Neuroglia in Neurologic and Psychiatric Disorders, Part II
- 1st Edition, Volume 210 - March 28, 2025
- Imprint: Elsevier
- Editors: Alexei Verkhratsky, Lotje D. De Witte, Eleonora Aronica, Elly M. Hol
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 9 1 0 2 - 2
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 9 1 0 3 - 9
Neuroglia in Neurologic and Psychiatric Disorders, Part II discusses glia relative to neurologic and psychiatric disorders, emphasizing cross-disease-glial cell dysfun… Read more
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Request a sales quoteNeuroglia in Neurologic and Psychiatric Disorders, Part II discusses glia relative to neurologic and psychiatric disorders, emphasizing cross-disease-glial cell dysfunctions. Driven by advances in genetics, transcriptomics, electrophysiologic and imaging techniques, as well as by the increase in knowledge on neuropathologic features and underlying disease mechanisms, this book bridges the gap between neuroglia basic science and neuroglia clinical research.
- Provides an overview of neuroglia biology
- Identifies neuroglia dysfunction in neurologic and psychiatric disorders
- Covers ALS, dementia, Alzheimer, Parkinson, Huntington diseases and more
- Includes TBI, Stroke, COVID
- Encompasses disorders of mood, eating, sleep, anxiety, schizophrenia, autism, and more
Practicing neurologists, research neurologists
- Neuroglia in Neurologic and Psychiatric Disorders, Part II
- Cover image
- Title page
- Table of Contents
- Series Page
- Copyright
- Handbook of Clinical Neurology 3rd Series
- Foreword
- Preface
- Contributors
- PART I: Glia in neurological disorders
- Chapter 1 General pathophysiology of neuroglia
- Abstract
- Keywords
- Neuroglia in Neuropathology: Historic Prelude
- Principles of Pathophysiology of Neuroglia
- Conclusions
- References
- Chapter 2 Neuroglia in neurodegeneration: Alzheimer, Parkinson, and Huntington disease
- Abstract
- Keywords
- Introduction: The Rise of Neurodegenerative Diseases
- Neuroglia in Alzheimer Disease
- Brief overview of AD pathogenesis and clinical presentation
- AD mouse models
- Astrocytes in AD
- Microglia in AD
- Oligodendrocytes in AD
- Neuroglia in PD
- Brief overview of PD pathogenesis and clinical picture
- PD animal models
- Astrocytes in PD
- Microglia in PD
- Oligodendrocytes and myelin in PD
- Neuroglia in Huntington Disease
- Brief overview of HD pathogenesis and clinical picture
- HD animal models
- Astrocytes in HD
- Microglia in HD
- Oligodendrocytes and myelin in HD
- Astrotaupathies
- Conclusions
- Conflict of interest
- References
- Chapter 3 Neuroglia in neurodegeneration: Amyotrophic lateral sclerosis and frontotemporal dementia
- Abstract
- Keywords
- Introduction
- Amyotrophic lateral sclerosis
- Frontotemporal dementia
- Animal Models of ALS and FTD
- SOD1 rodent models of ALS
- TDP-43 rodent models of ALS and FTD
- Chromosome 9 open reading frame 72 (C9ORF72) mutant models of ALS and FTD
- TBK1 mutant models of ALS and FTD
- OPTN mutant models of ALS and FTD
- Glial Involvement in ALS/FTD: In Human Evidence
- Glial histopathology in ALS and FTD: Postmortem evidence
- In vivo imaging of glia in ALS and FTD
- The Role of Glia in ALS and FTD
- Astrocytes in ALS and FTD
- Microglia in ALS and FTD
- Oligodendrocytes in ALS and FTD
- Glia-immunity cross talk
- Glial Biomarkers in CSF and Blood
- Glial-Based Clinical Trials in ALS and FTD
- Conclusions
- References
- Chapter 4 Neuroglia in epilepsy
- Abstract
- Keywords
- Epilepsy
- Glia
- Astroglia
- Astroglia and the BBB in epilepsy
- Cellular and molecular changes to astroglia in epilepsy
- Astroglial contribution to immune and inflammatory functions in the context of epilepsy
- Microglia
- Oligodendroglia
- Demyelination and epilepsy
- Cellular and molecular changes to oligodendroglia in epilepsy
- Potential Glial Therapeutic Targets
- References
