Skip to main content
View Cart

Books in Toxicology

Elsevier's Toxicology collection provides essential insights for researchers and scientists into mitigating the adverse effects of contaminants on organisms, covering research, analysis, risk assessment, detection, prevention, diagnosis, and treatment of toxic exposure. Including toxicity testing, environmental toxicology it offers valuable knowledge for addressing public health and safety challenges by examining the adverse effects of contaminants on human health, animals, and the environment.

  • A Textbook of Medical Jurisprudence and Toxicology

    • 6th Edition
    • Rai Bahadur Jaising P. Modi
    • English
    A Textbook of Medical Jurisprudence and Toxicology, Sixth Edition discusses medico-legal points concerning the different causes of death, examination of evidence, and crimes that merit medical attention and advice. The author reviews the legal procedures in criminal courts of medical jurisprudence, including the inquest procedures, the difficulties encountered in detecting crime, medical evidence, rules for presenting evidence, and the powers of criminal courts. The post-mortem examination concerns the external and internal examination of the deceased to establish identity (if unknown), to determine time and cause of death. Under the written orders of the court, an exhumation can take place when suspicions of foul play arises after death. The author discusses death in terms of somatic (physical) or molecular (tissues and cells dying individually after vital organs have stopped functioning). The book also describes in detail the primary modes of dying, namely, syncope, asphyxia, and coma. The book explains the medico-legal aspects of injuries, pregnancy, legitimacy, rape, miscarriage, infanticide, and insanity. This book is intended for medical students, but can also benefit students in law courses, and practitioners of legal jurisprudence and of the medical sciences.

  • Drug Therapy During Pregnancy

    • 1st Edition
    • Tom K. A. B. Eskes + 1 more
    • English
    Drug Therapy During Pregnancy is a collection of papers dealing with the risks and benefits of drug treatment for both mother and fetus. One paper notes that the total use of medication during pregnancy in the Netherlands has decreased from 82.7 % to 71.7 %. The paper also points out the lack of a relationship between the number or type of congenital anomalies and the use of medication. Another paper assesses fetal drug exposure in two ways: firstly, through the physicochemical characteristics of the drug and the way it is handled by the mother in order to estimate placental passage and fetal exposure. Secondly, through the utilization of pharmacokinetic models estimating the probable time course of drug concentrations in the feto-maternal unit. One paper investigates the effects of hypertension during pregnancy, in which the etiology of hypertension, a group of disorders with one common abnormality, remains unsolved with a clinical diagnosis that is not always accurate. Treatment differs widely depending on the type: chronic hypertension, albuminuric hypertension, and hypertensive crises during pregnancy. One paper suggests that to prove any environmental exposure to a particular substance affecting pregnancy, the exact timing of exposure must be established, large samples are necessary, possibly on a national or international scale. The paper cites as example the four-year documentation period of the 50% to 80% incidence of malformations due to thalidomide. General medicine practitioners, obstetricians, gynecologists, and researchers dealing with pharmacology, pharmocokinetics, toxicology, or embryology will find the collection valuable.

  • Progress in Chemical Toxicology

    Volume 3
    • 1st Edition
    • Abraham Stolman
    • English
    Progress in Chemical Toxicology, Volume 3 explores the developments in methods and instrumentation for toxicological analyses. This book is composed of eight chapters, and begins with a description of the pharmacologic and physiologic effects of aliphatic alcohols. The succeeding chapter deals with the methods of analysis of various volatile poisons, such as halogenated aliphatic compounds, aromatic hydrocarbons, and acid compounds. A chapter focuses on the methods of determination and classic procedures for carbon monoxide analysis in breath and blood. These topics are followed by discussions on the development of spectrochemical methods chemical and radiochemical methods of determination of radionuclides in human bones and tissues; and the toxic effects of combined drug action. The last chapter examines the poison residue occurrence in human tissues. This book is of great value to toxicologists and public health workers and researchers.

