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Handbook of Neuro-Oncology Neuroimaging
- 3rd Edition - August 21, 2022
- Editor: Herbert B. Newton
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 2 2 8 3 5 - 7
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 2 9 9 5 - 8
With treatment approaches and the field of neuro-oncology neuroimaging changing rapidly, this third edition of the Handbook of Neuro-Oncology Neuroimaging is very relevant… Read more
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Request a sales quoteWith treatment approaches and the field of neuro-oncology neuroimaging changing rapidly, this third edition of the Handbook of Neuro-Oncology Neuroimaging is very relevant to those in the field, providing a single-source, comprehensive, reference handbook of the most up-to-date clinical and technical information regarding the application of neuroimaging techniques to brain tumor and neuro-oncology patients. This new volume will have updates on all of the material from the second edition, and in addition features several new important chapters covering diverse topics such as imaging for the use of Laser Interstitial Thermal Therapy, advanced imaging techniques in radiation therapy, therapeutic treatment fields, response assessment in clinical trials, surgical planning of neoplastic disease of the spine, and more. Sections first overview neuro-oncological disorders before delving into the physics and basic science of neuroimaging and great focus on CT and MRI. The book then focuses on advances in the neuroimaging of brain tumors and neuroimaging of specific tumor types. There is also discussion of neuroimaging of other neuro-oncological syndromes. This book will serve as a resource of background information to neuroimaging researchers and basic scientists with an interest in brain tumors and neuro-oncology.
- Summarizes translational research on brain imaging for brain tumors
- Discusses limitations of neuroimaging for diagnosis and treatment
- Presents advanced imaging technologies, including CT, MRI, and PET
- Contains new coverage on Laser Interstitial Thermal Therapy, radiation therapy, clinical trials, and more
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication third edition
- Dedication
- Contributors
- About the editor
- Preface
- Section I. Overview of neuro-oncological disorders
- Chapter 1. Overview of brain tumour epidemiology
- Epidemiology of primary brain tumours
- Epidemiology of metastatic brain tumours
- Chapter 2. Overview of pathology and treatment of primary brain tumours
- Pathology of selected primary brain tumours
- Surgical therapy of primary brain tumours
- Radiation therapy of primary brain tumours
- Chemotherapy of primary brain tumours
- Molecular or ‘targeted’ treatment
- Tumour Treating Fields
- Diet modifications
- Chapter 3. Overview of pathology and treatment of metastatic brain tumors
- Pathology of metastatic brain tumors
- Surgical therapy of metastatic brain tumors
- Radiation therapy of metastatic brain tumors
- Chemotherapy of metastatic brain tumors
- Chapter 4. Overview of spinal cord tumour epidemiology
- Epidemiology of primary spinal cord tumours
- Epidemiology of intramedullary spinal cord metastases
- Chapter 5. Overview of pathology and treatment of primary spinal cord tumours
- Pathology of selected primary spinal cord tumours
- Surgical therapy of primary spinal cord tumors
- Radiation therapy of primary spinal cord tumors
- Chemotherapy of primary spinal cord tumours
- Molecular or ‘targeted’ treatment
- Chapter 6. Overview of pathology and treatment of intramedullary spinal cord metastases
- Pathology of intramedullary spinal cord metastases
- Surgical therapy of intramedullary spinal cord metastases
- Radiation therapy of intramedullary spinal cord metastases
- Chemotherapy of intramedullary spinal cord metastases
- Chapter 7. Epidural spinal cord compression in adult neoplasms
- Introduction
- Clinical features
- Diagnosis
- Steroids
- Treatment
- Summary
- Chapter 8. Leptomeningeal metastases from solid tumours
- Epidemiology
- Pathogenesis
- Clinical features
- Diagnosis
- Prognosis
- Evaluation and response to treatment
- Treatment
- Supportive care
- Conclusions
- Chapter 9. Vascular disorders: epidemiology
- Introduction
- Coagulopathy
- Intracranial tumour
- Treatment effects
- Infection
- Other
- Chapter 10. Intracranial haemorrhage in cancer patients
