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Elsevier

Books in Neurology

Covering clinical neurological disorders, diagnostics, and treatments, this collection supports neurologists, researchers, and clinicians. It features advances in stroke, epilepsy, and neurodegenerative diseases, promoting improved patient outcomes through innovative therapies and diagnostic tools.

  • Chronic Pain and Brain Abnormalities

    • 1st Edition
    • Carl Y. Saab
    • English
    It is only natural for someone in pain to attend to the body part that hurts. Yet this book tells the story of persistent pain having negative effects on brain function. The contributors, all leading experts in their respective fields of pain electrophysiology, brain imaging, and animal models of pain, strive to synthesize compelling and, in some ways, connected hypotheses with regard to pain-related changes in the brain. Together, they contribute their clinical, academic, and theoretical expertise in a comprehensive overview that attempts to define the broader philosophical context of pain (disentangling sensical from nonsensical claims), list the changes known to take place in the brains of individuals with chronic pain and animal models of pain, address the possible causes and mechanisms underlying these changes, and detail the techniques and analytical methods at our disposal to "visualize" and study these changes.

  • Pediatric Neurology, Part I

    • 1st Edition
    • Volume 111
    • Olivier Dulac + 2 more
    • English
    The child is neither an adult miniature nor an immature human being: at each age, it expresses specific abilities that optimize adaptation to its environment and development of new acquisitions. Diseases in children cover all specialties encountered in adulthood, and neurology involves a particularly large area, ranging from the brain to the striated muscle, the generation and functioning of which require half the genes of the whole genome and a majority of mitochondrial ones. Human being nervous system is sensitive to prenatal aggression, is particularly immature at birth and development may be affected by a whole range of age-dependent disorders distinct from those that occur in adults. Even diseases more often encountered in adulthood than childhood may have specific expression in the developing nervous system. The course of chronic neurological diseases beginning before adolescence remains distinct from that of adult pathology – not only from the cognitive but also motor perspective, right into adulthood, and a whole area is developing for adult neurologists to care for these children with persisting neurological diseases when they become adults. Just as pediatric neurology evolved as an identified specialty as the volume and complexity of data became too much for the general pediatician or the adult neurologist to master, the discipline has now continued to evolve into so many subspecialties, such as epilepsy, neuromuscular disease, stroke, malformations, neonatal neurology, metabolic diseases, etc., that the general pediatric neurologist no longer can reasonably possess in-depth expertise in all areas, particularly in dealing with complex cases. Subspecialty expertise thus is provided to some trainees through fellowship programmes following a general pediatric neurology residency and many of these fellowships include training in research. Since the infectious context, the genetic background and medical practice vary throughout the world, this diversity needs to be represented in a pediatric neurology textbook. Taken together, and although brain malformations (H. Sarnat & P. Curatolo, 2007) and oncology (W. Grisold & R. Soffietti) are covered in detail in other volumes of the same series and therefore only briefly addressed here, these considerations justify the number of volumes, and the number of authors who contributed from all over the world. Experts in the different subspecialties also contributed to design the general framework and contents of the book. Special emphasis is given to the developmental aspect, and normal development is reminded whenever needed – brain, muscle and the immune system. The course of chronic diseases into adulthood and ethical issues specific to the developing nervous system are also addressed.

  • Pediatric Neurology, Part III

    • 1st Edition
    • Volume 113
    • English
    The child is neither an adult miniature nor an immature human being: at each age, it expresses specific abilities that optimize adaptation to its environment and development of new acquisitions. Diseases in children cover all specialties encountered in adulthood, and neurology involves a particularly large area, ranging from the brain to the striated muscle, the generation and functioning of which require half the genes of the whole genome and a majority of mitochondrial ones. Human being nervous system is sensitive to prenatal aggression, is particularly immature at birth and development may be affected by a whole range of age-dependent disorders distinct from those that occur in adults. Even diseases more often encountered in adulthood than childhood may have specific expression in the developing nervous system. The course of chronic neurological diseases beginning before adolescence remains distinct from that of adult pathology – not only from the cognitive but also motor perspective, right into adulthood, and a whole area is developing for adult neurologists to care for these children with persisting neurological diseases when they become adults. Just as pediatric neurology evolved as an identified specialty as the volume and complexity of data became too much for the general pediatician or the adult neurologist to master, the discipline has now continued to evolve into so many subspecialties, such as epilepsy, neuromuscular disease, stroke, malformations, neonatal neurology, metabolic diseases, etc., that the general pediatric neurologist no longer can reasonably possess in-depth expertise in all areas, particularly in dealing with complex cases. Subspecialty expertise thus is provided to some trainees through fellowship programmes following a general pediatric neurology residency and many of these fellowships include training in research. Since the infectious context, the genetic background and medical practice vary throughout the world, this diversity needs to be represented in a pediatric neurology textbook. Taken together, and although brain malformations (H. Sarnat & P. Curatolo, 2007) and oncology (W. Grisold & R. Soffietti) are covered in detail in other volumes of the same series and therefore only briefly addressed here, these considerations justify the number of volumes, and the number of authors who contributed from all over the world. Experts in the different subspecialties also contributed to design the general framework and contents of the book. Special emphasis is given to the developmental aspect, and normal development is reminded whenever needed – brain, muscle and the immune system. The course of chronic diseases into adulthood and ethical issues specific to the developing nervous system are also addressed.

