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Elsevier

Books in Clinical neurophysiology

  • The Zebrafish Model of Neurodegenerative Disorders

    Knowing the Unknown
    • 1st Edition
    • Wael Mohamed
    • English
    The Zebrafish Model of Neurodegenerative Disorders: Knowing the Unknown reveals a ground-breaking method for decoding neurodegenerative disorders such as Parkinson's, Alzheimer's, ALS, and Huntington's through the lens of the zebrafish. This volume bridges the divide between fundamental science and clinical innovation, demonstrating how the genetic malleability, transparent embryos, and conserved neural pathways of zebrafish provide unparalleled insights into neurodegeneration. It illustrates the potential to uncover concealed pathological mechanisms, expedite drug discovery, and surmount the translational failings that impede current research using this gold-standard model species. Featuring contributions from global experts, this volume is systematically structured into five topical sections for ease of navigation. These sections explore the role of cutting-edge tools such as CRISPR-Cas9, AI-driven phenotyping, and high-throughput drug screening in the study of α-synuclein aggregation in Parkinson's Disease and amyloid-β toxicity in Alzheimer's Disease. The volume offers real-world applications, comparative analyses of zebrafish and mammalian models, and actionable protocols that translate zebrafish discoveries to clinical trials. The Zebrafish Model of Neurodegenerative Disorders is designed to empower researchers, clinicians, and healthcare professionals by addressing existing gaps in knowledge, particularly fragmentation in protocols and the translational disconnect between preclinical models and human trials. By fostering an integrated understanding of zebrafish as a model for neurodegeneration, it enhances research reproducibility, accelerates drug discovery, and promotes ethical, scalable research practices. Whether used as a teaching resource or a reference for experimental design, this volume offers invaluable insights to advance the understanding and treatment of devastating neurodegenerative diseases.

  • Epigenetic Mechanisms in Brain Physiology and Disorders

    • 1st Edition
    • Volume 219
    • Moshe Szyf + 1 more
    • English
    Epigenetic Mechanisms in Brain Physiology and Disorders provides a comprehensive summary of epigenetic mechanisms in brain development, from embryogenesis to aging, brain physiology and pathology. It discusses the role DNA methylation plays in regulating genomic functions, which in turn guide brain function. The book explores the epigenetic role in cell type differentiation, epigenetic processes in memory, learning, and neuronal functioning, the role of DNA methylation and other epigenetic mechanisms in sleep, feeding and metabolic control, sex, temperature regulation, and cardiovascular and blood pressure regulation. It further explores the role of epigenetic processes in neuropsychiatry disorders, neurological disease and behavioral disorders, as well as epigenetic diagnostics and therapeutics.

  • Clinician’s Guide to Headache

    Head, Neck, and Face Pain Syndromes
    • 1st Edition
    • Pravin Thomas
    • English
    Clinician’s Guide to Headache: Head, Neck, and Face Pain Syndromes is a clinically focused, case-based reference for neurologists, headache specialists, pain physicians, trainees, and allied clinicians caring for patients with head, neck, and facial pain. Rather than relying only on conventional disease-based descriptions, it reflects the realities of everyday practice: complex and overlapping syndromes, diagnostic uncertainty, secondary causes, comorbidities, and rapidly changing therapeutic options. Organized around real clinical scenarios, the book covers the full breadth of headache medicine, from classification, anatomy, history taking, examination, and pathophysiology to migraine, trigeminal autonomic cephalalgias, cranial neuralgias, CSF pressure disorders, neurovascular and inflammatory diseases, infections, metabolic causes, epilepsy-related headache, sleep-related disorders, ophthalmic presentations, pediatric headache, neck pain, and facial pain. Foundational sciences, such as anatomy, neuroradiology, pharmacology, and pathophysiology, are presented in a practical, case-oriented manner to support bedside decision-making. The text also addresses the important frontiers in modern headache care, biologics, percutaneous interventions, implantable and noninvasive neuromodulation, and integrative strategies, such as yoga, meditation, and nutrition.With contributions from an international faculty, this volume provides a pragmatic, modern, and multidisciplinary approach to one of the most challenging areas in clinical neuroscience

