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Methods in Tau Cell Biology

  • 1st Edition, Volume 141 - August 28, 2017
  • Latest edition
  • Editors: Stuart Feinstein, Nichole Lapointe
  • Language: English

Methods in Tau Cell Biology, Volume 141, the latest release in the Methods in Cell Biology series, looks at methods involved in tau cell biology. Edited by leaders in the field, th… Read more

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Description

Methods in Tau Cell Biology, Volume 141, the latest release in the Methods in Cell Biology series, looks at methods involved in tau cell biology. Edited by leaders in the field, this volume provides proven, state-of-art techniques and relevant historical background and theory that aids researchers with tactics for efficient design and effective implementation of experimental methodologies. Topics of note in this updated volume include sections on Recombinant tau expression and purification, In vitro MT dynamics and MT ends, Methods related to investigating tau structure and MT bundling, Neurite outgrowth and retraction, and Methods related to studying tau fragmentation.

Key features

  • Covers sections on Tau Cell Biology
  • Written by experts in the field of cell biology
  • Includes cutting-edge materials

Readership

Researchers and students in cell, molecular and developmental biology

Table of contents

1. Recombinant tau expression and purification
Stuart Feinstein

2. In vitro MT dynamics and MT ends
Nichole LaPointe

3. Methods related to investigating tau structure and MT bundling
Cyrus R. Safinya

4. Neurite outgrowth and retraction
Brett Cook

5. Methods related to studying tau fragmentation
Adrianna Ferrerira

6. Isoform-specific differences in tau in vitro aggregation
Truman C. Gamblin

7. Cosedimentation assays of microtubule binding
Holly Goodson

8. Methods to study tau aggregation
Songi Han

9. Methods to study tau phosphorylation
Diane Hanger

10. Structure of tau oligomers
Nicholas M. Kanaan

11. Use of mouse models for studies of pathological tau action
Virginia Lee and Sneha Narasimhan

12. Application of FRET and FCS to study tau structure-function
Elizabeth Rhoades

13. Use of the fly system to study tau action
Michelle Steinhilb

14. Single molecule assays with motor proteins
Christopher Berger

15. Tau clearance mechanisms in primary neurons with a focus on autophagy
Gail Johnson

16. Structural studies of tau
Eckhard Mandelkow

17. TIRF assays of tau effects on MT and actin cytoskeletons in vitro
Isabelle Arnal

18. TIRF assays of tau interactions with EB1
Isabelle Arnal

19. A novel approach to address tau biology, pathology, and propagation in vivo in mice using Adeno associated viruses
Susanne Wegmann

Product details

  • Edition: 1
  • Latest edition
  • Volume: 141
  • Published: August 29, 2017
  • Language: English

About the editors

SF

Stuart Feinstein

Dr. Feinstein earned his undergraduate degree in Biochemistry at the University of California, Berkeley and his Ph.D. from the Department of Biochemistry and Biophysics at the University of California School of Medicine, San Francisco. Subsequently, he was a postdoctoral fellow in the Department of Neurobiology at the Stanford University School of Medicine until 1986, at which time he joined the faculty at UCSB. He has served as a grant reviewer for the National Institutes of Health, the National Science Foundation and the Cancer Research Coordinating Committee of California. In 2011, he was appointed a National Academies Education Fellow in the Life Sciences by the National Academies of Science and previously has been awarded a UCSB Distinguished Teaching Award. Dr. Feinstein is presently Co-Director of the Neuroscience Research Institute.
Affiliations and expertise
Co-Director, Neuroscience Research Institute, University of California, Santa Barbara

NL

Nichole Lapointe

Dr. Lapointe has earned her undergraduate degree in Biology & Psychology at the University of Minnesota-Morris, and her Ph.D. in Neuroscience from Northwestern Univeristy. Subsequently, she was a postdoctoral fellow in Univeristy of California, Santa Barbara until 2013, and has continued to serve UCSB as an associate specialist. She is now an assistant project scientist at UCSB, and has participated in a number of research projects and publications, which her research is mainly focused on Tau proteins.
Affiliations and expertise
Assistant Project Scientist, University of California, Santa Barbara

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