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Books in Clinical neuropathology

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    • Immunotherapies for Neurologic Diseases

      • 1st Edition
      • Volume 214
      • January 2, 2026
      • English
      • Hardback
        9 7 8 0 3 2 3 9 0 8 8 7 0
      • eBook
        9 7 8 0 3 2 3 9 0 8 8 8 7
      The evolution of neuroimmunotherapies with the concurrent progress in autoimmune neurology will introduce the book, followed by an update on “non-targeted” therapies highlighting the value of immunosuppressants, plasmapheresis, IVIg or hematopoietic bone marrow transplantation and their mode of action in autoimmune neurology. The new agents in each of these categories, along with biomarkers for therapeutic monitoring and the application of reliable scales in assessing response, will be covered. Chapters will discuss how neuroimmunotherapies work when key molecules and pathways associated with CNS or PNS tissue damage are targeted or inhibited. The volume will describe the approved agents targeting: 1) T-cell intracellular signaling pathways and molecules associated with antigen presentation; 2) B cells, B-cell trophic factors, and autoantibodies; 3) Fc receptor modulation; 4) complement; and 5) cytokines, cell adhesion and transmigration molecules. Didactic schemes and illustrations on how these drugs work in autoimmune neurological diseases will be provided in each chapter.The second part of the book will discuss the latest therapeutics for each major autoimmune neurological disease, aimed to provide a reliable, comprehensive and up-to-date source of information useful for clinical practice and education. Didactic and practical algorithms, a step-by step approach on how best to apply the most suitable therapies for a given state of the disease or proceed to escalation therapies will be provided.Treatment controversies and uncertainties will be authoritatively emphasized by scholars in each field. A chapter addressing potential immunotherapeutic approaches, now on the pipeline or on early trials, as future means of treating some neurodegenerative diseases will be included. Another chapter will cover the new and popular-although controversial -concept of treating autoimmune pain.The book discusses practical therapies with traditional immunosuppressants, steroids and IVIg. It describes targeted therapies with monoclonal antibodies or fusion proteins against B cells , T cells, complement, and FcRn, discussing what happens when key factors related to neurological autoimmunity are inhibited. The book provides a “how- to- do” approach for each of the major autoimmune diseases with algorithms and escalation therapies. Dedicated chapters will cover current therapies on encephalitis, NMOSD, Multiple sclerosis , autoimmune neuropathies, myopathies, neuromuscular junction disorders and neuroexcitability disorders like stiff person syndrome. The book is aimed for practitioners and academicians as a reliable and comprehensive source for applying neuroimmunotherapies and understanding their mechanisms.

    • Tic Disorders and Tourette Syndrome

      • 1st Edition
      • January 1, 2026
      • Christos Ganos + 1 more
      • English
      Tic Disorders and Tourette Syndrome is an essential resource that delves into the clinical aspects, treatments, and ongoing research related to tic disorders and Tourette syndrome. It covers a range of topics from primary to secondary and functional tics, providing differential diagnosis. The book is designed to offer foundational knowledge to neurologists, psychiatrists, neuropsychiatrists, and psychologists, while also catering to the needs of advanced readers. In addition to clinical presentations, the book discusses the epidemiology, etiology, and pathophysiology of tics, along with common neuropsychiatric comorbidities such as obsessive-compulsive disorder, ADHD, mood disorders, and intermittent explosive disorder. The volume also includes treatment options and clinical scales to evaluate tics, illustrated with video accompaniments and animal models.

    • Coma, Stupor, and Related Disorders of Consciousness

      • 1st Edition
      • Volume 207
      • February 26, 2025
      • Peter W. Kaplan + 1 more
      • English
      • Hardback
        9 7 8 0 4 4 3 1 3 4 0 8 1
      • eBook
        9 7 8 0 4 4 3 1 3 4 2 5 8
      Coma, Stupor, and Related Disorders of Consciousness reviews recent research and best practice in the assessment and treatment of coma, stupor, and disorders of consciousness. It encompasses the neural circuits, anatomy & physiology of stupor and coma, differential diagnosis and clinical assessment, imagery, EEGs, therapy/intervention... decision making and prognosis.

    • Neuroglia in Neurologic and Psychiatric Disorders, Part II

      • 1st Edition
      • Volume 210
      • March 28, 2025
      • English
      • Hardback
        9 7 8 0 4 4 3 1 9 1 0 2 2
      • eBook
        9 7 8 0 4 4 3 1 9 1 0 3 9
      Neuroglia in Neurologic and Psychiatric Disorders, Part II discusses glia relative to neurologic and psychiatric disorders, emphasizing cross-disease-glial cell dysfunctions. Driven by advances in genetics, transcriptomics, electrophysiologic and imaging techniques, as well as by the increase in knowledge on neuropathologic features and underlying disease mechanisms, this book bridges the gap between neuroglia basic science and neuroglia clinical research.

    • Vestibular Schwannomas

      • 1st Edition
      • Volume 212
      • October 1, 2025
      • English
      • Hardback
        9 7 8 0 1 2 8 2 4 5 3 4 7
      • eBook
        9 7 8 0 3 2 3 8 5 9 9 7 4
      Vestibular Schwannomas covers multiple facets of vestibular schwannomas, including advancements in surgical techniques, radiological innovations, long-term patient outcomes, and implications for hearing preservation. It serves as a comprehensive guide for clinicians and researchers aiming to enhance diagnostic accuracy and therapeutic strategies in managing these complex tumors which are benign, slow-growing tumors that originate from the Schwann cells that line the vestibular nerve. They are the most prevalent neoplasms found in the cerebellopontine angle (CPA), the critical junction between the cerebellum and the brainstem.Their incidence, clinical presentation, and impact on surrounding neurological structures make them a focal point of research and medical intervention. Understanding their etiology, diagnosis, and treatment options requires an interdisciplinary approach bridging neurology, otology, and radiology.

