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Elsevier

Books in Neuroimaging

  • Primer on Cerebrovascular Research

    • 1st Edition
    • Dong-Eog Kim + 3 more
    • English
    Primer on Cerebrovascular Research provides both clinical and basic cerebrovascular knowledge that is required for physicians, vascular researchers, biomedical students, and trainees to understand or conduct evidence-based clinical practice and cutting-edge experimental research. This book outlines how to a design experimental cerebrovascular research in the context of clinical relevance, conduct the study using proper methods, analyze the data accurately, and make conclusions in an unbiased and statistically correct way. Chapters will include representative examples and experimental protocols.

  • Brain Point-of-Care Ultrasound

    Practical Guide and Protocols
    • 1st Edition
    • Camilo N. Rodríguez + 6 more
    • English
    Brain Point-of-Care Ultrasound: Practical Guide and Protocols explores brain hemodynamics and parenchyma examination, providing an orderly and protocolized approach that facilitates individualized clinical decisions with ease. Covering ultrasound configuration, in-depth anatomical knowledge, and advanced parameters, this guide aims to integrate brain ultrasound seamlessly into the Point-of-Care Ultrasound (POCUS) modality, addressing the critical need for comprehensive patient assessment. From basic principles to specialized clinical situations, each section of this guide is meticulously crafted to empower practitioners with practical insights. Chapters explore Doppler spectral wave interpretation, angle correction nuances, autoregulation dynamics, and non-invasive pressure estimations, among others, thus enabling precise monitoring and targeted decision-making. With a focus on integration across disciplines and specialties, this book bridges the gap between classical pathology and contemporary practice, positioning brain ultrasound as a pivotal tool in the armamentarium of modern critical care.

  • Applied Neuropsychology of Cerebrovascular Diseases

    A Practical Guide to Brain Arteries, Lesion Localization, and Rehabilitation Strategies
    • 1st Edition
    • Helmut Hildebrandt + 2 more
    • English
    Applied Neuropsychology of Cerebrovascular Diseases: A Practical Guide to Brain Arteries, Lesion Localization, and Rehabilitation Strategies addresses the critical intersection of vascular neurology and neuropsychological rehabilitation. The book explores the pathophysiology of stroke, emphasizing the importance of cerebrovascular anatomy and lesion localization in understanding cognitive deficits. It provides essential knowledge for clinicians involved in stroke assessment and treatment, highlighting the need for integration of neuroimaging interpretation into neuropsychological practice. Early sections offer foundational insights into cerebrovascular anatomy, stroke mechanisms, and their typical cognitive and emotional impairments.The second section equips clinicians with practical skills to independently interpret brain scans, utilizing tools like MRIcron to accurately localize lesions. The final section focuses on targeted rehabilitation strategies for common stroke syndromes, including neglect, aphasia, visual field deficits, and disorders of consciousness, all of which are supported by real-world clinical guidance and emerging neuromodulation techniques such as tDCS.

  • Behavioral Biometrics and Artificial Intelligence for Neurodegenerative Diseases Assessment

    • 1st Edition
    • Vincenzo Dentamaro + 2 more
    • English
    Behavioral Biometrics and Artificial Intelligence for Neurodegenerative Diseases Assessment explores cutting-edge, non-invasive techniques for the early detection of neurodegenerative diseases. The book focuses on behavioral biometrics, which analyzes patterns in a person’s actions rather than directly measurable traits. By utilizing artificial intelligence methods—like machine learning and deep neural networks—it enables the observation of subtle changes in gait, handwriting, and speech. These advanced approaches offer promise for earlier and more accurate diagnosis, potentially improving outcomes for millions affected by conditions such as Alzheimer’s and Parkinson’s diseases through timely intervention and personalized care.In addition to its core coverage, the book delves into the practical applications of wearable sensors and the use of everyday devices like smartphones and tablets in assessments. It provides comprehensive chapters on how these technologies can aid clinicians and researchers in monitoring disease progression outside traditional clinical settings.

