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Elsevier

Books in Neurological research

  • Advanced and Integrative Therapeutic Strategies in Parkinson’s Disease Management

    • 1st Edition
    • Wael Mohamed
    • English
    Advanced and Integrative Therapeutic Strategies in Parkinson’s Disease Management offers a comprehensive exploration of the latest innovations and multidisciplinary approaches in Parkinson’s Disease treatment. The volume is organized into sections covering genetic therapies, gut microbiota, artificial intelligence, virtual reality, neuroprotective strategies, polypharmacy, and combination therapies. It addresses the integration of personalized medicine, neuroprotective diets, natural products, cognitive enhancers, and ethical considerations. Additional chapters introduce traditional medicine, music therapy, and the synergy between pharmacotherapy and complementary modalities. The book equips readers with the knowledge to implement innovative therapies, navigate complex ethical landscapes, and integrate multidisciplinary and complementary approaches.This reference is essential for those seeking to advance clinical practice and research in Parkinson’s Disease through the adoption of cutting-edge strategies.

  • Advanced MR Techniques for Neurodegenerative Diseases

    • 1st Edition
    • Volume 14
    • Kannie Wy Chan + 3 more
    • English
    Advanced MR Techniques for Neurodegenerative Diseases covers state of the art developments in physiologic, metabolic, functional, and microstructural MRI of the brain. It provides an overview of these approaches and includes dynamic contrast enhanced (DCE) MRI, dynamic susceptibility contrast (DSC) MRI, arterial spin labeling (ASL), chemical exchange saturation transfer (CEST) MRI, magnetic resonance spectroscopy (MRS), resting state functional MRI (rsfMRI), microscopic diffusion imaging, and quantitative susceptibility mapping (QSM). Chapters then follow that present the application of these methods to Alzheimer’s Disease and vascular dementia, small vessel disease, Parkinson’s Disease, Lewy body dementia, Huntington’s Disease, Amyotrophic Lateral Sclerosis, and Multiple Sclerosis.Advanced MR Techniques for Neurodegenerative Diseases is a comprehensive resource on the latest advanced MR techniques and their application to neurodegenerative diseases, suitable for MR engineers and physicists as well as clinicians and neuroscientists who use MR techniques for diagnosis and research.

  • Vagus Nerve Stimulation

    • 1st Edition
    • Peter Staats + 3 more
    • English
    In the complex realm of our physiology, the vagus nerve stands as a silent orchestrator, influencing health and disease in ways that have long been underestimated. Vagus Nerve Stimulation delves into the profound significance of this 10th cranial nerve, tracing its course through the body and illuminating its role as a vital component of the parasympathetic nervous system.This comprehensive reference, contributed by leading experts at the forefront of medical science, unveils the groundbreaking field of vagus nerve stimulation—a non-invasive approach to harness the body's innate potential for health optimization, inflammation control, and disease modification. Contributed by leading experts in the field, this comprehensive volume serves as a compendium of current knowledge about stimulating the vagus nerve in many different disease states. This book starts with the foundational insights in Basic Science and Technical Considerations. From there, it continues to Neurologic Conditions, where chapters explore applications for epilepsy, cluster headaches, and concussions. Evolving Therapy for Neurologic Conditions introduces cutting-edge treatments for acute ischemic stroke, synaptic plasticity, and neurodegenerative disorders. The book extends into Psychiatric and Somatic Conditions, providing insights into anxiety, depression, addiction disorders, and more. Conventional Inflammatory Conditions shed light on vagus nerve stimulation's role in combatting sepsis, immune-mediated inflammatory diseases, and metabolic syndrome, among others. Concluding with a foray into Oncology, the book highlights the potential of vagus nerve stimulation in addressing the lingering effects of long covid and migraine. With an authoritative blend of scientific rigor and practical application, this reference serves as an indispensable guide to the vast landscape of vagus nerve stimulation, transforming our understanding of health and wellness.

  • Motor System Disorders, Part II

    Spinal Cord, Neurodegenerative, and Cerebral Disorders and Treatment
    • 1st Edition
    • Volume 196
    • David S. Younger
    • English
    Motor System Disorders, Volume 196, Part Two, Spinal Cord, Neurodegenerative, and Cerebral Disorders and Treatment provides a comprehensive review of research and best practice clinical management of spinal cord, neurodegenerative, and cerebral disorders. Encompassing hereditary and acquired disorders from disease and accident, the book explores motor control disorders associated with stroke, dementia, seizure, encephalitis, and more. Covering disorders of both children and adults, the book discusses the latest advances in treatments related to neuroplasticity, neural tissue transplantation, and immunotherapy.