  • Pediatric Neurology, Part II

    • 1st Edition
    • Volume 112
    • Olivier Dulac + 2 more
    • English
    The child is neither an adult miniature nor an immature human being: at each age, it expresses specific abilities that optimize adaptation to its environment and development of new acquisitions. Diseases in children cover all specialties encountered in adulthood, and neurology involves a particularly large area, ranging from the brain to the striated muscle, the generation and functioning of which require half the genes of the whole genome and a majority of mitochondrial ones. Human being nervous system is sensitive to prenatal aggression, is particularly immature at birth and development may be affected by a whole range of age-dependent disorders distinct from those that occur in adults. Even diseases more often encountered in adulthood than childhood may have specific expression in the developing nervous system. The course of chronic neurological diseases beginning before adolescence remains distinct from that of adult pathology – not only from the cognitive but also motor perspective, right into adulthood, and a whole area is developing for adult neurologists to care for these children with persisting neurological diseases when they become adults. Just as pediatric neurology evolved as an identified specialty as the volume and complexity of data became too much for the general pediatician or the adult neurologist to master, the discipline has now continued to evolve into so many subspecialties, such as epilepsy, neuromuscular disease, stroke, malformations, neonatal neurology, metabolic diseases, etc., that the general pediatric neurologist no longer can reasonably possess in-depth expertise in all areas, particularly in dealing with complex cases. Subspecialty expertise thus is provided to some trainees through fellowship programmes following a general pediatric neurology residency and many of these fellowships include training in research. Since the infectious context, the genetic background and medical practice vary throughout the world, this diversity needs to be represented in a pediatric neurology textbook. Taken together, and although brain malformations (H. Sarnat & P. Curatolo, 2007) and oncology (W. Grisold & R. Soffietti) are covered in detail in other volumes of the same series and therefore only briefly addressed here, these considerations justify the number of volumes, and the number of authors who contributed from all over the world. Experts in the different subspecialties also contributed to design the general framework and contents of the book. Special emphasis is given to the developmental aspect, and normal development is reminded whenever needed – brain, muscle and the immune system. The course of chronic diseases into adulthood and ethical issues specific to the developing nervous system are also addressed.

  • Functional Neural Transplantation III

    Primary and Stem Cell Therapies for Brain Repair, Part II
    • 1st Edition
    • Volume 201
    • English
    This issue of Progress in Brain Research is split over 2 volumes, bringing together cutting-edge research on Functional Neural Transplantation. The 2 volumes review current knowledge and understanding, provide a starting point for researchers and practitioners entering the field, and build a platform for further research and discovery.

  • Functional Neural Transplantation III

    Primary and Stem Cell Therapies for Brain Repair, Part I
    • 1st Edition
    • Volume 200
    • English
    This issue of Progress in Brain Research is split over 2 volumes, bringing together cutting-edge research on functional neural transplantation. The 2 volumes review current knowledge and understanding, provide a starting point for researchers and practitioners entering the field, and build a platform for further research and discovery.

  • Neurological Rehabilitation

    • 1st Edition
    • Volume 110
    • Michael P. Barnes + 1 more
    • English
    Neurological Rehabilitation is the latest volume in the definitive Handbook of Clinical Neurology series. It is the first time that this increasing important subject has been included in the series and this reflects the growing interest and quality of scientific data on topics around neural recovery and the practical applications of new research. The volume will appeal to clinicians from both neurological and rehabilitation backgrounds and contains topics of interest to all members of the multidisciplinary clinical team as well as the neuroscience community. The volume is divided into five key sections. The first is a summary of current research on neural repair, recovery and plasticity. The authors have kept the topics readable for a non-scientific audience and focused on the aspects of basic neuroscience that should be most relevant to clinical practice. The next section covers the basic principles of neurorehabilitation, including excellent chapters on learning and skill acquisition, outcome measurement and functional neuroimaging. The key clinical section comes next and includes updates and reviews on the management of the main neurological disabling physical problems, such as spasticity, pain, sexual functioning and dysphagia. Cognitive, emotional and behavioural problems are just as important and are covered in the next section, with excellent chapters, for example, on memory and management of executive dysfunction. The final part draws the sections on symptom management together by discussing the individual diseases that are most commonly seen in neurorehabilitation and providing an overview of the management of the disability associated with those disorders. The volume is a definitive review of current neurorehabilitation practice and will be valuable to a wide range of clinicians and scientists working in this rapidly developing field.

  • Visual Perception

    The Neurophysiological Foundations
    • 1st Edition
    • Lothar Spillmann + 1 more
    • English
    This book presents an interdisciplinary overview of the main facts and theories that guide contemporary research on visual perception. While the chapters cover virtually all areas of visual science, from philosophical foundations to computational algorithms, and from photoreceptor processes to neuronal networks, no attempt has been made to provide an exhaustive treatment of these topics. Rather, researchers from such diverse disciplines as psychology, neurophysiology, anatomy, and clinical vision sciences have worked together to review some of the most important correlations between perceptual phenomena and the underlying neurophysiological processes and mechanisms. The book is thus intended to serve as an advanced text for graduate students and as a guide for all vision researchers to understanding current progress outside their specialized fields of interest.

  • Neuroepidemiology

    Theory and Method
    • 1st Edition
    • Bozzano G Luisa
    • English
    As a collection of neuroepidemiology papers, this book captures the range and excitement of the discipline. Researchers in the field have been at the forefront in the study of slow viruses, retroviral epidemiology, chronic neuroloical diseases, as well as injuries and other disabilities of the neurological system. The intersection of epidemiology, neurology, and behavioral/social science is a unique feature of this book. Furthermore, Molgaard's collection differs from similar titles in that it focuses on minorities and international work in neuroepidemiology.

