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Books in Toxicology

Elsevier's Toxicology collection provides essential insights for researchers and scientists into mitigating the adverse effects of contaminants on organisms, covering research, analysis, risk assessment, detection, prevention, diagnosis, and treatment of toxic exposure. Including toxicity testing, environmental toxicology it offers valuable knowledge for addressing public health and safety challenges by examining the adverse effects of contaminants on human health, animals, and the environment.

BooksJournals

    • Nonclinical Development of Novel Biologics, Biosimilars, Vaccines and Specialty Biologics

      • 1st Edition
      • June 27, 2013
      • Lisa M. Plitnick + 1 more
      • English
      • Hardback
        9 7 8 0 1 2 3 9 4 8 1 0 6
      • eBook
        9 7 8 0 1 2 3 9 4 8 2 3 6
      Nonclinical Development of Novel Biologics, Biosimilars, Vaccines and Specialty Biologics is a complete reference devoted to the nonclinical safety assessment of novel biopharmaceuticals, biosimilars, vaccines, cell and gene therapies and blood products. This book compares and contrasts these types of biologics with one another and with small molecule drugs, while incorporating the most current and essential international regulatory documents. Each section discusses a different type of biologic, as well as early characterization strategies, principles of study design, preclinical pharmacokinetics and pharmacodynamics and preclinical assays. An edited book that is authored by leading experts in the field, this comprehensive reference provides critical insights to all researchers involved in early through late stage biologics.

    • Advances in Drug Research

      • 1st Edition
      • Volume 20
      • October 22, 2013
      • Bernard Testa
      • English
      • Hardback
        9 7 8 0 1 2 0 1 3 3 2 0 8
      • Paperback
        9 7 8 1 4 8 3 2 3 4 9 2 2
      • eBook
        9 7 8 1 4 8 3 2 6 5 4 3 8
      Advances in Drug Research, Volume 20 focuses on the general themes of drug research and description of specific drug classes. This book is divided into four chapters. Chapter 1 discusses the extrapolation of toxicological and pharmacological data from animals to humans. The second chapter deals with the tissue binding of drugs, considering the relative ponderal importance of tissue versus blood macromolecules. The therapeutic use of plants and consumption of medicinal plants are elaborated in Chapter 3. The last chapter covers the field of histaminergic agonists and antagonists, describing breakthroughs such as H2-receptor antagonists, non-sedating H1-receptor antagonists, and H3-receptors. This publication is valuable to drug researchers and students interested in advances in drugs.

    • Beyond Drugs

      • 1st Edition
      • October 22, 2013
      • Stanley Einstein
      • English
      • Paperback
        9 7 8 1 4 8 3 1 2 5 0 3 9
      • Hardback
        9 7 8 0 0 8 0 1 7 7 6 7 0
      • eBook
        9 7 8 1 4 8 3 1 5 7 4 5 0
      Beyond Drugs is a 12-chapter book that first presents the critical issues and definitions involved in the study of drug abuse. Subsequent chapters describe the effects of drugs, the drug users, and the contemporary drug culture. Other chapters talk about education, prevention, treatment, and legal control efforts of drug abuse. This book will be useful to those who are generally concerned about drug abuse.

    • Natural Toxins

      • 1st Edition
      • October 22, 2013
      • C.L. Ownby + 1 more
      • English
      • eBook
        9 7 8 1 4 8 3 2 8 6 8 1 5
      The 9th World Congress on Animal, Plant and Microbial Toxins was sponsored by the International Society on Toxinology which recently celebrated its 25th anniversary. The Society was organized to promote research into all aspects of natural toxins, and to help with the dissemination of knowledge. This book presents the most recent information on natural toxins from animal, plant and microbial origins and describes the state of research and clinical studies in the field. The material included is illustrated, referenced and fully indexed.

