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Elsevier

Books in Life sciences

  • Numerical Methods and Advanced Simulation in Biomechanics and Biological Processes

    • 1st Edition
    • Miguel Cerrolaza + 2 more
    • English
    Numerical Methods and Advanced Simulation in Biomechanics and Biological Processes covers new and exciting modeling methods to help bioengineers tackle problems for which the Finite Element Method is not appropriate. The book covers a wide range of important subjects in the field of numerical methods applied to biomechanics, including bone biomechanics, tissue and cell mechanics, 3D printing, computer assisted surgery and fluid dynamics. Modeling strategies, technology and approaches are continuously evolving as the knowledge of biological processes increases. Both theory and applications are covered, making this an ideal book for researchers, students and R&D professionals.

  • Functional Connectivity, An Issue of Neuroimaging Clinics of North America

    • 1st Edition
    • Volume 27-4
    • Jay J. Pillai
    • English
    This issue of Neuroimaging Clinics of North America focuses on Functional Connectivity, and is edited by Dr. Jay Pillai. Articles will include: Applications of rs-fMRI to presurgical mapping: sensorimotor mapping; Dynamic functional connectivity methods; Machine learning applications to rs-fMRI analysis; Frequency domain analysis of rs-fMRI; Applications of rs-fMRI to epilepsy; Data-driven analysis methods for rs-fMRI; Applications of rs-fMRI to presurgical mapping: language mapping; Limitations of rs-fMRI in the setting of focal brain lesions; Applications of rs-fMRI to neuropsychiatric disease; Applications of rs-fMRI to Traumatic Brain Injury; Applications of rs-fMRI to neurodegenerative disease; Graph theoretic analysis of rs-fMRI; and more!

  • Coronary Artery Disease

    From Biology to Clinical Practice
    • 1st Edition
    • Dimitris Tousoulis
    • English
    Coronary Artery Disease: From Biology to Clinical Practice links the most important basic concepts of atherosclerosis pathophysiology to treatment management of coronary artery disease. Comprehensive coverage starts with the basic pathophysiologic mechanisms of the disease, including molecular and genetic mechanisms, cells interaction and inflammation. In addition, sections on novel anti-atherosclerotic therapies and a thorough understanding of the recent trends in clinical management round out this comprehensive tome that is ideal for practitioners and researchers. By summarizing this novel knowledge and changes in diagnostic algorithm and treatment options, this is the perfect reference for cardiology researchers who want a volume with the most up-to-date experimental trends in the field of atherosclerosis, for cardiologists and physicians who manage patients with atherosclerotic risk factors and established coronary artery disease, and medical students who want to learn the basic concepts of atherosclerosis.

  • Neurocritical Care, An Issue of Neurologic Clinics

    • 1st Edition
    • Volume 35-4
    • Alejandro A. Rabinstein
    • English
    This issue of Neurologic Clinics, edited by Dr. Alejandro A. Rabinstein, will cover Neurocritical Care. Topics include, but are not limited to: Anoxic Brain Injury; Treatment of Intracranial Hypertension; Management of Traumatic Brain Injury; Cortical Spreading Depression and Ischemia in Neurocritical Patients; Temperature Control in Acute Brain Injury; HSV Encephalitis; Primary Acute Neuromuscular Respiratory Failure; ICU-Acquired Weakness; Emergency and Critical Care Management of Intracerebral Hemorrhage; New developments in Refractory Status Epilepticus; Acute Cardiac Complications in Critical Brain Disease; Nosocomial Infections in Neurocritical Patients; Neurological Complications after Solid Organ Transplantation; and Shared Decision Making in the NICU.

  • Food Microstructure and Its Relationship with Quality and Stability

    • 1st Edition
    • Sakamon Devahastin
    • English
    Food Microstructure and Its Relationship with Quality and Stability is a comprehensive overview of the effects that the properties of the underlying structures of food have on its perceived quality to the consumer. The book's first section consists of chapters outlining the fundamentals of food microstructure, food composition, molecular mobility of various food constituents, and their relationships with food quality and stability. The role of various processing technologies in the production of specific microstructures for enhanced quality and stability is outlined. The second part of the book consists of various chapters devoted to microstructures, constituents and their relationship with quality, functionality, and stability of selected foods, for example, food hydrocolloids, frozen seafood, dried foods, extruded products, and dietary fibers. This information is of paramount importance for both academic researchers in the areas of food quality, preservation, and stability, as well as for food developers and processors.

  • Cancer and Noncoding RNAs

    • 1st Edition
    • Volume 1
    • Jayprokas Chakrabarti + 1 more
    • English
    Cancer and Noncoding RNAs offers an in-depth exploration of noncoding RNAs and their role in epigenetic regulation of complex human disease, most notably cancer. In addition to examining microRNAs, this volume provides a unique evaluation of more recently profiled noncoding RNAs now implicated in carcinogenesis, including lncRNAs, piRNAs, circRNAs, and tRNAs, identifying differences in function between these noncoding RNAs and how they interact with the rest of the epigenome. A broad range of chapters from experts in the field detail epigenetic regulation of various cancer types, along with recent next generation sequencing technologies, genome-wide association studies (GWAS) and bioinformatics approaches. This book will help researchers in genomic medicine and cancer biology better understand the role of noncoding RNAs in epigenetics, aiding in the development of useful biomarkers for diagnosis, prognosis and new RNA-based disease therapies.