  • The Human Nervous System

    • 1st Edition
    • George Paxinos
    • English
    The Human Nervous System is a definitive account of human neuroanatomy, with a comprehensive coverage of the brain, spinal cord, and peripheral nervous system. The cytoarchitecture, chemoarchitecture, connectivity, and major functions of neuronal structures are examined by acknowledged authorities in the field, such as: Alheid, Amaral, Armstrong, Beitz, Burke, de Olmos, Difiglia, Garey, Gerrits, Gibbins, Holstege, Kaas, Martin, McKinley, Norgren, Ohye, Paxinos, Pearson, Pioro, Price, Saper, Sasaki, Schoenen, Tadork, Voogd, Webster, Zilles, and their associates.

  • Thirst and Sodium Appetite

    Physiological Basis
    • 1st Edition
    • Sebastian Grossman
    • English
    Thirst and Sodium Appetite: Physiological Basis describes the phenomenon of thirst and the mechanisms that define the need for water. Thirst and appetite has generated much study and research about the physiological, endocrinological, and pharmacological mechanisms that influence water intake. However, in this book, other concerns have been emphasized, such as the significance of brain mechanisms in the subject matter. This book, consisting of 11 chapters, starts with a basic description of thirst then to an analysis of basic physiological mechanisms that determine water intake. Another topic also discussed in this book is various experimental paradigms that resulted to the dual-depletion theory of thirst. The neuroanatomical, neuroendocrinologica... and neuropharmacological brain mechanisms are covered in three chapters of this book. These brain mechanisms respond to different peripheral signals that stimulate the thirst. The final chapters are dedicated to sodium appetite. Although it has lesser literature than thirst has, there have been significant developments in the understanding of the role of sodium appetite in extracellular thirst. The last chapter reviews the questions that has kept investigators at bay and recommends direction of where future research may go.

  • Spinal Cord Injury

    • 1st Edition
    • Volume 109
    • Joost Verhaagen + 1 more
    • English
    Handbook of Clinical Neurology: Spinal Cord Injury summarizes advances in the clinical diagnosis, monitoring, prognostication, treatment, and management of spinal cord injuries. More specifically, it looks at new and important developments in areas such as high-resolution noninvasive neuroimaging, surgery, and electrical stimulation of motor, respiratory, bladder, bowel, and sexual functions. It also reviews the latest insights into spontaneous regeneration and recovery of function following rehabilitation, with emphasis on novel therapeutic strategies, such as gene therapy, transcranial stimulation, brain-machine interfaces, pharmacological approaches, molecular target discovery, and the use of olfactory ensheathing cells, stem cells, and precursor cells. Organized in five sections, the book begins with an overview of the development, maturation, biomechanics, and anatomy of the spinal cord before proceeding with a discussion of clinical diagnosis and prognosis as well as natural recovery, ambulation, and function following spinal cord injury. It then examines clinical neurophysiology in the prognosis and monitoring of traumatic spinal cord injury; medical, surgical and rehabilitative management of spinal cord trauma; and some new approaches for improving recovery in patients, including restoration of function by electrical stimulation, locomotor training, and the use of robotics. Other chapters cover cell transplantation, artificial scaffolds, experimental pharmacological interventions, and molecular and combinatorial strategies for repairing the injured spinal cord. This volume should be of interest to neuroscience and clinical neurology research specialists and practicing neurologists.

  • Sleep Disorders, An Issue of Neurologic Clinics

    • 1st Edition
    • Volume 30-4
    • Bradley Vaughn
    • English
    Sleep disorders are a widely recognized consequence of many neurological pathologies. This issue of Neurologic Clinics features the following articles: Sleep Physiology; Sleep Assessment Tools for the Neurologist; Fitting Sleep into Neurological Practice; Insomnia; Parasomnias and look-alikes; Sleep Apnea: Obstructive and central; Restless Legs syndrome; Circadian Rhythm; Pediatric Sleep Disorders; Dementia; Stroke; Epilepsy; CNS Immunological and Infectious; Movement Disorders; Neuromuscular ; Headache; Traumatic Brain Injury; and Psychiatry in Sleep.

  • Paxinos and Franklin's the Mouse Brain in Stereotaxic Coordinates

    • 4th Edition
    • George Paxinos + 1 more
    • English
    In the years since its first publication, Paxinos and Franklin's the Mouse Brain in Stereotaxic Coordinates has received virtually universal acceptance in neuroscience as the authoritative source for stereotaxic coordinates and delineations. This atlas is constructed in the style of The Rat Brain in Stereotaxic Coordinates, the most cited publication in neuroscience. The completely revised and updated 4e of Paxinos and Franklin's the Mouse Brain in Stereotaxic Coordinates features high-quality color plates scanned by the renowned microscopy unit of the Allen Institute for Brain Science. Constructed by the leaders in neuroanatomical atlas development, the new edition will maintain the position of the atlas as an indispensable resource for scientists working on the mouse brain.

  • The Neuroscience of Autism Spectrum Disorders

    • 1st Edition
    • Joseph D. Buxbaum + 1 more
    • English
    Autism is no longer considered a rare disease, and the Center for Disease Control now estimates that upwards of 730,000 children in the US struggle with this isolating brain disorder. New research is leading to greater understanding of and ability to treat the disorder at an earlier age. It is hoped that further genetic and imaging studies will lead to biologically based diagnostic techniques that could help speed detection and allow early, more effective intervention. Edited by two leaders in the field, this volume offers a current survey and synthesis of the most important findings of the neuroscience behind autism of the past 20 years. With chapters authored by experts in each topic, the volume explores etiology, neuropathology, imaging, and pathways/models. Offering a broad background of ASDs with a unique focus on neurobiology, the volume offers more than the others on the market with a strictly clinical focus or a single authored perspective that fails to offer expert, comprehensive coverage. Researchers and graduate students alike with an interest in developmental disorders and autism will benefit, as will autism specialists across psychology and medicine looking to expand their expertise.

