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Elsevier

Books in Neurological research

  • Advanced MR Techniques for Neurodegenerative Diseases

    • 1st Edition
    • Volume 14
    • Kannie Wy Chan + 3 more
    • English
    Advanced MR Techniques for Neurodegenerative Diseases covers state of the art developments in physiologic, metabolic, functional, and microstructural MRI of the brain. It provides an overview of these approaches and includes dynamic contrast enhanced (DCE) MRI, dynamic susceptibility contrast (DSC) MRI, arterial spin labeling (ASL), chemical exchange saturation transfer (CEST) MRI, magnetic resonance spectroscopy (MRS), resting state functional MRI (rsfMRI), microscopic diffusion imaging, and quantitative susceptibility mapping (QSM). Chapters then follow that present the application of these methods to Alzheimer’s Disease and vascular dementia, small vessel disease, Parkinson’s Disease, Lewy body dementia, Huntington’s Disease, Amyotrophic Lateral Sclerosis, and Multiple Sclerosis.Advanced MR Techniques for Neurodegenerative Diseases is a comprehensive resource on the latest advanced MR techniques and their application to neurodegenerative diseases, suitable for MR engineers and physicists as well as clinicians and neuroscientists who use MR techniques for diagnosis and research.

  • Diabetes and Neurodegeneration

    • 1st Edition
    • Debasis Bagchi + 2 more
    • English
    Diabetes and Neurodegeneration unlocks the complex interplay between diabetes and Neurodegeneration, reviewing the relationship between these two prevalent health challenges. This book begins with a simple guide to understanding high blood sugar, tracing the historical milestones of hyperglycemia, and unveiling the primary factors that contribute to diabetes development, from genetic predisposition to lifestyle hazards. The second section aims to bridge the gap between diabetes and dementia, presenting early clinical evidence, case studies, and susceptibility assessments that underscore the strong link between hyperglycemia and neurodegeneration. Biomarkers and pathways connecting these conditions are explored, including the role of Advanced Glycated End (AGE) products and their implications in protein misfolding and aggregation. The narrative extends to therapeutic strategies, evaluating the efficacy of antidiabetic drugs, targeting insulin resistance, and introducing novel interventions to arrest amyloid-associated pathogenesis. This comprehensive guide provides both clinicians and researchers with a thorough understanding of the intricate link between diabetes and neurodegeneration.

  • Fundamentals of Brain Organoids for Neurological Diseases

    • 1st Edition
    • Balachandar Vellingiri + 1 more
    • English
    Researchers use brain organoids to study the formation of neural tissues, investigate the processes involved in brain development, and gain a better understanding of neurological disorders and diseases. Brain organoids are particularly useful in studying developmental disorders, neurodegenerative diseases, and infectious diseases that affect the brain. Fundamental of Brain Organoids for Neurological Diseases provides a practical resource for researchers on how to utilize and apply brain organoids. This book is organized into nine distinct sections, guiding the reader through each step from advanced overview of what organoids are to the use of brain organoids in various neurodevelopmental disorders and neurodegenerative diseases. In later sections, this book reviews the necessary methods involved in organoid development including the elements and challenges involved. This book will serve as a valuable tool for researchers, helping to advance the understanding of brain biology and disease mechanisms.

  • The Science of the Brain

    Function, Dysfunction and Disease
    • 1st Edition
    • Ari Rappoport
    • English
    The Science of the Brain: Function, Dysfunction and Disease delves into the intricate workings of the human brain, offering a groundbreaking examination of its complexities and the disorders that can arise when it malfunctions. This book, authored by a distinguished neuroscientist, unravels the mysteries of cognition, memory, and emotion while exploring how neurodegenerative diseases, mental health conditions, and brain injuries disrupt these processes. Designed to be accessible yet deeply informative, it bridges the gap between cutting-edge scientific research and real-world clinical applications, making it an invaluable resource for both professionals and curious readers.In addition to its comprehensive analysis of brain function, the book introduces readers to the latest innovations in neuroscience, including technological advancements in brain imaging and treatments. It also examines the ethical dilemmas posed by emerging technologies and their implications for society. With its blend of readability and scientific rigor, this work sheds light on the possibilities for future research and intervention, inspiring a deeper understanding of one of the most complex organs in the human body.