  • Progress in Motor Control

    Crossroads between Neurophysiology and Applications
    • 1st Edition
    • Mark L. Latash + 4 more
    • English
    Progress in Motor Control: Crossroads between Neurophysiology and Applications offers an in-depth look at the evolving field of motor control, synthesizing the latest research. This volume explores the complex roles of the central nervous system in movement, featuring contributions from leading experts who use approaches ranging from basic physical principles to advanced control theory. It addresses applied aspects of motor control, focusing on recovery strategies for functional movements in patients with spinal cord injuries, subcortical disorders, and strokes. Organized into five sections, the book covers theoretical advances, neurophysiological mechanisms, motor learning, neural plasticity, and motor disorders, including topics like neural population dynamics and vestibulospinal reflexes. The final sections highlight strategies for improving recovery after neurological events. This resource bridges foundational research and clinical application, making it invaluable for researchers, clinicians, and students in motor control, neuroscience and rehabilitation.Divid... into five comprehensive parts, the book covers theoretical advances, neurophysiological mechanisms, motor learning, neural plasticity, and motor disorders, including essential topics like neural population dynamics and the dual role of vestibulospinal reflexes. Final sections highlight practical strategies for improving recovery outcomes following neurological events.

  • The Brainstem

    • 1st Edition
    • Volume 216
    • English
    This volume on Brainstem consolidates research for a complete understanding of the anatomy and physiology of the Brainstem and how it affects assorted other systems in the body. The brainstem impacts breathing, the gastrointestinal system, the cardiac system, mood, pain, wakefulness, consciousness, and sleep. Pathologies can impact vision, motor control, hearing, balance, blood supply and is particularly involved in neurodegenerative diseases like Parkinson’s. The volume discusses how the brainstem operates in full health, pathologies associated with the brainstem and their impact, methods for monitoring brainstem function, and diagnosis and treatment of brainstem disorders. Monitoring and intervention is reliant on technologies to assess function. This volume will include CT, MRI, USG, angiography, BERA, and functional imaging.

  • Tic Disorders and Tourette Syndrome

    • 1st Edition
    • Volume 215
    • Christos Ganos + 1 more
    • English
    Tic Disorders and Tourette Syndrome is an essential resource that delves into the clinical aspects, treatments, and ongoing research related to tic disorders and Tourette syndrome. It covers a range of topics from primary to secondary and functional tics, providing differential diagnosis. The book is designed to offer foundational knowledge to neurologists, psychiatrists, neuropsychiatrists, and psychologists, while also catering to the needs of advanced readers. In addition to clinical presentations, the book discusses the epidemiology, etiology, and pathophysiology of tics, along with common neuropsychiatric comorbidities such as obsessive-compulsive disorder, ADHD, mood disorders, and intermittent explosive disorder. The volume also includes treatment options and clinical scales to evaluate tics, illustrated with video accompaniments and animal models.

  • Neuroglia in Neurologic and Psychiatric Disorders, Part II

    • 1st Edition
    • Volume 210
    • English
    Neuroglia in Neurologic and Psychiatric Disorders, Part II discusses glia relative to neurologic and psychiatric disorders, emphasizing cross-disease-glial cell dysfunctions. Driven by advances in genetics, transcriptomics, electrophysiologic and imaging techniques, as well as by the increase in knowledge on neuropathologic features and underlying disease mechanisms, this book bridges the gap between neuroglia basic science and neuroglia clinical research.

  • Neuroglia in the Healthy Nervous System, Part I

    • 1st Edition
    • Volume 209
    • English
    Neuroglia in the Healthy Nervous System, Part I provides insights into newly emerging developments in neuroglia biology, focusing on the healthy nervous system. Driven by advances in genetics, transcriptomics, electrophysiological... and imaging techniques, this volume bridges the gap between neuroglia basic science and neuroglia clinical research. The book provides an overview of neuroglia biology, highlighting emerging technologies used to unravel the role of neuroglial cells in specific brain functions. The book also discusses strategies using neuroglia as a therapeutic target.

  • Cerebral Asymmetries

    • 1st Edition
    • Volume 208
    • English
    Cerebral Asymmetries, Volume 208 summarizes research on cerebral hemispheric asymmetries and their implication for consciousness cognition, language emotion, behavior movement, and neurological disease. The book discusses anatomy and networks, genetics, hormones, and evolution, although it is primarily focused on animal research as it relates back to humans.

  • Coma, Stupor, and Related Disorders of Consciousness

    • 1st Edition
    • Volume 207
    • Peter W. Kaplan + 1 more
    • English
    Coma, Stupor, and Related Disorders of Consciousness reviews recent research and best practice in the assessment and treatment of coma, stupor, and disorders of consciousness. It encompasses the neural circuits, anatomy & physiology of stupor and coma, differential diagnosis and clinical assessment, imagery, EEGs, therapy/intervention... decision making and prognosis.

