Neuropsychological and Psychosocial Foundations of Neuro-Oncology

1st Edition - August 5, 2024
Editors: Herbert B. Newton, Ashlee R. Loughan
Language: English
Hardback ISBN:
9 7 8 - 0 - 4 4 3 - 1 5 6 6 3 - 2
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 5 6 6 4 - 9

Neuropsychological and Psychosocial Foundations of Neuro-Oncology provides an in-depth review of common cognitive, psychological, and social manifestations that occur in patients… Read more

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Neuropsychological and Psychosocial Foundations of Neuro-Oncology provides an in-depth review of common cognitive, psychological, and social manifestations that occur in patients with brain cancer and other neuro-oncological issues. Chapters discuss primary CNS tumors, brain metastases, leptomeningeal disease, paraneoplastic disorders, and many other topics. Effects of CNS and systemic cancer treatment (i.e., radiotherapy, chemotherapy, immunotherapy) are also examined, as are current practices for rehabilitation and targets for essential future interventions in vulnerable populations.

This book is fully illustrated with pathology photomicrographs, CT and MRI images, tables, and molecular pathway diagrams. Bringing neuropsychological and behavioral health trial knowledge from the bench to the bedside, this volume is an essential reference for practicing neuro-oncologists, neuropsychologists, nurses, and others working in the field of neuro-oncology.