  • Hazard Analysis and Risk-Based Preventive Controls

    Improving Food Safety in Human Food Manufacturing for Food Businesses
    • 1st Edition
    • Hal King + 1 more
    • English
    Hazard Analysis and Risk-Based Preventive Controls: Improving Food Safety in Human Food Manufacturing for Food Businesses is a comprehensive, first of its kind resource for the retail food industry on the Hazard Analysis and Risk-based Preventive Controls (PCHF) regulations of the Food Safety Modernization Act (FSMA). This book covers all aspects of PCHF, including the legislation's intent, applications to ensure safe food production, and resources to keep up-to-date on new food safety hazards and regulatory guidance. Written for food safety professionals and food business leaders, its emphasis on what the retail food industry needs to know about PCHF make it an indispensable resource for organizations buying food from companies required to demonstrate compliance with PCHF. PCHF implementation is (or soon will be) required for human food companies along the supply chain in the United States, as well as all food companies that import ingredients and products for human consumption into the U.S.

  • Back to Basics in Physiology

    Electrolytes and Non-electrolyte Solutes in the Body
    • 1st Edition
    • Juan Pablo Arroyo + 1 more
    • English
    Back to Basics in Physiology: Electrolytes and Non-electrolyte Solutes in the Body exploits the gap that exists in current physiology books. Instead of tackling one particular organ system at a time, the authors tackle specific problems, also evaluating their repercussions on systemic physiology. This original, six chapter book briefly reviews and integrates the basic concepts behind the function of electrolytes in the body, providing a bridge that allows students to understand basic science and its direct translation to the clinical setting, with a final aim of comprehending the basic science behind clinical observations. With the exploding amount of basic science information that is available today to physiology students (undergraduate, nursing, physician associate or medical), there is more and more of a disconnect between the basic and clinical sciences. The book allows students to gain sufficient background knowledge of physiology and its direct application to clinical skills as it is written as lectures in day-to-day language that is easy to comprehend.

  • Cellular Aspects of Membrane Permeability

    International Series of Monographs in Pure and Applied Biology: Modern Trends in Physiological Sciences
    • 1st Edition
    • E. Schoffeniels
    • P. Alexander + 1 more
    • English
    Cellular Aspects of Membrane Permeability describes the state of knowledge on permeability problems and interprets experimental results within the framework of working hypotheses. The book discusses membrane permeability with some biochemical perspective presented to explain the origin and adaptations of animal life. The text explains the process and the driving forces affecting the permeability characteristics of the experimental object. It then discusses the distribution of ions and molecules between two phases separated by a living membrane. Then the text analyzes the chemical nature of the molecular architecture that causes such permeability characteristics. The book addresses the electrical potential profiles of epithelial tissues, and then discusses the conducting membranes. It also explains the relationships between inorganic ions, sugar, amino acids, fatty acids, and bioelectric potentials. The book also explains the physical nature of such chemical nature and structure of living membranes. The text then describes the structure of the cellular surface and the structural organization of the cell. The selection can prove useful for biologists, microbiologists, zoologists, and students and professors of biology and its related disciplines.

  • G Protein-Coupled Receptors Part A

    • 2nd Edition
    • Volume 142
    • English
    G Protein Coupled Receptors, Second Edition, Volume 143, a new volume in the Methods in Cell Biology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. It contains a wide array of topics about the G protein coupled receptors, as well as updates of chapters from the first edition.

  • Medicinal Plants for Holistic Health and Well-Being

    • 1st Edition
    • Namrita Lall
    • English
    Medicinal Plants for Holistic Health and Well-Being discusses, in depth, the use of South African plants to treat a variety of ailments, including tuberculosis, cancer, periodontal diseases, acne, postmacular hypomelanosis, and more. Plants were selected on the basis of their traditional use, and the book details the scientific evidence that supports their pharmacological and therapeutic potential to safely and effectively treat each disease. Thus, this book is a valuable resource for all researchers, students and professors involved in advancing global medicinal plant research. Many plants found in South Africa are also found in other parts of the world. Each chapter highlights plants from other worldwide locations so that scientists can study which plants belong to the same family, and how similar qualities can be used to treat a specific disease.

  • The Handbook of Histopathological Practices in Aquatic Environments

    Guide to Histology for Environmental Toxicology
    • 1st Edition
    • Pedro M. Costa
    • English
    The Handbook of Histopathological Practices in Aquatic Environments: Guide to Histology for Environmental Toxicology offers readers in aquatic biology and other water-based environmental sciences a comprehensive resource on histopathology, which is a key tool in the growing field of ecotoxicology. This work brings together the necessary knowledge, from sample preparation, to trait identification, and scoring and data treatment. Furthermore, with examples from several groups of organisms (from worms to fish), these practices can be applied across a wide array of aquatic ecosystems. This book provides a step-by-step approach to solving the questions researchers encounter in aquatic biology and related fields.

  • Arachnoid Cysts

    Clinical and Surgical Management
    • 1st Edition
    • Knut Wester
    • English
    Arachnoid Cysts: Clinical and Surgical Management gives a broad and updated presentation of the condition, including symptomatology, diagnostics, management and treatment. The book covers the effects of surgical treatment on clinical symptoms and the effects cysts have on cognition, as well as cognitive improvement after surgical cyst decompression. This book is written for researchers, residents and clinical practitioners in clinical neuroscience, neurology, neurosurgery, neuroradiology and pediatrics.

  • Arachnoid Cysts

    Epidemiology, Biology, and Neuroimaging
    • 1st Edition
    • Knut Wester
    • English
    Intracranial arachnoid cysts are congenital malformations with a predilection for the middle cranial fossa and an estimated prevalence in the general population as high as 1.7%. The common assumption is that these cysts are incidental findings and the symptoms associated with them are not caused by the cyst and consequently, that surgical intervention will not benefit the patient. However, there is now a growing understanding reflected in the international literature among neurologists and neurosurgeons that arachnoid cysts do harm and that the patients’ complaints can be relieved by surgical treatment. Arachnoid Cysts: Epidemiology, Biology, and Neuroimaging gives a broad and updated presentation of the condition, including epidemiology, etiology, biology (including genetics and molecular biology), and neuroimaging of same. This book is written for researchers, residents, and clinical practitioners in clinical neuroscience, neurology, neurosurgery, neuroradiology, and pediatrics.

