseases with Co-Morbidity Factors Part B

    • 1st Edition
    • Volume 172
    • English
    Nanowired Delivery of Drugs and Antibodies for Neuroprotection in Brain Diseases with Co-morbidity Factors, Part B, Volume 172 in the International Review of Neurobiology series, includes chapters on Spinal cord injury induced exacerbation of Alzheimer's disease pathophysiology in the cord is reduced by topical application of nanowired cerebrolysin and antibodies to tumor necrosis factor alpha, Nanodelivery of histamine H3 receptor inverse agonist BF-2549 with clobenpropit a H3 receptor antagonist and H4 receptor agonist induced neuroprotection in spinal cord injury is potentiated by antioxidant compound H-290/51, and Neuromodulation and quality of life for patient with spasticity after spinal cord injury, and more.Other sections cover Efficacy of invasive and non-invasive methods for the treatment of Parkinson´s disease: nanodelivery and enriched environment, Co-administration of DL-3-n-butylphthalid... and neprilysin is neuroprotective in Alzheimer disease associated with brain injury, Nicotine Neurotoxicity Exacerbation following Engineered Ag and Cu (50-60 nm) nanoparticles intoxication, and Neuroprotection with nanowired delivery of antioxidant compound H-290/51 together with serotonin 5-HT3 receptor antagonist ondansetron.

  • Advances in Virus Research

    • 1st Edition
    • Volume 117
    • English
    Advances in Virus Research, Volume 117, the latest release in a series that highlights new advances in the field, includes invaluable updates written by an international board of authors. Chapters in this new release include Pathogenesis of neuroinvasive flaviviruses, Cellular entry and egress of astroviruses, Rift Valley Fever virus entry and infection, and more.

  • Artificial Intelligence in the Age of Neural Networks and Brain Computing

    • 2nd Edition
    • Robert Kozma + 3 more
    • English
    Artificial Intelligence in the Age of Neural Networks and Brain Computing, Second Edition demonstrates that present disruptive implications and applications of AI is a development of the unique attributes of neural networks, mainly machine learning, distributed architectures, massive parallel processing, black-box inference, intrinsic nonlinearity, and smart autonomous search engines. The book covers the major basic ideas of "brain-like computing" behind AI, provides a framework to deep learning, and launches novel and intriguing paradigms as possible future alternatives. The present success of AI-based commercial products proposed by top industry leaders, such as Google, IBM, Microsoft, Intel, and Amazon, can be interpreted using the perspective presented in this book by viewing the co-existence of a successful synergism among what is referred to as computational intelligence, natural intelligence, brain computing, and neural engineering. The new edition has been updated to include major new advances in the field, including many new chapters.

  • Epigenetics in Human Disease

    • 3rd Edition
    • Trygve O. Tollefsbol
    • English
    Epigenetics in Human Disease, Third Edition examines the diseases and conditions on which we have advanced knowledge of epigenetic mechanisms, such as cancer, autoimmune disorders, aging, metabolic disorders, neurobiological disorders and cardiovascular disease. From molecular mechanisms and epigenetic technology to clinical translation of recent research, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics to therapeutic interventions for epigenetic-based disorders, with an emphasis throughout on understanding and application of key concepts in new research and clinical practice. Fully revised and up-to-date, this Third Edition discusses topics of current interest in epigenetic disease research, including stem cell epigenetic therapy, bioinformatic analysis of NGS data, epigenetic mechanisms of imprinting disorders, microRNA in cancer, epigenetic approaches to control obesity, epigenetics and airway disease, and epigenetics in cardiovascular disease. Further sections explore online epigenetic tools and datasets; early-life programming of epigenetics in age-related diseases; the epigenetics of addiction and suicide, and epigenetic approaches to regulating and preventing diabetes, cardiac disease, allergic disorders, Alzheimer’s disease, respiratory diseases, and many other human maladies. In addition, each chapter now includes chapter summaries, definitions, and vibrant imagery and figures to reinforce understanding, as well as step-by-step methods and disease research case studies.

  • Renewable Energy - Volume 2: Wave, Geothermal, and Bioenergy

    Definitions, Developments, Applications, Case Studies, and Modelling and Simulation
    • 1st Edition
    • Abdul Ghani Olabi
    • English
    Renewable Energy - Volume 2: Wave, Geothermal, and Bioenergy: Definitions, Developments, Applications, Case Studies, and Modelling and Simulation is the next volume in this comprehensive resource for those wanting an extensive reference on these specialized technologies. Providing a structured approach to the emerging technologies and advances in implementation of Geothermal and Biofuels systems, this reference addresses geothermal and biofuel coverage in a logical and accessible arrangement. From definitions to developments in technology and applications, to case studies, modelling examples and lifecycle analysis, this book considers the most requested and desirable practical elements of geothermal and biofuel technologies from an applied perspective. This coordinated approach allows for stand alone, accessible and functioning chapters dedicated to particular energy sources. This is a suitable reference for students and post-doctoral research fellows working on projects related to renewable energy, sustainability and energy system design.

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