Cover image
Title page
Table of Contents
Copyright
Dedication
Contributors
About the editors
Preface
Section I: Neuropsychological foundations of neuro-oncology
Chapter 1 History of neuro-oncology and neuropsychology
Abstract
Introduction
History of neuro-oncology
History of neuropsychology
References
Chapter 2 Neurocognitive functioning: From brain structures to networks
Abstract
Introduction
Short historical background
Neurocognitive domains
A network approach
Individual differences and variability
Conclusion
References
Chapter 3 Taking a therapeutic and biopsychosocial approach to the neuropsychological interview for assessment of brain tumor survivors
Abstract
Introduction
Assessment models in neuropsychology
Informed consent as an ongoing process
Biopsychosocial model in the neuropsychological assessment of primary brain tumor patients
Assessment domains
Final thoughts
References
Chapter 4 Neuropsychological assessment in neuro-oncology
Abstract
Introduction
Foundations of objective neuropsychological assessment
Neuropsychological assessment in neuro-oncology
Prerequisites to neuropsychological assessment
Neurocognitive domains and the tests that measure them
Guidlines for objective neuropsychological assessment in neuro-oncology
Objective neuropsychological assessment in clinical trials
Future directions
Conclusions
References
Chapter 5 Patient-reported assessment: Identifying cognitive concerns in brain tumor patients
Abstract
Definitions and incidence
Subjective cognitive function
Clinical practice implementation
Subjective cognitive function measurement
Association with objective neuropsychological assessments
Implications for practice
References
Chapter 6 Quality of life and patient-reported outcomes in neuro-oncology clinical care and research
Abstract
Introduction
Quality of life in neuro-oncology
Quality of life measurement approaches
Applications of PROMs in neuro-oncology
Modern approaches to capture PROs in neuro-oncology
Future directions for PROs in neuro-oncology
Conclusion
References
Section II: Effects of neuro-oncology and systemic treatment on cognitive functioning
Chapter 7 Imaging in neuro-oncology
Abstract
Introduction
Gliomas
Adult-type diffuse gliomas
Pediatric-type diffuse low-grade gliomas
Pediatric-type diffuse high-grade gliomas
Circumscribed astrocytic gliomas
Neuronal and glioneuronal tumors
CNS lymphoma
Extra-axial tumors
Metastatic disease
References
Chapter 8 Pathology and treatment of primary and metastatic brain tumors
Abstract
Pathology and treatment of primary brain tumors
Pathology and treatment of metastatic brain tumors
References
Chapter 9 Overview of systemic treatment and toxicity in cancer patients
Abstract
Introduction
Primary central nervous system tumors
Breast cancer
Prostate cancer
Lung cancer
Colorectal cancer
Cutaneous melanoma
Non-Hodgkin lymphoma
Leukemia
Myeloma
Summary
References
Chapter 10 Delirium and mental status changes in neuro-oncology
Abstract
Introduction
Delirium due to brain lesion
Delirium due to local treatment
Delirium due to medication
Delirium due to complications of disease or treatment
Management of delirium
References
Chapter 11 The neuropsychological impact of surgical intervention and utility of awake craniotomies
Abstract
Introduction
Tools to define neurocognition in awake craniotomy patients
Anatomical basis of cognitive function in disease states indicating awake craniotomies
Awake brain mapping craniotomy
References
Chapter 12 Neuropsychological implications of radiotherapy
Abstract
Introduction
Pathophysiology
Neurocognitive and psychologic assessment and guidelines
Risk factors for psychosocial disorders
Radiation dosimetry and neuropsychological consequences
Treatment
Neurobehavioral impairment in pediatric brain tumor survivors
Conclusion
References
Chapter 13 Neuropsychological manifestations of chemotherapy
Abstract
CRCI—Risk factors
CRCI—Pathogenesis
Neurovascular features of CRCI
Neurostructural features of CRCI
Neuroimaging features of CRCI
Electrophysiologic features of CRCI
Neuropathological features of CRCI
Psychiatric features of CRCI
Neuropsychological assessment of CRCI
Socioeconomic toxicity of cancer and cancer therapy
CRCI—Treatment and prevention
Future directions
References
Chapter 14 Neuropsychological issues related to immunotherapy
Abstract
Introduction
Epidemiology and pathophysiology
Encephalitis
Aseptic meningitis
Hypophysitis
Other ICI-associated CNS immune-related adverse events
CAR T-cell-mediated neurotoxicity: Immune effector cell-associated neurotoxicity syndrome (ICANS)
Conclusion
References
Chapter 15 Neuropsychological aspects of blood or bone marrow transplantation
Abstract
The blood or marrow transplantation (BMT) procedure
Trajectory of cognitive functioning and prevalence of cognitive impairment post-BMT
Characterization of domain-specific cognitive deficits in BMT recipients
Risk factors for neurocognitive impairment in BMT recipients
Genetic biomarkers in BMT recipients
Mechanisms of neurocognitive impairment in BMT
Neuroimaging biomarkers in BMT
Symptom clusters related to cognitive impairment
Pharmacological and nonpharmacological interventions to improve neurocognitive impairment
Summary
References
Chapter 16 Pediatric brain tumors: Neuropsychological late effects and academic implications
Abstract
The medical experience
Neurocognitive late effects
Academic implications
Educational interventions after treatment for pediatric brain tumor
Conclusion
References
Section III: Psychosocial foundations of neuro-oncology
Chapter 17 Depression in neuro-oncology
Abstract
Definition, symptoms, and causes of depression
Screening for depression
Depression throughout the PBT illness trajectory
Treating depression
Psychosocial interventions
Conclusion
References
Chapter 18 Anxiety in neuro-oncology
Abstract
Introduction
Concept of anxiety
Prevalence of anxiety symptoms in adults with BT
Prevalence of anxiety symptoms in children with BTs
Social and demographic factors related to increased risk of anxiety symptoms in BT patients
Clinical factors associated with anxiety
Treatment-related factors
Impact of anxiety on treatment outcomes and prognoses
Conclusions
References
Chapter 19 Personality and behavioral changes in neuro-oncology
Abstract
Introduction
Classification of personality disorders in the general population
Personality change in glioma patients
References
Chapter 20 Existential distress in neuro-oncology
Abstract
Defining existential distress
Existential distress in neuro-oncology