  • Neurostimulation for Epilepsy

    Advances, Applications and Opportunities
    • 1st Edition
    • Vikram R. Rao
    • English
    **Association of American Publishers (AAP) PROSE Award Finalist in Biomedicine and Neuroscience, 2024**Neurostimulati... for Epilepsy: Advances, Applications, and Opportunities comprehensively reviews the diverse array of neurostimulation technologies currently in use and in development for the treatment of epilepsy. The book covers basic mechanisms of neurostimulation, technical characteristics of approved and investigational neurostimulation devices, clinical applications and programming considerations of these devices, and progress toward next-generation device technology. Leading experts in the field provide a contemporary appraisal of neurostimulation in epilepsy, one that highlights recent advances, outlines unanswered questions, and proposes future directions.Neurostim... for Epilepsy: Advances, Applications, and Opportunities will be of high interest to clinical, basic, and translational researchers seeking to understand leading-edge applications of neurostimulation in epilepsy and to clinicians managing patients with epilepsy who are treated with implanted and external neurostimulation devices. This book will also be of interest to trainees, to physicians in other areas of neurology where neurostimulation is employed, such as Pain and Movement Disorders, and to general medical practitioners, neurobiologists, and engineers.

  • Posttraumatic Epilepsy

    Basic and Clinical Aspects
    • 1st Edition
    • Carrie R. Jonak + 2 more
    • English
    Posttraumatic Epilepsy: Basic and Clinical Aspects provides a synthesized resource on the recent basic and clinical science developments in the field of posttraumatic epilepsy. This book provides a clear understanding of the history of studies and epidemiology of posttraumatic epilepsy after head injury. The book also considers the neuropathology of posttraumatic epilepsy and clinical trials of antiepileptogenic agents evaluated after traumatic brain injury. The book covers the basic science of animal models of traumatic brain injury and the necessary and sufficient changes that must occur to generate epilepsy after head trauma. The authors explore potential mechanisms and novel therapeutic approaches to prevent posttraumatic epilepsy. The book is written for basic and clinical researchers in neuroscience as well as for clinicians treating patients with epilepsy.

  • Nanomedicine-Based Approaches for the Treatment of Dementia

    • 1st Edition
    • Umesh Gupta + 1 more
    • English
    Nanomedicine-Based Approaches for the Treatment of Dementia explores a wide range of promising approaches for the diagnosis and treatment of dementia. The book begins with introductory sections on dementia and brain ailments that are followed by further chapters that discuss detailed information about challenges of drug delivery across the blood-brain barrier as well as the current status. This book helps readers design and develop novel drug delivery systems and devices for the treatment of dementia that take advantage of recent advances in nanomedical technologies. Numerous drug delivery systems have been developed recently for dementia. Unfortunately, most of them are ineffective since dementia is not a single disease. It is an umbrella term for several neurodegenerative conditions which alter brain functions. Due to this, there is an urgent need for innovative technologies/nano drug delivery systems to improve the targeting and delivery of therapeutic as well as diagnostic agents specifically for treating dementia.

  • Intraoperative Neuromonitoring

    • 1st Edition
    • Volume 186
    • Marc R. Nuwer + 1 more
    • English
    Interoperative Monitoring, Volume 186 provides a concise overview of advances in interoperative monitoring targeted for clinical neurologists. It identifies techniques (EEG, ECoG, EMG, etc.), optimal anesthesia for use, safety issues to be considered, and then discusses advances as they relate to intracranial, spinal, peripheral nerve and vascular surgery. Best practices and case studies are included for all chapters as well as surgical microscope views, illustrations, and medical imaging.

  • Heart and Neurologic Disease

    • 1st Edition
    • Volume 177
    • English
    The Handbook of Clinical Neurology series volumes provide comprehensive summaries of recent research on the brain and nervous system as they relate to clinical neurology. Cardiac disorders and diseases may often co-occur with, or cause, subsequent neurological disorders. Heart and Neurologic Disease identifies the top cardiac diseases and disorders most likely to have neurological disorders, how they will present, and how they are best treated. It identifies the mechanisms of action explaining why the conditions co-occur, and what clinicians should look for symptom wise, and how risk may be assessed. Coverage includes genetic cardiac disorders, cardiac trauma, surgery, infection, disease, and arrhythmia.

