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Books in Toxicology

Elsevier's Toxicology collection provides essential insights for researchers and scientists into mitigating the adverse effects of contaminants on organisms, covering research, analysis, risk assessment, detection, prevention, diagnosis, and treatment of toxic exposure. Including toxicity testing, environmental toxicology it offers valuable knowledge for addressing public health and safety challenges by examining the adverse effects of contaminants on human health, animals, and the environment.

  • Advances in Drug Delivery Systems, 6

    Proceedings of the Sixth International Symposium on Recent Advances in Drug Delivery Systems, Salt Lake City, UT, U.S.A., February 21-24, 1993
    • 1st Edition
    • James M. Anderson + 2 more
    • English
    Advances in Drug Delivery Systems, 6 focuses on the progress in drug delivery systems as manifested in the fields of international pharmaceutics, polymer science, biotechnology, molecular biology, and cell biology. The selection first tackles biologically engineered microstructures and approaches to targeting bioactive compounds. Discussions focus on therapeutic efficiency of fatty acylated antiviral antibodies; effect of artificial fatty acylation on protein binding and uptake; and controlled release of proteins from lipid microcylinders. The text then elaborates on mucosal delivery of macromolecules and targeted delivery of diagnostic agents by surface-modified liposomes. The book examines the factors on in vitro micelle stability of adriamycin-block copolymer conjugates; vaginal and reproductive system treatments using a bioadhesive polymer; and control of the disposition profiles of proteins in the kidney via chemical modification. The publication also takes a look at drug delivery using biodegradable microspheres; approaches to improved antibody- and peptide-mediated targeting for imaging and therapy of cancer; and biodegradable microspheres for the delivery of oral vaccines. The selection is a valuable source material for scientists and readers interested in the advances in the systems of drug delivery.

  • Algal and Fungal Toxins

    A Comprehensive Treatise
    • 1st Edition
    • Solomon Kadis + 2 more
    • English
    Microbial Toxins, Volume VII: Algal and Fungal Toxins reviews research and investigations on algal and fungal toxins. This book discusses the distribution of poisonous dinoflagellates; pharmacology of blue-green algal toxins; control of Prymnesium and detection of toxin in nature; and F-2 (zearalenone) estrogenic mycotoxin from Fusarium. The effect of Fusarium toxins in animals; mycotoxins produced by Fusarium tricinctum NRRL 3249; and mold growth and production and isolation of trichothecenes are also elaborated. This publication likewise covers the chemistry of scirpene toxic substances of Fusarium nivale; isolation of salivation factor; and mammalian toxicity of epidithiadioxopipera... This volume is a useful reference for scientists and graduate students in various disciplines —microbiology, biochemistry, pharmacology, epidemiology, oncology, and related fields.

  • Marijuana

    Effects on Human Behavior
    • 1st Edition
    • Loren L. Miller
    • English
    Marijuana: Effects on Human Behavior attempts to synthesize much of the existing experimentation concerning the acute and chronic effects of marijuana and its derivatives on human behavior. The book opens with a chapter on the strategies for conducting research on marijuana. It also describes a clinical study at the University of British Columbia. The next chapter discusses the issues that have beclouded the question of legalization of marijuana in the United States. This is followed by separate chapters on the effects of marijuana on motor and mental performance; marijuana-memory research; a model of attention which can be used to describe the effects of marijuana use on cognition; and the effects of marijuana on neuropsychological functioning and learning. Subsequent chapters examine the behavioral actions of cannabis in man; compare the behavioral actions of cannabinoids in humans with those found in infrahumans, with special reference to acquisition and retention processes, timing behavior, state-dependent learning, and attention; and investigate the long-term effects of cannabis use.

  • Toxicology of Chemical Mixtures

    Case Studies, Mechanisms, and Novel Approaches
    • 1st Edition
    • Raymond S.H. Yang
    • English
    Although toxicologic studies in the laboratory often focus on a single chemical, in the larger world, mixtures of chemicals are routinely encountered. Toxicology of Chemical Mixtures examines the mechanisms of interactions and health effects stemming from chemical mixtures in the environment. Toxicologists, pharmacologists, environmental scientists, and professionals involved in environmental clean-ups will benefit from its content.Emphasis is on low-level, long-term exposure.

  • Bioreduction in the Activation of Drugs

    Proceedings of the Second Biochemical Pharmacology Symposium, Oxford, UK, 25-26 July 1985
    • 1st Edition
    • P. Alexander + 2 more
    • English
    Bioreduction in the Activation of Drugs covers the proceedings of the Second Biochemical Pharmacology Symposium. The book presents papers that cover the applications of bioreduction in drug activation, along with its concerns. The text first presents materials about enzymology, such as overview of enzyme systems involved in bioreduction of drugs and in redox cycling, and reductive role of glutathione in the redox cycling of oxidizable drugs. Next, the book covers papers on bacterial and parasites infection, which include reduction by the gut microflora of animals and human and reduction of nitroimidazoles in vitro and DNA damage. The remaining articles deal with cancer treatment, such as hypoxia-mediated nitro-heterocyclic drugs in the radio- and chemotherapy of cancer, and the biological properties of reduced nitroheterocyclics and possible underlying biochemical mechanisms. The text will be of great use to researchers and practitioners of medicine, pharmacology, and biochemistry.