    • Chemical Structure–Biological Activity Relationships: Quantitative Approaches

      • 1st Edition
      • October 22, 2013
      • F. Darvas
      • English
      • Paperback
        9 7 8 1 4 8 3 1 1 5 4 3 6
      • eBook
        9 7 8 1 4 8 3 1 4 7 8 5 7
      Chemical Structure-Biological Activity Relationships: Quantitative Approaches, Volume III, documents the proceedings of the 3rd Congress of the Hungarian Pharmacological Society held in Budapest, 1979. This volume focuses on the methodological aspects of QSAR. It also aims to inform the reader about the QSAR research conducted in East-European countries. This volume contains 38 presentations organized into six sections. Several lecturers deal with ""real prediction"" cases, i.e. activity estimation prior to the synthesis of the compounds. A particularly abundant section is devoted to the question of how the receptor models can be built up by means of QSAR calculations. Other sections present mathematical models and algorithms which could be applied to improve further the effectiveness of QSAR calculations. As another unique feature, a separate section treats the quantitative aspects of peptide structure-activity relationships—a field seemingly backward despite its evident importance. Hydrophobicity and its influence on biological potency along with the relationship of steric properties and biological activity are also discussed.

    • Asthma

      • 1st Edition
      • October 22, 2013
      • K. Frank Austen + 1 more
      • English
      • Paperback
        9 7 8 1 4 8 3 2 0 2 8 3 9
      • eBook
        9 7 8 1 4 8 3 2 1 6 2 6 3
      Asthma: Physiology, Immunopharmacology, and Treatment is a collection of essays that discusses the clinical signs and symptoms of allergic bronchial asthma and the effects of a number of intricate sequences of biochemical reactions initiated by the combination of antigen and antibody. It presents such topic as the pathobiologic mechanisms of asthma. The book discusses the physiologic changes in the acute asthmatic attack. It focuses on the autonomic regulation of airway smooth muscle and the nervous regulation of respiration. Another topic of interest is the genetic aspects of asthma. The section that follows is a review of the biochemical, pharmacological, and immunological factors in the release of chemical mediators from human lung. The book also presents the characteristics of pharmacologic receptor systems and the role of parasympathetic nervous system in asthma. The text will provide valuable insights for physicians, scientists, students, and researchers in the field of human anatomy.

    • Prostaglandins-Immunopharmacology

      • 1st Edition
      • October 22, 2013
      • B. B. Vargaftig
      • English
      • Paperback
        9 7 8 1 4 8 3 1 2 3 9 3 6
      • Hardback
        9 7 8 0 0 8 0 2 3 1 9 4 5
      • eBook
        9 7 8 1 4 8 3 1 5 6 3 5 4
      Advances in Pharmacology and Therapeutics, Volume 4: Prostaglandins-Immun... contains the proceedings of the 7th International Congress of Pharmacology held in Paris, France, in 1978. The papers explore advances in the understanding of prostaglandins, their immunopharmacology, and their therapeutic applications. Topics covered range from the biochemistry of prostaglandins, thromboxanes, and prostacyclin to the pharmacology of blood platelets and pharmacological approaches to enhancement of immunity. This volume is comprised of 23 chapters and opens with a discussion on the discovery of prostaglandins and their possible biological functions, including platelet aggregation and adrenergic neurotransmission. The reader is then introduced to unstable metabolites of arachidonic acid in relation to thrombosis; pharmacological interference in biotransformation of arachidonic acid; participation of prostaglandins in inflammatory pain; and factors affecting the formation and actions of cyclic AMP in blood platelets. The following chapters explore the role of thymosin and the endocrine thymus in the maintenance of immune balance; effects of thymosin fraction 5 in cancer patients; and the immunoregulatory activities of non-toxic synthetic polyribonucleotides. This book will be of interest to practitioners in biosciences, pharmacology, physiology, and medicine.

