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Books in Clinical neuropathology

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Circadian Rhythms, Sleep, and Sleep Disorders

  • 1st Edition
  • Volume 206
  • March 3, 2025
  • Luigi Ferini-Strambi + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 3 2 3 - 9 0 9 1 8 - 1
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 0 9 1 9 - 8
Circadian rhythms, sleep, and sleep disorders covers the topic in two sections focusing on basic science and clinical application. In the basic section, new developments and research findings focusing on basic circadian rhythm and sleep physiology in animals and humans is highlighted. The chapters are written in short mini-review formats in order to concisely describe the fundamentals, and current hot topics.The basic part starts with a chapter on the fundamentals and new discoveries on oscillating circuitries in the sleeping rodent and human brain. This sets the stage for chap 2, focusing on circadian and homeostatic aspects of human sleep regulation. Chap 3 extends these aspects to human cognition. The next chapter reports on visual and non-visual effects of light on human behavior, particularly endocrine and electrophysiological correlates. Chap 5 covers chronic sleep restriction effects on functional connectivity states. The last two chapters (6 and 7) give a broad overview on sleep modeling across physiological levels, with a focus on a quantitative model of sleep-wake dynamics based on the physiology of the brainstem ascending arousal system.The clinical section of the book describes the circadian rhythm sleep-wake disorders, from epidemiology to clinical picture and treatment. Disorders covered include delayed and advanced sleep phase syndrome, Irregular sleep-wake rhythm disorder, shift work disorder, restless legs syndrome, nocturnal eating syndrome, narcolepsy, and sleep apnea. Pharmacological and non-pharmacological treatments of insomnia are explored, as well as the role of sleep-wake modulation in the pathogenesis and clinical profile of neurodegenerative disorders, such as Parkinson’s disease and Alzheimer’s disease.

Coma, Stupor, and Related Disorders of Consciousness

  • 1st Edition
  • Volume 207
  • March 1, 2025
  • Peter W. Kaplan + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 4 4 3 - 1 3 4 0 8 - 1
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 3 4 2 5 - 8
Coma, Stupor, and Related Disorders of Consciousness reviews recent research and best practice in the assessment and treatment of coma, stupor, and disorders of consciousness. It encompasses the neural circuits, anatomy & physiology of stupor and coma, differential diagnosis and clinical assessment, imagery, EEGs, therapy/intervention, decision making and prognosis.

Cell and Gene Therapies for Neurologic Diseases

  • 1st Edition
  • Volume 205
  • October 2, 2024
  • Howard J. Federoff + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 3 2 3 - 9 0 1 2 0 - 8
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 0 1 2 1 - 5
Cell and Gene Therapies for Neurologic Diseases, Volume 205 comprehensively covers the scientific background, translational efforts, clinical developments and registered biologics that have entered into clinical practice. Coverage includes types of therapies available and in development, and best practice uses for a variety of neurological disorders including Parkinson’s, Huntington’s, ALS, stroke, spinal cord RP, demyelination, and epilepsy. As the emergence of gene and cellular therapeutics has changed the clinical landscape for a variety of disorders, and is now ready to do so for neurological diseases, these therapeutic modalities currently complement, and may in time, supplant small molecule drugs.

Inherited White Matter Disorders and Their Mimics

  • 1st Edition
  • Volume 204
  • September 23, 2024
  • David S. Lynch + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 3 2 3 - 9 9 2 0 9 - 1
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 9 2 1 0 - 7
Inherited White Matter Disorders and Their Mimics, Volume 204 discusses where imaging abnormalities and pathology lie predominantly in the CNS white matter. Many acquired causes, such as multiple sclerosis, are readily diagnosed and familiar to the majority of neurologists. However, less common acquired causes and genetic disorders (the leukodystrophies and genetic leukoencephalopathies) often present a diagnostic challenge. The evaluation of patients with White matter disorders (WMDs) has evolved enormously in recent decades, due to advances in genetics, radiology, and the development of treatments for specific disorders. This book brings together WMD research, spanning basic science, molecular genetics, and clinical and radiological phenotyping.This volume presents both common WMDs and rare disorders according to their presentations or pathophysiology. Chapters lay out the clinical and radiological presentation of the disorder, followed by genetics and diagnostics, and finally discussion of pathophysiology and treatment. Chapter contain imaging, clinical pearls to diagnosis, and reference tables for genotype-phenotype correlation. For diagnostic work-up, easy to read algorithms are presented as well as clear guidance on indications for treatment, where applicable.