- Introduction
- Aetiology
- Clinical presentation
- Diagnosis
- Management
- Chapter 11. Central nervous system infarction
- Introduction
- Imaging evaluation of CNS infarction
- CNS infarction in neuro-oncology
- Conclusion
- Chapter 12. Intracranial veno-occlusive disease
- Introduction
- Aetiology
- Clinical features
- Diagnosis
- Treatment
- Chapter 13. Paraneoplastic syndromes
- Introduction
- Epidemiology
- Antibodies and paraneoplastic neurological disorders
- Clinical features
- Paraneoplastic cerebellar degeneration
- Autoimmune encephalitis
- Brainstem encephalitis
- Opsoclonus–myoclonus ataxia syndrome
- Paraneoplastic chorea
- Paraneoplastic myelopathies
- Peripheral nervous system disorders
- Myasthenia gravis and Lambert–Eaton syndrome
- Diagnostic evaluations
- Tumour surveillance
- Treatment
- Conclusions
- Chapter 14. Neoplastic plexopathies
- Introduction
- Classification
- Plexus anatomy
- Epidemiology and risk factors
- Pathogenesis and pathophysiology
- Clinical features
- Associated neoplastic disorders
- Differential diagnosis
- Evaluation
- Management
- Prognosis and future perspectives
- Chapter 15. Neurologic complications of oncologic therapy
- Complications of radiotherapy
- Vasculopathy
- Spinal cord
- Plexuses and peripheral nerve
- Complications of chemotherapy, targeted therapy and immunotherapy
- Summary
- Section II. Physics and basic science of neuro-imaging
- Chapter 16. Physics of computed tomography scanning
- Historical development
- Image reconstruction
- Chapter 17. Physics of computed tomography: contrast agents
- History
- General principle of X-ray contrast agents
- Current applications of contrast agents in computed tomography
- Side effects and toxicity
- Chapter 18. Introductory magnetic resonance imaging physics
- Introduction
- External magnetic field, protons and equilibrium magnetisation
- Larmor precession and MRI signal
- Radiofrequency energy and resonance
- Relaxation
- Image contrast mechanisms
- Dixon techniques for fat suppression
- Making an image
- Additional topics relevant to neuroimaging
- Making more with less: rapid, continuous and comprehensive imaging
- Artificial intelligence and MR physics
- Conclusion
- Chapter 19. Advanced magnetic resonance imaging of brain tumours
- Diffusion-weighted imaging
- Magnetic resonance spectroscopy
- Microvascular imaging in brain tumours: perfusion-weighted imaging and T1-Weighted permeability imaging
- Conclusion
- Chapter 20. Magnetic resonance contrast agents for neuroradiology
- Introduction
- Contrast media in neuroimaging
- Chapter 21. Physics of high-field magnetic resonance imaging and applications to brain tumour imaging
- Introduction
- Magnetic resonance imaging physics
- Indirect measure of pathology
- How magnetic resonance imaging compares with other imaging techniques
- High-field imaging: PROS and CONS
- High-resolution imaging
- Magnetic susceptibility
- Static magnetic field: signal-to-noise ratio and magnetic susceptibility
- Radio frequency penetration
- Other radio frequency issues
- Conclusion
- Section III. Advances in neuro-imaging of brain tumours
- Chapter 22. Magnetic resonance image guided neurosurgery
- Image-guided therapy systems
- Brain tumor resection under intraoperative MRI guidance
- Conclusion
- Chapter 23. Neurosurgical treatment planning
- Introduction
- General considerations in brain Tumour surgery
- Pre-operative imaging and mapping strategies
- Functional applications
- Intraoperative image-guided surgery
- Limitations and future directions
- Conclusion
- Chapter 24. Use of neuro-imaging for radiation therapy planning
- Introduction
- Neuro-imaging
- Radiation planning and delivery
- Quality assurance of imaging and dose delivery
- Stereotactic radiosurgery
- Practical application of radiotherapy in high-grade glioma
- Treatment toxicities
- Delineating pseudo-progression, true disease progression and radiation necrosis
- Future directions
- Conclusion
- Chapter 25. Tumour treating fields: therapy preclinical and clinical data
- Introduction
- Basic principles of TTFields and preclinical findings
- Clinical application of TTFields
- Electric field distribution within cranium and brain
- Conclusions
- Chapter 26. Advanced imaging techniques and planning for laser interstitial thermal therapy
- Clinical applications of laser interstitial thermal therapy
- Pre-operative imaging for laser interstitial thermal therapy