  • Finding the Nerve

    The Story of Impedance Neurography
    • 1st Edition
    • Philip C Cory
    • English
    Finding the Nerve: The Story of Impedance Neurography discusses research that elucidates the nature of nerve simulation via externally applied electrical fields, and how it has led to an entirely new understanding of neuronal cell membrane biophysics and defined a novel nerve imaging technology. It details how these discoveries came about and the nature of research that derives from unexplained clinical observations. The primary technology, impedance neurography, is a wholly new way of nerve-specific visualization in 2-D or 3-D, with the ability to define both normal and abnormal functioning of nerves, heretofore unavailable from techniques such as MRI neurography. This is of particular importance with respect to the obesity epidemic where physicians performing nerve-related procedures cannot use ultrasound visualization due to the depth limitations of that technology.

  • Environmental Causes and Prevention Measures for Alzheimer’s Disease

    • 1st Edition
    • George J. Brewer
    • English
    Environmental Causes and Prevention Measures for Alzheimer’s Disease examines the increased incidence of the disease in developed countries and aims to educate neuroscientists, medical practitioners and other educated individuals on new insights into environmental causation, primarily metals. This book looks into the web of evidence around the hypothesis of copper toxicity and the additional role that a high fat diet plays in disease progression and cognition loss. The data and its implications are discussed, along with potential prevention measures. This book will generate excitement and interest among neuroscientists, medical practitioners and other biomedical researchers.

  • Mutagenicity: Assays and Applications

    • 1st Edition
    • Ashutosh Kumar + 3 more
    • English
    Mutagenicity: Assays and Applications presents an extensive examination of the detection, assessment and future of mutagenicity, particularly as it concerns human health and the environment. Chapters focused on specific types of mutagens or testing methods for their detection collectively explore the current state of human and environmental mutagenesis, future perspectives and regulatory needs. The test procedures for measuring mutagenicity, their advantages and limitations are described with practical and procedural detail, along with their presentation and data processing aspects. It is an essential reference covering the breadth and depth of the field of mutagenicity studies and regulation. By providing both important introductory material and practical assays and applications, this book is useful to graduate students, academic and industry researchers and regulators at various stages of their careers, leading to improved risk assessment and regulation.

  • Endocrine Biomarkers

    Clinicians and Clinical Chemists in Partnership
    • 1st Edition
    • Hossein Sadrzadeh + 1 more
    • English
    Endocrine Biomarkers: Clinical Aspects and Laboratory Determination covers all the pre-analytical variables that can affect test results, both in the clinic and laboratory. Biomarkers of endocrine and bone diseases are discussed from both clinical and laboratory perspectives, and the authors elaborate on the teamwork-based app+roach between the clinician and the laboratory professional in the diagnosis and management of endocrine and bone disorders. Discussions include test utilization, laboratory measurement methods, harmonization and standardization, interpretation of results, and reference intervals. Each chapter ends with a discussion of one or two relevant cases with shared opinions from both a clinician and a clinical chemist. Each chapter also includes a summary box outlining key points and common pitfalls in the use of specific disease biomarkers and tests.

  • Therapeutic Foods

    • 1st Edition
    • Volume 8
    • Alexandru Mihai Grumezescu + 1 more
    • English
    Therapeutic Foods, Volume 8 in the Handbook of Food Bioengineering series, is an essential resource for anyone investigating foods that may be utilized as therapeutic agents. Plants and animal products have been utilized since ancient times as medicine to treat diseases, and the properties within foods and ingredients are still investigated for food therapy and prophylaxis. The book is a comprehensive resource for researchers and scientists already in the field or those just entering. It covers many spices, plant extracts, essential oils and vegetal mixtures that have immune-stimulatory effects and can be efficiently utilized in the treatment of infections and cancer.

  • G Protein-Coupled Receptors in Immune Response and Regulation

    • 1st Edition
    • Volume 136
    • English
    G Protein-Coupled Receptors in Immune Response and Regulation, Volume 136 presents emerging concepts related to the role of GPCRs in immune response and regulation. Users will find updated chapters on a variety of topics, including Beta-adrenergic signaling in the onset and progression of asthma, the Emerging roles of Regulators of G protein signaling (RGS) proteins in the immune system, information on Kinin receptors in immune response and pathogenic infections, and sections on GPCR signaling in C. elegans and its implications in immune response, GPCR Kinases in Inflammatory response and signaling, and GRK2 in Inflammation: Regulation of T cell receptors and IgE signaling. Chapters in this book discuss not only the well-known aspects of GPCR signaling in immunology, but also presents many emerging paradigms that have not yet been reported in classical textbooks. Each chapter presents a forward-looking discussion, providing a glimpse of the tremendous potential associated with the specific receptor systems discussed.

  • Functionalised Cardiovascular Stents

    • 1st Edition
    • Gerard Wall + 2 more
    • English
    Cardiovascular disease is a major cause of mortality in the western world and about half of these deaths are caused by coronary artery disease. One of the most commonly used interventions to treat arterial blockages is to deploy an arterial stent to keep the vessel open. Traditionally, some cardiovascular stents have been associated with serious side-effects, such as thrombosis. This book describes the fundamentals of cardiovascular stents, technologies to functionalize their surfaces and the market status of these important implants. The chapters provide specific focus on the production and evolution of cardiovascular stents, providing essential knowledge for researchers on advances in the field and knowledge of how cardiovascular stents are currently being "functionalized" in order to improve their biocompatibility and minimize negative outcomes in vivo.