  • Computational and Network Modeling of Neuroimaging Data

    • 1st Edition
    • Kendrick Kay
    • English
    Computational and Network Modeling of Neuroimaging Data provides an authoritative and comprehensive overview of the many diverse modeling approaches that have been fruitfully applied to neuroimaging data. As neuroimaging is witnessing a massive increase in the quality and quantity of data being acquired, this book gives an accessible foundation to the field of computational neuroimaging, suitable for graduate students, academic researchers, and industry practitioners who are interested in adopting or applying model-based approaches in neuroimaging.It is widely recognized that effective interpretation and extraction of information from complex data requires quantitative modeling. However, modeling the brain comes in many diverse forms, with different research communities tackling different brain systems, different spatial and temporal scales, and different aspects of brain structure and function. This book takes a critical step towards synthesizing and integrating across different modeling approaches.

  • Brain Responses to Auditory Mismatch and Novelty Detection

    Predictive Coding from Cocktail Parties to Auditory-Related Disorders
    • 1st Edition
    • Jos J. Eggermont
    • English
    Brain Responses to Auditory Mismatch and Novelty Detection: Predictive Coding from Cocktail Parties to Auditory-Related Disorders provides the connections between changes in the ‘error-generating network’ and disorder-specific changes while also exploring its diagnostic properties. The book allows the reader to appreciate the outcomes of predictive coding theory in fields of auditory streaming (including the cocktail-party effect) and psychiatric disorders with an auditory component. These include mild cognitive impairment (MCI), Alzheimer’s disease, attention-deficit and hyperactivity disorder (ADHD), autism spectrum disorder (ASD), schizophrenia and the cognitive aspects of Parkinson’s disease. The book combines animal experiments on adaptation, human auditory evoked potentials, including MMN and their maturational, as well as aging aspects into one comprehensive resource.

  • Neuroimaging in Neurogenic Communication Disorders

    • 1st Edition
    • Kostas Konstantopoulos + 1 more
    • English
    Neuroimaging in Neurogenic Communication Disorders provides a comprehensive review of cases utilizing neuroimaging in neurogenic communication disorders. Basic knowledge of neuroanatomy and medical conditions related to these speech and language disorders are discussed. Each case study includes information on neuroanatomy, case presentation, neuroimaging, differential diagnosis, and final diagnosis. This book is written for medical students, practitioners and researchers in neuroscience and speech language pathology. Neurogenic communication disorders are caused by damage to the central or peripheral nervous system. This damage can be caused by Parkinson’s disease, stroke, dementia, traumatic brain injury, brain tumors, and other neurologic disorders and causes issues such as aphasia, dysarthria and apraxia.

  • Cerebral Dural Arteriovenous Fistulas

    • 1st Edition
    • Bradley A. Gross + 3 more
    • English
    Cerebral Dural Arteriovenous Fistulas serves as an authoritative, comprehensive resource for these vascular lesions, describing their anatomy, diagnosis, natural history, and thorough treatment options. Rooted in well-illustrated anatomy and depictions of dAVFs, readers can better understand their pathophysiology, historical discovery, and avenues for treatment, including embolization, surgery, and radiosurgery. Imaging modalities are also discussed extensively as well as the management of these lesions. This reference is appropriate for neurosurgeons, neurologists, interventional radiologists and intensivists that manage these patients, providing clarity, and at the same time, comprehensiveness.

  • Neuroimaging Atlas of the Human Brain

    MRI, DTI, and Histology
    • 1st Edition
    • Jacopo Annese
    • English
    The field of human brain mapping is exhibiting an increased focus on the study of neural functional architecture at the system level and on individual neurological characteristics. rather than pm population-based averages. This new direction has resulted in a need for a new brain atlas that incorporates correlated radiologic and histological images representing the whole brain. Initiatives such as the Human Connectome Project are based on non-invasive techniques that afford images of the brain only at the macroscopic level, creating a growing need for an atlas that provides histological images of entire (coronal) sections that can then be easily compared to corresponding MRI and DTI images, making the correlation across modalities direct and intuitive. Neuroimaging Atlas of the Human Brain: MRI, DTI, and Histology is just such an atlas, representing the first market offering of histologic, radiologic, and labeled anatomical images of the same, entire human brain.

