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    • Fundamentals of Recombinant Protein Production, Purification and Characterization

      • 1st Edition
      • September 10, 2024
      • Deepti Yadav + 2 more
      • English
      • Paperback
        9 7 8 0 3 2 3 9 8 3 8 8 4
      • eBook
        9 7 8 0 3 2 3 9 8 5 8 4 0
      Fundamentals of Recombinant Protein Production, Purification and Characterization is organized into nine chapters in a logical fashion that cover an introduction to recombinant proteins and expression in different host expression systems, extraction, purification and analysis of proteins. This important reference features protocols, along with the advantages and disadvantage of each expression hosts and characterization technique (presented in tabular format) and offers detailed coverage of all aspects of protein production and processing (upstream and downstream processing) in one place. Finally, the book ends with different characterization techniques. Production of recombinant proteins for biotechnological and therapeutic applications at a large scale is an essential need of mankind. With the huge application potential of therapeutic and industrial proteins, there has been increasing demand for effective and efficient bioprocessing strategies. Recent progress around recombinant DNA technologies and bioprocessing strategies has paved the way for efficient production of recombinant proteins. Important factors such as insolubility and cost of production need to be considered for large scale production of these recombinant proteins.

    • Myopathies and Tendinopathies of the Diabetic Foot

      • 1st Edition
      • September 10, 2024
      • Claude Pierre-Jerome
      • English
      • Hardback
        9 7 8 0 4 4 3 3 3 9 7 7 6
      • eBook
        9 7 8 0 4 4 3 1 3 3 2 9 9
      Myopathies and Tendinopathies of the Diabetic Foot: Anatomy, Pathomechanics, and Imaging is a unique reference of valuable instructive data that reinforces the understanding of myopathies and tendinopathies related to diabetes-induced Charcot foot. Diabetic myopathies usually precede other complications (i.e., deformity, ulceration, infection) seen in the diabetic foot. Oftentimes, these myopathies may be isolated especially during their initial stage. In the absence of clinical information relevant to diabetes, the solitaire occurrence of myopathies may lead to confusion, misinterpretation, and misdiagnosis. The misdiagnosis can cause delay of management and consequent high morbidity. This book emphasizes the complications of diabetic myopathies and tendinopathies and all their aspects, including pathophysiology, pathomechanics, imaging protocols, radiological manifestations, histological characteristics, and surgical management.Diabetes type II and its complications (diabetic myopathies and tendinopathies) have reached a dreadful high incidence worldwide. Likewise, the need for better understanding of these complications becomes indispensable. In this book, the readers of all genres will find all they need to know about these conditions. This book serves as a classic academic reference for educators, healthcare specialists, healthcare givers, and healthcare students.

    • Zinc in Plants

      • 1st Edition
      • September 10, 2024
      • Durgesh Kumar Tripathi + 4 more
      • English
      • Paperback
        9 7 8 0 3 2 3 9 1 3 1 4 0
      • eBook
        9 7 8 0 3 2 3 9 1 3 1 5 7
      Zinc in Plants: Current Knowledge and Recent Advances addresses zinc hunger, the transport of zinc in the soil-plant interphase, zinc and abiotic stress in plants, and zinc and plant disease. Written by experts in the field, this title is an essential resource to all scientists and students interested in plant physiology, biochemistry and agriculture. During their life, plants encounter various challenges, including their normal development under changing environmental conditions. Zinc (Zn) is an essential component of thousands of proteins in plants, although it is toxic in excess, and is essential for many processes throughout the plant lifecycle.