  • SPEC – Handbook of Clinical Neurology, Volume 144, Huntington Disease, 12-Month Access, eBook

    • 1st Edition
    • Volume 144
    • English
    Huntington Disease summarizes the most recent findings related to the disease, providing both cutting edge coverage for clinical/research specialists looking to expand their knowledge base of Huntington disease information, as well as solid groundwork for advanced students from various backgrounds (neurology, psychiatry, neuropsychology, genetics). The volume includes all major areas of Huntington disease clinical care and research, whereas many other HD texts focus solely on neurological symptoms. This book also addresses behavioral and cognitive symptoms, brain imaging, and family dynamics and therapeutic alliances in working with individuals affected by HD. Clinical trials are covered extensively, including design considerations for therapeutic studies. The devastating nature of Huntington’s disease is well appreciated throughout the neuroscience, neurology, and psychiatric communities, and a great amount of basic and clinical research is currently taking place. However, much of that occurs in isolated research silos, and it is critical that an interdisciplinary resource be developed to provide in depth information to enhance communication and collaboration. This volume in the Handbook of Clinical Neurology series is that resource.

  • Advances in Agronomy

    • 1st Edition
    • Volume 146
    • English
    Advances in Agronomy, Volume 146 is the latest in a series that continues to be recognized as a leading reference for the latest research in agronomy. Updated chapters in this new release include the Significance and Role of Si in Crop Production, National Comparison of the Total and Sequestered Organic Matter Contents of Conventional and Organic Farm Soils, Purine – N Metabolism in Drought or Salinity Challenged Food Security Crops, Plant Rooting and Cropping Systems Management to Improve N Use Efficiency, and The Important Role of Layered Double Hydroxides in Soil Chemical Processes and Remediation: What We Have Learned Over the Past 20 Years. Each volume in the evolving series contains an eclectic group of reviews by leading scientists throughout the world. As always, the subjects covered are rich, varied and exemplary of the abundant subject matter addressed by this long-running serial.

  • Federal Data Science

    Transforming Government and Agricultural Policy Using Artificial Intelligence
    • 1st Edition
    • Feras A. Batarseh + 1 more
    • English
    Federal Data Science serves as a guide for federal software engineers, government analysts, economists, researchers, data scientists, and engineering managers in deploying data analytics methods to governmental processes. Driven by open government (2009) and big data (2012) initiatives, federal agencies have a serious need to implement intelligent data management methods, share their data, and deploy advanced analytics to their processes. Using federal data for reactive decision making is not sufficient anymore, intelligent data systems allow for proactive activities that lead to benefits such as: improved citizen services, higher accountability, reduced delivery inefficiencies, lower costs, enhanced national insights, and better policy making. No other government-dedicated work has been found in literature that addresses this broad topic. This book provides multiple use-cases, describes federal data science benefits, and fills the gap in this critical and timely area. Written and reviewed by academics, industry experts, and federal analysts, the problems and challenges of developing data systems for government agencies is presented by actual developers, designers, and users of those systems, providing a unique and valuable real-world perspective.

  • Advances in Parasitology

    • 1st Edition
    • Volume 98
    • English
    Advances in Parasitology, Volume 98, first published in 1963, contains comprehensive and up-to-date reviews on all areas of interest in contemporary parasitology. The latest release in this series contains chapters on The battle against flystrike – past research and new prospects through genomics, Life history, systematics and evolution of the Diplostomoidea Poirier, 1886: progress, promises and challenges emerging from molecular studies, Hook, line and infection: a guide to culturing parasites, establishing infections and assessing immune responses in the three-spined stickleback, and Trypanosoma congolense: a molecular toolkit and resources for studying a major livestock pathogen and model trypanosome. The series includes medical studies of parasites of major influence, such as Plasmodium falciparum and trypanosomes. The series also contains reviews of more traditional areas, such as zoology, taxonomy, and life history, which help to shape current thinking and applications.

  • Neuroepidemiology in Tropical Health

    • 1st Edition
    • Pierre-Marie Preux + 1 more
    • English
    Neuroepidemiology in Tropical Health covers major neurological diseases of relevance in tropical settings and examines the specificities of epidemiology of neurological diseases in the context of tropical countries that face many challenges when compared to the developed world. Part One focuses on methods and their eventual specificities, and how such methods, like sampling, can be adapted for specific scenarios. Parts Two and Three discuss environmental factors and their consequences for neurology in the tropical world, as well as large geographical areas and their specificities. Finally, Part Four presents relevant neurological diseases in in-depth chapters. This invaluable information will help readers recognize the various neurological conditions presented, with the inclusion of their aetiologies and treatment in tropical areas. The book therefore fills a gap in the neuroepidemiology literature, with chapters written by an international collection of experienced authors in the field.