  • Pharmacology for Student and Pupil Nurses and Student Pharmacy Technicians

    • 1st Edition
    • Bernard R. Jones
    • English
    Pharmacology for Student and Pupil Nurses and Student Pharmacy Technicians is based on lectures presented to nurses in training for the State Registration and State Enrollment Examinations and to Students in Dispensing. The book presents an account of drugs that are in use or are very likely to be used. The text includes description of drug administration; antacids, gastric sedatives, laxatives, antidiarrheal, and diuretics are discussed in detail. The intravenous infusions, cardiovascular drugs, anti-anemics, hemostatics, and anticoagulants are described as to their effects and functions. A brief anatomy of the human circulatory process is presented. The next types of drugs discussed are those that target the respiratory system — expectorants and cough sedatives. The effects of sedatives, stimulants, analgesics, and anesthesia on the nervous system are discussed in detail. Antibiotics, drugs combating infection, tropical diseases, sera, and vaccines as prophylactic and therapeutic remedies are explained. Other drugs, such as antiseptic and disinfectants, drugs used in endoctrine therapy and malignant diseases, as well as drugs that are locally applied and those used in diagnosis are explained. The process of ordering, storage, and administration of drugs; calculations used in determining safe dosages; and the poisons regulations concerning dangerous and potentially harmful drugs are covered in detail. Pharmacists, student pharmacy technicians, professors of pharmacology, practitioners of general medicines, and specialists with interests in drug therapy will find this reference valuable.

  • Neonatal Clinical Pharmacology and Therapeutics

    • 1st Edition
    • George Rylance + 2 more
    • English
    Neonatal Clinical Pharmacology and Therapeutics covers the significant advances in clinical pharmacology and the principles of neonatal therapeutics. This book is composed of 20 chapters that tackle various neonatal diseases and their corresponding therapeutic options. The opening chapters review the pharmacological principles and kinetics, placental drug transfer, and drug therapy in pregnancy. The next chapters consider the other aspects of clinical pharmacology, including tocolytics, oxytocin, maternal drug use, neonatal withdrawal, prophylaxis, and the effect of material analgesia and anesthetics on newborn. Considerable chapters are devoted to the treatment options of neonatal diseases, including apnea, pulmonary and systemic disorders, cardiac diseases, jaundice, hypoglycemia, and nutrient deficiencies. The remaining chapters discuss other therapeutic options, such as blood cell component therapy, the use of analgesia and muscle relaxants, and parenteral nutrition. This book is intended primarily for all doctors who care for newborn babies and clinical pharmacologists.

  • Experiments with Drugs

    Studies in the Relation between Personality, Learning Theory and Drug Action
    • 1st Edition
    • H. J. Eysenck
    • English
    Experiments With Drugs: Studies in the Relation between Personality, Learning Theory and Drug Action provides a report of a series of experiments, conducted to test the effects of certain groups of drugs, depressants and stimulants, on human behavior. The book presents a number of experiments, together with the theoretical rationale underlying their development. The text begins with a chapter that sets the stage for the exposition of the various concepts and findings on drug effects on behavior. Subsequent chapters deal with particular subjects such as personality and drug effects; the effects of stimulant and depressant drugs on visual and auditory masking; excitation-inhibitio... and the theory of neurosis; interaction effects of drugs; and the influence of stimulant and depressant drugs on the central nervous system. Psychologists, biochemists, and researchers in the field of psychopharmacology will find the book useful and incisive.

