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    • DNA Damage and Chromosomal Instability

      • 1st Edition
      • Volume 182
      • February 12, 2024
      • English
      • Hardback
        9 7 8 0 4 4 3 1 8 8 9 8 5
      • eBook
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      DNA Damage and Chromosomal Instability, Volume 182 in the Methods in Cell Biology series, presents interesting chapters on a variety of timely topics, including Induction of chromosome-specific micronuclei and chromothripsis by centromere inactivation, Generation of aneuploid cells and assessment of their ability to survive in presence of chemotherapeutic agents, Genetic reporters to detect and quantify homologous recombination in yeast, Mapping histone variant genomic distribution: exploiting SNAP- Tag labelling to follow the dynamics of incorporation of H3 variants, Enrichment of DNA replication intermediates by EdU pull down, Nascent DNA sequencing and its diverse applications in genome integrity research, and much more. Additional chapters cover Enrichment of DNA replication intermediates by EdU pull down, DNA curtains for studying phase separation mechanisms of DNA-organizing proteins, Visualizing the Dynamics of DNA Replication and Repair at the Single-Molecule Molecule Level, Cloning and Expansion of Repetitive DNA Sequences, Using an ImageJ-based script to detect replication stress and associated cell cycle exit from G2 phase by fluorescence microscopy Arne Lindqvist

    • Systems Biology Approaches for Host-Pathogen Interaction Analysis

      • 1st Edition
      • February 12, 2024
      • Mohd. Tashfeen Ashraf + 2 more
      • English
      • Paperback
        9 7 8 0 3 2 3 9 5 8 9 0 5
      • eBook
        9 7 8 0 3 2 3 9 5 8 9 1 2
      Application and utilization of data science approaches has revolutionized scientific research including host–pathogen interaction analyses. Host–pathogen interactions are generally considered highly specific interactions, resulting in a variety of consequences. Data science approaches coupled with network biology has taken host–pathogen interaction analysis from specific interaction to a new paradigm of understanding the consequences of these interactions within a biological network. Unfortunately, basic biological researchers are mostly unaware of these advancements. Conversely, data scientists are not familiar with biological aspects of such data.Systems Biology Approaches for Host–Pathogen Interaction Analyses benefits biological researchers by expanding the scope of their research and utilization of their accumulated data using recent technological advancements. In addition, the book also opens avenues for bioinformatics and computer science researchers to utilize their expertise in biologically meaningful ways.

    • A Comprehensive Guide to Toxicology in Nonclinical Drug Development

      • 3rd Edition
      • February 11, 2024
      • Ali S. Faqi
      • English
      • Hardback
        9 7 8 0 3 2 3 8 5 7 0 4 8
      • eBook
        9 7 8 0 3 2 3 9 8 4 6 2 1
      **Selected for 2025 Doody’s Core Titles® in Toxicology**A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Third Edition is a valuable reference providing a complete understanding of all aspects of nonclinical toxicology in pharmaceutical research. This updated edition has been expanded and re-developed covering a wide-range of toxicological issues in small molecules and biologics. Topics include ADME in drug discovery, pharmacokinetics, toxicokinetics, formulations, and genetic toxicology testing. The book has been thoroughly updated throughout to reflect the latest scientific advances and includes new information on antiviral drugs, anti-diabetic drugs, immunotherapy, and a discussion on post-pandemic drug development challenges and opportunities. This is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings.

    • Federated Learning

      • 1st Edition
      • February 9, 2024
      • Lam M. Nguyen + 2 more
      • English
      • Paperback
        9 7 8 0 4 4 3 1 9 0 3 7 7
      • eBook
        9 7 8 0 4 4 3 1 9 0 3 8 4
      Federated Learning: Theory and Practi ce provides a holisti c treatment to federated learning as a distributed learning system with various forms of decentralized data and features. Part I of the book begins with a broad overview of opti mizati on fundamentals and modeling challenges, covering various aspects of communicati on effi ciency, theoretical convergence, and security. Part II featuresemerging challenges stemming from many socially driven concerns of federated learning as a future public machine learning service. Part III concludes the book with a wide array of industrial applicati ons of federated learning, as well as ethical considerations, showcasing its immense potential for driving innovation while safeguarding sensitive data.Federated Learning: Theory and Practi ce provides a comprehensive and accessible introducti on to federated learning which is suitable for researchers and students in academia, and industrial practitioners who seek to leverage the latest advance in machine learning for their entrepreneurial endeavors.

    • Dysphagia

      • 1st Edition
      • February 9, 2024
      • Michael B. Ujiki + 1 more
      • English
      • Paperback
        9 7 8 0 4 4 3 1 9 0 6 3 6
      • eBook
        9 7 8 0 4 4 3 1 9 0 6 4 3
      Dysphagia: A Clinical Guide will help practitioners and surgeons learn and understand how best to diagnose and treat dysphagia. It provides a complete picture of dysphagia through the experiences of leaders who cover the latest techniques and evidence-based outcomes in the field. Coverage includes recent advances in the diagnosis and treatment of the disease processes that cause dysphagia, gastric problems, and surgical intervention. The book includes the latest research and perspectives from both gastroenterologists and surgeons to enable clinicians to stay up-to-date on the most current and effective management strategies. Each chapter provides summary statements and recommendations based on recent literature.Recent discoveries regarding the diagnosis and management of dysphagia are exemplified by illustrations of both diagnostic methods and descriptions of interventional techniques. This an important reference for general surgeons, general practitioners, and ENT surgeons while also bringing new data dedicated specifically to gastroenterologists and foregut surgeons.