Interventions for existential distress
Future directions
References
Chapter 21 Appetite, nutrition, and body image in neuro-oncology
Abstract
Body image in patients with central nervous system tumors
Appetite changes in neuro-oncology
Nutrition and neuro-oncology
Recommendations for providers
Future directions
Summary
References
Chapter 22 Fatigue and sleep-related issues in neuro-oncology
Abstract
Fatigue and sleep disturbance in neuro-oncology
Fatigue
Assessment of fatigue
Treatment of fatigue
Sleep disturbance
Future directions
References
Chapter 23 The impact of brain tumor location and treatment on sexual function: Implications for clinical practice
Abstract
Introduction
Overview of brain cancer and sexuality
Location: Impact of brain tumor (patho-anatomic) location on sexuality
Treatment: Impact of brain tumor treatment on sexuality
Summation
References
Section IV: Cognitive and psychological interventions
Chapter 24 Evidence and clinical considerations for cognitive rehabilitation
Abstract
Introduction
Clinical and sociocultural considerations for cognitive rehabilitation
An overview and discussion of evidence for cognitive rehabilitation in the acute, early outpatient, and postacute outpatient phase
Access to care, reimbursement, and outpatient resources
Chapter conclusion
References
Chapter 25 Unpacking the psychological, cognitive, and psycho-pharmacologic burdens of neuro-oncology
Abstract
Introduction
Impact of neuro-oncologic diagnoses, tumor location, and treatment on patient's psychosocial, neurocognitive, and mental wellbeing
Unraveling the tapestry: The psychosocial burden of brain cancer
Common psychopharmacologic interventions, mechanisms of action, contraindications, and special considerations in neuro-oncology
References
Chapter 26 Psychotherapeutic interventions in neuro-oncology
Abstract
Introduction
Types of psychotherapeutic interventions used with benefits in cancer populations
Psychotherapeutic needs in neuro-oncology
The dearth of psychotherapeutic interventions in neuro-oncology
Efficacy of psychotherapeutic interventions trialed in neuro-oncology
Conclusion
References
Chapter 27 Alternative and holistic approaches to neuro-oncological healthcare
Abstract
Exercise
Yoga
Mindfulness
Acupuncture
Supplements and experimental drug treatments
References
Chapter 28 Support groups and self-help resources
Abstract
References
Chapter 29 Role of social work in neuro-oncology
Abstract
The clinician
The case manager
Role on interdisciplinary medical team
Research
Community involvement
References
Chapter 30 Music therapy and art therapy: Functional neurobiology and applications in oncology
Abstract
Introduction
Paleo-archeology and evolution of music and art
Neurobiology of music and art
Overview of music therapy
Music therapy in medical settings
Music therapy vs music medicine
Mental health needs of cancer patients
Conclusion
Overview of art therapy
Art therapy
Art therapy and neuroscience_ A promising partnership
Mental health needs of cancer patients
Art therapy with cancer patients
Theory and evidence to practice
Art therapy interventions for cancer patients
Conclusion
References
Chapter 31 Spirituality in neuro-oncology
Abstract
Spirituality in oncology
Spirituality in the care of patients with neuro-oncologic illness
The impact of spirituality on common symptom domains in neuro-oncologic illness
Religiosity as a behavioral symptom
Religiosity, spirituality, and decision-making
The role of religion and spirituality for caregivers
Current models of addressing and measuring spiritual and existential distress in neuro-oncology patients and caregivers
The role of the chaplain as spiritual care specialist
References
Section V: Supportive and palliative care in neuro-oncology
Chapter 32 Symptom management in neuro-oncology
Abstract
Introduction
Seizures and anticonvulsant therapy
Corticosteroids
Novel antiangiogenic agents
Gastric acid inhibitors
Thromboembolic complications and anticoagulation
Dysphagia and swallowing disorders
Psychiatric issues
Pain control issues
Conclusion
References
Chapter 33 Physical rehabilitation in neuro-oncology
Abstract
Introduction
Impairments
Other neuro-oncologic etiologies with functional impairments
Settings of brain cancer rehabilitation
Rehabilitation disciplines
Conclusion
References
Chapter 34 Advance care planning in neuro-oncology
Abstract
Introduction
New diagnosis
Phase II—Treatment and plateau
Phase III—Recurrence
Phase IV—End of life
The role of the HCP
Conclusion
Useful websites
References
Chapter 35 Delirium and psychoses
Abstract
Introduction
Psychiatric disorders
Terminal delirium and agitation
Clinical manifestations and diagnosis
Causes
Care strategies and management
Implications for prognosis and impact on family members
Psychoses
Pharmacologic treatment of psychoses
Nonpharmacologic treatment of psychoses
References
Chapter 36 Palliative care and hospice care in neuro-oncology
Abstract
Introduction
Palliative medicine in neuro-oncology
Hospice care in neuro-oncology
Conclusion
References
Chapter 37 Ethical issues in neuro-oncology
Abstract
Introduction
Discussing diagnosis and prognosis
To treat or not to treat?
Quality of life during and after therapy
When is it appropriate to stop therapy?
Should hospice care be implemented?
Conclusion
References
Chapter 38 Comprehensive psychosocial resources for cancer patients: The Gathering Place—An evolving model
Abstract
Introduction
History
Venues
Funding
Introduction to programming
Research
Expanding delivery of services
References
Chapter 39 Legal issues in cancer and neuro-oncology
Abstract
Introduction
Civil torts in cancer care
Malpractice risk in context
Informed consent and capacity
Right to refuse treatment
Considerations in criminal law
Disability insurance
Healthcare consumer rights and protections
Research and innovation
Conclusion
References
Section VI: Caregiving in neuro-oncology
Chapter 40 The experience of caregivers of patients in neuro-oncology
Abstract
Introduction
The experience of caregiving in neuro-oncology
The implications and associated outcomes of caregiving
Avenues for intervention and supportive services for caregivers
Clinical challenges in providing care to caregivers of PwPMBT
Gaps and challenges in neuro-oncology research
Future directions
References
Chapter 41 In-home care resources in neuro-oncology
Abstract
Introduction
Home health services
Special considerations with regard to home health services
Insurance and financial services
Terminal care at home
References
Index

