Motor System Disorders, Part II
Spinal Cord, Neurodegenerative, and Cerebral Disorders and Treatment
- 1st Edition, Volume 196 - August 22, 2023
- Imprint: Elsevier
- Editor: David S. Younger
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 9 8 8 1 7 - 9
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 5 8 5 5 - 4
Motor System Disorders, Volume 196, Part Two, Spinal Cord, Neurodegenerative, and Cerebral Disorders and Treatment provides a comprehensive review of research and best practice… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quoteMotor System Disorders, Volume 196, Part Two, Spinal Cord, Neurodegenerative, and Cerebral Disorders and Treatment provides a comprehensive review of research and best practice clinical management of spinal cord, neurodegenerative, and cerebral disorders. Encompassing hereditary and acquired disorders from disease and accident, the book explores motor control disorders associated with stroke, dementia, seizure, encephalitis, and more. Covering disorders of both children and adults, the book discusses the latest advances in treatments related to neuroplasticity, neural tissue transplantation, and immunotherapy.
- Summarizes assessment, disease course, and best practice treatment
- Includes hereditary disorders and disorders from disease or accident
- Discusses advances in neuroplasticity, tissue transplantation, immunotherapy, and other treatments
- Reviews effects of dementia, stroke, seizure, encephalitis, cancer, and more
Practicing neurologists, research neurologists; General MDs interested in motor disfunction
- Cover image
- Title page
- Table of Contents
- Series Page
- Copyright
- Handbook of Clinical Neurology 3rd Series
- Foreword
- Preface
- Contributors
- Section 1: Spinal cord diseases
- Chapter 1: Spinal cord motor disorders
- Abstract
- Introduction
- Neuroanatomy
- Spinal Motor Control
- Spinal Cord Lesions
- History and Physical Examination
- Laboratory Evaluation
- Tumors
- CNS Demyelinating Diseases
- Stroke
- Motor Neuron Disease
- Spinal Cord Injury
- Future Research
- References
- Chapter 2: Childhood spinal muscular atrophy
- Abstract
- History
- Classification
- Epidemiology
- Classification
- Laboratory Evaluation
- Genetics
- Other Forms of Spinal Muscular Atrophy
- Etiopathogenesis
- Management
- Natural History and Prognosis
- Disease-Modifying Molecular Therapy
- Conclusion and Future Directions
- References
- Chapter 3: The hereditary spastic paraplegias
- Abstract
- Introduction
- Definitions
- Classification
- Epidemiology
- Simplex Cases
- Clinical Presentation
- Clinical Aspects and Disease Course
- Diagnosis
- Neuroimaging
- Neurophysiology
- Genetic Testing
- Genetic Counseling
- Neuropathology (Schwarz, 1952; Schwarz and Liu, 1956; Behan and Maia, 1974; Sack et al., 1978; Buge et al., 1979; Harding, 1993; White et al., 2000; Deluca et al., 2004)
- Genetic Basis
- Treatment and Prognosis
- Conclusions
- Future Directions
- Acknowledgments
- References
- Chapter 4: Primary lateral sclerosis
- Abstract
- Introduction
- Clinical Description
- Neuropathology
- Electrophysiology
- Neuroimaging
- Differential Diagnosis
- Neurodegeneration and Relation to Motor Neuron Disease
- Genetics of Primary Lateral Sclerosis
- Treatment
- Conclusions
- References
- Chapter 5: Transverse myelitis in children and adults
- Abstract
- Introduction
- Infectious Myelitis
- Noninfectious Myelitis
- Idiopathic Myelitis
- Transverse Myelitis and Vaccines
- Systemic Disorders
- Conclusions
- References
- Chapter 6: Multiple sclerosis: Motor dysfunction
- Abstract
- Introduction
- Epidemiology and Etiopathogenic Factors
- Diagnosis
- MS Variants: AQP4, NMOSD, and MOGAD
- Pathology
- Pharmacotherapy
- Future Directions
- References
- Chapter 7: Tropical spastic paraparesis
- Abstract
- Introduction
- Tropical Myelopathy
- Chronic Tropical Myelopathy
- Tropical Neuropathy
- Toxic Neuropathy