Neurologic Channelopathies

  • 1st Edition
  • Volume 203
  • August 20, 2024
  • Michael G. Hanna
  • English
  • Hardback
    9 7 8 - 0 - 3 2 3 - 9 0 8 2 0 - 7
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 0 8 2 1 - 4
Neurological Channelopathies, Volume 203 begins with an introductory overview highlighting common mechanistic themes that cut across different CNS and PNS presentations, but that also have potential for common treatment approaches, considering classification, genetics, and fundamental physiology of ion channels. Subsequent chapters present a detailed consideration of all genetic and immunological channelopathies. Each chapter considers Pathophysiological underpinnings - genetic or immunological; Clinical presentations; Diagnostic approach; and Treatment and management.In the last 15 years, a combination of detailed clinical, genetic, molecular electrophysiological, and immunological research has combined to result in a deep understanding of a subgroup of neurological diseases spanning the central and peripheral nervous system and which have become known collectively as the Neurological Channelopathies. Although it was originally considered that significant ion channel dysfunction would not be compatible with life, we now know this is often not the case, although severe disease can often be the result. Given these major advances, it is now the right time to combine this knowledge into a single HCN volume dedicated to the topics at hand.

Hematopoietic Stem Cell Transplantation for Neurologic Diseases

  • 1st Edition
  • Volume 202
  • August 5, 2024
  • Matilde Inglese + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 3 2 3 - 9 0 2 4 2 - 7
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 0 2 4 3 - 4
Hematopoietic Stem Cell Transplantation for Neurological Diseases (HSCT), Volume 201 provides the latest information on what has been evaluated as a possible therapeutic tool in severe autoimmune diseases for the last 20 years. In the neurological field, HSCT has been widely investigated for the treatment of multiple sclerosis and evidence is accumulating about its potential use in neuromyelitis optica, stiff person syndrome, myasthenia gravis, and many immune neuropathies. Besides their strong clinical relevance, studies on HSCT in neurological diseases have contributed to new insights on the pathological mechanisms underlying CNS autoimmunity, hence this volume summarizes that research.

Learning Deep Brain Stimulation Management through Clinical Cases

  • 1st Edition
  • July 20, 2024
  • Martijn Beudel
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 1 8 9 1 0 - 4
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 8 9 1 1 - 1
Learning Deep Brain Stimulation Management through Clinical Cases reviews the clinical practice of applying deep brain stimulation (DBS) to patients with movement disorders. The book explores the cardinal aspects of applying DBS in diverse movement disorders based on patient’s needs. Every case answers all questions, providing case descriptions and step-by-step procedures for optimal replication. Every chapter includes a clinical decision support system (CDSS) depicted in flowcharts that can be used for reference. Deep Brain Stimulation (DBS) uses electrical stimulation to regulate electrical signals in neural circuits to and from identified areas in the brain to improve movement symptoms.The management of DBS in a movement disorders can be challenging, optimizing patient journeys and grasping all clinical aspects of the highly technological therapy. Hence, this book provides the informaiton necessary to embrace new breakthroughs.

Internet of Things and Machine Learning for Type I and Type II Diabetes

  • 1st Edition
  • July 7, 2024
  • Sujata Dash + 4 more
  • English
  • Paperback
    9 7 8 - 0 - 3 2 3 - 9 5 6 8 6 - 4
  • eBook
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Internet of Things and Machine Learning for Type I and Type II Diabetes: Use Cases provides a medium of exchange of expertise and addresses the concerns, needs, and problems associated with Type I and Type II diabetes. Expert contributions come from researchers across biomedical, data mining, and deep learning. This is an essential resource for both the AI and Biomedical research community, crossing various sectors for broad coverage of the concepts, themes, and instrumentalities of this important and evolving area. Coverage includes IoT, AI, Deep Learning, Machine Learning and Big Data Analytics for diabetes and health informatics.

Migraine Management

  • 1st Edition
  • Volume 199
  • February 1, 2024
  • Jerry W. Swanson + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 8 2 3 3 5 7 - 3
  • eBook
    9 7 8 - 0 - 1 2 - 8 2 3 4 8 1 - 5
Migraine Management, Volume 199 covers the effective treatment of migraines, including different subtypes of migraines in different patient populations. The classification and diagnostic criteria of common and uncommon subtypes of migraine is explored in detail, including childhood variants. An in-depth analysis of the pharmacology of acute and prophylactic agents is presented, along with an evidence-based review of pharmacologic management. This includes recently developed CGRP monoclonal antibodies and non-peptide small molecule CGRP antagonists. Advances in neuromodulatory treatments, both noninvasive and implantable are also critically reviewed.Finally, specific treatment-related issues in pregnancy and lactation and childhood as well as the elderly are covered. Issues related to the diagnosis and management of vestibular migraine and the co-morbid disorder of persistent postural-perceptual dizziness are also explored.

Mitochondrial Diseases

  • 1st Edition
  • Volume 194
  • February 20, 2023
  • Rita Horvath + 2 more
  • English
  • Hardback
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  • eBook
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Mitochondrial Diseases, Volume 194 presents the most common clinical manifestations, providing an up-to-date summaries on the clinical presentations, diagnostic processes, genetic counseling and treatment options in mitochondrial diseases. Contents include specialist biochemical analyses and targeted molecular genetic testing, as well as first-line genome-wide sequencing to accelerate speed of diagnosis while avoiding time-consuming, expensive and invasive investigations. Establishing a genetic diagnosis allows patients with mitochondrial diseases to have reproductive options, all of which are covered within.This book is intended for neurologists to help them recognize and manage patients with mitochondrial diseases.