    • Mononuclear Non-heme Iron Dependent Enzymes

      • 1st Edition
      • Volume 703
      • September 10, 2024
      • English
      • Hardback
        9 7 8 0 4 4 3 3 1 3 0 4 2
      • eBook
        9 7 8 0 4 4 3 3 1 3 0 5 9
      Mononuclear Non-heme Iron Dependent Enzymes, Volume 703 focuses on methods for studying, characterizing, and leveraging the chemistry of mononuclear non-heme iron dependent enzymes. Chapters in this new release include Photoreduction for Rieske oxygenase chemistry, Insights into the Mechanisms of Rieske Oxygenases from Studying the Unproductive Activation of Dioxygen, Non-heme iron and 2-oxoglutarate enzymes catalyze cyclopropane and azacyclopropane formations, Obtaining precise metrics of substrate positioning in Fe(II)/2OG dependent enzymes using Hyperfine Sublevel Correlation Spectroscopy, Xe-pressurization studies for revealing substrate-entrance tunnels, and much more.Additional chapters cover A tale of two dehydrogenases involved in NADH recycling, Rieske oxygenases and/or their partner reductase proteins, Expression, assay and inhibition of 9-cis-epoxycarotenoi... dioxygenase (NCED) from Solanum lycopersicum and Zea mays, Biocatalysis and non-heme iron enzymes, In vitro analysis of the three-component Rieske oxygenase cumene dioxygenase from Pseudomonas fluorescens IP01, Structure and function of carbazole 1,9a-dioxygenase, Characterization of a Mononuclear Nonheme Iron-dependent Mono-oxygenase OzmD in Oxazinomycin Biosynthesis, and much more.

    • Medical and Educational Needs for Autism

      • 1st Edition
      • September 10, 2024
      • Michelle Hartley-McAndrew + 1 more
      • English
      • Paperback
        9 7 8 0 4 4 3 1 5 6 8 2 3
      • eBook
        9 7 8 0 4 4 3 1 5 6 8 3 0
      Medical and Educational Needs for Autism aims to provide understanding and assistance to clinicians interacting with ASD patients and their caregivers. This book is divided into two clear sections, first the medical coverage and second, an educational section. The first section includes chapters on sleep disorders, feeding/nutrition concerns, and medication. The second section focuses on the education component which includes IEP processes and activities for daily living.

    • Chemokine Receptors in Health and Disease

      • 1st Edition
      • Volume 388
      • September 10, 2024
      • English
      • Hardback
        9 7 8 0 4 4 3 2 2 1 7 2 9
      • eBook
        9 7 8 0 4 4 3 2 2 1 7 3 6
      This volume reviews the current research in Chemokine Receptors and their role in physiological processes in the body, as well as their role in different pathological conditions. Chemokine Receptors are important for the migration of different types of cells, including immune cells to lymphoid organs and non-lymphoid organs thanks to the interaction with chemokines. The presence of different chemokine receptors on the cells’ surface was studied in normal states and diseases, some of them correlating with migration of subsets that play pro-disease roles or other help controlling the condition. Currently, state-of-the-art technology is helping researchers to better identify gene and protein expression of chemokine receptors at the single cell level. This large new data reveals the complexity of co-expression of various markers in the same cells and as well among different types of cells. Moreover, chemokine receptors are also helpful to identify different stages among subsets, and their correlation with better or worst responses in disease. Finally, treatments designed to inhibit or to block chemokine receptors are designed and tested at the preclinical and clinical level with different results. Here, we focus on the main chemokine receptors described in the current literature that play a role in health and diseases such as infections, autoimmune disorders, and cancer.

    • Understanding Autism

      • 1st Edition
      • September 9, 2024
      • Neophytos L. Papaneophytou + 1 more
      • English
      • Paperback
        9 7 8 0 4 4 3 2 7 3 6 6 7
      • eBook
        9 7 8 0 4 4 3 2 7 3 6 7 4
      Understanding Autism: Perspectives, Assessment, Interventions, and the Journey Toward Inclusion is a compelling book offering a multifaceted examination, providing readers with a comprehensive understanding of autism spectrum disorder from both biological and social perspectives. From the role of bioactive lipids in the pathobiology of autism to the challenges faced by individuals with autism within the criminal justice system, this book explores critical aspects of autism, assessment strategies, and innovative interventions. From a biological perspective, readers will be introduced to the gut-brain connection and the impact of vitamin D on the gut microbiota. Meanwhile, the social perspective sheds light on sensory processing, autonomic regulation, and socio-emotional development in autism, as well as the pressing issue of justice and representation. Through the assessment section, readers will explore the unique challenges faced by parents with autism spectrum disorder and delve into linguistic anomalies in autism. Finally, the interventions section introduces groundbreaking programs and strategies designed to improve the lives of individuals with autism. Whether you’re a healthcare professional, educator, or simply curious about autism, this book is an essential guide that offers diverse insights into this complex condition, ultimately fostering greater awareness, understanding, and support for individuals on the spectrum.