  • Epilepsy, Part I: Basic Principles and Diagnosis

    • 1st Edition
    • Volume 107
    • Hermann Stefan + 1 more
    • English
    Epilepsy, Part I, Basic Principles and Diagnosis, Volume 107, in the Handbook of Clinical Neurology series offers a comprehensive review of our knowledge of the field today, including epidemiology, basic mechanisms, animal models, and topics of increasing interest such as the role of inflammation in epilepsy. It provides a comprehensive approach to description of the clinical, electrographic and imaging aspects of the epilepsies, with a clear outline of contemporary classification and the role of modern diagnostic techniques, as well as neuropsychological and psychiatric aspects of epilepsy. Chapters are authored by internationally respected neurologists with varied perspectives insuring depth to the content. Epilepsy, Part II, Treatment, Volume 108, continues coverage of epilepsy with a focus on treatment. The volumes will be a very important resource for basic scientists, clinical investigators, and all health professionals treating patients with epilepsy.

  • Epilepsy, Part II: Treatment

    • 1st Edition
    • Volume 108
    • Hermann Stefan + 1 more
    • English
    Epilepsy, Part II, Treatment, Volume 108, provides a full description of epilepsy pathology and etiology, antiepileptic drug treatment, the approach to surgical evaluation and alternative procedures to be considered, in both children and adults, as well as brain stimulation and diet treatment. Economic and psychosocial issues such as stigma are fully covered. The special problems of epilepsy treatment in the developing world are described. Chapters are authored by internationally respected neurologists with varied perspectives insuring depth to the content. Epilepsy, Part I, Basic Principles and Diagnosis, Volume 107, establishes the scientific and practical diagnosis of epilepsy. The volumes will be a very important resource for basic scientists, clinical investigators, and all health professionals treating patients with epilepsy.

  • Neuropsychological Rehabilitation

    Principles and Applications
    • 1st Edition
    • Jamuna Rajeswaran
    • English
    Traumatic Brain Injury (TBI) can occur through road traffic incidents, falls, or violence, and is therefore an extremely prevalent type of injury, constituting a significant burden on health care around the world. As more people are able to recover physically from TBI, it is important to consider how to help repair the cognitive functions of the brain. The cognitive functions could be greatly maximized by appropriate Neuropsychological rehabilitation, which occurs within months of the damage. This book discusses both the theoretical and practical applications of Neuropsychological rehabilitation techniques, offering a comprehensive overview of the process. Using several case studies from India, gained over years of clinical practice, research and academic teaching, this book offers an excellent guide to the procedures and tasks needed to respond effectively to patients with TBI. Although focused on the Indian context, this book will appeal to students and practitioners around the world as a useful resource on Neuropsychological rehabilitation techniques in India.

  • Pregnancy and Neurologic Illness, An Issue of Neurologic Clinics

    • 1st Edition
    • Volume 30-3
    • Autumn Klein
    • English
    Neurologic illness in pregnant women requires special consideration on the part of the neurologist. These disorders can impact pregnancy in distinct ways, and their therapies must often be modified to protect the health of the mother and fetus. This issue of Neurologic Clinics features 11 articles on the interaction of the main neurologic disorders and pregnancy.

  • Inflammation in Neuropsychiatric Disorders

    • 1st Edition
    • Volume 88
    • English
    Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology serial has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/express... proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics.

  • Modern Management of High Grade Glioma, Part II, An Issue of Neurosurgery Clinics

    • 1st Edition
    • Volume 23-3
    • Isaac Yang + 1 more
    • English
    Standard therapy for high grade glioma is a topic that is evolving, timely, and relevant. Guest Editors Isaac Yang, MD and Seunggu Han, MD have assembled a group of experts on management of high grade glioma. Some of the articles in this issue include: Use of language mapping to aid resection of eloquent gliomas; Clinical trials with immunotherapy; Clinical trials for small molecule inhibitors; Nanotechnology potential applications for GBM therapy; High Grade Gliomas in children; Modern Advances in Brain Tumor Treatments; Molecular pathways of Avastin interactions for the treatment of glioblastoma; and Quality of Life and Outcomes in Glioblastoma management.

  • Neurobiology of Psychiatric Disorders

    • 1st Edition
    • Volume 106
    • Thomas E Schlaepfer + 1 more
    • English
    This new volume in the Handbook of Clinical Neurology presents a comprehensive review of the fundamental science and clinical treatment of psychiatric disorders. Advances in neuroscience have allowed for dramatic advances in the understanding of psychiatric disorders and treatment. Brain disorders, such as depression and schizophrenia, are the leading cause of disability worldwide. It is estimated that over 25% of the adult population in North America are diagnosed yearly with at least one mental disorder and similar results hold for Europe. Now that neurology and psychiatry agree that all mental disorders are in fact, "brain diseases," this volume provides a foundational introduction to the science defining these disorders and details best practices for psychiatric treatment.

  • Molecular Biology of Neurodegenerative Diseases

    • 1st Edition
    • Volume 107
    • English
    Neurodegenerative diseases result in progressive degeneration and / or death of nerve cells which leads to problems with movement and mental functioning. Examples include Parkinson’s, Alzheimer’s and Huntington’s disease. Much research is taking place to try to identify ways to prevent or lessen the impact of these diseases. This volume reviews the latest research and developments in the molecular biology of neurodegenerative diseases.