  • Finding the Nerve

    The Story of Impedance Neurography
    • 1st Edition
    • Philip C Cory
    • English
    Finding the Nerve: The Story of Impedance Neurography discusses research that elucidates the nature of nerve simulation via externally applied electrical fields, and how it has led to an entirely new understanding of neuronal cell membrane biophysics and defined a novel nerve imaging technology. It details how these discoveries came about and the nature of research that derives from unexplained clinical observations. The primary technology, impedance neurography, is a wholly new way of nerve-specific visualization in 2-D or 3-D, with the ability to define both normal and abnormal functioning of nerves, heretofore unavailable from techniques such as MRI neurography. This is of particular importance with respect to the obesity epidemic where physicians performing nerve-related procedures cannot use ultrasound visualization due to the depth limitations of that technology.

  • Human Brain in Standard MNI Space

    A Comprehensive Pocket Atlas
    • 1st Edition
    • Juergen K Mai + 1 more
    • English
    Human Brain in Standard MNI Space: A Comprehensive Pocket Atlas is a thorough pocket atlas designed for easy reference and interpretation of medical and scientific MR-images. It is intended for both early career and advanced medical students, for residents in radiology and neurology, and those involved in neuroscience research, emphasizing anatomy’s relationship to radiology. In addition, the book is ideal for non-specialists interested in issues relating to the brain or the determination of imaging features.

  • Imaging the Addicted Brain

    • 1st Edition
    • Volume 129
    • English
    Imaging the Addicted Brain, the latest volume in the International Review of Neurobiology series will appeal to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume focusses on the imaging of the brain addicted to food, gambling, tobacco, and opiates.

  • Neuroimaging, Part I

    • 1st Edition
    • Volume 135
    • English
    Neuroimaging, Part One, a text from The Handbook of Clinical Neurology illustrates how neuroimaging is rapidly expanding its reach and applications in clinical neurology. It is an ideal resource for anyone interested in the study of the nervous system, and is useful to both beginners in various related fields and to specialists who want to update or refresh their knowledge base on neuroimaging. This first volume specifically covers a description of imaging techniques used in the adult brain, aiming to bring a comprehensive view of the field of neuroimaging to a varying audience. It brings broad coverage of the topic using many color images to illustrate key points. Contributions from leading global experts are collated, providing the broadest view of neuroimaging as it currently stands. For a number of neurological disorders, imaging is not only critical for diagnosis, but also for monitoring the effect of therapies, and the entire field is moving from curing diseases to preventing them. Most of the information contained in this volume reflects the newness of this approach, pointing to this new horizon in the study of neurological disorders.

  • Neuroimaging, Part II

    • 1st Edition
    • Volume 136
    • English
    Neuroimaging, Part Two, a volume in The Handbook of Clinical Neurology series, illustrates how neuroimaging is rapidly expanding its reach and applications in clinical neurology. It is an ideal resource for anyone interested in the study of the nervous system, and is useful to both beginners in various related fields and to specialists who want to update or refresh their knowledge base on neuroimaging. This second volume covers imaging of the adult spine and peripheral nervous system, as well as pediatric neuroimaging. In addition, it provides an overview of the differential diagnosis of the most common imaging findings, such as ring enhancement on MRI, and a review of the indications for imaging in the most frequent neurological syndromes. The volume concludes with a review of neuroimaging in experimental animals and how it relates to neuropathology. It brings broad coverage of the topic using many color images to illustrate key points. Contributions from leading global experts are collated, providing the broadest view of neuroimaging as it currently stands. For a number of neurological disorders, imaging is not only critical for diagnosis, but also for monitoring the effect of therapies, with the entire field moving from curing diseases to preventing them. Most of the information contained in this volume reflects the newness of this approach, pointing to the new horizon in the study of neurological disorders.

  • MRI/DTI Atlas of the Rat Brain

    • 1st Edition
    • George Paxinos + 4 more
    • English
    MRI/DTI Atlas of the Rat Brain offers two major enhancements when compared with earlier attempts to make MRI/DTI rat brain atlases. First, the spatial resolution at 25µm is considerably higher than previous data published. Secondly, the comprehensive set of MRI/DTI contrasts provided has enabled the authors to identify more than 80% of structures identified in The Rat Brain in Stereotaxic Coordinates.

