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Books in Toxicology

Elsevier's Toxicology collection provides essential insights for researchers and scientists into mitigating the adverse effects of contaminants on organisms, covering research, analysis, risk assessment, detection, prevention, diagnosis, and treatment of toxic exposure. Including toxicity testing, environmental toxicology it offers valuable knowledge for addressing public health and safety challenges by examining the adverse effects of contaminants on human health, animals, and the environment.

  • Drug-Induced Liver Disease

    • 3rd Edition
    • April 18, 2013
    • Neil Kaplowitz + 1 more
    • English
    This field has shown tremendous growth in recent years, primarily due to the recognition that drug-induced liver disease is the most common cause of liver failure and one of the major contributors to the withdrawal of drugs developed by the pharmaceutical industry. Drug-Induced Liver Disease, 3rd edition is a comprehensive reference that covers mechanisms of injury, diagnosis and management, major hepatotoxins, regulatory perspectives and much more. Written by highly respected authorities, this new edition is an updated and definitive reference for clinicians and scientists in academia, the pharmaceutical industry and government settings. This book contains 4 new chapters on key topics in the area and provides a current and extensive review of the latest developments concerning the toxicology, pharmacology, genetics and immunology of drug-induced liver disease.

  • Nonclinical Study Contracting and Monitoring

    A Practical Guide
    • 1st Edition
    • December 31, 2012
    • William F. Salminen + 2 more
    • English
    Nonclinical Study Contracting and Monitoring: A Practical Guide offers a systematic and straightforward handbook for obtaining high quality preclinical Good Laboratory Practice (GLP) studies. This book is full of real-world examples, processes, procedures, useful templates, checklists and sample reports to provide readers with a better understanding of exactly what happens during all stages of a GLP study and the critical aspects of GLP study design and conduct. Designed for both the novice and experienced scientist, this book covers the GLP regulations and how they impact preclinical studies, the differences between GLP, non-GLP and peer-reviewed studies, preclinical GLP study design, laboratory selection, contracts and business ethics, how to obtain test material for the study, animal sourcing and release for study, preparation of a draft report and much more. By illustrating the overall big picture and tying it together with the individual steps, this book is an essential resource to help scientists ensure a high quality GLP study that passes both scientific and regulatory scrutiny.

  • Xenobiotics and Inflammation

    Roles of Cytokines and Growth Factors
    • 1st Edition
    • December 2, 2012
    • Schook + 1 more
    • English
    The affect of xenobiotics on host resistance in general and specific immune functions has become the focus of much current research. This book synthesises current information on how chemicals (xenobiotics) can affect the immune system to cuse dysfunction, focusing on the process of inflammation. It provides a much needed, single-source reference for researchers investigation the mechanisms responsible for altered host resistance following exposture to xenobiotics. Emphasis is placed on the roles of cytokines and growth factors in the inflammatory process and how such processes are altered and modulated by xenobiotics. This volume contains information pertinent to those exploring cell growth, angiogenesis, hematopoetic differentiation, and recruitment to and proliferation of cells in various tissue sites. This volume brings together experts in inflammation, cytokines, cell growth, immunology and toxicology to provide a highly yseful volume modulated by chemicals. Divided into three sections, the book offers an organ system approach to understanding inflammation and xenobiotics.

  • Pyrethrum

    The Natural Insecticide
    • 1st Edition
    • December 2, 2012
    • John Casida
    • English
    Pyrethrum: the Natural Insecticide covers the papers presented at the 1972 ""International Symposium on Recent Advances with Pyrethrum the Natural Insecticide"" held in conjunction with the American Institute of Biological Sciences Silver Anniversary Meeting at the University of Minnesota, Minneapolis. It deals with all aspects of pyrethrum, including its history, production, chemistry, biochemistry, toxicology, pharmacology, and agricultural applications. The introductory part addresses the early history of pyrethrum, its recognition as a modern insecticide, and its worldwide production. The chemistry and biochemistry parts discuss the composition, isolation, structure, synthesis, biosynthesis, metabolism, and action on enzyme systems of natural pyrethrins extracted from pyrethrum flower. The book also examines the toxicology of pyrethrum and its constituents to mammals, fish, and wildlife, as well as tests for possible teratogenic, carcinogenic, mutagenic, and allergenic activities. Finally, it discusses the domestic and agricultural applications of pyrethrum. Considering its desirable features, researchers find pyrethrum unsurpassed by any type of synthetic organic insecticide and even by the best synthetic analogs or pyrethroids.

  • Enzymatic Basis of Detoxication Volume 2

    • 1st Edition
    • December 2, 2012
    • William B. Jakoby
    • English
    Enzymatic Basis of Detoxication, Volume II, reviews the state of knowledge on foreign compound metabolism at the level of what specific enzymes can do. The book attempts to provide a holistic view of the information gleaned from work with specific, purified enzymes encompassing as many mammalian sources as have been studied. The book is organized into two parts. Part I on conjugation reactions and related systems includes studies on the properties of glucuronide formation; the physiological function, assay, and purificatgion of function of bilirubin-glucuronos... glucuronosyltransfer... the roles of N- and O-methylation reactions and glutathione transferases in detoxication; and amino acid conjugation. Part II presents studies on hydrolytic systems, covering the role of epoxide hydrolase, carboxylesterases, and amidases in detoxication and the regulatory effects of these enzymes. This book provides pharmacologists and toxicologists with the biochemical view of detoxication, and biochemists with the corresponding pharmacological and toxicological aspects.