  • Vagus Nerve Stimulation

    • 1st Edition
    • Peter Staats + 3 more
    • English
    In the complex realm of our physiology, the vagus nerve stands as a silent orchestrator, influencing health and disease in ways that have long been underestimated. Vagus Nerve Stimulation delves into the profound significance of this 10th cranial nerve, tracing its course through the body and illuminating its role as a vital component of the parasympathetic nervous system.This comprehensive reference, contributed by leading experts at the forefront of medical science, unveils the groundbreaking field of vagus nerve stimulation—a non-invasive approach to harness the body's innate potential for health optimization, inflammation control, and disease modification. Contributed by leading experts in the field, this comprehensive volume serves as a compendium of current knowledge about stimulating the vagus nerve in many different disease states. This book starts with the foundational insights in Basic Science and Technical Considerations. From there, it continues to Neurologic Conditions, where chapters explore applications for epilepsy, cluster headaches, and concussions. Evolving Therapy for Neurologic Conditions introduces cutting-edge treatments for acute ischemic stroke, synaptic plasticity, and neurodegenerative disorders. The book extends into Psychiatric and Somatic Conditions, providing insights into anxiety, depression, addiction disorders, and more. Conventional Inflammatory Conditions shed light on vagus nerve stimulation's role in combatting sepsis, immune-mediated inflammatory diseases, and metabolic syndrome, among others. Concluding with a foray into Oncology, the book highlights the potential of vagus nerve stimulation in addressing the lingering effects of long covid and migraine. With an authoritative blend of scientific rigor and practical application, this reference serves as an indispensable guide to the vast landscape of vagus nerve stimulation, transforming our understanding of health and wellness.

  • Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease, Seventh Edition

    Volume 2
    • 7th Edition
    • Volume 2
    • Roger N. Rosenberg + 1 more
    • English
    Rosenberg’s Molecular and Genetic Basis of Neurologic and Psychiatric Disease, Seventh Edition provides a comprehensive introduction and reference to the foundations and practical aspects relevant to the majority of neurologic and psychiatric disease. This updated volume focuses on degenerative disorders, movement disorders, neuro-oncology, neurocutaneous disorders, epilepsy, white matter diseases, neuropathies and neuronopathies, muscle and neuromuscular junction disorders, stroke, psychiatric disease, and a neurologic gene map. This volume includes new chapters on Von Hippel-Lindau disease, antisocial and violent behavior and Autism. A favorite of over four generations of students, clinicians and scholars, this new edition retains and expands on the informative, concise and critical tone of the previous edition. This is an essential reference for general medical practitioners, neurologists, psychiatrists, geneticists, related professionals, and for the neuroscience and neurology research community at large.

  • Motor System Disorders, Part II

    Spinal Cord, Neurodegenerative, and Cerebral Disorders and Treatment
    • 1st Edition
    • Volume 196
    • David S. Younger
    • English
    Motor System Disorders, Volume 196, Part Two, Spinal Cord, Neurodegenerative, and Cerebral Disorders and Treatment provides a comprehensive review of research and best practice clinical management of spinal cord, neurodegenerative, and cerebral disorders. Encompassing hereditary and acquired disorders from disease and accident, the book explores motor control disorders associated with stroke, dementia, seizure, encephalitis, and more. Covering disorders of both children and adults, the book discusses the latest advances in treatments related to neuroplasticity, neural tissue transplantation, and immunotherapy.

  • Neurostimulation for Epilepsy

    Advances, Applications and Opportunities
    • 1st Edition
    • Vikram R. Rao
    • English
    **Association of American Publishers (AAP) PROSE Award Finalist in Biomedicine and Neuroscience, 2024**Neurostimulati... for Epilepsy: Advances, Applications, and Opportunities comprehensively reviews the diverse array of neurostimulation technologies currently in use and in development for the treatment of epilepsy. The book covers basic mechanisms of neurostimulation, technical characteristics of approved and investigational neurostimulation devices, clinical applications and programming considerations of these devices, and progress toward next-generation device technology. Leading experts in the field provide a contemporary appraisal of neurostimulation in epilepsy, one that highlights recent advances, outlines unanswered questions, and proposes future directions.Neurostim... for Epilepsy: Advances, Applications, and Opportunities will be of high interest to clinical, basic, and translational researchers seeking to understand leading-edge applications of neurostimulation in epilepsy and to clinicians managing patients with epilepsy who are treated with implanted and external neurostimulation devices. This book will also be of interest to trainees, to physicians in other areas of neurology where neurostimulation is employed, such as Pain and Movement Disorders, and to general medical practitioners, neurobiologists, and engineers.