  • Advances in Endogenous and Exogenous Opioids

    Proceedings of the International Narcotic Research Conference (Satellite Symposium of the 8th International Congress of Pharmacology) Held in Kyoto, Japan on July 26–30, 1981
    • 1st Edition
    • Hiroshi Takagi + 1 more
    • English
    Advances in Endogenous and Exogenous Opioids contains the proceedings of the International Narcotic Research Conference (Satellite Symposium of the 8th International Congress of Pharmacology) held in Kyoto, Japan on July 26-30, 1981. The conference provided a forum for discussing advances that have been made in the understanding of endogenous and exogenous opioids and tackled a wide array of topics ranging from novel opiate binding sites selective for benzomorphan drugs to the purification of opioid receptors and sequellae of receptor binding. Comprised of 156 chapters, this book begins with an analysis of the interaction of opioid peptides and alkaloid opiates with mu-, delta-, and kappa-binding sites. The reader is then systematically introduced to biochemical evidence for kappa and sigma opiate receptors; the action of morphine and oxymorphone as partial agonists on the field-stimulated rat vas deferens; mechanisms of supersensitivity in the enkephalinergic system; and properties of the solubilized opiate receptor from human placenta. Subsequent chapters explore the biosynthesis of opioid peptides as well as their localization, release, and degradation; physiological and pharmacological actions of opioids; and the use of analgesia in acupuncture. Results of behavioral and clinical studies of endogenous and exogenous opioids are also presented, and the structure-activity relationships of opioids are examined. This monograph will be of interest to students, practitioners, and researchers in the fields of psychiatry and pharmacology.

  • Mechanisms of Drug Resistance in Neoplastic Cells

    Bristol-Myers Cancer Symposia, Vol. 9
    • 1st Edition
    • Paul V. Woolley + 1 more
    • English
    Bristol-Myers Cancer Symposia, Volume 9: Mechanisms of Drug Resistance in Neoplastic Cells provides information on both basic scientific and clinical studies on the causes and implications of tumor cell resistance to common antineoplastic agents. The book describes the colon cancer as a model for resistance to antineoplastic drugs; mathematical modeling of drug resistance; and the mechanism of induced gene amplification in mammalian cells. The text also discusses the cellular concomitants of multidrug resistance; resistance to alkylating agents; and the phosphoprotein and protein kinase C changes in human multidrug-resistant cancer cells. Novel drugs that affect glutathione metabolism; the regulation of genes encoding drug-metabolizing enzymes in normal and preneoplastic tissues; and the relevance of glutathione S-transferases to anticancer drug resistance are also considered. The book further tackles the cellular resistance to cyclophosphamide; the preclinical and clinical experiences with drug combinations designed to inhibit DNA repair in resistant human tumor cells; and the modification of the cytotoxicity of DNA-directed chemotherapeutic agents by polyamine depletion. The text also demonstrates multidrug resistance and the circumvention of resistance. Oncologists, molecular biologists, biochemists, geneticists, and pharmacologists will find the book invaluable.

  • Toxicology and Occupational Medicine

    Proceedings of the Tenth Inter-American Conference on Toxicology and Occupational Medicine, Key Biscayne (Miami), Florida, October 22-25, 1978
    • 1st Edition
    • William B. Deichmann
    • English
    Toxicology and Occupational Medicine documents the proceedings of the Tenth Inter-American Conference on Toxicology and Occupational Medicine held in Key Biscayne (Miami), Florida, on 22-25 October 1978. The purpose of the conference was the presentation by delegates of research reports on subjects in the broad field of Toxicology and Occupational Medicine, followed by free discussions by all participants. This volume contains 47 papers and begins by tracing the history of the Inter-American Conferences. Subsequent chapters present papers on topics such as legal and scientific concerns over food safety; factors to consider to ensure the validity of the design of the experiment, the procedure for carrying it out, and the method of interpreting the results; and comparison of mutagenic, carcinogenic, and epidemiological data on known human carcinogens. Other papers cover the hidden carcinogen in the manufacture of isopropyl alcohol; developments in protecting workers from chemical hazards on the job; and safety evaluation of cosmetic ingredients.

  • Man and Biologically Active Substances

    The Effect of Drugs, Diet and Pollution on Health
    • 1st Edition
    • I. I. Brekhman
    • English
    Man and Biologically Active Substances: The Effect of Drugs, Diet and Pollution on Health discusses the theory and the aims of pharmacosanation; the pharmacosanation medicaments; and the future of pharmacosanation.

Related subjects