  • Innovative Technologies for Food Preservation

    Inactivation of Spoilage and Pathogenic Microorganisms
    • 1st Edition
    • Francisco J. Barba + 3 more
    • English
    Innovative Technologies for Food Preservation: Inactivation of Spoilage and Pathogenic Microorganisms covers the latest advances in non-thermal processing, including mechanical processes (such as high pressure processing, high pressure homogenization, high hydrodynamic pressure processing, pressurized fluids); electromagnetic technologies (like pulsed electric fields, high voltage electrical discharges, Ohmic heating, chemical electrolysis, microwaves, radiofrequency, cold plasma, UV-light); acoustic technologies (ultrasound, shockwaves); innovative chemical processing technologies (ozone, chlorine dioxide, electrolysis, oxidized water) and others like membrane filtration and dense phase CO2. The title also focuses on understanding the effects of such processing technologies on inactivation of the most relevant pathogenic and spoilage microorganisms to ensure food safety and stability. Over the course of the 20th century, the interest and demand for the development and application of new food preservation methods has increased significantly. The research in the last 50 years has produced various innovative food processing technologies and the use of new technologies for inactivation of spoilage and/or pathogenic microorganisms will depend on several factors. At this stage of development there is a need to better understand the mechanisms that govern microbial inactivation as induced by new and innovative processing technologies, as well as suitable and effective conditions for inactivating the microorganism.

  • Advances in Genetics

    • 1st Edition
    • Volume 98
    • English
    Advances in Genetics, Volume 98 provides the latest information on the rapidly evolving field of genetics, presenting new medical breakthroughs that are occurring as a result of advances in our knowledge of the topic. The book continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines, critically analyzing future directions. Topics of interest in this updated volume include the Genetics of Mitochondrial Disease, a Genetic analysis of depression, happiness and other normal personality traits, The Evolving Centromere and Kinetochore, and The Genetics of Parkinson’s Disease.

  • Basic Finite Element Method as Applied to Injury Biomechanics

    • 1st Edition
    • King-Hay Yang
    • English
    Basic Finite Element Method as Applied to Injury Biomechanics provides a unique introduction to finite element methods. Unlike other books on the topic, this comprehensive reference teaches readers to develop a finite element model from the beginning, including all the appropriate theories that are needed throughout the model development process. In addition, the book focuses on how to apply material properties and loading conditions to the model, how to arrange the information in the order of head, neck, upper torso and upper extremity, lower torso and pelvis and lower extremity. The book covers scaling from one body size to the other, parametric modeling and joint positioning, and is an ideal text for teaching, further reading and for its unique application to injury biomechanics. With over 25 years of experience of developing finite element models, the author's experience with tissue level injury threshold instead of external loading conditions provides a guide to the "do’s and dont's" of using finite element method to study injury biomechanics.

  • The Bifidobacteria and Related Organisms

    Biology, Taxonomy, Applications
    • 1st Edition
    • Paola Mattarelli + 3 more
    • English
    The Bifidobacteria and Related Organisms: Biology, Taxonomy, Applications brings together authoritative reviews on all aspects of Bifidobacteria and related genera. Their place within the Phylum Actinobacteria is discussed first, and this is followed by descriptions of the genera Bifidobacterium, Alloscardovia, Aeriscardovia, Bombiscardovia, Gardnerella, Metascardovia, Parascardovia and Scardovia and the currently accredited species within those genera. The increased availability of genome sequences and molecular tools for studying bifidobacteria provides important information about their taxonomy, physiology and interactions with their host. Also considerations about common bifidobacterial core maintenance during the mutual coevolution of a host and its intestinal microbes could be relevant for health claims for the ability of symbiotic gut bacteria to provide health benefits to their host, and for evaluating such claims in scientifically valid experiments. Chemotaxonomy is important to our understanding of these genera and so is considered along with physiological and biochemical aspects before proceeding to examine clinical and other practical aspects. The ability to maintain pure cultures and to grow cells in industrial quantities when required for applications requires that the cells’ environmental and nutritional needs are well understood. Some species are important clinically and as animal digestive tract synbionts—and even play a part in honey production—so these matters are considered along with milk oligosaccharides’ roles in gut flora development in neonates.

  • History of Risk Assessment in Toxicology

    • 1st Edition
    • Sol Bobst
    • English
    History of Risk Assessment in Toxicology guides the reader through the historical narrative of the evolution of risk assessment thinking in human and environmental practices. Risk assessment concepts are used in many different professional practice areas. In the health and environmental practices of risk assessment, the critical issue is often what chemical concentration in air, water, food, or a solid substance is acceptable, or considered not to result in any adverse effect. The book reviews examples from early scientific and health studies to showcase the foundations of risk assessment. The book also explores the development of risk assessment as practiced by major regulatory bodies such as the US Food and Drug Administration (FDA), the Occupational Safety & Health Administration (OSHA), and the US Environmental Protection Agency (EPA) to reveal how risk assessment has evolved in the 20th and 21st centuries. Modern technology has created opportunities in silicon in vitro, computational modeling, omics, and big data techniques to assess the toxicity of chemicals, while traditional approaches to risk assessment are being challenged with new and innovative approaches. Finally, current issues being debated and tested in risk assessment are outlined with possible future avenues suggested.

  • Mechanical Circulatory and Respiratory Support

    • 1st Edition
    • Shaun D. Gregory + 2 more
    • English
    Mechanical Circulatory and Respiratory Support is a comprehensive overview of the past, present and future development of mechanical circulatory and respiratory support devices. Content from over 60 internationally-reno... experts focusses on the entire life-cycle of mechanical circulatory and respiratory support – from the descent into heart and lung failure, alternative medical management, device options, device design, implantation techniques, complications and medical management of the supported patient, patient-device interactions, cost effectiveness, route to market and a view to the future. This book is written as a useful resource for biomedical engineers and clinicians who are designing new mechanical circulatory or respiratory support devices, while also providing a comprehensive guide of the entire field for those who are already familiar with some areas and want to learn more. Reviews of the most cutting-edge research are provided throughout each chapter, along with guides on how to design new devices and which areas require specific focus for future research and development.