    • Acute Drug Abuse Emergencies

      • 1st Edition
      • October 22, 2013
      • Peter G. Bourne
      • English
      • Hardback
        9 7 8 0 1 2 1 1 9 5 6 5 6
      • Paperback
        9 7 8 1 4 8 3 2 3 6 4 8 3
      • eBook
        9 7 8 1 4 8 3 2 6 4 4 6 2
      Acute Drug Abuse Emergencies: A Treatment Manual presents the most commonly encountered drug abuse emergencies. This book discusses how various drug-related conditions should be managed by practicing physicians and all those who are dealing with drug abusers. Organized into nine parts encompassing 28 chapters, this book begins with an overview of the various emergency drug reactions, including behavioral disturbances, organ malfunction, central nervous system depression, exacerbation of pre-existing illness, or combinations. This text then examines the profile of a typical heroin overdose victim. Other chapters consider severe poisoning due to nonbarbiturate sedative overdosage. This book discusses as well the types of adverse reactions to marihuana and the dangers of marihuana use. The final chapter deals with the ease of synthesis and the potency of arylcyclohexylamines as a mind-altering drug. This book is a valuable resource for toxicologists, emergency room physicians, and nurses. Readers who are dealing with drug abusers will also find this book extremely useful.

    • Pharmacology of Cardiac Function

      • 1st Edition
      • October 22, 2013
      • Otto Krayer
      • English
      • Paperback
        9 7 8 1 4 8 3 1 3 2 1 0 5
      • Hardback
        9 7 8 0 0 8 0 1 0 8 0 7 0
      • eBook
        9 7 8 1 4 8 3 1 6 4 5 2 6
      Pharmacology of Cardiac Function brings together the proceedings of the Second International Pharmacological Meeting of the International Union of Physiological Sciences, held in Prague, Czechoslovakia, on August 20-23, 1963. The meeting provided a forum for discussing advances in the understanding of the pharmacology of cardiac function and addressed topics ranging from the link between muscle physiology and the heart to the development of tension in cardiac muscle. This volume is comprised of 21 chapters and begins with an overview of the structural aspects of contraction in cardiac and skeletal muscle, followed by a description of muscle physiology and its effect on the heart. The next section deals with the effects of drugs on the interval-strength relationship of heart muscle, paying particular attention to acetylstrophanthidin... levarterenol, and carbacliol as well as metabolic inhibitors. The nature of the restitution process occurring between beats in cardiac muscle is also considered. Subsequent chapters explore how the heart is affected by the action of the vagus and of acetylcholine and other parasympathomimetic drugs; membrane effects of epinephrine and digitalis; and the mode of action of antifibrillatory drugs. This book will be of particular value to pharmacologists and physiologists.

    • The Psychopharmacology of Hallucinogens

      • 1st Edition
      • October 22, 2013
      • Richard C. Stillman + 1 more
      • English
      • Paperback
        9 7 8 1 4 8 3 1 1 3 6 4 7
      • eBook
        9 7 8 1 4 8 3 1 4 6 0 6 5
      The Psychopharmacology of Hallucinogens focuses on the properties, compositions, functions, transformations, and reactions of hallucinogens. The selection first offers information on the biosynthesis and action of hallucinogens in mammals; role of biogenic amines in the actions of monomethoxy-amphetam... and molecular mechanism of action of hallucinogens. The book then takes a look at the molecular determinants for interaction with the LSD receptor, including biological studies, molecular reactivity, and summation of the molecular polarization complexes. The text examines the progress on the development of a receptor model for hallucinogenic amphetamines; characterization of psychotomimetics; physical identification of hallucinogenic compounds; and aspects of the pharmacology of phencyclidine. The book also underscores the effects of LSD, mescaline, and DMT, including effects on humans, proposed model, and effects of monoamine manipulations. The text also presents analysis of hallucinogens by Pavlovian conditioning, behavioral measures of hallucinogenic behavior, and drug model of hallucinosis. The selection is a dependable reference for readers interested in the study of hallucinogens.

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Analytic forensic toxicology

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Immunotoxicology

Metal toxicology

Neurobehavioral toxicology

Occupational toxicology

Pesticide toxicology

Plant and animal toxins

Radiation toxicology

Regulatory toxicology

Renal toxicology

Reproductive endocrine toxicology

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Risk assessment

Solvent and vapor toxicology

Toxicology environmental

Toxicology general

Toxicology principles

Toxicology testing and evaluation