  • Biomedical Imaging

    Applications and Advances
    • 1st Edition
    • Peter Morris
    • English
    Biomedical Imaging: Applications and Advances discusses the technologies and latest developments in the increasingly important field of imaging techniques for the diagnosis of disease, monitoring of medical implants, and strategies for personalized medicine. Chapters in part one explore the full range of imaging technologies from atomic force microscopy (AFM) to positron emission tomography (PET), as well as the next-generation techniques that could provide the basis for personalized medicine. Part two highlights application-specific biomedical imaging methods, including ophthalmic imaging of ocular circulation, imaging methods for detection of joint degeneration, neural brain activation imaging, and the use of brain imaging to assess post-therapy responses. Further chapters review intravascular, cardiovascular, and whole-body magnetic resonance imaging (MRI). Biomedical Imaging is a technical resource for those concerned with imaging and diagnosis, including materials scientists and engineers as well as clinicians and academics.

  • Quantitative MRI of the Spinal Cord

    • 1st Edition
    • Julien Cohen-Adad + 1 more
    • English
    Quantitative MRI of the Spinal Cord is the first book focused on quantitative MRI techniques with specific application to the human spinal cord. This work includes coverage of diffusion-weighted imaging, magnetization transfer imaging, relaxometry, functional MRI, and spectroscopy. Although these methods have been successfully used in the brain for the past 20 years, their application in the spinal cord remains problematic due to important acquisition challenges (such as small cross-sectional size, motion, and susceptibility artifacts). To date, there is no consensus on how to apply these techniques; this book reviews and synthesizes state-of-the-art methods so users can successfully apply them to the spinal cord. Quantitative MRI of the Spinal Cord introduces the theory behind each quantitative technique, reviews each theory’s applications in the human spinal cord and describes its pros and cons, and suggests a simple protocol for applying each quantitative technique to the spinal cord.

  • Magnetic Resonance Spectroscopy

    Tools for Neuroscience Research and Emerging Clinical Applications
    • 1st Edition
    • Charlotte Stagg + 1 more
    • English
    Magnetic Resonance Spectroscopy: Tools for Neuroscience Research and Emerging Clinical Applications is the first comprehensive book for non-physicists that addresses the emerging and exciting technique of magnetic resonance spectroscopy. Divided into three sections, this book provides coverage of the key areas of concern for researchers. The first, on how MRS is acquired, provides a comprehensive overview of the techniques, analysis, and pitfalls encountered in MRS; the second, on what can be seen by MRS, provides essential background physiology and biochemistry on the major metabolites studied; the final sections, on why MRS is used, constitutes a detailed guide to the major clinical and scientific uses of MRS, the current state of teh art, and recent innovations. Magnetic Resonance Spectroscopy will become the essential guide for people new to the technique and give those more familiar with MRS a new perspective.

  • Diffusion MRI

    From Quantitative Measurement to In vivo Neuroanatomy
    • 2nd Edition
    • Heidi Johansen-Berg + 1 more
    • English
    Diffusion MRI remains the most comprehensive reference for understanding this rapidly evolving and powerful technology and is an essential handbook for designing, analyzing, and interpreting diffusion MR experiments. Diffusion imaging provides a unique window on human brain anatomy. This non-invasive technique continues to grow in popularity as a way to study brain pathways that could never before be investigated in vivo. This book covers the fundamental theory of diffusion imaging, discusses its most promising applications to basic and clinical neuroscience, and introduces cutting-edge methodological developments that will shape the field in coming years. Written by leading experts in the field, it places the exciting new results emerging from diffusion imaging in the context of classical anatomical techniques to show where diffusion studies might offer unique insights and where potential limitations lie.

  • Introduction to Diffusion Tensor Imaging

    And Higher Order Models
    • 1st Edition
    • Susumu Mori + 1 more
    • English
    The concepts behind diffusion tensor imaging (DTI) are commonly difficult to grasp, even for magnetic resonance physicists. To make matters worse, a many more complex higher-order methods have been proposed over the last few years to overcome the now well-known deficiencies of DTI. In Introduction to Diffusion Tensor Imaging: And Higher Order Models, these concepts are explained through extensive use of illustrations rather than equations to help readers gain a more intuitive understanding of the inner workings of these techniques. Emphasis is placed on the interpretation of DTI images and tractography results, the design of experiments, and the types of application studies that can be undertaken. Diffusion MRI is a very active field of research, and theories and techniques are constantly evolving. To make sense of this constantly shifting landscape, there is a need for a textbook that explains the concepts behind how these techniques work in a way that is easy and intuitive to understand—Introduct... to Diffusion Tensor Imaging fills this gap.