  • Posttraumatic Epilepsy

    Basic and Clinical Aspects
    • 1st Edition
    • Carrie R. Jonak + 2 more
    • English
    Posttraumatic Epilepsy: Basic and Clinical Aspects provides a synthesized resource on the recent basic and clinical science developments in the field of posttraumatic epilepsy. This book provides a clear understanding of the history of studies and epidemiology of posttraumatic epilepsy after head injury. The book also considers the neuropathology of posttraumatic epilepsy and clinical trials of antiepileptogenic agents evaluated after traumatic brain injury. The book covers the basic science of animal models of traumatic brain injury and the necessary and sufficient changes that must occur to generate epilepsy after head trauma. The authors explore potential mechanisms and novel therapeutic approaches to prevent posttraumatic epilepsy. The book is written for basic and clinical researchers in neuroscience as well as for clinicians treating patients with epilepsy.

  • Nanomedicine-Based Approaches for the Treatment of Dementia

    • 1st Edition
    • Umesh Gupta + 1 more
    • English
    Nanomedicine-Based Approaches for the Treatment of Dementia explores a wide range of promising approaches for the diagnosis and treatment of dementia. The book begins with introductory sections on dementia and brain ailments that are followed by further chapters that discuss detailed information about challenges of drug delivery across the blood-brain barrier as well as the current status. This book helps readers design and develop novel drug delivery systems and devices for the treatment of dementia that take advantage of recent advances in nanomedical technologies. Numerous drug delivery systems have been developed recently for dementia. Unfortunately, most of them are ineffective since dementia is not a single disease. It is an umbrella term for several neurodegenerative conditions which alter brain functions. Due to this, there is an urgent need for innovative technologies/nano drug delivery systems to improve the targeting and delivery of therapeutic as well as diagnostic agents specifically for treating dementia.

  • Intraoperative Neuromonitoring

    • 1st Edition
    • Volume 186
    • Marc R. Nuwer + 1 more
    • English
    Interoperative Monitoring, Volume 186 provides a concise overview of advances in interoperative monitoring targeted for clinical neurologists. It identifies techniques (EEG, ECoG, EMG, etc.), optimal anesthesia for use, safety issues to be considered, and then discusses advances as they relate to intracranial, spinal, peripheral nerve and vascular surgery. Best practices and case studies are included for all chapters as well as surgical microscope views, illustrations, and medical imaging.

  • TDP-43 and Neurodegeneration

    From Bench to Bedside
    • 1st Edition
    • Vijay Kumar + 1 more
    • English
    Aggregates of the TAR DNA binding protein 43 (TDP-43), are hallmark features of the neurodegenerative diseases Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (FTD), with overlapping clinical, genetic and pathological features. TDP-43 and Neurodegeneration: From Bench to Bedside summarizes new findings in TDP-43 pathobiology and proteinopathies. The book summarizes TDP-43’s structure, function, biology, misfolding, aggregation, pathogenesis and therapeutics. It includes autophagy-mediated therapy, role of stress granule, novel genetic, cell culture-based models, systems biology for precision medicine, development of stem cells and mechanism-based therapies that can target ALS and other related neurodegenerative diseases. This book is written for neuroscientists, neurologists, clinicians, advanced graduate students, drug discovery researchers, as well as cellular and molecular biologists involved in ALS, motor neuron disease (MND) and other neurodegenerative disorders.

  • Heart and Neurologic Disease

    • 1st Edition
    • Volume 177
    • English
    The Handbook of Clinical Neurology series volumes provide comprehensive summaries of recent research on the brain and nervous system as they relate to clinical neurology. Cardiac disorders and diseases may often co-occur with, or cause, subsequent neurological disorders. Heart and Neurologic Disease identifies the top cardiac diseases and disorders most likely to have neurological disorders, how they will present, and how they are best treated. It identifies the mechanisms of action explaining why the conditions co-occur, and what clinicians should look for symptom wise, and how risk may be assessed. Coverage includes genetic cardiac disorders, cardiac trauma, surgery, infection, disease, and arrhythmia.