  • Nonhuman Primates in Biomedical Research

    Diseases
    • 2nd Edition
    • Volume 2
    • Christian R. Abee + 3 more
    • English
    The 2e of the gold standard text in the field, Nonhuman Primates in Biomedical Research provides a comprehensive, up-to-date review of the use of nonhuman primates in biomedical research. The Diseases volume provides thorough reviews of naturally occurring diseases of nonhuman primates, with a section on biomedical models reviewing contemporary nonhuman primate models of human diseases. Each chapter contains an extensive list of bibliographic references, photographs, and graphic illustrations to provide the reader with a thorough review of the subject.

  • Neuro-Oncology Part I

    • 1st Edition
    • Volume 104
    • Wolfgang Grisold + 1 more
    • English
    Handbook of Clinical Neurology: Neuro-Oncology, Part I summarizes the present state of scientific and clinical knowledge in the field of neuro-oncology, including information related to diagnostic techniques such as imaging, along with immunology, molecular biology, and clinical aspects of tumors. Management and new therapeutic strategies for tumors, including gene therapy and molecularly targeted treatments, are also covered. Divided into eight sections encompassing 61 chapters, the book begins with an overview of the basic principles of tumors, including the epidemiology of primary central nervous system tumors, angiogenesis and invasion in cancer, the link between blood-brain barrier and brain edema, and the role of stem cells in gliomas. It proceeds with a discussion of diagnostic tools such as neuroimaging, the principles of tumor therapy such as radiotherapy and immunotherapy, and clinical trials in neuro-oncology. The reader is also introduced to specific tumor types such as low-grade gliomas, anaplastic astrocytomas, and medulloblastoma and primitive neuroectodermal tumors, along with rare brain tumors like neurofibromatosis and other genetic syndromes. Furthermore, the book explains the neurological complications of systemic cancer and complications from treatments. This volume will appeal to clinicians and neuroscientists as well as researchers who want to gain a better understanding of the clinical features and management of the neurological manifestations of tumors.

  • Neuro-Oncology, Part II

    • 1st Edition
    • Volume 105
    • Wolfgang Grisold + 1 more
    • English
    Handbook of Clinical Neurology: Neuro-Oncology, Part II provides an overview of the most recent developments in the field of neuro-oncology, including new diagnostic imaging techniques, along with immunology, molecular biology, and clinical aspects of different types of tumors. It also considers management and new therapeutic strategies for tumors, such as gene therapy, radiation therapy, and molecularly targeted treatments. Divided into five sections encompassing 33 chapters, the book begins with a description of specific tumor types such as low-grade gliomas, anaplastic astrocytomas, and medulloblastoma and primitive neuroectodermal tumors, along with rare brain tumors like neurofibromatosis and other genetic syndromes. It then discusses tumors at special sites, from brainstem tumors to peripheral nerve tumors, tumors of the meninges, and optic, hypothalamic, and thalamic tumors. It also explains the neurological complications of systemic cancer and the adverse effects of some treatments. Clinicians and neuroscientists, as well as researchers who read this book, will gain a better understanding of the clinical features and management of the neurological manifestations of tumors.

  • Evolution of the Primate Brain

    From Neuron to Behavior
    • 1st Edition
    • Volume 195
    • English
    This volume of Progress in Brain Research provides a synthetic source of information about state-of-the-art research that has important implications for the evolution of the brain and cognition in primates, including humans. This topic requires input from a variety of fields that are developing at an unprecedented pace: genetics, developmental neurobiology, comparative and functional neuroanatomy (at gross and microanatomical levels), quantitative neurobiology related to scaling factors that constrain brain organization and evolution, primate palaeontology (including paleoneurology), paleo-anthropology, comparative psychology, and behavioural evolutionary biology. Written by internationally-reno... scientists, this timely volume will be of wide interest to students, scholars, science journalists, and a variety of experts who are interested in keeping track of the discoveries that are rapidly emerging about the evolution of the brain and cognition.

  • Les troubles du sommeil

    • 2nd Edition
    • Michel Billiard + 1 more
    • French
    La médecine du sommeil est une discipline récente et les manuels qui lui sont consacrés sont encore peu nombreux. Les troubles du sommeil et de l'éveil touchent pourtant une part importante de la populati on et ont de graves répercussions sur la santé physique et mentale ainsi que sur la qualité de vie. Cette 2° édition, largement revue et augmentée fait le point sur le sommeil normal, l'exploration du sommeil et de l'éveil, la somnolence et la vigilance, les troubles du sommeil et de l'éveil, et sur les nombreuses maladies organiques et psychiatriques dépendant du sommeil ou ayant un impact sur lui. D'un usage très pratique, cet ouvrage de référence est agrémenté d'index et de questionnaires, d'inventaires et échelles utilisés pour préciser les troubles du sommeil et de l'éveil. Il est complété par un glossaire étendu nécessaire à une bonne compréhension de la terminologie du sommeil et de ses troubles. Cet ouvrage s'adresse aux médecins généralistes et spécialistes. Ils y trouveront des réponses à leurs questi ons ainsi que de nombreuses indicati ons pour la prise en charge des pati ents et la prescripti on de traitements. Il s'adresse également aux étudiants en médecine, aux infi rmiers, aux psychologues désireux de s'ouvrir à un domaine encore peu enseigné dans les facultés et écoles, et enfin, à tous les chercheurs intéressés par ce sujet. Il est rédigé par une équipe de spécialistes du sommeil, chercheurs et cliniciens, européens et nord-américains reconnus internationalement.