  • Kent’s Technology of Cereals

    An Introduction for Students of Food Science and Agriculture
    • 5th Edition
    • Kurt A. Rosentrater + 1 more
    • English
    Kent’s Technology of Cereals: An Introduction for Students of Food Science and Agriculture, Fifth Edition, is a classic and well-established book that continues to provide students, researchers and practitioners with an authoritative and comprehensive study of cereal technology. This new edition has been thoroughly updated with new sections, including extrusion cooking and the use of cereals for animal feed. In addition, it offers information on statistics, new products, the impact of climate changes and genetics, new economic trends, nutrition regulations and new technologies. The book is useful for students, researchers, and industrial practitioners alike, covering the full spectrum of cereal grain production, processing, and use for foods, feeds, fuels, industrial materials, and other uses.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 82
    • English
    Advances in Clinical Chemistry, Volume 82, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. This updated volume includes chapters on Calcium and Bone Metabolism Indices, Cytokines and MicroRNA in Coronary Artery Disease, Biological and molecular characterization of circulating tumor cells: A creative strategy for precision medicine?, Towards a blood-borne biomarker of chronic hypoxemia: Red cell distribution width and respiratory disease, miRNAs: nanomachines that microManage the pathophysiology of Diabetes mellitus, and Fortilin, A Potential Target for the Prevention and Treatment of Human Diseases. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, and is the benchmark for novel analytical approaches in the clinical laboratory.

  • Environmental Factors in Neurodegenerative Diseases

    • 1st Edition
    • Volume 1
    • English
    Environmental Factors in Neurodegenerative Diseases, Volume One addresses contemporary advances in neurotoxicology, with thematic volumes providing authoritative review articles on key issues in the field. Updates in this new volume include chapters on Air pollution and neurodegenerative diseases, Mercury and Parkinson’s disease, Pesticides and PD: current evidence, Aluminum and neurodegeneration, Microglia and neurodegeneration, Dietary factors, Mitochondria in neurodegeneration, and Manganese and neurodegeneration. Edited by leading experts, volumes are designed as in-depth overviews of the latest topic developments that analyze the effect of varied chemical agents on the nervous system. It is an essential resource for researchers and graduate students alike.

  • Computational Psychiatry

    Mathematical Modeling of Mental Illness
    • 1st Edition
    • Alan Anticevic + 1 more
    • English
    Computational Psychiatry: Mathematical Modeling of Mental Illness is the first systematic effort to bring together leading scholars in the fields of psychiatry and computational neuroscience who have conducted the most impactful research and scholarship in this area. It includes an introduction outlining the challenges and opportunities facing the field of psychiatry that is followed by a detailed treatment of computational methods used in the service of understanding neuropsychiatric symptoms, improving diagnosis and guiding treatments. This book provides a vital resource for the clinical neuroscience community with an in-depth treatment of various computational neuroscience approaches geared towards understanding psychiatric phenomena. Its most valuable feature is a comprehensive survey of work from leaders in this field.

  • Chemical Glycobiology

    Synthesis, Manipulation and Applications of Glycans
    • 1st Edition
    • Volume 597
    • English
    Chemical Glycobiology, Volume 597, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume, the first on chemical glycobiology, contains comprehensive chapters on the Discovery of New Glycosidases from Metagenomic Libraries, Structure-guided directed evolution of glycosidases: A case study in engineering a blood group antigen-cleaving enzyme, A Pipeline for Studying and Engineering Single-Subunit Oligosaccharyltransf... Directed evolution of glycopeptides using mRNA display, Chemoenzymatic Synthesis and Applications of Prokaryote-Specific UDP-Sugars, and Biosynthesis of Legionaminic Acid and its Incorporation into Glycoconjugates. Readers will find the latest information on this developing area of research, as reported by leaders in the field.

  • Gas Bubble Dynamics in the Human Body

    • 1st Edition
    • Saul Goldman + 2 more
    • English
    Gas Bubble Dynamics in the Human Body provides a broad range of professionals, from physicians working in a clinic, hospital or hyperbaric facility, to physical scientists trying to understand and predict the dynamics of gas bubble behavior in the body, with an interdisciplinary perspective on gas-bubble disease. Both iatrogenic and decompression-induce... gas bubbles are considered. The basic medical and physiological aspects are described first, in plain language, with numerous illustrations that facilitate an intuitive grasp of the basic underlying medicine and physiology. Current issues in the field, particularly microbubbles and microparticles, and their possible role in gas-bubble disease are included. The physical and mathematical material is given at several levels of sophistication, with the "hard-core" math separated out in sections labelled "For the Math Mavens", so that the basic concepts can be grasped at a descriptive level. The field is large and multi-disciplinary, so that some of the discussion that is at a greater depth is given separately in sections labelled "In Greater Detail". Skipping these sections for whatever reason, shouldn’t materially hamper acquiring an overall appreciation of the field.

  • Animals and Human Society

    • 1st Edition
    • Colin G. Scanes + 1 more
    • English
    Animals and Human Society provides a solid, scientific, research-based background to advance understanding of how animals impact humans. Animals have had profound effects on people from the earliest times, ranging from zoonotic diseases, to the global impact of livestock, poultry and fish production, to the influences of human-associated animals on the environment (on extinctions, air and water pollution, greenhouse gases, etc.), to the importance of animals in human evolution and hunter -gatherer communities.As a resource for both science and non-science, Animals and Human Society can be used as a text for courses in Animals and Human Society or Animal Science, or as supplemental material for Introduction to Animal Science. It offers foundational background to those who may have little background in animal agriculture and have focused interest on companion animals and horses. The work introduces livestock production (including poultry and aquaculture) but also includes coverage of companion and lab animals. In addition, animal behavior and animal perception are covered.Animals and Human Society is likewise an excellent resource for researchers, academics, or students newly entering a related field or coming from another discipline and needing foundational information, as well as interested laypersons looking to augment their knowledge on the many impacts of animals in human society.