  • Biomarkers for Traumatic Brain Injury

    • 1st Edition
    • Alan H.B. Wu + 1 more
    • English
    Biomarkers for Traumatic Brain Injury provides a comprehensive overview on the selection and implementation of serum-based and saliva-based biomarkers for traumatic brain injury. The book presents an economic analysis for implementing TBI biomarkers into clinical practice. In addition, it discusses the analytical tools needed to implement TBI biomarkers, including specifications for testing instruments and interpretative software. Neurologists, emergency department physicians, intensivists, and clinical laboratorians will find this book a great resource from which to familiarize themselves with the issues and processes regarding TBI biomarkers. Approximately 2 million people in the U.S. sustain a traumatic brain injury (TBI) each year with over 250,000 hospitalizations and 50,000 deaths. There has been a significant rise in interest in diagnosing mild concussions, particularly in the sports world. While imaging has been the gold standard, these procedures are costly and not always available. There is great potential in using serum-based biomarkers, hence the book seeks to enlighten readers on new possibilities.

  • Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease

    Volume 1
    • 6th Edition
    • Roger N. Rosenberg + 1 more
    • English
    Rosenberg’s Molecular and Genetic Basis of Neurologic and Psychiatric Disease, Sixth Edition: Volume One, provides a comprehensive introduction and reference to the foundations and key practical aspects relevant to neurologic and psychiatric disease. A favorite of over three generations of students, clinicians and scholars, this new edition retains and expands the informative, concise and critical tone of the first edition. This is an essential reference for general medical practitioners, neurologists, psychiatrists, geneticists, and related professionals, and for the neuroscience and neurology research community. The content covers all aspects essential to the practice of neurogenetics to inform clinical diagnosis, treatment and genetic counseling. Every chapter has been thoroughly revised or newly commissioned to reflect the latest scientific and medical advances by an international team of leading scientists and clinicians. The contents have been expanded to include disorders for which a genetic basis has been recently identified, together with abundant original illustrations that convey and clarify the key points of the text in an attractive, didactic format.

  • Neurophysiology in Neurosurgery

    A Modern Approach
    • 2nd Edition
    • Vedran Deletis + 3 more
    • English
    Over the last 18 years, there have been many advances in the field of intraoperative monitoring. This new edition of Neurophysiology in Neurosurgery: A Modern Approach provides updates on the original techniques, as well as other more recent methodologies that may either prove beneficial or are commonly used in neuromonitoring. The purpose of this book is to describe the integration of neuromonitoring with surgical procedures. Each methodology is discussed in detail as well as chapters describing how those methodologies are applied to multiple surgical procedures and the evidence used to support those uses. The second edition features a surgical procedure section, which focuses on specific surgical procedures and the type of monitoring used during these procedures. The original chapters have been updated, expanded, and the structure modified to ensure the book is beneficial to both physiologists and surgeons. This book is written for neurosurgeons, neurophysiologists, neurologists, anesthesiologists, interventional neuroradiologists, orthopedic surgeons, and plastic surgeons.

  • Neuroblastoma

    Molecular Mechanisms and Therapeutic Interventions
    • 1st Edition
    • Swapan K. Ray
    • English
    Neuroblastoma: Molecular Mechanisms and Therapeutic Interventions comprehensively reviews current concepts in molecular and histopathological mechanisms that influence the growth of human malignant neuroblastoma, along with exciting therapeutic interventions. This book features a broad collection of contributions from leading investigators in histopathology, molecular mechanisms, genetics, epigenetics, microRNAs, proteomics, and metabolism in controlling growth and death in neuroblastoma. Recent developments in therapeutic interventions for neuroblastoma are also covered extensively, including chapters on surgery, chemotherapy, targeted therapy and immunotherapy. This book is ideal for advanced undergraduate students, graduate students, medical students, postdoctoral fellows, and investigators with an interest in current molecular concepts and therapeutic interventions.

  • Neurosensory Disorders in Mild Traumatic Brain Injury

    • 1st Edition
    • Michael E. Hoffer + 1 more
    • English
    Mild traumatic Brain Injury (mTBI or Concussion) is an increasingly common public health issue in sports, military environments, and life in today’s active world. Despite a great deal of study and public attention to this disorder, knowledge about optimal diagnostic, prognostic, and treatment information remains lacking. Neurosensory symptoms have been shown to be the most frequent complications of mTBI in both the acute and chronic setting. Neurosensory Disorders in Mild Traumatic Brain Injury brings together both the basic science work as well as the clinical work in mTBI into one volume to provide a comprehensive examination of the neurosensory issues associated with this disorder. Coverage includes chapters on defining mild Traumatic Brain Injury, neurosensory consequences, neurosensory disorders in clinical practice, and diagnosis and treatment for neurosensory disorders in mTBI. This book is written for clinicians, researchers, residents and students in neurology and neuroscience.