  • Ataxic Disorders

    • 1st Edition
    • Volume 103
    • Sankara H. Subramony + 1 more
    • English
    This volume’s primary goal is to provide a comprehensive understanding of recent developments and advancements in the study of ataxic disorders. Beginning with an examination of the cerebellar region, and then progressing to a fresh perspective on the clinical aspects of the various forms of ataxia, this handbook gives clinicians a state-of-the-art reference for the management of the many etiologies and neurological manifestations of ataxic disorders. Clinicians will gain a broader understanding of generative ataxias and the genetic disorders associated with them. In addition, new neurophysiological and imaging techniques are discussed, along with an in-depth examination of the treatment and management protocols of ataxic diseases.

  • Early Development in Neurogenetic Disorders

    • 1st Edition
    • Volume 40
    • English
    This special issue is among the first volumes to examine the topic of early development in children with neurogenetic disorders associated with intellectual disability. It includes discussions of theoretical issues regarding the emergence of behavioural profiles during early development, as well as comprehensive accounts of early development in specific disorders such as Down syndrome, fragile X syndrome, Williams syndrome, and sex chromosome disorders. In addition, several contributions examine the latest clinical applications of this work for diagnosis, treatment, and education.

  • Translating Mechanisms of Orofacial Neurological Disorder

    From the Peripheral Nervous System to the Cerebral Cortex
    • 1st Edition
    • Volume 97
    • English
    In this volume, members of the International Translational Research Network on Orofacial Neurological Disorders and invited experts provide authoritative overviews of new aspects of motor function and sensation relating to neurological disorders in orofacial regions. Orofacial movements constitute fundamental motor patterns with essential roles in consummatory behavior, self-care, defensive and attack behaviors, vocalization and, in higher mammals, verbal as well as non-verbal communication. Clinically, dysfunction in orofacial movement is evident in numerous dental, cranio-maxillo-facia... and neuropsychiatric disorders, including dysphagia, Huntington's disease, Parkinson's disease and schizophrenia.

  • Neuro-ophthalmology

    • 1st Edition
    • Volume 102
    • Christopher Kennard + 1 more
    • English
    The Handbook of Clinical Neurology Vol 102: Neuro-Ophthalmology provides a comprehensive discussion of the field of neuro-ophthalmology. The book is organized into four sections. Section 1 lays out fundamental concepts of the visual system and eye movements. It discusses the anatomy and physiology of the afferent visual system and the ocular motor system, and the neuro-ophthalmologic... examination. Section 2 deals with disorders of the afferent visual system, covering retinal disorders; abnormalities of the optic disc; lesions of the optic nerve; the optic chiasm; disorders of the optic tract, radiation, and occipital lobe; disorders of higher visual processing; and rehabilitative techniques. Section 3 discusses ocular motor abnormalities, including infranuclear ocular motor disorders; nuclear, internuclear, and supranuclear ocular motor disorders; nystagmus and saccadic intrusions; disorders of higher gaze control; and normal and abnormal lid function. Section 4 covers disorders of the pupil; neuro-ophthalmology of orbital disease; and functional neuro-ophthalmology. This book will be useful to early-stage physicians, as well as specialists interested in the latest developments in neuro-ophthalmology.

  • Muscular Dystrophies

    • 1st Edition
    • Volume 101
    • Robert C. Griggs + 1 more
    • English
    The Handbook of Clinical Neurology Vol 101: Muscular Dystrophies discusses the pathogenesis and treatment prospects for muscular dystrophies. It summarizes the advances in molecular and cell biology, biochemistry, and other biological sciences, with an emphasis on their application to this group of muscle disorders and to their clinical implications. Starting with an overview of muscular dystrophies, the book’s 16 chapters discuss dystrophinopathies; sarcoglycanopathies; congenital muscular dystrophies; collagen VI-related myopathies; limb-girdle muscular dystrophy 2A; dysferlinopathies; limb-girdle muscular dystrophy 2H and the role of TRIM32; and caveolinopathies. The book also covers myofibrillar myopathies; Emery–Dreifuss muscular dystrophy; facioscapulohumeral dystrophy and scapuloperoneal syndromes; oculopharyngeal muscular dystrophy; myotonic dystrophy types 1 and 2; and distal muscular dystrophies. This book is useful to basic investigators, as it offers an increased understanding of muscular dystrophies; and to clinicians, with its emphasis on issues that are relevant to the care, diagnosis, and management of patients with these disorders.

  • Hyperkinetic Movement Disorders

    • 1st Edition
    • Volume 100
    • William J. Weiner + 1 more
    • English
    The Handbook of Clinical Neurology Vol 100: Hyperkinetic Movement Disorders discusses hyperkinetic disorders related mainly to basal ganglia dysfunction and pathology. It contains 13 sections and 51 chapters written by authoritative and experienced investigators and clinicians in this extremely broad and diverse group of diseases and syndromes. The first section on choreoathetoid diseases and syndromes includes chapters on Huntington’s disease and Huntington’s disease look-alikes; spinocerebellar degenerations; neuroacanthocytosis; entatorubral-pallido... atrophy; neuroferritinopathy; neurodegeneration with brain iron accumulation; mitochondrial disorders; acquired hepatocerebral degeneration; benign hereditary chorea; and “senile chorea.” The remaining chapters focus on the abnormal involuntary movements associated with each disease or syndrome. These include immune-related chorea, vascular chorea, metabolic disturbances that can induce chorea, chorea in other medical settings (e.g., postpump chorea in children, cancer-related paraneoplastic syndromes), myoclonus, essential tremor, and dystonia, including dystonia plus syndromes. There are also chapters on tardive dyskinesia, unusual clinical syndromes, and tics and stereotyped movements in children. The text is a valuable resource for neurology and psychiatry residents, practicing neurologists and psychiatrists, and specialists in movement disorders.