  • Handbook of Mutagenicity Test Procedures

    • 2nd Edition
    • December 2, 2012
    • B.J. Kilbey + 3 more
    • English
    The compilation of this book was prompted by the necessity of a bench volume which could provide the necessary background information on materials, experimental design, pitfalls and dificulties, in order to perform a particular test in an acceptable way with a minimal need for additional expert help. This Second Edition updates this information, providing: - a comprehensive bench guide - methods known to be reliable - a broad spectrum of approaches - tips to avoid pitfalls when using unfamiliar techniques - data from population records - safety aspects of mutagens and carcinogens - basic statistical concepts for experiment design This `on the bench' methodological text provides the necessary information for most of the common assays for genetic damage in use. The book includes methods which have been sufficiently used and tested to make their use reliable, but also presents methods which are not widely used at present, but which might prove most useful in screening for mutagenic effects.

  • Agricultural and Industrial Applications Environmental Interactions

    An Advanced Treatise
    • 1st Edition
    • December 2, 2012
    • Dewayne Torgeson
    • English
    Fungicides, Volume I: Agricultural and Industrial Applications, Environmental Interactions discusses the application, use, and environmental interactions of fungicides. This book is organized into 15 chapters that cover the commercial development of fungicide and the organism's interaction with the environment. After discussing the history of fungicides, the book presents data on world fungicide usage and how this usage is influenced by epidemiology. It then describes procedures and approaches for commercial fungicide development; practical tests and laboratory techniques for agricultural fungicide toxicity; and significance of fungicide formulation that is determined by a variety of factors, including cost and biological efficiency. The following chapters discuss technological evolution, both in chemical fungicides and in the machinery for their application for soil and seed treatment. The application of foliar and postharvest fungicides and the use of other fungicides as industrial and wood preservatives is also tackled. The last four chapters are concerned with the various interactions between fungicides and the environment which may cause them to be more or less effective. The book will be useful to researchers, advanced students, and professional workers in the fungicide field of study who are concerned with the synthesis and development of better fungicides or their mode of action.

  • Enzymatic Basis of Detoxication Volume 1

    • 1st Edition
    • December 2, 2012
    • William B. Jakoby
    • English
    Enzymatic Basis of Detoxication, Volume I focuses on the catalytic mechanisms and physiological expression of the enzymes that are involved in the detoxication of foreign compounds. The book explores foreign compound metabolism at the level of what specific enzymes can do. This book is organized into three sections and comprised of 17 chapters. The discussion begins with an overview of detoxication and covers both catalytic and non-catalytic removal of foreign substances, along with the general properties of the enzymes that are active in detoxication. The reader is then introduced to the physiological aspects of detoxication, paying particular attention to the kinetic aspects of metabolism and elimination of foreign compounds in animals, human genetic variation in detoxication enzymes, and how such enzymes are induced. The next section focuses on mixed function oxygenase systems and includes chapters on cytochrome P-450 and the detoxication reactions it catalyzes. The book also considers other oxidation-reduction systems, with reference to alcohol dehydrogenase, aldehyde reductase, aldehyde oxidizing enzymes, ketone reductases, xanthine oxidase and aldehyde oxidase, glutathione peroxidase, and superoxide dismutases. The final chapter is devoted to monoamine oxidase, its properties, substrate specificity, inhibitors, kinetics and mechanism, and multiple forms. Pharmacologists, toxicologists, and biochemists will find this book extremely helpful.

  • Titrations in Nonaqueous Solvents

    • 1st Edition
    • December 2, 2012
    • Huber Walter
    • English
    Titrations in Nonaqueous Solvents discuss the theory, practice, and data on acidic and basic strength of nonaqueous solvents. This book is organized into three parts encompassing six chapters. The first part considers the general principles of acids and bases and methods of end-point determination. This part also covers the fundamentals, advantages, and limitations of titration instruments, such as potentiometers, burets, titration vessels, and electrodes. The classification of titration solvents according to their functions as color indicators and titrant solutions is provided in this part. The remaining parts describe the analytical procedures for acidity and basicity of nonaqueous solvents. These parts also provide a tabulated data on the acidic and basic strengths, stability, and dissociation constants of various titration solvents. Analytical chemists, and analytical chemistry teachers and students will find this book invaluable.

  • Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products

    • 2nd Edition
    • December 2, 2012
    • R.D. Kimbrough + 1 more
    • English
    The chemical industry is increasingly faced with problems arizing from chemicals produced during the manufacture of halogenated biphenyls or phenols. Knowledge of these chemicals and their destructive properties is sporadic, and the acute toxicity of this group varies widely. This informative revised edition presents the chemistry, environmental pollution problems, animal toxicology and information about structure-activity relationships. A brief overview is given of worker exposure and occupational illness. The book is divided into three parts: chemistry and environmental contamination; experimental toxicology; and human exposure and effects. Because of the great deal of interest in these compounds much new research work has been conducted since the first edition of this book was published. This revised edition has retained the effectiveness and clarity of the first edition, while being supplemented with new information, condensed old information, and examples of recent incidents.

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