  • Introduction to Electrophysiological Methods and Instrumentation

    • 2nd Edition
    • Franklin Bretschneider + 1 more
    • English
    Introduction to Electrophysiological Methods and Instrumentation, Second Edition covers all topics of interest to electrophysiologists... neuroscientists and neurophysiologists, from the reliable penetration of cells and the behavior and function of the equipment, to the mathematical tools available for analyzing data. It discusses the pros and cons of techniques and methods used in electrophysiology and how to avoid pitfalls. Although the basics of electrophysiological techniques remain the principal purpose of this second edition, it now integrates several current developments, including, amongst others, automated recording for high throughput screening and multimodal recordings to correlate electrical activity with other physiological parameters collected by optical means. This book provides the electrophysiologist with the tools needed to understand his or her equipment and how to acquire and analyze low-voltage biological signals.

  • Gene Therapy in Neurological Disorders

    • 1st Edition
    • Mingjie Li + 1 more
    • English
    Gene therapy has tremendous potential for the treatment of neurological disorders. There has been substantial progress in the development of gene therapy strategies for neurological disorders over the last two decades. Gene Therapy in Neurological Disorders thoroughly reviews currently available gene therapy tools and presents examples of their application in a variety of neurological diseases. The book begins with general reviews of gene therapy strategies with a focus on neurological disorders. The remainder of the chapters present approaches to specific neurological disorders. Each chapter gives an in-depth introduction to the relevant field before diving into the specific tool or application. The book aims to help investigators, students and research staff better understand the principles of gene therapy and its application in the nervous system.

  • Intracranial Aneurysms

    • 1st Edition
    • Andrew J. Ringer
    • English
    Intracranial aneurysm result from complex interactions between cerebrovascular anatomy, vascular injury, and adaptive remodeling of the arterial wall and represent a cerebrovascular disorder with the potential for substantial morbidity and mortality. Most intracranial aneurysms occur in the larger arteries near the skull base, in or around the circle of Willis, but variants may appear virtually anywhere in the cerebral vasculature. The aneurysm can leak or rupture, causing life-threatening bleeding, and is the most common cause of spontaneous subarachnoid hemorrhage, the third most common form of stroke. Intracranial aneurysms affect about 1 in 10,000 people per year in the United States (approximately 27,000). Intracranial Aneurysms will address the natural history, biology, and basic management principles and treatment of aneurysms. The chapters also explore the unique features of each type or location of aneurysm while considering the medical, surgical, and endovascular options. Contributions are by members of the Endovascular Neurosurgery Research Group, a group of recognized expert neurosurgeons who specialize in cerebrovascular and endovascular management of aneurysms.

  • The Auditory System in Sleep

    • 2nd Edition
    • Ricardo Velluti
    • English
    The Auditory System in Sleep, Second Edition presents a view of a sensory system working in a different state, that of the sleeping brain. This updated edition contains new chapters on topics such as implanted deaf patients and sleep and tinnitus treatments. It is written for basic auditory system and sleep researchers, as well as practitioners and clinicians in the Auditory/Sensory Neurosciences and Sleep Medicine. As the auditory system is always “open”, thus receiving information from the environment and the body itself (conscious and unconscious data), the incoming sensory information may alter sleep and waking physiology, and conversely, the sleeping brain. This book draws information from evoked potentials, fMRI, PET, SPECT, lesions, and more.

  • Signal Processing for Neuroscientists

    • 2nd Edition
    • Wim van Drongelen
    • English
    Signal Processing for Neuroscientists, Second Edition provides an introduction to signal processing and modeling for those with a modest understanding of algebra, trigonometry and calculus. With a robust modeling component, this book describes modeling from the fundamental level of differential equations all the way up to practical applications in neuronal modeling. It features nine new chapters and an exercise section developed by the author. Since the modeling of systems and signal analysis are closely related, integrated presentation of these topics using identical or similar mathematics presents a didactic advantage and a significant resource for neuroscientists with quantitative interest. Although each of the topics introduced could fill several volumes, this book provides a fundamental and uncluttered background for the non-specialist scientist or engineer to not only get applications started, but also evaluate more advanced literature on signal processing and modeling.