  • La maladie de Parkinson

    • 2nd Edition
    • Luc Defebvre + 1 more
    • French
    La maladie de Parkinson est, après la maladie d'Alzheimer, l'affection neurologique la plus répandue au sein de la population après 50 ans. Elle touche près de 2% des personnes de plus de 65 ans. Ce pourcentage augmentant avec l'âge, on peut prévoir qu'avec le vieillissement de la population, le nombre de patients ne cessera d'augmenter dans les années à venir. Cette deuxième édition rend compte de façon didactique des avancées de ces cinq dernières années, en abordant de façon exhaustive tous les aspects de cette pathologie : l'épidémiologie, l'étiopathogénie, les aspects génétiques, la physiopathologie, les signes moteurs et non moteurs, notamment les troubles cognitifs, psychiques et comportementaux. Sont aussi détaillés les critères diagnostiques, les échelles et questionnaires d'évaluation, la place de l'imagerie morphologique et fonctionnelle ainsi que les stratégies thérapeutiques actuelles : médicamenteuses, chirurgicales, rééducatives et orthophoniques.

  • Ocular Periphery and Disorders

    • 1st Edition
    • Darlene A. Dartt + 5 more
    • English
    This selection of articles from the Encyclopedia of the Eye is the first single-volume overview presenting articles on the function, biology, physiology, and pathology of the structures of the ocular periphery, as well as the related disorders and their treatment. The peripheral structures are implicated in a number of important diseases, including optic neuritis, thyroid eye disease, and strabismus. The volume offers a basic science background of these topics rather than a strictly clinical focus.

  • Neuroinflammation

    • 1st Edition
    • Alireza Minagar
    • English
    Inflammation is a central mechanism in many neurological diseases, including stroke, multiple sclerosis, and brain trauma as well as meningitis and contributes to the generation of pain. We are now beginning to understand the impact of the immune system on different nervous system functions and diseases, ranging from damage through tolerance to modulation and repair.This book discusses some of the more common neuro-inflammatory diseases. Topics covered include multiple sclerosis, optic neuritis and Susac syndrome.

  • Sleep Disorders Part I

    • 1st Edition
    • Volume 98
    • Pasquale Montagna + 1 more
    • English
    Sleep Disorders Part 1 offers a glimpse of developments that focus on diagnostic techniques in the field of neurobiology of sleep. This part discusses the models of the rapid eye movement (REM) sleep mechanism; issues regarding sleep states, stages, and memory consolidation; and advances in the understanding of the sleep-wake genes, gene products, the circadian clock, and the role of sleep duration. This book explains noninvasive neuroimaging studies, particularly positron emission tomographic and single photon emission computed tomographic scans. It further discusses advances in clinical science, including concepts about neurobiology of sleep, narcolepsy-cataplexy... therapy, and laboratory techniques. The significant advances in therapy have led to the addition of new drugs for the treatment of different sleeping disorders, as described in this book. Sleep is essential to humans. Awareness of its true importance leads to the development and acceptance of sleep medicines in the market.

  • Sleep Disorders Part II

    • 1st Edition
    • Volume 99
    • Pasquale Montagna + 1 more
    • English
    Sleep Disorders II covers various aspects of sleep disorders. These include the different classification of sleep disorders, the genetic influences of sleep disorders, abnormality in the sleeping pattern, and the circadian rhythm sleep disorder. A sleep disorder is a medical disorder that affects the sleeping patterns of humans (and sometimes animals). The disruptions in sleep can be caused by different factors, such as teeth grinding, night terrors, and the like. The book also discusses different perspectives on insomnia and hypersomnia. According to the International Classification of Sleep Disorders, insomnia is a sleep that is low in quality or a difficulty in sleeping. On the other hand, hypersomnia is a sleeping disorder characterized by excessive daytime sleepiness (EDS) or prolonged nighttime sleep. The book discusses narcolepsy, a syndrome that is characterized by excessive daytime sleepiness that is associated with cataplexy and other REM sleep phenomena. The different medicines for this disease are also discussed. People who are practicing neurology and internal medicine, especially those in pulmonary, cardiovascular, gastrointestinal, renal and endocrine specialties, will find this book valuable.

  • Neurological Disorders and Pregnancy

    • 1st Edition
    • Alireza Minagar
    • English
    Timely diagnosis and management of neurological diseases during pregnancy poses major therapeutic challenges to neurologists and other non-neurologist health care providers. Pregnancy is a unique period in life associated with significant hormonal and other physiologic changes in female patients, which may trigger or alter the course of neurological and psychiatric disorders. In addition, many diagnostic procedures that can be performed in non-pregnant women are prohibited during pregnancy for safety reasons. Therapeutic decisions and management of a pregnant patient with neurological disorders heavily depends on the issue of the reasonable balance between the risks of no treatment versus active treatment for the mother and her fetus. This book provides a review of the latest findings in this field, giving the neurologist and non-neurologist the information they need to determine the best treatment. Neurological disorders covered include multiple sclerosis, stroke and epilepsy.

  • Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors

    • 1st Edition
    • Volume 95
    • English
    Volume 95 of International Review of Neurobiology focuses on Catechol-O-methyltra... inhibition, and its clinical application in relation to Parkinson’s disease. Chapters cover COMT gene and proteins, L-dopa treatment in Parkinson’s disease, the latest research on COMT inhibitors and their clinical applications, as well as future prospects for their use.

