
Diabetes and Neurodegeneration
- 1st Edition - December 1, 2025
- Imprint: Academic Press
- Editors: Debasis Bagchi, Samudra Prosad Banik, Rameshwar Nath Chaurasia
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 3 3 3 5 5 - 2
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 3 3 3 5 6 - 9
Diabetes and Neurodegeneration unlocks the complex interplay between diabetes and Neurodegeneration, reviewing the relationship between these two prevalent health challe… Read more
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- Identifies the cognitive impairment symptoms and the direct impact on the nervous system's structure and electrophysiology
- Explores disruptions in insulin signaling as key contributors to neurodegeneration in hyperglycemic individuals
- Highlights early diagnostic and prognostic indicators of diabetes and cognitive impairment
- Evaluates the efficacy of antidiabetic drugs, targets insulin resistance, and critically assesses RAGE-based therapeutic interventions
1. Why and when does one have high blood sugar?
2. The History of hyperglycemia: key milestones in the inception of the disease in human health
3. Neurodegeneration: How to identify the primary symptoms of cognitive impairment
4. Direct consequences of diabetes over the nervous system: Structural and electrophysiological changes
DISCOVERING THE BRIDGE BETWEEN DIABETES AND DEMENTIA
5. Early Clinical Evidence that suggest a strong link between Hyperglycemia and onset of neurodegeneration
6. Case studies for a systematic understanding of development of dementia in diabetic or pre-diabetic patients
7. Susceptibility assessment of dementia in diabetic or prediabetic conditions
8. Metabolic connections between Diabetes and AD
9. Role of diabetes and altered metabolic homeostasis in age related dementia
10. Oxidative stress in brain accelerates the onset of neurodegeneration in hyperglycemic individuals
11. Cardiovascular diseases in diabetic individuals aggravate the propensity of dementia
12. Disruption of insulin signaling causes major cognitive impairment
BIOMARKERS AND PATHWAYS WHICH CONNECT DIABETES AND DEMENTIA
13. Early diagnostic and prognostic biomarkers of diabetes and cognitive impairment
14. Periphery biomarkers to assess the vulnerability of Type 2 diabetic patients to AD
15. Advanced Glycated End (AGE) Product: the most significant metabolic by-product implicated in dementia
16. The Physiological role of AGE: RAGE axis in the body: Implications in cellular defense
17. Role of AGE molecules in protein misfolding and aggregation
18. AGE molecules as major culprits behind amyloidogenic protein aggregation
19. Shared pathways of Type 2 diabetes and Alzheimer’s Disease
20. Role of gut microbial amyloids in progressive cognitive decline
21. Exploring the unknown territory of Gut: Brain axis in diabetic patients: impact of elevated blood sugar on microbial amyloids
THERAPEUTIC STRATEGIES TO ARREST AND/OR DELINK DIABETES AND DEMENTIA
22. Evaluation of efficacy of antidiabetic drugs to arrest dementia
23. Targeting Insulin resistance to treat cognitive impairment
24. RAGE based therapeutic interventions: Do they aggravate or ameliorate dementia?
25. Soluble form of RAGE (sRAGE) receptors as novel therapeutic intervention to arrest amyloid associated pathogenesis
26. Assessing the efficacy of antidiabetic phytotherapeutic interventions towards improvement of cognitive functions
FUTURE FRONTIERS IN DIABETES AND DEMENTIA
27. Commentary: Diabetes and cognitive health: How can we save the future generation
- Edition: 1
- Published: December 1, 2025
- Imprint: Academic Press
- Language: English
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Debasis Bagchi
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Samudra Prosad Banik
Samudra Prosad Banik, Ph.D., received his PhD degree in Life Sciences from Jadavpur University in 2009 after working in the field of Fungal Biotechnology from the CSIR –Indian Institute of Chemical Biology, Kolkata, India. Dr. Banik is currently working as Assistant Professor at the Department of Microbiology, Maulana Azad College, University of Calcutta at Kolkata, India. After completing his Masters in Biophysics and Molecular Biology at the University of Kolkata in 2003, Dr. Banik was awarded a travel grant to work in a short project of genetically engineered rice with increased photosynthetic efficiency at International Rice Research Institute, Philippines. Thereafter he completed his PhD. at IICB where he identified an alternative pathway of vesicles mediated protein secretion in filamentous fungus, and performed biophysical characterization of the glycosylated fungal enzyme assemblies. Upon joining Maulana Azad College, Dr. Banik continued his research on behavior of glycosylated/glycated proteins in higher eukaryotes. In the process, he eventually shifted his attention towards glycated proteins formed during hyperglycemia and its associated consequences chiefly with regards to neuronal disorders. He has been the recipient of three research projects and has published more than 32 research articles in SCOPUS/Web of Science indexed journals along with 15 book chapters published by CRC Press/Wiley/CRC Press. Dr. Banik has edited one book on Biofuels which is scheduled to come out early next year from CRC Press/Taylor and Francis. He is an active reviewer of significant journals including Heliyon, PLOS One and Journal of American Nutrition Association. He is presently the Joint-Convenor of Research Committee at Maulana Azad College. His current research interests include understanding the mechanism of stabilization of proteins by osmolytes as well as structural changes inflicted in proteins due to glycation.
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