Chemokine Receptors in Health and Disease
- 1st Edition, Volume 388 - September 10, 2024
- Editors: Rodney Macedo Gonzales, Lorenzo Galluzzi
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 2 2 1 7 2 - 9
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 2 1 7 3 - 6
This volume reviews the current research in Chemokine Receptors and their role in physiological processes in the body, as well as their role in different pathological co… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quoteThis volume reviews the current research in Chemokine Receptors and their role in physiological processes in the body, as well as their role in different pathological conditions. Chemokine Receptors are important for the migration of different types of cells, including immune cells to lymphoid organs and non-lymphoid organs thanks to the interaction with chemokines. The presence of different chemokine receptors on the cells’ surface was studied in normal states and diseases, some of them correlating with migration of subsets that play pro-disease roles or other help controlling the condition. Currently, state-of-the-art technology is helping researchers to better identify gene and protein expression of chemokine receptors at the single cell level. This large new data reveals the complexity of co-expression of various markers in the same cells and as well among different types of cells. Moreover, chemokine receptors are also helpful to identify different stages among subsets, and their correlation with better or worst responses in disease. Finally, treatments designed to inhibit or to block chemokine receptors are designed and tested at the preclinical and clinical level with different results. Here, we focus on the main chemokine receptors described in the current literature that play a role in health and diseases such as infections, autoimmune disorders, and cancer.
- Chemokine receptors in the era of single cell gene and protein analysis
- Chemokine receptor’s role in COVID-19
- Update in the role of chemokine receptors in health and disease
- Cover image
- Title page
- Table of Contents
- Series Page
- Copyright
- Contributors
- Chapter One: Chemokine receptors in primary and secondary lymphoid tissues
- Abstract
- 1 Introduction
- 2 Primary lymphoid tissues
- 3 Secondary lymphoid tissues
- 4 Conclusions
- Acknowledgments
- References
- Chapter Two: Role of chemokine receptors in gastrointestinal mucosa
- Abstract
- 1 Introduction
- 2 Role of chemokine receptors in inflammatory bowel disease
- 3 Role of chemokine receptors in gastrointestinal cancer
- 4 Role of chemokine receptors in other gastrointestinal conditions
- 5 Concluding remarks
- References
- Chapter Three: Chemokine receptors in COVID-19 infection
- Abstract
- 1 Introduction
- 2 Chemokine receptors in the respiratory system
- 3 Chemokine receptors in SARS-CoV infection
- 4 Chemokine receptor-based therapeutic strategies
- 5 Concluding remarks
- References
- Chapter Four: Role of chemokine receptors in transplant rejection and graft-versus-host disease
- Abstract
- 1 Introduction
- 2 Transplant rejection
- 3 Chemokine receptors in allograft transplant rejection
- 4 Graft-versus-host disease (GVHD)
- 5 Chemokine receptors in graft-versus-host disease
- 6 Conclusions
- References
- Chapter Five: Chemokine receptors and their ligands in breast cancer: The key roles in progression and metastasis
- Abstract
- 1 Introduction
- 2 Chemokines/chemokine receptors in breast cancer
- 3 Targeting chemokines receptors and their ligands for breast cancer metastasis
- Acknowledgments
- References
- Further reading
- Chapter Six: Chemotactic signaling pathways in prostate cancer: Implications in the tumor microenvironment and as potential therapeutic targets
- Abstract
- 1 Introduction
- 2 Tumor initiation and immune escape
- 3 Chemokine receptors, immune cell migration, and tumor microenvironment
- 4 Prominent chemotactic signaling pathways in prostate cancer
- 5 Improving clinical responses through chemotactic modulation
- 6 Conclusions and future perspectives
- References
- No. of pages: 277
- Language: English
- Edition: 1
- Volume: 388
- Published: September 10, 2024
- Imprint: Academic Press
- Hardback ISBN: 9780443221729
- eBook ISBN: 9780443221736
LG