  • Developmental Disorders and Interventions

    • 1st Edition
    • Volume 39
    • English
    Volume 39 of the Advances in Child Development and Behavior series is concerned with Developmental Disorders and Interventions. This volume provides an overview of contemporary research into cognitive, neurodevelopmental and genetic disorders of learning. The social, emotional and cognitive functioning of children with William’s syndrome, Down syndrome, Fragile X and autism, reading difficulties, mathematical difficulties and working memory problems are discussed by some of the leading researchers in the field. Within each chapter, the authors consider current interventions and methods for remediating difficulties associated with each disorder, which will be of particular interest to clinical and educational practitioners.

  • Year Book of Neurology and Neurosurgery

    • 1st Edition
    • Volume 2010
    • Alejandro A. Rabinstein
    • English

  • Recent Advances in Parkinsons Disease

    Part II: Translational and Clinical Research
    • 1st Edition
    • Volume 184
    • English
    This second volume follows on from Part I by reviewing the variety of animal models of PD current available (from drosophila to rodents to non-human primate species) and their specific contributions to PD research. This is followed by comprehensive coverage of functional neuroimaging studies that explore different pathophysiological questions and evaluate treatment outcome in PD patients. Different areas of experimental therapeutics and outstanding challenges to PD treatment are presented in a concluding group of articles.

  • Headache

    • 1st Edition
    • Volume 97
    • Giuseppi Nappi + 1 more
    • English
    Handbook of Clinical Neurology: Headache covers various aspects of headaches. It covers up-to-date information about the cultural developments and the scientific advances in the field of neurological science. One of the most frequent symptoms that people encounter is migraine or other type of headaches. At least 40% of neurological consultations are headache-related. With this, significant advances in basic and applied brain sciences have emerged in the field of headache-related problems. Divided into six sections, the book discusses the socioeconomic aspects of headaches, the contribution of biological sciences to the study of the pathophysiology of headache, and the management of headache and other related problems. It also deals with headache-related issues, such as pathogenic (chronobiological, endocrinological, and neuroimaging correlates), nosographic (i.e., migraine, vertigo, and headache in children), and treatment-related issues. The book will serve as a reference for researchers, clinical physicians, and other readers who want additional knowledge about the clinical features of headaches.

  • Recent Advances in Parkinsons Disease

    Part I: Basic Research
    • 1st Edition
    • Volume 183
    • English
    This first volume starts with an overview on current perspectives in genetic research and on the molecular mechanisms of neurodegeneration. This is followed by a selection of hot topics in pathophysiological research, from molecular studies to system-level investigations based on in vivo electrophysiological recordings and neurocomputational methods.

  • Transcranial Sonography in Movement Disorders

    • 1st Edition
    • Volume 90
    • English

  • Mental and Neurological Public Health

    A Global Perspective
    • 1st Edition
    • Vikram Patel + 4 more
    • English
    Colin Mathers who leads the Global Burden of Disease group in WHO has confirmed that, in the 2004 GBD, 13.1% of global Daily Adjusted Life Years are attributable to mental or neurological disorders. While the proportions vary very widely from about 10% in low income countries to over 25% in high income countries, it is clear that there is a need for understanding how to address this issue. This volume aims to provide a comprehensive overview of the public health principles of mental and neurological disorders. This vast range of health conditions affects people across the life course, from developmental disabilities in childhood, to schizophrenia and substance abuse in adults, and dementia in old age. Despite this diversity, they all share many features: they are mostly mediated through brain dysfunction or abnormalities, are often chronic in course, typically benefit from multi-component interventions, and are amongst the most neglected conditions in global health. The volume will bring together chapters from the Psychiatry, Neurology, Substance Abuse and Child Development sections of the Encyclopedia of Public Health. The volume will be the first comprehensive text on a public health approach to this diverse group of health conditions and has no obvious competitor.

  • Encyclopedia of Movement Disorders

    • 1st Edition
    • Katie Kompoliti + 1 more
    • English
    The Encyclopedia of Movement Disorders is a comprehensive reference work on movement disorders, encompassing a wide variety of topics in neurology, neurosurgery, psychiatry and pharmacology. This compilation will feature more than 300 focused entries, including sections on different disease states, pathophysiology, epidemiology, genetics, clinical presentation, diagnostic tools, as well as discussions on relevant basic science topics. This Encyclopedia is an essential addition to any collection, written to be accessible for both the clinical and non-clinical reader. Academic clinicians, translational researchers and basic scientists are brought together to connect experimental findings made in the laboratory to the clinical features, pathophysiology and treatment of movement disorders. The Encyclopedia targets a broad readership, ranging from students to general physicians, basic scientists and Movement Disorder specialists. Published both in print and via Elsevier’s online platform of Science Direct, this Encyclopedia will have the enhanced option of integrating traditional print with online multimedia.

  • Bacterial Infections of the Central Nervous System

    • 1st Edition
    • Volume 96
    • Karen L. Roos + 1 more
    • English
    Bacterial Infections of the Central Nervous System aims to provide information useful to physicians taking care of patients with bacterial infections in the central nervous system (CNS), which can lead to morbidity and mortality. The increased number of patients suffering from this infection has led to the development of vaccines and antibiotics. Comprised of four chapters, the book explains the general approach to patients with bacterial CNS infection. It also discusses various CNS infection concepts and terms. These include the characteristic neuroimaging appearance of specific bacterial infections, the limitations of neuroimaging, the cerebrospinal fluid analysis, the pathogenesis and pathophysiology of bacterial CNS infections, the developments of specific adjunctive strategies, and the principles of antimicrobial therapy. It also includes discussions on various diseases that target the CNS, such as meningitis, focal CNS infections, neurological complications of endocarditis, suppurative venous sinus thrombosis, infections in the neurosurgical patient, and CNS diseases caused by selected infectious agents and toxins. This book will serve as a guide for clinical physicians who have patients suffering from bacterial CNS infection.

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