  • Natural and Artificial Flavoring Agents and Food Dyes

    • 1st Edition
    • Volume 7
    • Alexandru Mihai Grumezescu + 1 more
    • English
    Natural and Artificial Flavoring Agents and Dyes, Volume 7 in the Handbook of Food Bioengineering series, examines the use of natural vs. artificial food dyes and flavors, highlighting some of the newest production and purification methods. This solid resource explores the most recent trends and benefits of using natural agents over artificial in the production of foods and beverages. Using the newest technologies and evidence-based research methods, the book demonstrates how natural flavoring agents and dyes can be produced by plants, microorganisms and animals to produce higher quality foods that are more economical and safe to the consumer.

  • Why Penguins Communicate

    The Evolution of Visual and Vocal Signals
    • 1st Edition
    • Pierre Jouventin + 1 more
    • English
    Why Penguins Communicate: The Evolution of Visual and Vocal Signals is a comprehensive and condensed review of several hundred publications on the evolution of penguin behaviors, particularly signaling, linking genetics and ecology via such behavioral adaptations as nuptial displays. This exciting work has developed from the authors’ many years researching on the behavioral strategies of penguins, such as the unique vocal signatures for individual recognition. Studies of penguins on islands surrounding Antarctica are presented, fully showcasing the behavioral significance of visual ornaments (mating displays) and how and why penguins behave via adaptive evolutionary explanations. Through this evolutionary lens, the authors address several questions involving their identification and taxonomy, habitat and location, breeding, and differences between penguins and other seabirds. Each species occupies a unique ecological niche, and behaviors permit separating the species through mutual display. Although model organisms in science are diverse and specialized, we see the entire integration in penguins, from acoustical and optical physics, to behavioral display and speciation. This work highlights the adaptive significance of their behavior through an evolutionary point- of-view.

  • Transfusion Medicine, Apheresis, and Hemostasis

    Review Questions and Case Studies
    • 1st Edition
    • Huy P. Pham + 1 more
    • English
    Transfusion Medicine, Apheresis, and Hemostasis: Review Questions and Case Studies is the collaborative effort that spanned a time period of 2 years and included 50 experts, many whom are national leaders in their respected fields. It also represents the passion and privilege we feel to teach the next generation of physicians in Transfusion Medicine and Apheresis.The main goal for this book is to help the readers build a solid foundation of both basic and advanced conceptual knowledge to prepare for the American Board of Pathology (ABP) certification exam in Transfusion Medicine. This book is not intended to be a substitute for textbooks, original research or review articles, and/or clinical training. Further, since the field of medicine, both from a scientific and regulatory perspective, rapidly changes, the readers are advised to continuously update their knowledge by attending national meetings and reading clinical journals. To equip the readers with the basic knowledge in critical reading and data analysis, which is an essential skill in daily medical practice, a novel chapter titled “Data Interpretation in Laboratory Medicine” was included in this book. In this chapter, the readers are asked to make logical conclusions based on the given data and/or statistical results. Moreover, there is also a chapter on “Practical Calculations in Transfusion Medicine, Apheresis, and Hemostasis” to help consolidate all the necessary formulas commonly used in daily practice for easy reference. These chapters are unique to our book and will not be found in any other currently on the market.All of the questions in this book were originally created by the authors of each chapter. Each question can either be standalone or part of a case scenario representing challenge cases in Transfusion Medicine, Apheresis, and Hemostasis. These questions often represent both rare and common clinical scenarios that the authors have seen during their clinical practice. Each question is then followed by 5 possible answers, with only one being correct (or the best answer). After the question, there is a conceptual explanation followed by a more factual explanation of the right and wrong answers. We gave the individual authors the freedom to choose how they explained the wrong answer choices. Some authors chose to be more direct (e.g. Answer A is incorrect because…), while other authors chose a more conversational style (e.g. Human resources (answer A) includes staffing, selection, orientation, training, and competency assessment of employees). This format is designed to help the student linking the conceptual and factual knowledge together to form a solid foundation for use in clinical practice. At the end of each chapter, there is a list of articles and textbooks that will prove useful to the motivated student who wishes to become an expert in the field. Another special feature to our textbook is the presence of a pre-test and post-test, which are provided to help the readers with self-assessment.As stated above, the main focus of this book is to help the readers preparing for the ABP certification exam in Transfusion Medicine. However, due to the interdisciplinary nature of the field of Transfusion Medicine, Apheresis, and Hemostasis, we believe that this book is also beneficial to and can be used by all clinicians involved in the management of complex transfusion, apheresis, and hemostasis issues, such as hematologists, anesthesiologists, surgeons, and critical care physicians. We further believe that it is a helpful guide for these specialists to prepare for their own specialty certification exam, when the topics are related to Transfusion Medicine, Apheresis, and Hemostasis.

  • Advances in Molecular Toxicology Vol 11

    • 1st Edition
    • Volume 11
    • English
    Advances in Molecular Toxicology, Volume 11, features the latest advances in the subspecialties of the broad area of molecular toxicology. This series details the study of the molecular basis of toxicology by which a vast array of agents encountered in the human environment, and produced by the human body, manifest themselves as toxins. The book is not strictly limited to documenting these examples, but also covers the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events are also reviewed by leading experts in the field.

