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Huntington’s Disease

Pathogenic Mechanisms and Implications for Therapeutics

  • 1st Edition - February 7, 2024
  • Editors: X. William Yang, Myriam Heiman, Leslie M. Thompson
  • Language: English
  • Paperback ISBN:
    9 7 8 - 0 - 3 2 3 - 9 5 6 7 2 - 7
  • eBook ISBN:
    9 7 8 - 0 - 3 2 3 - 9 5 6 7 3 - 4

Huntington's disease (HD) is one of the most common dominantly inherited neurodegenerative disorders, characterized by a clinical triad of movement disorder, cognitive deficits, an… Read more

Huntington’s Disease

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Huntington's disease (HD) is one of the most common dominantly inherited neurodegenerative disorders, characterized by a clinical triad of movement disorder, cognitive deficits, and psychiatric symptoms. Huntington’s Disease: Pathogenic Mechanisms and Implications for Therapeutics reviews the most up-do-date content on HD pathogenic mechanisms and cutting-edge thinking on therapeutic strategies for HD. Chapters explore areas that include the clinical features and genetic studies of HD, the cellular and molecular biology of normal huntingtin, a range of HD models, the diverse pathogenic mechanisms linked to mutant huntingtin, new approaches to HD pathogenesis, as well as emerging preclinical therapeutic approaches and clinical programs in the field.