- Chapter 5 Neuroglia pathology in genetic and epigenetic disorders of the central nervous system
- Abstract
- Keywords
- Introduction
- MicroRNAs of Individual Glial Cells
- Examples of Genetic/Metabolic Diseases in Which Glial Cells Are Altered
- Agenesis of the corpus callosum
- Alexander disease
- Rett syndrome
- Fragile-X syndrome
- Aicardi-Goutières syndrome
- Down syndrome
- Fetal alcohol spectrum disorder
- Other Neuropathological Features That Involve Glial Cells
- Satellitosis
- α-B-crystallin as a glial marker of epileptic foci
- Loss of subpial granular glial layer of Brun
- Fetal astrocytic synthesis of keratan sulfate to guide axonal projections and insulate fascicles
- Conclusions
- Disclosures
- References
- Chapter 6 Neuroglia in stroke
- Abstract
- Keywords
- Historic Prelude: From Hippocratic Apoplexy to Stroke
- Stroke: General Remarks
- Loss of Ion, Water, and Metabolic Homeostasis in the Ischemic Core and Penumbra
- Astrocytes in Stroke: Neuroprotection and Reactive Astrogliosis
- Astrocytic protection of neurons
- Astrocytic perilesional limitans border formation around fibrotic scar tissue
- Neuroglia and Brain-Wide Poststroke Pathology
- Oligodendrocytes and White Matter Stroke
- Microglia in Stroke
- Conclusions
- References
- Chapter 7 Unraveling the complexity of microglial responses in traumatic brain and spinal cord injury
- Abstract
- Keywords
- Introduction
- Origin and Function of Microglia
- Microglia in the Injured CNS: Primed for Immune Dysfunction and Chronic Neuroinflammation
- Identification of Novel Microglial Phenotypic States in CNS Injury States
- Microglia as a Therapeutic Target in TBI
- Could Microglial Elimination or Forced Turnover in the Injured Brain be Neuroprotective for TBI?
- Understanding Microglia Responses in Large Animal Models of TBI
- Microglia in Human TBI: What Is the Current Evidence of Their Phenotypic and Functional Roles?
- The Therapeutic Potential of Targeting Microglia Responses in SCI
- Conclusion
- References
- Chapter 8 Astrocytes and microglia in multiple sclerosis and neuromyelitis optica
- Abstract
- Keywords
- Historic Prelude
- Overview of Multiple Sclerosis and Neuromyelitis Optica
- Overview of Neuroglia in the Context of MS and NMO
- Microglia in Multiple Sclerosis
- Microglial phenotypes
- Microglia contribution to pathogenesis of multiple sclerosis
- Astrocytes in Multiple Sclerosis
- Cross Talk Between Astrocytes and Microglia
- Neurodegeneration as a Feature of MS: Role for Neuroglia
- Neuroglia as a Therapeutic Target in Multiple Sclerosis
- Targeting microglia
- Targeting astrocytes
- Neuroglia in NMO
- Microglia
- Astrocytes
- Interaction of microglia and astrocytes with immune cells
- Interaction of microglia and astrocytes with brain resident cells
- Neuroglia as a Therapeutic Target in NMO
- Microglia
- Astrocytes
- Conclusions
- References
- Chapter 9 Neuroglia in autoimmune encephalitis
- Abstract
- Keywords
- Introduction
- Astrocytes
- Autoimmune GFAP astrocytopathy
- Oligodendrocytes
- MOG ab-associated AE
- Microglia
- Conclusions and Future Perspectives
- References
- Chapter 10 Neuroglia in leukodystrophies
- Abstract
- Keywords
- Introduction
- Astroglial Leukodystrophies
- Alexander disease
- Vanishing white matter disease
- Megalencephalic leukoencephalopathy with subcortical cysts
- Aicardi–Goutières syndrome
- Genetic Etiology, Molecular Pathogenesis, and Genotype–Phenotype Correlation
- Oligodendroglial Leukodystrophies
- Krabbe disease or globoid cell leukodystrophy
- Adult-onset autosomal dominant leukodystrophy
- Metachromatic leukodystrophy
- Canavan disease
- Pelizaeus–Merzbacher disease
- Hypomyelination with atrophy of basal ganglia and cerebellum
- Microglial Leukodystrophies
- Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy or Nasu–Hakola disease
- Hereditary adult-onset leukoencephalopathy with axonal spheroids and pigmented glia
- Conclusions