    • Circadian Rhythms, Sleep, and Sleep Disorders

      • 1st Edition
      • Volume 206
      • January 24, 2025
      • English
      • Hardback
        9 7 8 0 3 2 3 9 0 9 1 8 1
      • eBook
        9 7 8 0 3 2 3 9 0 9 1 9 8
      Circadian rhythms, sleep, and sleep disorders covers the topic in two sections focusing on basic science and clinical application. In the basic section, new developments and research findings focusing on basic circadian rhythm and sleep physiology in animals and humans is highlighted. The chapters are written in short mini-review formats in order to concisely describe the fundamentals, and current hot topics.The basic part starts with a chapter on the fundamentals and new discoveries on oscillating circuitries in the sleeping rodent and human brain. This sets the stage for chap 2, focusing on circadian and homeostatic aspects of human sleep regulation. Chap 3 extends these aspects to human cognition. The next chapter reports on visual and non-visual effects of light on human behavior, particularly endocrine and electrophysiological correlates. Chap 5 covers chronic sleep restriction effects on functional connectivity states. The last two chapters (6 and 7) give a broad overview on sleep modeling across physiological levels, with a focus on a quantitative model of sleep-wake dynamics based on the physiology of the brainstem ascending arousal system.The clinical section of the book describes the circadian rhythm sleep-wake disorders, from epidemiology to clinical picture and treatment. Disorders covered include delayed and advanced sleep phase syndrome, Irregular sleep-wake rhythm disorder, shift work disorder, restless legs syndrome, nocturnal eating syndrome, narcolepsy, and sleep apnea. Pharmacological and non-pharmacological treatments of insomnia are explored, as well as the role of sleep-wake modulation in the pathogenesis and clinical profile of neurodegenerative disorders, such as Parkinson’s disease and Alzheimer’s disease.

    • Neuroglia in the Healthy Nervous System, Part I

      • 1st Edition
      • Volume 209
      • March 22, 2025
      • English
      • Hardback
        9 7 8 0 4 4 3 1 9 1 0 4 6
      • eBook
        9 7 8 0 4 4 3 1 9 1 0 5 3
      Neuroglia in the Healthy Nervous System, Part I provides insights into newly emerging developments in neuroglia biology, focusing on the healthy nervous system. Driven by advances in genetics, transcriptomics, electrophysiological... and imaging techniques, this volume bridges the gap between neuroglia basic science and neuroglia clinical research. The book provides an overview of neuroglia biology, highlighting emerging technologies used to unravel the role of neuroglial cells in specific brain functions. The book also discusses strategies using neuroglia as a therapeutic target.

    • Focal Neuropathies

      • 1st Edition
      • Volume 201
      • April 30, 2024
      • English
      • Hardback
        9 7 8 0 3 2 3 9 0 1 0 8 6
      • eBook
        9 7 8 0 3 2 3 9 0 1 0 9 3
      Facial Neuropathies, Volume 202 summarizes research and treatment on focal neuropathies to update clinicians on nerve biology and new diagnostic techniques to guide investigation and treatment of mononeuropathies. The book explores research broadly applicable to all types of mononeuropathies as well as individual mononeuropathy syndromes. Chapters on individual mononeuropathies include anatomy, causes, controversial diagnoses, and current or potential future treatments.

    • Inherited White Matter Disorders and Their Mimics

      • 1st Edition
      • Volume 204
      • September 23, 2024
      • English
      • Hardback
        9 7 8 0 3 2 3 9 9 2 0 9 1
      • eBook
        9 7 8 0 3 2 3 9 9 2 1 0 7
      Inherited White Matter Disorders and Their Mimics, Volume 204 discusses where imaging abnormalities and pathology lie predominantly in the CNS white matter. Many acquired causes, such as multiple sclerosis, are readily diagnosed and familiar to the majority of neurologists. However, less common acquired causes and genetic disorders (the leukodystrophies and genetic leukoencephalopathie... often present a diagnostic challenge. The evaluation of patients with White matter disorders (WMDs) has evolved enormously in recent decades, due to advances in genetics, radiology, and the development of treatments for specific disorders. This book brings together WMD research, spanning basic science, molecular genetics, and clinical and radiological phenotyping.This volume presents both common WMDs and rare disorders according to their presentations or pathophysiology. Chapters lay out the clinical and radiological presentation of the disorder, followed by genetics and diagnostics, and finally discussion of pathophysiology and treatment. Chapter contain imaging, clinical pearls to diagnosis, and reference tables for genotype-phenotype correlation. For diagnostic work-up, easy to read algorithms are presented as well as clear guidance on indications for treatment, where applicable.

    • Hematopoietic Stem Cell Transplantation for Neurologic Diseases

      • 1st Edition
      • Volume 202
      • August 5, 2024
      • English
      • Hardback
        9 7 8 0 3 2 3 9 0 2 4 2 7
      • eBook
        9 7 8 0 3 2 3 9 0 2 4 3 4
      Hematopoietic Stem Cell Transplantation for Neurological Diseases (HSCT), Volume 201 provides the latest information on what has been evaluated as a possible therapeutic tool in severe autoimmune diseases for the last 20 years. In the neurological field, HSCT has been widely investigated for the treatment of multiple sclerosis and evidence is accumulating about its potential use in neuromyelitis optica, stiff person syndrome, myasthenia gravis, and many immune neuropathies. Besides their strong clinical relevance, studies on HSCT in neurological diseases have contributed to new insights on the pathological mechanisms underlying CNS autoimmunity, hence this volume summarizes that research.