  • Pharmacology of Central Synapses

    • 1st Edition
    • V. V. Zakusov
    • English
    Pharmacology of Central Synapses deals with the pharmacology of the central nervous system and the mode of action of neurotropic drugs based on their influence on synaptic transmission. The neuronal structure of the nervous system, the structure of the synapses, and the phenomena of electrochemical transmission are discussed in this context. The main propositions of the synaptic theory of the action of neurotropic drugs, based on morphological, physiological, and biochemical findings, form the conceptual basis of this book. Comprised of eight chapters, this book examines the effect of neurotropic drugs on the synaptic transmission in reflex, projection, and association (commissural) tracts. The specific effects of various narcotics, neuroleptics, tranquillizers, analgesics, antidepressants, and stimulants on synaptic transmission in various structures of the central nervous system and at its different levels are described. This text also considers the differences in the sensitivity to such drugs of various synapses and their influence on the selectivity of drug action. This book explains the influence of neurotropic drugs on such aspects of nervous activity as impulse summation, after-discharge and functional lability, central inhibition, and the neurochemical mechanisms, particularly those involving monoaminergic, cholinergic, serotoninergic, and GABA-ergic components of synaptic transmission. The final chapter focuses on the effect of psychotropic drugs on behavior. This book will be helpful to scientists representing all the major areas of pharmacology, including clinical pharmacology and toxicology, as well as to internists, psychiatrists, neurologists, and anesthesiologists.

  • Fungal Toxins

    • 1st Edition
    • Solomon Kadis + 2 more
    • English
    Microbial Toxins: A Comprehensive Treatise, Volume VIII, Fungal Toxins is devoted to topics related to algal and fungal toxins and includes critically reviewed articles from different experts in related fields. The text is divided into three sections. Section A covers coumarins — its isolation, identification, biological action, natural occurrence, and uses. Section B deals with the epizootiology, clinical characteristics, and pathological findings of Stachybotryotoxicosi... Section C talks about phytopathogenic and helminthosporium toxins, toxic peptides found in Amanita species as well as other mushroom toxins, compounds accumulating in plants after an infection, and ergot. The book is recommended for microbiologists and toxicologists, especially those who would like to know more about the toxins produced by algae and fungi and their effects.

  • Advances in Drug Research

    • 1st Edition
    • Volume 22
    • Bernard Testa
    • English
    Advances in Drug Research, Volume 22 focuses on the concepts and facts of drug research. This book is divided into four chapters. Chapter 1 discusses the use of atomic properties and atom-centered indices in QSAR models, while Chapter 2 describes the pharmacokinetics of peptides and proteins. The nuclear receptors, emphasizing the aspects of molecular and genomic pharmacology are elaborated in Chapter 3. The last chapter covers the medicinal chemistry of a vast group of agents acting on nuclear receptors. This publication is valuable to drug researchers and students interested in advances in drugs.

  • The Physiology and Pharmacology of the Microcirculation

    • 1st Edition
    • Nicholas A. Mortillaro
    • English
    The Physiology and Pharmacology of the Microcirculation, Volume 2, discusses the microcirculatory function of specific organ systems. The first volume of The Physiology and Pharmacology of the Microcirculation presented some general aspects of microcirculatory function and then concentrated on the microcirculation of a specific organ system, namely, brain, eye, heart, and kidneys. This second and final volume continues the presentation of microcirculatory function of specific organ systems. The book begins with a chapter on the microcirculation of the lungs, with a description of its microcirculatory features and current methods of study. This is followed by separate chapters on the microcirculation of the splanchnic organs. These include the stomach, emphasizing hemodynamics, tissue oxygenation, and control of blood flow; the small and large intestine. Subsequent chapters deal with the microcirculatory responses of both the liver and spleen to different physiological and pharmacological challenges; the microcirculation of the skin, with emphasis on human microcirculation; normal and abnormal microcirculatory dynamics in skeletal muscle; microcirculation of bone; and microcirculation of the salivary glands and exocrine pancreas. The final chapter presents a selective review of pathological events involving the microcirculation, with the emphasis directed toward human diseases.

  • Symposium on Clinical Pharmacology

    Biochemical Pharmacology
    • 1st Edition
    • William A. Creasey + 2 more
    • English
    Symposium on Clinical Pharmacology reviews advances in clinical pharmacology, with emphasis on how to materially improve the efficacy of cancer chemotherapy. Topics range from absorption, protein binding, distribution, and excretion of antineoplastic drugs to factors affecting the biotransformation and activity of antitumor drugs. The transport of tumor-inhibitory agents across cell membranes is also examined, together with factors influencing drug selectivity and the mechanisms of clinical drug resistance. This volume is comprised of 23 chapters and begins with a brief summary of the different kinds of pharmacokinetic models and how detailed kinetic investigations of a drug in animals may provide further insight into modes of its clinical use. The next chapter considers the chief factors in determining the effective concentration of a drug at a receptor site as well as the duration and intensity of drug effect, citing antineoplastic agents as examples. The role of enzymatic activation and inactivation in drug selectivity is also discussed, along with the general mechanisms of clinical resistance to cancer chemotherapy; biochemical and pharmacological principles of combination chemotherapy; and the reaction and effects of nitrosoureas. This book will be of interest to clinicians, pharmacologists, and biochemists.

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