    • mRNA Therapeutics

      • 1st Edition
      • September 9, 2024
      • Anya Hillery
      • English
      • Paperback
        9 7 8 0 4 4 3 2 8 9 3 4 7
      • eBook
        9 7 8 0 4 4 3 2 8 9 3 5 4
      mRNA Therapeutics: Foundations, Innovations and Clinical Applications aims to provide a comprehensive text that covers all aspects of mRNA therapeutics, from the foundational science that underpins this disruptive new drug class, through the scientific and technological breakthroughs crucial for therapeutic success, to the current clinical applications and the innovative advances driving future directions. The book begins with foundational knowledge covering mRNA biology, the immune system, and vaccines. The second section addresses the major challenges associated with mRNA as a therapeutic modality, and the molecular engineering innovations and delivery technologies that have allowed these hurdles to be largely overcome. The third section describes the current and future clinical applications of mRNA therapeutics that are transforming, or are poised to transform, medicine and health. This includes the use of mRNA vaccines for COVID-19 and other infectious diseases, as well as mRNA's role in revolutionizing cancer immunotherapy, covering immunostimulants, cancer vaccines including personalized neoantigen vaccines, and CAR T cell technologies. Additional chapters describe the use of mRNA therapeutics for protein replacement therapy and gene-editing, as well as newer mRNA constructs, including self-amplifying mRNA. The final section addresses the safety and regulatory considerations of mRNA therapeutics, along with broader cultural issues including vaccine hesitancy, global vaccine inequality, and pandemic preparedness. Currently, mRNA texts either provide personal accounts from key players involved in COVID-19 vaccine development, with limited scientific depth, or focus on highly specialized, more esoteric applications of mRNA in advanced molecular biology. This book aims to bridge this gap by providing a scientifically rigorous and wide-ranging exploration of mRNA's role in therapeutics. This pioneering textbook serves as a vital addition to the academic canon, providing an essential tool for the current and next generation of students, scientists, researchers and professionals in a wide variety of related disciplines including molecular biology, biomedical engineering, pharmaceutical science, oncology, and the health sciences.

    • Fundamentals of Soft Interfaces in Colloid and Surface Chemistry

      • 1st Edition
      • Volume 37
      • September 9, 2024
      • Hiroyuki Ohshima
      • English
      • Paperback
        9 7 8 0 4 4 3 1 6 1 1 6 2
      • eBook
        9 7 8 0 4 4 3 1 6 1 1 7 9
      This book explains and summarizes the fundamentals of soft interfaces and soft particles from a colloid and surface chemistry standpoint, bringing knowledge together into a single resource for the first time. It provides detailed mathematical description of colloidal and interfacial systems, with a particular emphasis on ionic, electrokinetic, and electrostatic phenomena. Hiroyuki Ohshima covers the most recent theoretical advances in the field of electrostatic interactions between soft interfaces, electrophoresis, diffusiophoresis, gel electrophoresis of soft particles including ionic size effects, ion-partitioning effects, and the effects of hydrodynamic slip on hydrophobic surfaces. It will help readers by providing a range of approximate analytic formulas which can be used to interpret various interfacial phenomena of soft interfaces and analyze experimental data in various fields. Fundamentals of Soft Interfaces in Colloid and Surface Chemistry is written for graduate students and researchers chiefly in chemistry but also chemical engineering, physics, and materials science.

    • Advances in Child Development and Behavior

      • 1st Edition
      • Volume 67
      • September 9, 2024
      • English
      • Hardback
        9 7 8 0 4 4 3 2 9 4 2 4 2
      • eBook
        9 7 8 0 4 4 3 2 9 4 2 5 9
      Advances in Child Development and Behavior, Volume 67, the latest release in this classic resource on the field of developmental psychology, includes a variety of timely updates, with this new volume presenting interesting chapters on topics such as Conceptual and Empirical Advances in Afterschool Research, Unraveling the Transracial Adoption Paradox: Construction race and racism in adoptive families, Risk and Resilience Models in Child Development, The Dual Journey: The Development of Twins’ Relationships Throughout Childhood, A sociocultural perspective of multimodal learning by infants and young children, and Defining the Role of Executive Function in Children's Sociomoral Reasoning.

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