Herbert B. Newton

Dr. Newton is currently the Director of the Neuro-Oncology Center and CNS Oncology Program at the Advent Health Cancer Institute and Advent Health Orlando Campus. He recently retired as Professor of Neurology and Neurosurgery at the Ohio State University Medical Center and the James Cancer Hospital, and was the holder of the Esther Dardinger Endowed Chair in Neuro-Oncology. He trained in Neuro-Oncology with Drs. Jerome Posner and William Shapiro at Memorial Sloan-Kettering Cancer Center in New York, and since then had been in academic Neuro-Oncology for over 25 years. He has published more than 220 peer-reviewed articles and book chapters, and is the Chief Editor or Co-Editor of ten textbooks in the field of Neurology and Neuro-Oncology. In addition, he has been listed as a Best Doctor (Neurology) and Top Doctor for Cancer (Neuro-Oncology) for the past 18 years.

Affiliations and expertise

Advent Health Cancer Institute, FL, USA

Ashlee R. Loughan

Dr. Loughan is a licensed clinical neuropsychologist and Associate Professor in Neurology at Virginia Commonwealth University School of Medicine. She has developed a thriving neuropsychological and quality survival program at Massey Cancer Center, LiveNOW (Neuro-Oncology Wellness). Dr. Loughan is committed to a career in neuro-oncology and conducts practice-changing cancer prevention and control research aimed to improve patients cognitive and psychological outcomes. She has demonstrated a strong record of internal and external funding, focused on understanding and improving quality survival of those challenged by brain tumors. She has authored over 40 peer-reviewed manuscripts, 9 invited book chapters, and produced 100+ abstracts at local, national, and international academic conferences. Dr. Loughan was recently recognized as a VCU Emerging Scholar and serves on the American Brain Tumor Association Clinical Advisory Counsel. She is a clinician scientist invested in the field of neuro-oncology and psycho-oncology, especially the future of quality oncology care.

Affiliations and expertise

Associate Professor, Department of Neurology, Virginia Commonwealth University USA

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