- Acknowledgment
- References
- Chapter 11 Reciprocal interactions between glioma and tissue-resident cells fueling tumor progression
- Abstract
- Keywords
- TAM-Glioma Cell Interactions
- Soluble Factors Mediating TAM-Glioma Cross Talk
- Modulation of the extracellular matrix
- Contributions of TAM-Glioma Interactions for Tumor Behavior
- Neuron-Glioma Interactions
- Neuronal activity promotes tumor growth while glioma cells affect local neuronal network activities
- Synaptic influences on glioma cells
- Glutamatergic signaling and glioma excitatory drive
- GABAergic signaling and chloride regulation in gliomas
- Concluding remarks
- Acknowledgments
- References
- Chapter 12 Neuroglia in hepatic encephalopathy
- Abstract
- Keywords
- Hepatic Encephalopathy: Basic Information
- Types of HE
- Causes
- Symptoms
- Experimental Models
- Alzheimer II Astrocytes: The Response of Astrocytes to Chronic HE
- Metabolic Remodeling of Astrocytes at the Onset of ALF
- Astrocytic Impact on the Excitation/Inhibition Balance
- Astrocytic contribution to alterations of glutamate and GABA synthesis in HE
- Astrocytic interference with the glutamatergic/GABAergic neurotransmission balance at steps beyond neurotransmitter synthesis
- Malfunctional Astrocyte and Impaired Ion Fluxes
- Astrocyte Swelling and Brain Edema
- Intracellular osmotic imbalance
- The oxidative/nitrosative stress and mitochondrial dysfunction
- Neurogliovascular unit and perivascular edema
- The Asthenic Astrocyte
- Neuroinflammation: A Consequence of Systemic Inflammation and Reactive Microgliosis
- Concluding Remarks
- Acknowledgments
- References
- Chapter 13 Neuroglial responses to bacterial, viral, and fungal neuroinfections
- Abstract
- Keywords
- Neuroinfections and the Nervous System
- Neuroinvasiveness, Neurotropism, and Neurovirulence of Pathogens: An Overview
- Neuroglial Roles in Bacterial Infections: A Spotlight on Meningoencephalitis-Causing E. coli K1
- Bacterial CNS infection
- Microglia and astrocytes in meningoencephalitis-causing E. coli K1 infection
- Microglial Roles in Viral Infections
- Non-neurotropic viral infection and the CNS
- Toll-like receptors and IFN type 1-mediated response
- Purinergic signaling as a driver of microglial chemotaxis in viral infection immune response
- Glial Roles in Fungal Infections
- Microglia and astrocytes in neuroinvasive C. neoformans infection
- Neuroglia in SARS-COV-2 and COVID-19: A Spotlight
- SARS-CoV-2 pathway to the brain
- Neurodegenerative susceptibility following SARS-CoV-2 infection
- Macrophages and Microglia as Viral Reservoirs in HIV: A Spotlight
- Neuroglia as Pharmacologic Targets During Neuroinvasive Infections
- Neuroglia as therapeutic target in HIV
- Neuroglia as therapeutic targets in nematode infection
- Bacterial CNS infection: Therapeutic insight
- Concluding Remarks
- References
- Chapter 14 Physiology and pathophysiology of the retinal neuroglia
- Abstract
- Keywords
- The Retina and the Visual System
- Cellular Organization of the Retina
- Retinal Astroglia: Müller Cells and Astrocytes
- Astroglia: General remarks
- Müller cells: The morpho-functional integrators of the retina
- Müller glia: Numbers and morphology
- Physiology of Müller glia
- Functions of Müller glia
- Retinal astrocytes
- Oligodendroglia of the Retina
- Microglia of the Retina
- Pathophysiology of Retinal Neuroglia
- Macular telangiectasia type 2
- Glaucoma
- Age-related macular degeneration
- Retinitis pigmentosa
- Diabetic retinopathy
- Retinopathy of prematurity
- Endophthalmitis
- Conclusions
- Acknowledgments
- References
- Chapter 15 From womb to world: The interplay between maternal immune activation, neuroglia, and neurodevelopment
- Abstract
- Keywords
- The Dynamic Role of Neuroglia in Brain Development and Adulthood
- Maternal Immune Activation
- Inflammation and Cytokines Associated With MIA
- Temporal Stage of Infection and Cytokine Exposure