- Neurologic Disorders Associated With Dietary Cyanide Intoxication
- References
- Section 2: Progressive neurodegenerative diseases
- Chapter 8: Cerebellum: From the identification of the cerebellar motor syndrome to the internal models
- Abstract
- Introduction: History of Cerebellar Research Since the 18th Century
- Anatomy: Microscopy and Macroscopy
- Cellular Physiology
- Cerebro-Cerebellar Structural Connectivity
- Cerebello-Cortical Circuits: Neurophysiological Aspects
- The Three Clinical Syndromes to the Light of Internal Models
- Conclusions
- Competing interests
- Ethical committee request
- References
- Chapter 9: Synucleinopathies
- Abstract
- Introduction
- Historical Perspective
- Pure Autonomic Failure
- Multiple System Atrophy
- Lewy Body Disorders—Parkinson Disease and Dementia with Lewy Bodies
- Conclusions
- References
- Chapter 10: Amyotrophic lateral sclerosis
- Abstract
- Introduction
- Neuropathology
- Clinical Presentation
- Diagnosis
- Genetic Basis of ALS
- Disease Pathogenesis
- A Role for Glia in ALS
- Genetic Biomarkers
- Paraneoplastic Mechanisms
- Treatment
- Conclusions
- Future Directions
- Acknowledgments
- References
- Chapter 11: Paraneoplastic motor disorders
- Abstract
- Introduction
- General Considerations
- Historical Perspective
- Epidemiology
- Clinical Syndromes
- Laboratory Evaluation
- Immunopathogenesis
- Treatment and Prognosis
- Future Direction
- References
- Chapter 12: The tauopathies
- Abstract
- Introduction
- Structure and Function
- Primary Tauopathies
- Tauopathies Due to Environmental Exposures
- Secondary Tauopathies
- Conclusions
- References
- Chapter 13: Gait dysfunction in Alzheimer disease
- Abstract
- Introduction
- Differing Gait Abnormalities and Assessment Methods
- Prognostic Utility of Gait Dysfunction Across AD Stages
- Biomarkers Associated With AD and Gait Dysfunction
- Gait and ApoE4
- Conclusions
- Acknowledgment
- References
- Section 3: Non-progressive cortical and subcortical disorders
- Chapter 14: Motor symptoms in nonparaneoplastic CNS disorders associated with neural antibodies
- Abstract
- Introduction
- Antibody-Mediated Encephalitis
- Antibody-Associated Nonparaneoplastic Cerebellar Ataxias
- Autoimmune CNS Disorders and Antibodies Against the Inhibitory Synapsis
- Autoimmune CNS Disorders and Glial Antibodies
- Antibody-Associated CNS Disorders With Prominent Sleep Dysfunction
- Conclusions
- Author disclosures
- References
- Chapter 15: Motor seizure semiology
- Abstract
- Introduction
- Tonic Seizures
- Clonic Seizures
- Tonic–Clonic Seizures
- Epileptic Spasms
- Myoclonic Seizures
- Automatisms
- Hyperkinetic Seizures
- Negative Motor Phenomena
- Motor Semiology With High Lateralizing Values
- Future Directions
- Summary
- References
- Chapter 16: Motor sequela of adult and pediatric stroke: Imminent losses and ultimate gains
- Abstract
- Introduction
- Epidemiology
- Neurovascular Topography and Clinical Deficits
- History
- Physical Examination
- Laboratory Evaluation
- Classification
- Childhood Stroke
- Adult Pure Motor Stroke
- Prognosis and Outcome
- Acute Stroke Management in Adults
- Acute Pediatric Stroke Management
- Rehabilitation Modalities to Enhance Stroke Recovery
- Conclusions
- Future Directions
- References
- Further reading
- Chapter 17: Paroxysmal movement disorders: Paroxysmal dyskinesia and episodic ataxia
- Abstract
- Introduction
- Paroxysmal Dyskinesia
- Episodic Ataxia
- Conclusions
- References
- Chapter 18: Pediatric neuropsychiatric disorders with motor and nonmotor phenomena
- Abstract
- Introduction
- Background
- Brain Milieu
- Neuropsychiatric Disorders
- PANDAS
- PANS
- Etiopathogenesis
- Future Directions
- Conclusions
- References
- Chapter 19: Essential tremor
- Abstract
- Introduction
- History
- Etiology: Epidemiology and Genetics
- Clinical Presentation and Natural History
- Diagnosis
- Pathophysiology
- Essential Tremor or Essential Tremors?