  • Biomarkers for Traumatic Brain Injury

    • 1st Edition
    • Alan H.B. Wu + 1 more
    • English
    Biomarkers for Traumatic Brain Injury provides a comprehensive overview on the selection and implementation of serum-based and saliva-based biomarkers for traumatic brain injury. The book presents an economic analysis for implementing TBI biomarkers into clinical practice. In addition, it discusses the analytical tools needed to implement TBI biomarkers, including specifications for testing instruments and interpretative software. Neurologists, emergency department physicians, intensivists, and clinical laboratorians will find this book a great resource from which to familiarize themselves with the issues and processes regarding TBI biomarkers. Approximately 2 million people in the U.S. sustain a traumatic brain injury (TBI) each year with over 250,000 hospitalizations and 50,000 deaths. There has been a significant rise in interest in diagnosing mild concussions, particularly in the sports world. While imaging has been the gold standard, these procedures are costly and not always available. There is great potential in using serum-based biomarkers, hence the book seeks to enlighten readers on new possibilities.

  • Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease

    Volume 1
    • 6th Edition
    • Roger N. Rosenberg + 1 more
    • English
    Rosenberg’s Molecular and Genetic Basis of Neurologic and Psychiatric Disease, Sixth Edition: Volume One, provides a comprehensive introduction and reference to the foundations and key practical aspects relevant to neurologic and psychiatric disease. A favorite of over three generations of students, clinicians and scholars, this new edition retains and expands the informative, concise and critical tone of the first edition. This is an essential reference for general medical practitioners, neurologists, psychiatrists, geneticists, and related professionals, and for the neuroscience and neurology research community. The content covers all aspects essential to the practice of neurogenetics to inform clinical diagnosis, treatment and genetic counseling. Every chapter has been thoroughly revised or newly commissioned to reflect the latest scientific and medical advances by an international team of leading scientists and clinicians. The contents have been expanded to include disorders for which a genetic basis has been recently identified, together with abundant original illustrations that convey and clarify the key points of the text in an attractive, didactic format.

  • Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease

    Volume 2
    • 6th Edition
    • Roger N. Rosenberg + 1 more
    • English
    Rosenberg’s Molecular and Genetic Basis of Neurologic and Psychiatric Disease, Sixth Edition: Volume Two provides a comprehensive introduction and reference to the foundations and practical aspects relevant to the majority of neurologic and psychiatric disease. This updated volume focuses on degenerative disorders, movement disorders, neuro-oncology, neurocutaneous disorders, epilepsy, white matter diseases, neuropathies and neuronopathies, muscle and neuromuscular junction disorders, stroke, psychiatric disease, and a neurologic gene map. A favorite of over three generations of students, clinicians and scholars, this new edition retains and expands on the informative, concise and critical tone of the first edition. This is an essential reference for general medical practitioners, neurologists, psychiatrists, geneticists, related professionals, and for the neuroscience and neurology research community at large. The content covers all aspects essential to the practice of neurogenetics to inform clinical diagnosis, treatment and genetic counseling.

  • Neurophysiology in Neurosurgery

    A Modern Approach
    • 2nd Edition
    • Vedran Deletis + 3 more
    • English
    Over the last 18 years, there have been many advances in the field of intraoperative monitoring. This new edition of Neurophysiology in Neurosurgery: A Modern Approach provides updates on the original techniques, as well as other more recent methodologies that may either prove beneficial or are commonly used in neuromonitoring. The purpose of this book is to describe the integration of neuromonitoring with surgical procedures. Each methodology is discussed in detail as well as chapters describing how those methodologies are applied to multiple surgical procedures and the evidence used to support those uses. The second edition features a surgical procedure section, which focuses on specific surgical procedures and the type of monitoring used during these procedures. The original chapters have been updated, expanded, and the structure modified to ensure the book is beneficial to both physiologists and surgeons. This book is written for neurosurgeons, neurophysiologists, neurologists, anesthesiologists, interventional neuroradiologists, orthopedic surgeons, and plastic surgeons.

  • Lymphatic Structure and Function in Health and Disease

    • 1st Edition
    • Felicity N.E. Gavins + 1 more
    • English
    Lymphatic Structure and Function in Health and Disease serves as a resource book on what has been learned about lymphatic structure, function and anatomy within different organ systems. This is the first book to bring together lymphatic medicine as a whole, with in-depth analysis of specific aspects of lymphatics in different vascular pathologies. This book is a useful tool for scientists, practicing clinicians and residents, in particular, those in vascular biology, neurology, cardiology and general medicine. Chapters discuss topics such as ontogeny and phylogeny of lymphatics, lymphatic pumping, CNS lymphatics, lymphatics in transplant and lymphatic reconstruction.