  • Neuropsychological and Psychosocial Foundations of Neuro-Oncology

    • 1st Edition
    • Herbert B. Newton + 1 more
    • English
    Neuropsychological and Psychosocial Foundations of Neuro-Oncology provides an in-depth review of common cognitive, psychological, and social manifestations that occur in patients with brain cancer and other neuro-oncological issues. Chapters discuss primary CNS tumors, brain metastases, leptomeningeal disease, paraneoplastic disorders, and many other topics. Effects of CNS and systemic cancer treatment (i.e., radiotherapy, chemotherapy, immunotherapy) are also examined, as are current practices for rehabilitation and targets for essential future interventions in vulnerable populations.This book is fully illustrated with pathology photomicrographs, CT and MRI images, tables, and molecular pathway diagrams. Bringing neuropsychological and behavioral health trial knowledge from the bench to the bedside, this volume is an essential reference for practicing neuro-oncologists, neuropsychologists, nurses, and others working in the field of neuro-oncology.

  • Headache and Migraine in Practice

    • 1st Edition
    • Mansoureh Togha + 4 more
    • English
    Headache and Migraine in Practice provides practical and precise approaches to the headaches and facial pains commonly encountered in hospitals and clinics. The book pays specific attention to the clinical features of headaches to present treatment solutions, while also recommending ICHD3 differential diagnoses based on diagnostic criteria. Topics covered were developed by colleagues with expertise in Neurology, Nutrition, Psychiatry, Physical Medicine, and Sports Medicine, thus providing a collaborative authorship that adds interdisciplinary value. Sections cover the diagnosis and treatment of various types of headaches in children, the elderly and women during different periods of pregnancy, lactation and hormone-related stages. This book is recommended for general practitioners, internists, neurologists, headache nurse specialists, and all others who would like to contribute to better diagnoses and more effective treatment plans for patients with headaches and facial pains.

  • Neuroinflammation

    • 1st Edition
    • Alireza Minagar
    • English
    Inflammation is a central mechanism in many neurological diseases, including stroke, multiple sclerosis, and brain trauma as well as meningitis and contributes to the generation of pain. We are now beginning to understand the impact of the immune system on different nervous system functions and diseases, ranging from damage through tolerance to modulation and repair.This book discusses some of the more common neuro-inflammatory diseases. Topics covered include multiple sclerosis, optic neuritis and Susac syndrome.

  • Atlas of Ambulatory EEG

    • 1st Edition
    • Steven C. Schachter + 2 more
    • English
    Atlas of Ambulatory EEG covers the areas of clinical neurophysiology, an atlas that comprehensively depicts normal, abnormal, and artifactual findings from actual ambulatory EEG recordings in a convenient and easily accessible format. As the use of ambulatory EEG has increased in recent years, the need for a concise atlas of ambulatory EEG has grown significantly, since ambulatory EEG tracings are subject to their own unique issues and artifacts, often not discussed in standard EEG atlases. This book begins with several chapters that introduce the history, technology, and clinical utility of ambulatory EEG. The bulk of the atlas consists of a page-by-page display of high-quality ambulatory EEG excerpts that are easy to review and come with short annotations describing the relevant findings. Atlas of Ambulatory EEG is a critical resource for anyone involved in the interpretation of ambulatory EEG studies.

  • The Histamine H<INF>3</INF> Receptor

    A Target for New Drugs
    • 1st Edition
    • Volume 30
    • R. Leurs + 1 more
    • English
    In the early eighties when the H3 receptor was identified, many thought that an H3 ligand, an agonist or an antagonist, would become available as a therapeutic agent. This has not occurred. The reason for this could be the fact that many investigators consider histamine mainly, if not only, as a mediator present in for example mast cells being released during allergic events. However, it has become apparent that histamine is an important neurotransmitter. Its role in the nervous system, especially in the central part of it, is rather extensive.The H3 receptor is mainly found as a presynaptic one, both on histaminergic neurons (the auto-type) and on other neuronal systems (the hetero-type). Both the H3 agonist and the H3 antagonist cause important pharmacological effects. Several ligands have become available now, including radiolabelled analogues.In this book, the current state of affairs with regards to the medicinal chemistry and pharmacology of the H3 receptor and the several ligands available are presented by a number of experts in the field. The book presents an extended review of what has happened since the first H3 paper appeared. The editors hope that publication of this work will lead to an increase in interest of both academia and industry for the H3 receptor, especially as a target for drug development.