- Modeling MIA: Animal and Human
- Influenza A-mediated MIA model
- The poly(I:C)-mediated MIA model
- Lipopolysaccharide (LPS)-mediated MIA model
- Human-induced pluripotent stem cell (iPSC) technology
- Double-hit MIA models
- Maternal Immune Activation Effect on Neuroglia
- MIA and astroglia
- MIA and oligodendroglia
- MIA and microglia
- The COVID-19 Pandemic
- Conclusions, Speculations, and Future Directions
- References
- Part II: Neuroglia in psychiatric disorders
- Chapter 16 Neuroglia in mood disorders
- Abstract
- Keywords
- Introduction
- Mood Disorders
- Total Glia
- Imaging
- Animal models
- Human postmortem
- Biomarkers in blood and CSF
- Summary
- Astrocytes
- Imaging
- Animal models
- Human postmortem
- Biomarkers in blood and CSF
- Neurotrophic factors
- Other astrocytic markers
- Summary
- Oligodendrocytes
- Imaging
- Animal models
- Human postmortem
- Biomarkers in blood and CSF
- Summary
- Microglia
- Imaging
- Animal models
- Human postmortem
- Biomarkers
- Other microglia specific markers
- Summary
- Mood Disorder Treatments
- Antidepressants
- Lithium
- Deficiencies in Glia–Glia Crosstalk and Mood Disorders
- Conclusions and Future Directions
- References
- Chapter 17 Neuroglia in autism spectrum disorders
- Abstract
- Keywords
- ASD Diagnosis and Symptoms
- Genetic Factors Associated With ASD
- Prenatal Inflammation Is a Risk Factor for ASD
- The Role of Neuroglia in ASD-Associated Changes in Neurons
- Myelin Alterations Underlying Brain Connectivity
- References
- Chapter 18 Neuroglia in eating disorders (obesity, Prader-Willi syndrome and anorexia nervosa)
- Abstract
- Keywords
- Introduction
- Homeostatic and Non-homeostatic Control of Feeding Behavior
- Obesity
- Tanycytes
- Microglia
- Astrocytes
- Oligodendrocytes
- Prader-Willi Syndrome
- Microglia and astrocytes
- Oligodendrocytes
- Anorexia Nervosa
- Microglia
- Astrocytes
- Conclusion
- References
- Chapter 19 Neuroglia in Tourette syndrome and obsessive-compulsive disorder
- Abstract
- Keywords
- Gilles de la Tourette's Syndrome
- Microglia dysfunction in TS
- Are astrocytes involved in TS?
- Oligodendroglia, myelin and TS
- Obsessive-Compulsive Disorder
- OCD as a microgliopathy
- Astrocytes, glutamate, and pathologic grooming
- Oligodendroglia and myelination in OCD
- The Particular Case of PANDAS/PANS
- Final Notes
- References
- Chapter 20 Neuroglia in anxiety disorders
- Abstract
- Keywords
- Introduction
- Overview of Neuroglia
- Preclinical Animal Models of Stress and Anxiety
- Overview of Specific Brain Regions Involved in PTSD
- Microglia
- Microglia and epigenetics
- Microglia and the neuroimmune system
- Oligodendrocytes
- Oligodendrocytes in preclinical models
- Oligodendrocytes in clinical PTSD
- Astrocytes
- Astroglia in clinical PTSD
- Astroglia in neuroimmune response
- Pharmacologic Treatments for PTSD
- Future Steps for Understanding Neurobiology of Anxiety
- Conclusion
- Acknowledgments
- References
- Chapter 21 Neuroglia in substance use disorders
- Abstract
- Keywords
- Introduction
- Neuroglia
- Neuroglial Mechanisms Underlying Substance Use
- Opioids
- Opioid use disorder treatments
- Stimulants
- Stimulant use disorder treatments
- Alcohol
- Alcohol use disorder treatments
- Nicotine
- Nicotine use treatments
- Cannabis
- Cannabis use treatments
- Gut Microbiome
- Gut microbiome and neuroglia
- Conclusions
- References
- Chapter 22 Neuroglia in suicide
- Abstract
- Keywords
- Risk Factors and Treatments for Suicide
- Neuroglia Biology Provides Molecular Features of Suicide
- Astroglia in suicide
- Microglia in suicide
- Oligodendroglia in suicide
- Pitfalls in Suicide Research
- Animal models of suicide
- Human postmortem brain samples in suicide studies
- Novel Neuroglial Changes in Suicide
- Suicide and psychiatric disorders: Commonalities and differences in neuroglia
- Neuroglia changes in suicide can be similar in different psychiatric disorders