  • Neuroprotection in Autism, Schizophrenia and Alzheimer's disease

    • 1st Edition
    • Illana Gozes + 1 more
    • English
    Neuroprotection in Autism, Schizophrenia and Alzheimer's Disease provides an up-to-date overview on recent clinical studies and the similarities discovered in the most prevalent brain disorders. The book's content will help shed light on basic mechanisms and provide new avenues for early diagnosis toward disease prevention and disease modification. It is written for researchers, clinicians and medical physicians in neuroscience, neurology and psychiatry. Sections discuss the shared pathophysiological mechanisms that underlie autism, schizophrenia/mood disorders and Alzheimer’s disease, i.e. neurodevelopmental disorders, neuropsychiatric diseases and neurodegenerative disorders.

  • New Techniques for Management of ‘Inoperable’ Gliomas

    • 1st Edition
    • Michael E. Sughrue + 1 more
    • English
    New Techniques for Management of 'Inoperable' Gliomas radically challenges the assumption that certain gliomas cannot be removed with modern techniques, contesting stereotypical thinking and establishing new paradigms in the field. Gliomas are primary brain tumors which are often fatal. Recent data has demonstrated that despite the fact that surgery cannot cure gliomas, patient survival is substantially improved by removing as much of the tumor as possible. This fact has raised the imperative that neurologists try to improve techniques to bring surgical resection to as many patients as possible. This book brings new insights and technologies to the forefront, giving hope to patients.

  • Nervous System Drug Delivery

    Principles and Practice
    • 1st Edition
    • Russell R. Lonser + 2 more
    • English
    Nervous System Drug Delivery: Principles and Practice helps users understand the nervous system physiology affecting drug delivery, the principles that underlie various drug delivery methods, and the appropriate application of drug delivery methods for drug- and disease-specific treatments. Researchers developing nervous system putative therapeutic agents will use this book to optimize drug delivery during preclinical assessment and to prepare for regulatory advancement of new agents. Clinicians will gain direct insights into pathophysiologic alterations that impact drug delivery and students and trainees will find this a critical resource for understanding and applying nervous system drug delivery techniques.

  • Omega Fatty Acids in Brain and Neurological Health

    • 2nd Edition
    • Ronald Ross Watson + 1 more
    • English
    Research has clearly established a link between omega fatty acids and general health, particularly cardiovascular health. Omega Fatty Acids in Brain and Neurological Health, Second Edition, illustrates the importance of omega-3 fatty acids in longevity, cognitive impairment and structure and function of the brain's neurons and also the adverse effects of omega-6 fatty acids on neurological function. This book encompasses some of the most recent research on the links between omega fatty acids and the developing brain, aging, dementia, Alzheimer's disease and multiple sclerosis, including the role of omega-3 fatty acid supplements on hippocampal neurogenesis, substantia nigra modulation, migraine headaches, the developing brain in animals, sleep and neurodegenerative diseases. This completely updated second edition focuses on the counterbalancing dietary and tissue omega-6 fatty acids as well as it studies the effects in pregnancy and early infancy, animal model studies and autoimmune neurological diseases.

  • Curcumin for Neurological and Psychiatric Disorders

    Neurochemical and Pharmacological Properties
    • 1st Edition
    • Tahira Farooqui + 1 more
    • English
    Curcumin for Neurological and Psychiatric Disorders: Neurochemical and Pharmacological Properties focuses on the different molecular mechanisms underlying curcumin-mediated beneficial effects in neurological diseases. The book's editors discuss the neurochemical and pharmacological properties of curcumin, followed by the effect of curcumin in neurotraumatic diseases, neurodegenerative diseases, and neuropsychiatric diseases. The book also offers a perspective on future studies on the treatment of neurological disorders. The beneficial effects of curcumin have been observed both in cultured cells and in animal models, thus paving the way for ongoing present and future human clinical trials. Curcumin produces antioxidant and anti-inflammatory effects not only by blocking oxidative stress and neuroinflammation in neurotraumatic and neurodegenerative diseases, but also by restoring cellular homeostasis and rebalancing redox equilibrium.

  • Neuroblastoma

    Molecular Mechanisms and Therapeutic Interventions
    • 1st Edition
    • Swapan K. Ray
    • English
    Neuroblastoma: Molecular Mechanisms and Therapeutic Interventions comprehensively reviews current concepts in molecular and histopathological mechanisms that influence the growth of human malignant neuroblastoma, along with exciting therapeutic interventions. This book features a broad collection of contributions from leading investigators in histopathology, molecular mechanisms, genetics, epigenetics, microRNAs, proteomics, and metabolism in controlling growth and death in neuroblastoma. Recent developments in therapeutic interventions for neuroblastoma are also covered extensively, including chapters on surgery, chemotherapy, targeted therapy and immunotherapy. This book is ideal for advanced undergraduate students, graduate students, medical students, postdoctoral fellows, and investigators with an interest in current molecular concepts and therapeutic interventions.