  • Medical Imaging Technology

    • 1st Edition
    • Victor I. Mikla + 1 more
    • English
    Medical Imaging Technology reveals the physical and materials principles of medical imaging and image processing, from how images are obtained to how they are used. It covers all aspects of image formation in modern imaging modalities and addresses the techniques, instrumentation, and advanced materials used in this rapidly changing field. Covering conventional and modern medical imaging techniques, this book encompasses radiography, fluoroscopy, computed tomography, magnetic resonance imaging, ultrasound, and Raman spectroscopy in medicine. In addition to the physical principles of imaging techniques, the book also familiarizes you with the equipment and procedures used in diagnostic imaging.

  • Paxinos and Franklin's the Mouse Brain in Stereotaxic Coordinates

    • 4th Edition
    • George Paxinos + 1 more
    • English
    In the years since its first publication, Paxinos and Franklin's the Mouse Brain in Stereotaxic Coordinates has received virtually universal acceptance in neuroscience as the authoritative source for stereotaxic coordinates and delineations. This atlas is constructed in the style of The Rat Brain in Stereotaxic Coordinates, the most cited publication in neuroscience. The completely revised and updated 4e of Paxinos and Franklin's the Mouse Brain in Stereotaxic Coordinates features high-quality color plates scanned by the renowned microscopy unit of the Allen Institute for Brain Science. Constructed by the leaders in neuroanatomical atlas development, the new edition will maintain the position of the atlas as an indispensable resource for scientists working on the mouse brain.

  • Translational Neuroimaging

    Tools for CNS Drug Discovery, Development and Treatment
    • 1st Edition
    • Robert A. McArthur
    • English
    Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment combines the experience of academic, clinical and industrial neuroimagers in a unique collaborative approach to provide an integrated perspective of the use of small animal and human brain imaging in developing and validating translational models and biomarkers for the study and treatment of neuropsychiatric disorders. Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment examines the translational role of neuroimaging in model development from preclinical animal models, to human experimental medicine, and finally to clinical studies. The focus of this book is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This book covers methodical issues in human and animal neuroimaging translational research as well as detailed applied examples of the use of neuroimaging in neuropsychiatric disorders and the development of drugs for their treatment. Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment appeals to non-clinical and clinical neuroscientists working in and studying neuropsychiatric disorders and their treatment as well as providing the novice researcher or researcher outside of his/her expertise the opportunity to understand the background of translational research and the use of imaging in this field.

  • A Combined MRI and Histology Atlas of the Rhesus Monkey Brain in Stereotaxic Coordinates

    • 2nd Edition
    • Kadharbatcha S. Saleem + 1 more
    • English
    A Combined MRI and Histology Atlas of the Rhesus Monkey Brain in Stereotaxic Coordinates, Second Edition maps the detailed architectonic subdivisions of the cortical and subcortical areas in the macaque monkey brain using high-resolution magnetic resonance (MR) images and the corresponding histology sections in the same animal. This edition of the atlas is unlike anything else available as it includes the detailed cyto- and chemoarchitectonic delineations of the brain areas in all three planes of sections (horizontal, coronal, and sagittal) that are derived from the same animal. This is a significant progress because in functional imaging studies, such as fMRI, both the horizontal and sagittal planes of sections are often the preferred planes given that multiple functionally active regions can be visualized simultaneously in a single horizontal or sagittal section. This combined MRI and histology atlas is designed to provide an easy-to-use reference for anatomical and physiological studies in macaque monkeys, and in functional-imaging studies in human and non-human primates using fMRI and PET.

  • The Human Cerebral Cortex

    An MRI Atlas of the Sulci and Gyri in MNI Stereotaxic Space
    • 1st Edition
    • Michael Petrides
    • English
    As MRI research becomes more detailed and specialized, it becomes essential to have detailed atlases that also explain individual variability, but other atlases do not provide this detail and leave users without illustration of, or guidance regarding how to deal with the variability they inevitably encounter in research and practice. This book serves as the first cortex atlas to address this growing need, appealing to clinicians, researchers and graduate students in neuroscience, neurology, neurosurgery and radiology. The atlas provides nearly 200 photographs of 3D reconstructions of human brains in a standard series of coronal, sagittal, and horizontal sections. It illustrates in detail and labels 95% of the cortex sulci and gyri, and images are presented in the MNI stereotaxic space. In addition to the standard brain and its sections are numerous examples of brains that exhibit patterns of deviating sulci and gyri. Examples of these variants are presented next to the standard illustration, accompanied by brief commentary aimed at helping users identify these variants and use them in their own work