- Post-LITT imaging
- Conclusion
- Disclosures
- Chapter 27. Applications of stereotactic radiosurgery in neuro-oncology
- Introduction
- Foundations of radiosurgery
- Delivery of radiosurgery
- Cranial immobilisation during radiosurgery
- Neuroimaging and radiosurgery
- Clinical applications of radiosurgery
- Radiation-associated tumour formation
- Radiation necrosis
- Conclusion
- Chapter 28. Diffusion magnetic resonance imaging in brain tumours
- Introduction
- Physical basis
- Clinical applications of diffusion MRI in brain tumours
- Limitations and potential future perspectives
- Summary
- Chapter 29. Imaging and measuring diffusion in brain tumours
- Magnetic resonance diffusion imaging
- Quantitative characterisation of brain tumours with a single diffusion coefficient derived from conventional diffusion-weighted images
- Characterisation of brain tumours with multiple diffusion parameters derived from higher-order model analysis of highly diffusion-weighted images
- Diffusion anisotropy for the assessment of nerve fiber tract integrity
- Advanced quantitative methods
- Considerations in the comparison of quantitative diffusion values
- Conclusion
- Chapter 30. Functional magnetic resonance imaging
- Introduction
- General fMRI considerations
- Sensory/motor fMRI
- Language fMRI
- Lateralisation
- Localisation
- Special considerations for fMRI measurements using brain Tumour patients
- The effects of brain tumours and prior surgery on the BOLD fMRI signal
- Interpretation pitfalls
- Surgical outcomes and future developments
- Chapter 31. Magnetic resonance spectroscopy
- Introduction
- Clinical applications
- MRSI guidance for therapy
- Assessment of treatment efficacy/response
- Differential diagnosis
- Future directions
- Chapter 32. Perfusion magnetic resonance imaging for brain tumour characterisation and assessment of treatment response
- Introduction
- Dynamic contrast agent MRI perfusion techniques
- Dynamic contrast-enhanced imaging
- Dynamic susceptibility contrast imaging
- Arterial spin labelling techniques
- Summary
- Chapter 33. Positron emission tomography and single-photon emission computed tomography physics
- Introduction
- SPECT imaging
- PET imaging
- Chapter 34. Positron emission tomography and single photon emission computed tomography imaging
- Overview
- SPECT imaging
- Labelled amino acids: [123I]Iodo-α-methyltyrosine
- Labelled somatostatin analogs: [111In]octreotide
- PET imaging
- Tumour detection
- Tumour grading and degree of malignancy
- Follow-up assessment and monitoring treatment
- Other applications
- Novel PET tracers [11C]MET, [18F]FET and [18F]FLT
- 3′-Deoxy-3′-[18F]fluorothymidine
- Conclusions
- Chapter 35. Methionine PET – overview and application to brain tumour imaging and treatment
- Limitations of anatomic imaging
- Amino acid PET in neuro-oncology
- Guiding stereotactic biopsy
- Chapter 36. Ultra-high field magnetic resonance imaging of brain tumours
- Introduction
- Multinuclear imaging and chemical exchange saturation transfer imaging
- Chapter 37. Imaging of brain tumours in animal models of central nervous system cancer
- Introduction
- Magnetic resonance imaging and spectroscopy
- In vivo bioluminescence imaging
- Recent advances
- Conclusions
- Chapter 38. Response assessment in neuro-oncology criteria: overview and future directions
- Introduction and background
- A brief history of radiologic grading schema in neuro-oncology
- RANO criteria for gliomas
- Key aspects of imaging and clinical criteria used for RANO evaluation
- Modified RANO criteria
- Assessment of patient well-being and neurological functioning – the neurologic assessment in neurooncology scale
- RANO criteria for low-grade gliomas
- RANO criteria for brain metastases
- Application of RANO criteria in the setting of immunotherapy – immunotherapy response assessment in neurooncology
- Future directions for RANO
- Conclusion
- Section IV. Neuro-imaging of brain tumours
- Chapter 39. Imaging of malignant astrocytomas
- Introduction
- Chapter 40. Low-grade astrocytomas
- Introduction
- Physiologic imaging
- Diffuse astrocytoma
- Non-infiltrative astrocytomas
- Gliomatosis cerebri
- Chapter 41. Imaging of oligodendrogliomas
- Introduction
- Characteristics of oligodendrogliomas on routine CT and MR images
- Diffusion-weighted imaging
- MR spectroscopy
- MR perfusion and permeability imaging