  • Neurosensory Disorders in Mild Traumatic Brain Injury

    • 1st Edition
    • Michael E. Hoffer + 1 more
    • English
    Mild traumatic Brain Injury (mTBI or Concussion) is an increasingly common public health issue in sports, military environments, and life in today’s active world. Despite a great deal of study and public attention to this disorder, knowledge about optimal diagnostic, prognostic, and treatment information remains lacking. Neurosensory symptoms have been shown to be the most frequent complications of mTBI in both the acute and chronic setting. Neurosensory Disorders in Mild Traumatic Brain Injury brings together both the basic science work as well as the clinical work in mTBI into one volume to provide a comprehensive examination of the neurosensory issues associated with this disorder. Coverage includes chapters on defining mild Traumatic Brain Injury, neurosensory consequences, neurosensory disorders in clinical practice, and diagnosis and treatment for neurosensory disorders in mTBI. This book is written for clinicians, researchers, residents and students in neurology and neuroscience.

  • Introduction to Electrophysiological Methods and Instrumentation

    • 2nd Edition
    • Franklin Bretschneider + 1 more
    • English
    Introduction to Electrophysiological Methods and Instrumentation, Second Edition covers all topics of interest to electrophysiologists... neuroscientists and neurophysiologists, from the reliable penetration of cells and the behavior and function of the equipment, to the mathematical tools available for analyzing data. It discusses the pros and cons of techniques and methods used in electrophysiology and how to avoid pitfalls. Although the basics of electrophysiological techniques remain the principal purpose of this second edition, it now integrates several current developments, including, amongst others, automated recording for high throughput screening and multimodal recordings to correlate electrical activity with other physiological parameters collected by optical means. This book provides the electrophysiologist with the tools needed to understand his or her equipment and how to acquire and analyze low-voltage biological signals.

  • Neuroinflammation

    • 2nd Edition
    • Alireza Minagar
    • English
    Neuroinflammation, Second Edition, discusses the role inflammation plays in neuro-inflammatory diseases. As research in neuroinflammation has dramatically increased in recent years, this new edition covers all of the new developments and findings since the first publication nearly a decade ago. Comprehensive coverage of topics includes chapters on multiple sclerosis, optic neuritis and Susac syndrome. New chapters cover the latest research in Epilepsy and Neuroinflammation, Pediatric MS, Pediatric Lupus and Traumatic Brain Injury, amongst other topics. Inflammation is a central mechanism in many neurological diseases, including stroke, multiple sclerosis, brain trauma and meningitis, and it contributes to the generation of pain. Researchers are now beginning to understand the impact of the immune system on different nervous system functions and diseases, ranging from damage, through tolerance, and to modulation and repair.

  • Gene Therapy in Neurological Disorders

    • 1st Edition
    • Mingjie Li + 1 more
    • English
    Gene therapy has tremendous potential for the treatment of neurological disorders. There has been substantial progress in the development of gene therapy strategies for neurological disorders over the last two decades. Gene Therapy in Neurological Disorders thoroughly reviews currently available gene therapy tools and presents examples of their application in a variety of neurological diseases. The book begins with general reviews of gene therapy strategies with a focus on neurological disorders. The remainder of the chapters present approaches to specific neurological disorders. Each chapter gives an in-depth introduction to the relevant field before diving into the specific tool or application. The book aims to help investigators, students and research staff better understand the principles of gene therapy and its application in the nervous system.

  • Intracranial Aneurysms

    • 1st Edition
    • Andrew J. Ringer
    • English
    Intracranial aneurysm result from complex interactions between cerebrovascular anatomy, vascular injury, and adaptive remodeling of the arterial wall and represent a cerebrovascular disorder with the potential for substantial morbidity and mortality. Most intracranial aneurysms occur in the larger arteries near the skull base, in or around the circle of Willis, but variants may appear virtually anywhere in the cerebral vasculature. The aneurysm can leak or rupture, causing life-threatening bleeding, and is the most common cause of spontaneous subarachnoid hemorrhage, the third most common form of stroke. Intracranial aneurysms affect about 1 in 10,000 people per year in the United States (approximately 27,000). Intracranial Aneurysms will address the natural history, biology, and basic management principles and treatment of aneurysms. The chapters also explore the unique features of each type or location of aneurysm while considering the medical, surgical, and endovascular options. Contributions are by members of the Endovascular Neurosurgery Research Group, a group of recognized expert neurosurgeons who specialize in cerebrovascular and endovascular management of aneurysms.