- Treatment
- References
- Chapter 20: Anatomy, physiology, and evaluation: Bowel, bladder, and sexual disorders
- Abstract
- Control of Urination
- Pathology
- Diagnosis
- Disorders of Defecation
- Patient Evaluation
- Erectile Function
- Neurogenic Erectile Dysfunction
- References
- Chapter 21: Isolated and combined dystonias: Update
- Abstract
- Introduction
- Phenomenology
- Clinical Clues
- Clinical Presentation
- Laboratory Evaluation
- Classification
- Pathogenesis
- Dystonia Syndromes
- Future Directions
- Conclusions
- References
- Chapter 22: Frontal lobe motor syndromes
- Abstract
- Introduction
- Frontal Motor Cortical Areas
- Clinical Neurologic Signs of Frontal Motor Syndromes
- Alien Limb Syndrome
- Utilization Behavior, Imitation Behavior, and Environmental Dependency
- Stereotypies
- Perseveration and Motor Impersistence
- Apraxia
- Frontal Gait Syndromes
- Facial Expression in Frontal Lobe Syndromes
- Catatonia and the Frontal Lobes
- Concluding Remarks
- References
- Chapter 23: Tourette syndrome and other tic disorders of childhood
- Abstract
- Background
- Definitions and Clinical Characteristics
- Diagnostic Criteria
- Differential Diagnosis
- Comorbidities
- Risk Factors
- Pathophysiology
- Treatment
- Conclusions
- References
- Chapter 24: Mild traumatic brain injury and sports-related concussion
- Abstract
- Introduction
- Historical Background
- Definitions
- Epidemiology
- History and Physical Examination
- Laboratory Evaluation
- Neuroradiologic Approaches
- Clinicopathologic Correlation
- Prognosis and Management
- Public Health Policy and Impact
- Future Research
- References
- Further reading
- Section 4: Therapeutics
- Chapter 25: Treatment of spasticity
- Abstract
- Spasticity: Introduction, Definition, and Presentation
- Pathophysiology of Spasticity
- Assessment of Spasticity
- Managing Trigger Factors
- Management of Spasticity
- Conclusions
- References
- Chapter 26: Novel therapeutic approaches for motor neuron disease
- Abstract
- Background
- Neuroinflammation
- Protein aggregation
- RNA metabolism
- Oxidative stress
- Future directions
- Conclusions
- References
- Chapter 27: Botulinum toxin for motor disorders
- Abstract
- Dystonia
- Tremor
- Spasticity
- References
- Chapter 28: Lysosomal storage disorders: Clinical and therapeutic aspects
- Abstract
- Introduction
- Therapeutic Options
- Conclusions
- References
- Chapter 29: Growth factors and molecular-driven plasticity in neurological systems
- Abstract
- Neurotrophin Growth Factors: General Comments
- Specific Neurotrophin Growth Factors
- Non-neurotrophin growth factors
- Growth Factor Delivery
- Growth Factor Signaling Cascades
- Neurotrophins, Other Growth Factors and Human Disease
- Specific Clinical Trials
- Acknowledgment
- References
- Chapter 30: Applied strategies of neuroplasticity
- Abstract
- Introduction
- Somatotopic Organization
- Neuroplasticity
- Adaptive Neuroplasticity
- Maladaptive Neuroplasticity
- Applied Neuroplasticity
- Rehabilitation and Neuroplasticity
- Learning and Neuroplasticity
- Conclusions
- References
- Chapter 31: Passive tau-based immunotherapy for tauopathies
- Abstract
- Introduction
- Primary Tauopathies Considered to Be Diseases
- Tau Protein Strucure and Function and Tauopathies
- Disease-Modifying Approaches for Treating Tauopathies
- Reduction of Tau Aggregates: Passive Immunotherapeutics for Tauopathies
- Conclusions
- Conflicts of interest
- Authors’ contributions
- References
- Index
- Edition: 1
- Volume: 196
- Published: August 22, 2023
- Imprint: Elsevier
- No. of pages: 670
- Language: English
- Hardback ISBN: 9780323988179
- eBook ISBN: 9780323958554
DY
David S. Younger
David S. Younger MD DrPH, MPH MS, Affiliate Professor of Neuroscience at City University of New York Medical School and Attending Physician at White Plains Hospital, NY, has vast experience in both clinical and academic neurology and public health. He mentors students at his alma mater Columbia University College of Physicians and Surgeons. He has been Board certified in Neurology, Internal Medicine, Electrodiagnostic Medicine (AANEM) and Neurophysiology (ABCN). As Associate Editor of the Seminars in Neurology he prepared the 1st edition of his widely-acclaimed textbook, Motor Disorders, now in its 4th edition. He is best recognized as a highly trained electrophysiologist and neuromuscular specialist. For the past decade his work has focused on autoimmunity of the nervous system and the use of immunotherapy and most recently, in COVID-19 neurological illnesses. He is the author of Human Lyme Neuroborreliosis, Science of Medical Cannabis, The Vasculitides, and The Autoimmune Brain; and he has been Guest Editor of the multiple volumes of the Neurological Clinics. He has also authored more than 300 peer-reviewed articles, book chapters, correspondence and scientific abstracts on a wide variety of topics.
Affiliations and expertise
Affiliated Professor of Neuroscience, City University of New York Medical School, New York, NY, United States; Attending Physician in Neurology, White Plains Hospital, White Plains, NY, United StatesRead Motor System Disorders, Part II on ScienceDirect