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    • Proteomics Mass Spectrometry Methods

      • 1st Edition
      • February 13, 2024
      • Paula Meleady
      • English
      • Paperback
        9 7 8 0 3 2 3 9 0 3 9 5 0
      • eBook
        9 7 8 0 3 2 3 9 0 6 5 2 4
      Proteomics Mass Spectrometry Methods: Sample Preparation, Protein Digestion, and Research Protocols shares best practices collected across key laboratories and core facilities, taking the reader through key tactics for executing the most usual mass spectrometry experiments. Sections review research making use of MS proteomics experiments, focus on critical sample preparation, cover mammalian cell lines and samples from clinical tissue and biological fluids, discuss subcellular fractionation, provide methods for protein digestion both for in gel and in solution, and delve into key MS proteomics analysis protocols, including label-free LC-MS, TMT and iTRAQ labelled LC-MS, phosphorylation enrichment, ubiquination enrichment, and more. This book is the perfect lab manual for research teams or for use as a new staff training material. Core facility managers may also find it useful for sharing best practices with their staff and researchers.

    • DNA Damage and Chromosomal Instability

      • 1st Edition
      • Volume 182
      • February 12, 2024
      • English
      • Hardback
        9 7 8 0 4 4 3 1 8 8 9 8 5
      • eBook
        9 7 8 0 4 4 3 1 8 8 9 9 2
      DNA Damage and Chromosomal Instability, Volume 182 in the Methods in Cell Biology series, presents interesting chapters on a variety of timely topics, including Induction of chromosome-specific micronuclei and chromothripsis by centromere inactivation, Generation of aneuploid cells and assessment of their ability to survive in presence of chemotherapeutic agents, Genetic reporters to detect and quantify homologous recombination in yeast, Mapping histone variant genomic distribution: exploiting SNAP- Tag labelling to follow the dynamics of incorporation of H3 variants, Enrichment of DNA replication intermediates by EdU pull down, Nascent DNA sequencing and its diverse applications in genome integrity research, and much more. Additional chapters cover Enrichment of DNA replication intermediates by EdU pull down, DNA curtains for studying phase separation mechanisms of DNA-organizing proteins, Visualizing the Dynamics of DNA Replication and Repair at the Single-Molecule Molecule Level, Cloning and Expansion of Repetitive DNA Sequences, Using an ImageJ-based script to detect replication stress and associated cell cycle exit from G2 phase by fluorescence microscopy Arne Lindqvist

    • Rare and Complex Urology

      • 1st Edition
      • February 12, 2024
      • Jen Tidman + 1 more
      • English
      • Paperback
        9 7 8 0 3 2 3 9 9 9 3 4 2
      • eBook
        9 7 8 0 3 2 3 9 9 9 3 5 9
      Rare and Complex Urology has been produced by the European Reference Network (ERN) for rare urogenital diseases and complex conditions, ERN eUROGEN.The book combines information on network developments and clinical and surgical aspects, allowing for better diagnoses, treatments, and patient outcomes.The expertise areas covered include those relating to the bladder, stone and kidney diseases, congenital malformations, pelvic floor disorders, the urethra, reconstruction, and rare cancers and tumours.This is a must-have reference for clinicians and basic scientists interested in translational urology and surgery, including urologists, paediatric surgeons, and multidisciplinary team members seeking guidance on how to implement novel research.

    • Systems Biology Approaches for Host-Pathogen Interaction Analysis

      • 1st Edition
      • February 12, 2024
      • Mohd. Tashfeen Ashraf + 2 more
      • English
      • Paperback
        9 7 8 0 3 2 3 9 5 8 9 0 5
      • eBook
        9 7 8 0 3 2 3 9 5 8 9 1 2
      Application and utilization of data science approaches has revolutionized scientific research including host–pathogen interaction analyses. Host–pathogen interactions are generally considered highly specific interactions, resulting in a variety of consequences. Data science approaches coupled with network biology has taken host–pathogen interaction analysis from specific interaction to a new paradigm of understanding the consequences of these interactions within a biological network. Unfortunately, basic biological researchers are mostly unaware of these advancements. Conversely, data scientists are not familiar with biological aspects of such data.Systems Biology Approaches for Host–Pathogen Interaction Analyses benefits biological researchers by expanding the scope of their research and utilization of their accumulated data using recent technological advancements. In addition, the book also opens avenues for bioinformatics and computer science researchers to utilize their expertise in biologically meaningful ways.

    • A Comprehensive Guide to Toxicology in Nonclinical Drug Development

      • 3rd Edition
      • February 11, 2024
      • Ali S. Faqi
      • English
      • Hardback
        9 7 8 0 3 2 3 8 5 7 0 4 8
      • eBook
        9 7 8 0 3 2 3 9 8 4 6 2 1
      **Selected for 2025 Doody’s Core Titles® in Toxicology**A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Third Edition is a valuable reference providing a complete understanding of all aspects of nonclinical toxicology in pharmaceutical research. This updated edition has been expanded and re-developed covering a wide-range of toxicological issues in small molecules and biologics. Topics include ADME in drug discovery, pharmacokinetics, toxicokinetics, formulations, and genetic toxicology testing. The book has been thoroughly updated throughout to reflect the latest scientific advances and includes new information on antiviral drugs, anti-diabetic drugs, immunotherapy, and a discussion on post-pandemic drug development challenges and opportunities. This is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings.