  • The Auditory System in Sleep

    • 2nd Edition
    • Ricardo Velluti
    • English
    The Auditory System in Sleep, Second Edition presents a view of a sensory system working in a different state, that of the sleeping brain. This updated edition contains new chapters on topics such as implanted deaf patients and sleep and tinnitus treatments. It is written for basic auditory system and sleep researchers, as well as practitioners and clinicians in the Auditory/Sensory Neurosciences and Sleep Medicine. As the auditory system is always “open”, thus receiving information from the environment and the body itself (conscious and unconscious data), the incoming sensory information may alter sleep and waking physiology, and conversely, the sleeping brain. This book draws information from evoked potentials, fMRI, PET, SPECT, lesions, and more.

  • Ischemic and Traumatic Brain and Spinal Cord Injuries

    Mechanisms and Potential Therapies
    • 1st Edition
    • Akhlaq A. Farooqui
    • English
    Ischemic and Traumatic Brain and Spinal Cord Injuries: Mechanisms and Potential Therapies presents readers with comprehensive and cutting-edge information on molecular mechanisms, including the signal transduction processes associated with neurodegeneration and neuroprotection in ischemic, spinal cord, severe and mild brain injuries. The book also covers the molecular mechanisms of drugs used for the treatment of neurotraumatic disease. Chapters are organized by molecular aspects and neuroprotective strategies by disease, including ischemic injury, spinal cord injury, traumatic brain injury, and chronic traumatic encephalopathy. The book integrates and consolidates knowledge on neurotraumatic diseases, with the hope of bringing forth more dramatic advances and developments, not only on molecular mechanisms, but also on the causes of, and treatments for, neurotraumatic diseases.

  • Quality and Safety in Neurosurgery

    • 1st Edition
    • Daniel J. Guillaume + 1 more
    • English
    Quality and Safety in Neurosurgery covers recent improvements and presents solutions for problems that impact patient care. This book is written for anyone who works at the intersection of quality, safety and neurosurgery, including neurosurgeons, neurologists, clinical researchers looking to improve outcomes in neurosurgery, hospital quality and safety officers, department leaders, fellows and residents. Edited by neurosurgeons who helped build the culture of quality and safety in the Department of Neurosurgery at UMN, this work emphasizes quality and safety, whether through ‘value based purchasing’, finding specialty specific quality and safety metrics, or just the professional desire to provide quality care.

  • Arachnoid Cysts

    Clinical and Surgical Management
    • 1st Edition
    • Knut Wester
    • English
    Arachnoid Cysts: Clinical and Surgical Management gives a broad and updated presentation of the condition, including symptomatology, diagnostics, management and treatment. The book covers the effects of surgical treatment on clinical symptoms and the effects cysts have on cognition, as well as cognitive improvement after surgical cyst decompression. This book is written for researchers, residents and clinical practitioners in clinical neuroscience, neurology, neurosurgery, neuroradiology and pediatrics.

  • Arachnoid Cysts

    Epidemiology, Biology, and Neuroimaging
    • 1st Edition
    • Knut Wester
    • English
    Intracranial arachnoid cysts are congenital malformations with a predilection for the middle cranial fossa and an estimated prevalence in the general population as high as 1.7%. The common assumption is that these cysts are incidental findings and the symptoms associated with them are not caused by the cyst and consequently, that surgical intervention will not benefit the patient. However, there is now a growing understanding reflected in the international literature among neurologists and neurosurgeons that arachnoid cysts do harm and that the patients’ complaints can be relieved by surgical treatment. Arachnoid Cysts: Epidemiology, Biology, and Neuroimaging gives a broad and updated presentation of the condition, including epidemiology, etiology, biology (including genetics and molecular biology), and neuroimaging of same. This book is written for researchers, residents, and clinical practitioners in clinical neuroscience, neurology, neurosurgery, neuroradiology, and pediatrics.