    • Renewable Energy Systems

      • 3rd Edition
      • February 8, 2024
      • Henrik Lund
      • English
      • Hardback
        9 7 8 0 4 4 3 1 4 1 3 7 9
      • eBook
        9 7 8 0 4 4 3 1 4 1 3 6 2
      Renewable Energy Systems: A Smart Energy Systems Approach to the Choice and Modeling of Fully Decarbonized Societies Third Edition includes updates from globally recognized renewable energy researcher and professor, Henrik Lund, who sets forth a comprehensive methodology for comparing different energy systems’ abilities to integrate fluctuating and intermittent renewable energy sources to achieve a fully decarbonized society. The book presents an energy system analysis methodology, providing the results of more than 15 comprehensive studies, examining the large-scale integration of renewable energy and presenting concrete design examples derived from a dozen renewable energy systems around the globe.The book also undertakes the socio-political realities governing the implementation of renewable energy systems by introducing a theoretical framework approach aimed at understanding how major technological changes, such as renewable energy, can be implemented at both the national and international levels. This is a valuable resource for researchers, scientists, engineers, project managers, policymakers, consultants, and graduate students with an interest in planning, modelling, and implementation of renewable energy systems.

    • Advances in Agronomy

      • 1st Edition
      • Volume 184
      • February 7, 2024
      • English
      • Hardback
        9 7 8 0 4 4 3 2 9 5 2 4 9
      • eBook
        9 7 8 0 4 4 3 2 9 5 2 5 6
      Advances in Agronomy, Volume 184, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field. Each chapter is written by an international board of authors, with this new release including new chapters on The Role of Artificial Intelligence in Crop Improvement, Dealing with the Impact of Climate Change-Induced Drought on the Management of Soil, Challenges and Emerging Opportunities of Weed Management in Organic Agriculture, The Broadbalk Wheat Experiment, Rothamsted, UK: Crop Yields and Soil Changes During the Last 50 Years.

    • Modeling and Analysis of Longitudinal Data

      • 1st Edition
      • Volume 50
      • February 7, 2024
      • English
      • Hardback
        9 7 8 0 4 4 3 1 3 6 5 1 1
      • eBook
        9 7 8 0 4 4 3 1 3 6 5 2 8
      Longitudinal Data Analysis, Volume 50 in the Handbook of Statistics series covers how data consists of a series of repeated observations of the same subjects over an extended time frame and is thus useful for measuring change. Such studies and the data arise in a variety of fields, such as health sciences, genomic studies, experimental physics, sociology, sports and student enrollment in universities. For example, in health studies, intra-subject correlation of responses must be accounted for, covariates vary with time, and bias can arise if patients drop out of the study.

    • Translational Approaches to Unravelling Non-Motor Symptoms of Parkinson’s disease

      • 1st Edition
      • Volume 174
      • February 7, 2024
      • English
      • Hardback
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      • eBook
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      Translational Approaches to Non-Motor Symptoms of Neurodegenerative Diseases, Volume 173 in the International Review on Neurobiology series, highlights new advances in the field with this new volume presenting interesting chapters on topics such as A general clinical overview of the non-motor symptoms, Stress/fatigue/cogni... decline Sleep/autonomic failure, A general clinical overview of the non-motor symptoms – psychiatric symptoms, Psychosis, Cognitive Decline, Non-clinical Aspect of non-motor symptoms: Animal Models, Assessment and treatment of cognitive decline in rodent and primate models, Pain in PD models, Affective disorders in PD models, Sleep and circadian dysregulation and EEG disruption in rodent models, and much more.

    • Huntington’s Disease

      • 1st Edition
      • February 7, 2024
      • X. William Yang + 2 more
      • English
      • Paperback
        9 7 8 0 3 2 3 9 5 6 7 2 7
      • eBook
        9 7 8 0 3 2 3 9 5 6 7 3 4
      Huntington's disease (HD) is one of the most common dominantly inherited neurodegenerative disorders, characterized by a clinical triad of movement disorder, cognitive deficits, and psychiatric symptoms. Huntington’s Disease: Pathogenic Mechanisms and Implications for Therapeutics reviews the most up-do-date content on HD pathogenic mechanisms and cutting-edge thinking on therapeutic strategies for HD. Chapters explore areas that include the clinical features and genetic studies of HD, the cellular and molecular biology of normal huntingtin, a range of HD models, the diverse pathogenic mechanisms linked to mutant huntingtin, new approaches to HD pathogenesis, as well as emerging preclinical therapeutic approaches and clinical programs in the field.

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