  • MRI Atlas of Human White Matter

    • 2nd Edition
    • Kenichi Oishi + 3 more
    • English
    MRI Atlas of Human White Matter presents an atlas to the human brain on the basis of T 1-weighted imaging and diffusion tensor imaging. A general background on magnetic resonance imaging is provided, as well as the basics of diffusion tensor imaging. An overview of the principles and limitations in using this methodology in fiber tracking is included. This book describes the core white-matter structures, as well as the superficial white matter, the deep gray matter, and the cortex. It also presents a three-dimensional reconstruction and atlas of the brain white-matter tracts. The Montreal Neurological Institute coordinates, which are the most widely used, are adopted in this book as the primary coordinate system. The Talairach coordinate system is used as the secondary coordinate system. Based on magnetic resonance imaging and diffusion tensor imaging, the book offers a full segmentation of 220 white-matter and gray-matter structures with boundaries.

  • Transcranial Sonography in Movement Disorders

    • 1st Edition
    • Volume 90
    • English

  • Essential Bioimaging Methods

    • 1st Edition
    • P. Michael Conn
    • English
    Need a tested, reliable method that works? Put Essential Bioimaging Methods to work for you. Editor Michael Conn has hand-picked the most robust methods from his previously-published volumes in the Methods in Enzymology series. Many of these methods have been briefly updated by the authors that created them and use them in their research, and this book further refines and organizes existing content and focuses on methods that work, including MRI, fMRI, PET, Microscopic optical imaging and other. Part of the Reliable Lab Solution series, this volume provides clear advice and explicit protocols, providing updates to classic, tried-and-true methods and an essential addition to the bookshelf or workbench of any researcher in the field.

  • Magnetoencephalography

    • 1st Edition
    • Volume 68
    • English
    Magnetoencephalograp... (MEG) is the only neuroimaging method that provides high spatial and temporal information of human brain activation. In addition, MEG is completely non-invasive and allows recordings with minimal preparation time. This makes it suitable to investigate even fetuses in utero. This volume in the International Review of Neurobiology series addresses the most relevant research areas and shows how MEG could be used for investigations over the whole life span in humans.

  • MRI Atlas of Human White Matter

    • 1st Edition
    • Susumu Mori + 3 more
    • English
    Recent advances in modern imaging techniques that can be used non-invasively for the visualization of the human brain have greatly enhanced the knowledge of brain anatomy and the understanding of its relationship to brain function. A unique new MRI modality, called diffusion tensor imaging (DTI) allows the three-dimensional study of the large white matter (WM) fiber bundles at macroscopic resolution (millimeter scale). MRI Atlas of Human White Matter provides a three-dimensional and two-dimensional in vivo atlas of various white matter tracts in the human brain. The images are based on diffusion tensor imaging and various tracts are reconstructed three-dimensionally from the data. Following an introduction and description of the methodology (Chapters 1 and 2), the 3D anatomy of individual tracts is delineated in Chapter 3. Chapter 4 consists of a series of color-coded orientation maps to delineate white matter anatomy in a slice-by-slice manner, in which the structures are extensively annotated. This richly illustrated Atlas is a valuable resource for students studying white matter anatomy and researchers working in brain research and radiology. This book also provides the structural assignment, which will assist neuroradiologists when interpreting diffusion tensor images in routine clinical studies.

  • Quantitative Functional Brain Imaging with Positron Emission Tomography

    • 1st Edition
    • Richard E. Carson + 2 more
    • English
    This book presents the latest scientific developments in the field of positron emission tomography (PET) dealing with data acquisition, image processing, applications, statistical analysis, tracer development, parameter estimation, and kinetic modeling. It covers improved methodology and the application of existing techniques to new areas. The text also describes new approaches in scanner design and image processing, and the latest techniques for modeling and statistical analyses. This volume will be a useful reference for the active brain PET scientist, as well as a valuable introduction for students and researchers who wish to take advantage of the capabilities of PET to study the normal and diseased brain.