  • Functional Neurologic Disorders

    • 1st Edition
    • Volume 139
    • English
    Functional Neurologic Disorders, the latest volume in the Handbook of Clinical Neurology series, summarizes state-of-the-art research findings and clinical practice on this class of disorders at the interface between neurology and psychiatry. This 51-chapter volume offers an historical introduction, chapters on epidemiology and pathophysiolology, a large section on the clinical features of different type of functional neurologic symptoms and disorders (including functional movement disorders, non-epileptic seizures, dizziness, vision, hearing, speech and cognitive symptoms), and then concluding with approaches to therapy. This group of internationally acclaimed experts in neurology, psychiatry, and neuroscience represent a broad spectrum of areas of expertise, chosen for their ability to write clearly and concisely with an eye toward a clinical audience. This HCN volume sets a new landmark standard for a comprehensive, multi-authored work dealing with functional neurologic disorders (also described as psychogenic, dissociative or conversion disorders).

  • Brain-Computer Interfacing for Assistive Robotics

    Electroencephalograms, Recurrent Quantum Neural Networks, and User-Centric Graphical Interfaces
    • 1st Edition
    • Vaibhav Gandhi
    • English
    Brain-computer interface (BCI) technology provides a means of communication that allows individuals with severely impaired movement to communicate with assistive devices using the electroencephalogram (EEG) or other brain signals. The practicality of a BCI has been possible due to advances in multi-disciplinary areas of research related to cognitive neuroscience, brain-imaging techniques and human-computer interfaces. However, two major challenges remain in making BCI for assistive robotics practical for day-to-day use: the inherent lower bandwidth of BCI, and how to best handle the unknown embedded noise within the raw EEG. Brain-Computer Interfacing for Assistive Robotics is a result of research focusing on these important aspects of BCI for real-time assistive robotic application. It details the fundamental issues related to non-stationary EEG signal processing (filtering) and the need of an alternative approach for the same. Additionally, the book also discusses techniques for overcoming lower bandwidth of BCIs by designing novel use-centric graphical user interfaces. A detailed investigation into both these approaches is discussed.

  • Multiple Sclerosis and Related Disorders

    • 1st Edition
    • Volume 122
    • Douglas S. Goodin
    • English
    Multiple Sclerosis (MS) is generally understood to be an inflammatory autoimmune disease of the central nervous system. While we still are not certain of the root cause of MS, research results suggest that unknown environmental factors and the presence of specific genes seem the most probable targets. MS causes an inflammatory response in the central nervous system leading to neurodegeneration, oligodendrocyte death, axonal damage, and gliosis. Over the past five years ongoing research has greatly expanded our understanding of the pathogenesis of MS, detailed insight into the epidemiology and genetic factors related to MS, the introduction of new technologies and tests to better diagnose and predict the future course of the disease and the introduction of new treatments targeting MS. This collection of review chapters provides a comprehensive reference into the science and clinical applications of the latest Multiple Sclerosis research and will be a valuable resource for the neuroscience research community and the clinical neurology community of researchers and practitioners.

  • Research Funding in Neuroscience

    A Profile of the McKnight Endowment Fund
    • 1st Edition
    • Gabrielle Strobel
    • Sylvia Lindman
    • English
    The book is a history of the McKnight Endowment Fund for Neuroscience and an assessment of its effectiveness in advancing neuroscience. The book discusses the Fund's early and steady commitment to basic science as well as it's tradition of leveraging relatively modest dollars to make a big difference in careers and the field overall. The fund exists strictly to give awards and create a community of peers through an annual conference dedicated to research. In near unison, scientists who have received awards say they were able to test a risky idea, get their career off the ground, or make a significant change in their career because of McKnight's flexible dollars. The book consists of three parts: (1) origins--including both the funder and the scientists who shaped the program; (2) a review of the science to show how McKnight awardees have advanced the field; and (3) 10 keys to success. We also have an interview with Julius Axelrod (one of the early advisors, done shortly before his death in 2004) and stories of how awardees used their McKnight grants, plus other information.

  • Creating Coordination in the Cerebellum

    • 1st Edition
    • Volume 148
    • Chris I. De Zeeuw + 1 more
    • English
    Creating Coordination in the Cerebellum provides a multidisciplinary collection of chapters on the cerebellum with topics covering the entire spectrum from development and molecular neurobiology, cell physiology and plasticity to motor control, system physiology, functional imaging and pathology. The book not only presents novel discoveries obtained with recently developed technologies, but also gives new general concepts in global issues of cerebellar development and functions. By doing so it sets the standard for cerebellar research of the 21st century.