    • Dysphagia

      • 1st Edition
      • February 9, 2024
      • Michael B. Ujiki + 1 more
      • English
      • Paperback
        9 7 8 0 4 4 3 1 9 0 6 3 6
      • eBook
        9 7 8 0 4 4 3 1 9 0 6 4 3
      Dysphagia: A Clinical Guide will help practitioners and surgeons learn and understand how best to diagnose and treat dysphagia. It provides a complete picture of dysphagia through the experiences of leaders who cover the latest techniques and evidence-based outcomes in the field. Coverage includes recent advances in the diagnosis and treatment of the disease processes that cause dysphagia, gastric problems, and surgical intervention. The book includes the latest research and perspectives from both gastroenterologists and surgeons to enable clinicians to stay up-to-date on the most current and effective management strategies. Each chapter provides summary statements and recommendations based on recent literature.Recent discoveries regarding the diagnosis and management of dysphagia are exemplified by illustrations of both diagnostic methods and descriptions of interventional techniques. This an important reference for general surgeons, general practitioners, and ENT surgeons while also bringing new data dedicated specifically to gastroenterologists and foregut surgeons.

    • Huntington’s Disease

      • 1st Edition
      • February 7, 2024
      • X. William Yang + 2 more
      • English
      • Paperback
        9 7 8 0 3 2 3 9 5 6 7 2 7
      • eBook
        9 7 8 0 3 2 3 9 5 6 7 3 4
      Huntington's disease (HD) is one of the most common dominantly inherited neurodegenerative disorders, characterized by a clinical triad of movement disorder, cognitive deficits, and psychiatric symptoms. Huntington’s Disease: Pathogenic Mechanisms and Implications for Therapeutics reviews the most up-do-date content on HD pathogenic mechanisms and cutting-edge thinking on therapeutic strategies for HD. Chapters explore areas that include the clinical features and genetic studies of HD, the cellular and molecular biology of normal huntingtin, a range of HD models, the diverse pathogenic mechanisms linked to mutant huntingtin, new approaches to HD pathogenesis, as well as emerging preclinical therapeutic approaches and clinical programs in the field.

    • Advances in Agronomy

      • 1st Edition
      • Volume 184
      • February 7, 2024
      • English
      • Hardback
        9 7 8 0 4 4 3 2 9 5 2 4 9
      • eBook
        9 7 8 0 4 4 3 2 9 5 2 5 6
      Advances in Agronomy, Volume 184, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field. Each chapter is written by an international board of authors, with this new release including new chapters on The Role of Artificial Intelligence in Crop Improvement, Dealing with the Impact of Climate Change-Induced Drought on the Management of Soil, Challenges and Emerging Opportunities of Weed Management in Organic Agriculture, The Broadbalk Wheat Experiment, Rothamsted, UK: Crop Yields and Soil Changes During the Last 50 Years.

    • The Neuroscience of Bach’s Music

      • 1st Edition
      • February 7, 2024
      • Eric Altschuler
      • English
      • Paperback
        9 7 8 0 4 4 3 1 3 5 1 9 4
      • eBook
        9 7 8 0 4 4 3 1 3 5 2 0 0
      The Neuroscience of Bach’s Music: Perception, Action, and Cognition Effects on the Brain is a comprehensive study of Johann Sebastian Bach’s music through the lens of neuroscience, examining neuroscience using Bach’s music as a tool. This book synthesizes cognitive neuroscience, music theory, and musicology to provide insights into human cognition and perception. It also explores how a neuroscience perspective can improve listening and performing experiences for Bach’s music. Written by a physician-neuroscien... recognized for scholarly articles on Bach’s music, this book uses specific examples to explore neuroscience across Bach’s compositions.The book is structured to discuss the brain’s action, perception, and cognition as connected to specific Bach concertos, tones, notes, and performances. Two guest contributors provide insight into exact mathematical, or topologic, and music theoretic aspects of Bach’s music with implications for cognitive neuroscience.

    • Translational Approaches to Unravelling Non-Motor Symptoms of Parkinson’s disease

      • 1st Edition
      • Volume 174
      • February 7, 2024
      • English
      • Hardback
        9 7 8 0 3 2 3 9 9 1 8 3 4
      • eBook
        9 7 8 0 3 2 3 9 9 1 8 4 1
      Translational Approaches to Non-Motor Symptoms of Neurodegenerative Diseases, Volume 173 in the International Review on Neurobiology series, highlights new advances in the field with this new volume presenting interesting chapters on topics such as A general clinical overview of the non-motor symptoms, Stress/fatigue/cogni... decline Sleep/autonomic failure, A general clinical overview of the non-motor symptoms – psychiatric symptoms, Psychosis, Cognitive Decline, Non-clinical Aspect of non-motor symptoms: Animal Models, Assessment and treatment of cognitive decline in rodent and primate models, Pain in PD models, Affective disorders in PD models, Sleep and circadian dysregulation and EEG disruption in rodent models, and much more.

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