  • Chordomas and Chondrosarcomas of the Skull Base and Spine

    • 2nd Edition
    • Griffith R. Harsh IV + 1 more
    • English
    Chordomas and Chondrosarcomas of the Skull Base and Spine, Second Edition, is a major reference and guide for neurosurgeons, medical oncologists, neuroscientists, orthopedic surgeons, head and neck surgeons and radiation oncologists that treat patients and research chordomas and chondrosarcomas of the axial skeleton. This book is the unique result of the collaboration of multidisciplinary specialists from a wide variety of fields (neurological sciences, medical oncology, molecular biology, orthopedics and radiation oncology), offering the most relevant information about chordomas and chondrosarcomas of the axial skeleton from each of these fields condensed into one single volume. It contains new medical knowledge and scientific advances regarding the treatment of these types of tumors. Additionally, the book includes chapters written by the Chordoma Foundation and Sarcoma Foundation of America, providing the most valuable information and support for patients and their relatives.

  • New and Future Developments in Microbial Biotechnology and Bioengineering

    Penicillium System Properties and Applications
    • 1st Edition
    • Vijai G. Gupta + 1 more
    • English
    New and Future Developments in Microbial Biotechnology and Bioengineering: Penicillium System Properties and Applications covers important research work on the applications of penicillium from specialists from an international perspective. The book compiles advancements and ongoing processes in the penicillium system, along with updated information on the possibilities for future developments. All chapters are derived from current peer reviewed literature as accepted by the international scientific community. These important fungi were found to secrete a range of novel enzymes and other useful proteins, and are still being extensively studied and improved for specific use in the food, textile, pulp and paper, biocellulosic ethanol production and other industries. The book caters to the needs of researchers/academic... dealing with penicillium spp. related research and applications, outlining emerging issues on recent advancements made in the area of research and its applications in bioprocess technology, chemical engineering, molecular taxonomy, biofuels/bioenergy research and alternative fuel development. In addition, the book also describes the identification of useful compound combinations/enzyme cocktails and the fermentation conditions required to obtain them at an industrial scale. Finally, the book provides updated information on the best utilization of these fungi as a natural tool to meet the next challenges of biotechnology.

  • Biotechnology for Sustainable Agriculture

    Emerging Approaches and Strategies
    • 1st Edition
    • Ram Lakhan Singh + 1 more
    • English
    Biotechnology for Sustainable Agriculture: Emerging Approaches and Strategies is an outstanding collection of current research that integrates basic and advanced concepts of agricultural biotechnology with future development prospects. Using biotechnology with sustainable agriculture effectively contributes to gains in agricultural productivity, enhanced food security, reduced poverty and malnutrition, and more ecologically sustainable means of food production. Written by a panel of experts, this book is unique in its coverage of the broad area of biotechnology for sustainable agriculture. It includes intriguing topics and discussions of areas such as recombinant DNA technology and genetic engineering.

  • Measurement and Analysis of Kinetic Isotope Effects

    • 1st Edition
    • Volume 596
    • English
    Experimental Analysis of Enzyme Mechanism Using Isotope Effects, Volume 596, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this comprehensive update include Measurement of enzyme binding isotope effects, Chemical ligation and isotope labeling to locate dynamic effects, Measurement of heavy enzyme isotope effects, Extracting kinetic isotope effects from a global analysis of reaction progress curves, KIE of metabolic flux and enzymes, Solvent and Primary KIE on Flavin Enzymes, and The Rapid Determination of Primary Deuterium Isotope Effects on Enzyme-Catalyzed Proton Transfer at Carbon in 50/50 HOH/DOD. Readers who are interested in applying or understanding this research will find useful methods currently used for measuring isotope effects on solution and enzyme reactions.

  • Current Developments in Biotechnology and Bioengineering

    Current Advances in Solid-State Fermentation
    • 1st Edition
    • Ashok Pandey + 2 more
    • English
    Current Developments in Biotechnology and Bioengineering: Current Advances in Solid-State Fermentation provides knowledge and information on solid-state fermentation involving the basics of microbiology, biochemistry, molecular biology, genetics and principles of genetic engineering, metabolic engineering and biochemical engineering. This volume of the series is on Solid-State fermentation (SSF), which would cover the basic and applied aspects of SSF processes, including engineering aspects such as design of bioreactors in SSF. The book offers a pool of knowledge on biochemical and microbiological aspects as well as chemical and biological engineering aspects of SSF to provide an integrated knowledge and version to the readers.

  • Comparative Mammalian Haematology

    Cellular Components and Blood Coagulation of Captive Wild Animals
    • 1st Edition
    • C. M. Hawkey
    • English
    Comparative Mammalian Haematology: Cellular Components and Blood Coagulation of Captive Wild Mammals presents a critical review of the hematology of the vertebrates. It discusses the characteristics of blood components of primates; the features of the red cells of carnivores; and the different species of canine. The book covers the blood components of cats, monkeys, bears, mouse, horse, rhinoceros, pig, llama, boars, camels, and deer. The book can provide useful information to hematologists, biologists, students, and researchers.

  • The Prevention of Cardiovascular Disease through the Mediterranean Diet

    • 1st Edition
    • Almudena Sánchez Villegas + 1 more
    • English
    The Prevention of Cardiovascular Disease through the Mediterranean Diet presents dietary habits that will have maximum impact on cardiovascular health and other major chronic diseases. Data collected through the results of large clinical trials, such as PREDIMED, one of the longest trials ever conducted, has allowed researchers to conclude that the Mediterranean Diet provides the best evidence for health benefits. Studies have shown that the Mediterranean Diet is able to reduce the risk of cardiovascular hard clinical events by 30%. This book explores the components of this diet, including the consumption of extra virgin olive oil, nuts, fresh fruits and vegetables, fatty fish, poultry and red wine for optimal health benefits.

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