- Psychiatric suicides and nonpsychiatric suicides may have shared or independent neuroglia changes
- Microglia are involved in resilience to suicide
- Neuroglia and Antisuicidal Therapies
- Conclusions
- References
- Index
- Edition: 1
- Volume: 210
- Published: March 28, 2025
- Imprint: Elsevier
- No. of pages: 404
- Language: English
- Hardback ISBN: 9780443191022
- eBook ISBN: 9780443191039
AV
Alexei Verkhratsky
Professor Alexei Verkhratsky, PhD, DSc, is an internationally recognised scholar in the field of cellular neurophysiology, best known for his contributions to our knowledge of the physiology and pathophysiology of neuroglia. He started glial research in 1989 in Heidelberg in the laboratory of Helmut Kettenmann. In a series of highly cited conceptual papers, he outlined basic principles of glial physiology and pathophysiology, which significantly influenced this rapidly developing area of neuroscience.
Affiliations and expertise
University of Manchester, Manchester, UKLD
Lotje D. De Witte
Dr. de Witte is a psychiatrist with a background in preclinical research in the fields of virology and immunology. She is an MD PhD interested in how the immune system plays a role in psychotic disorders. In parallel to her residencies in psychiatry, she started her own research group at the Brain Center Rudolf Magnus in Utrecht, the Netherlands investigating the prevalence and role of neuronal auto-antibodies and neurotropic pathogens in psychotic disorders. He research has resulted in a novel and distinctive research line studying the phenotype and function of microglia in psychotic disorders.
Affiliations and expertise
Psychiatrist, Icahn School of Medicine at Mount Sinai. New York, USAEA
Eleonora Aronica
Prof. E.M.A. Aronica is professor of Neuropathology at the University of Amsterdam’s Faculty of Medicine (AMC-UvA).
Her research focuses on understanding the pathogenesis, epileptogenesis and pharmacoresistance of focal chronic pharmacoresistant epilepsy, as well as featuring translational aspects. The aim is to find an effective treatment for patients with epilepsy by mapping biological and molecular signalling pathways that contribute towards the development and progression of epilepsy and associated comorbidity. Aronica studies the control mechanisms of inflammatory processes, microRNAs, biomarkers to predict and diagnose the development of disease. Aronica focuses on neuropathological and applied research for patients with neurological diseases. She has published more than 300 peer-reviewed articles and several chapters for books.
Affiliations and expertise
Neuropathologist, Department of (Neuro) Pathology, Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, the NetherlandsEH
Elly M. Hol
Elly Hol is professor of “Glia biology of brain diseases” at the Utrecht University and professor of "Biology of glia and neural stem cells” at the University of Amsterdam. Her research is focused on the role of glial cells in brain diseases, including Alzheimer’s disease, stroke, schizophrenia and glioma. The overall aim is to elucidate the molecular and functional changes in glia that contribute to the pathogenesis of neurological and psychiatric diseases. Her work is translational and includes studies on glial cells in human post-mortem brain tissue, in human cell models, and in mouse models for brain diseases. She is a member of Academia Europaea, member of the editorial board of Glia, chair of the scientific advisory board of Alzheimer Nederland, chair of GliaNed, director of the Neuroscience Master and PhD program of the Utrecht University Graduate School of Life Sciences, and director of education for the Division Brain at the UMCU.
Affiliations and expertise
Neuroscientist, Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The NetherlandsRead Neuroglia in Neurologic and Psychiatric Disorders, Part II on ScienceDirect