  • Arachnoid Cysts

    Epidemiology, Biology, and Neuroimaging
    • 1st Edition
    • Knut Wester
    • English
    Intracranial arachnoid cysts are congenital malformations with a predilection for the middle cranial fossa and an estimated prevalence in the general population as high as 1.7%. The common assumption is that these cysts are incidental findings and the symptoms associated with them are not caused by the cyst and consequently, that surgical intervention will not benefit the patient. However, there is now a growing understanding reflected in the international literature among neurologists and neurosurgeons that arachnoid cysts do harm and that the patients’ complaints can be relieved by surgical treatment. Arachnoid Cysts: Epidemiology, Biology, and Neuroimaging gives a broad and updated presentation of the condition, including epidemiology, etiology, biology (including genetics and molecular biology), and neuroimaging of same. This book is written for researchers, residents, and clinical practitioners in clinical neuroscience, neurology, neurosurgery, neuroradiology, and pediatrics.

  • Arachnoid Cysts

    Clinical and Surgical Management
    • 1st Edition
    • Knut Wester
    • English
    Arachnoid Cysts: Clinical and Surgical Management gives a broad and updated presentation of the condition, including symptomatology, diagnostics, management and treatment. The book covers the effects of surgical treatment on clinical symptoms and the effects cysts have on cognition, as well as cognitive improvement after surgical cyst decompression. This book is written for researchers, residents and clinical practitioners in clinical neuroscience, neurology, neurosurgery, neuroradiology and pediatrics.

  • Functional Neurologic Disorders

    • 1st Edition
    • Volume 139
    • English
    Functional Neurologic Disorders, the latest volume in the Handbook of Clinical Neurology series, summarizes state-of-the-art research findings and clinical practice on this class of disorders at the interface between neurology and psychiatry. This 51-chapter volume offers an historical introduction, chapters on epidemiology and pathophysiolology, a large section on the clinical features of different type of functional neurologic symptoms and disorders (including functional movement disorders, non-epileptic seizures, dizziness, vision, hearing, speech and cognitive symptoms), and then concluding with approaches to therapy. This group of internationally acclaimed experts in neurology, psychiatry, and neuroscience represent a broad spectrum of areas of expertise, chosen for their ability to write clearly and concisely with an eye toward a clinical audience. This HCN volume sets a new landmark standard for a comprehensive, multi-authored work dealing with functional neurologic disorders (also described as psychogenic, dissociative or conversion disorders).

  • Research Funding in Neuroscience

    A Profile of the McKnight Endowment Fund
    • 1st Edition
    • Gabrielle Strobel
    • Sylvia Lindman
    • English
    The book is a history of the McKnight Endowment Fund for Neuroscience and an assessment of its effectiveness in advancing neuroscience. The book discusses the Fund's early and steady commitment to basic science as well as it's tradition of leveraging relatively modest dollars to make a big difference in careers and the field overall. The fund exists strictly to give awards and create a community of peers through an annual conference dedicated to research. In near unison, scientists who have received awards say they were able to test a risky idea, get their career off the ground, or make a significant change in their career because of McKnight's flexible dollars. The book consists of three parts: (1) origins--including both the funder and the scientists who shaped the program; (2) a review of the science to show how McKnight awardees have advanced the field; and (3) 10 keys to success. We also have an interview with Julius Axelrod (one of the early advisors, done shortly before his death in 2004) and stories of how awardees used their McKnight grants, plus other information.

  • Creating Coordination in the Cerebellum

    • 1st Edition
    • Volume 148
    • Chris I. De Zeeuw + 1 more
    • English
    Creating Coordination in the Cerebellum provides a multidisciplinary collection of chapters on the cerebellum with topics covering the entire spectrum from development and molecular neurobiology, cell physiology and plasticity to motor control, system physiology, functional imaging and pathology. The book not only presents novel discoveries obtained with recently developed technologies, but also gives new general concepts in global issues of cerebellar development and functions. By doing so it sets the standard for cerebellar research of the 21st century.

  • Human Brain Function

    • 2nd Edition
    • Richard S.J. Frackowiak + 7 more
    • English
    This updated second edition provides the state of the art perspective of the theory, practice and application of modern non-invasive imaging methods employed in exploring the structural and functional architecture of the normal and diseased human brain. Like the successful first edition, it is written by members of the Functional Imaging Laboratory - the Wellcome Trust funded London lab that has contributed much to the development of brain imaging methods and their application in the last decade. This book should excite and intrigue anyone interested in the new facts about the brain gained from neuroimaging and also those who wish to participate in this area of brain science.