- Functional MRI and fractional anisotropy
- Positron emission tomography
- Imaging differentiation of tumour progression from pseudo-progression
- Other treatment-related imaging changes
- Conclusion
- Chapter 42. Primary central nervous system lymphoma
- Introduction
- General imaging features
- Uncommon manifestations of primary CNS lymphoma
- Chapter 43. Imaging of CNS ependymomas
- Introduction
- Imaging characteristics of intracranial ependymomas
- Imaging characteristics of spinal ependymomas
- Conclusions
- Chapter 44. Pituitary and sellar region lesions
- Introduction
- Anatomy
- Imaging
- Solid lesions
- Mixed solid and cystic lesions
- Pituitary stalk lesions
- Miscellaneous lesions
- Chapter 45. Neoplasms of the cranial nerves
- Nerve sheath neoplasms
- Glial neoplasms
- Primary central nervous system lymphoma
- Chapter 46. Meningeal tumours
- Introduction
- Imaging of extra-axial tumours
- Chapter 47. Intracranial schwannomas
- Introduction – historical
- Schwannoma origin
- Pathology
- Epidemiology
- Neurofibromatosis 2
- Imaging
- Current therapy for VS
- Ongoing clinical trials
- Non-vestibular schwannomas
- Summary
- Chapter 48. Diencephalic and other deep brain tumours
- Primary diencephalic tumours
- Tumours that secondarily invade the deep brain
- Chapter 49. Neuro-imaging of glioneuronal tumors
- Introduction
- Central and extraventricular neurocytoma
- Cerebellar liponeurocytoma
- Ganglioglioma and gangliocytoma
- Desmoplastic infantile astrocytoma and ganglioglioma
- Dysembryoplastic neuroepithelial tumour
- Dysplastic cerebellar gangliocytoma (Lhermitte–Duclos disease)
- Papillary glioneuronal tumour
- Rosette-forming glioneuronal tumour
- Diffuse leptomeningeal glioneuronal tumour
- Spinal paraganglioma
- Multinodular and vacuolating neuronal tumor
- Myxoid glioneuronal tumor
- Polymorphous low-grade neuroepithelial tumor of the young
- Chapter 50. Pineal region tumours
- Introduction
- Anatomy, function, and normal imaging
- Epidemiology and pathology
- Clinical
- Imaging
- Germinoma
- Non-germinomatous germ cell Tumours
- Pineoblastomas
- Pineocytomas
- Pineal parenchymal Tumours of intermediate differentiation
- Papillary tumours of the pineal region
- Chapter 51. Chordomas and other skull base tumours
- Chordoma
- Chondrosarcoma
- Other skull base tumours
- Chapter 52. Paediatric brain tumours
- Introduction
- 2021 WHO classification of brain tumours (focus on paediatric population)
- Role of the radiologist in paediatric brain tumour diagnosis
- Specific paediatric brain tumours
- Conclusion
- Chapter 53. Papillary glioneuronal tumours
- Introduction
- General imaging features
- Uncommon manifestations of PGNT
- Differential diagnosis on MRI
- Chapter 54. Intracranial metastases
- Introduction
- Epidemiology
- Anatomy
- Clinical presentation
- Diagnosis
- Prognosis
- Recursive partitioning analysis
- Management
- Symptom management
- Steroids
- Anticonvulsants
- Radiation necrosis
- Systemic therapies
- Leptomeningeal metastases
- Response assessment
- Management of recurrences
- Conclusion
- Chapter 55. Non-neoplastic mass lesions of the central nervous system
- Developmental anomalies
- Inflammatory disorders
- Infections
- Cerebrovascular lesions
- Other entities
- Chapter 56. Neuroimaging issues in assessing glioma response to brain tumour therapy
- Introduction
- Characteristics and management of gliomas
- Response assessment following treatment
- Related practical issues
- Role of advanced imaging
- Summary
- Chapter 57. Pseudo-progression in neuro-oncology: overview, pathophysiology and interpretation
- Overview of pseudo-progression
- History
- Pathophysiology
- Theories of pathophysiology
- Methods of differentiation between progression and pseudo-progression
- Novel imaging techniques
- Diffusion-weighted MRI
- Perfusion imaging
- Delayed contrast extravasation MRI
- MR spectroscopy
- Arterial spin imaging
- PET imaging
- Amide proton transfer-weighted imaging
- Radiomics
- Biologic differentiation
- Conclusions
- Chapter 58. Pitfalls in the neuro-imaging of brain tumours
- Introduction
- Imaging features
- Intra-axial lesions
- Section V. Neuro-imaging of other neuro-oncological syndromes
- Chapter 59. Neuroradiology of leptomeningeal metastases
- Introduction
- Brain and spine MRI
- Radioisotope CSF flow studies
- Other neuroradiographic modalities
- Conclusion
- Chapter 60. Imaging of epidural spinal cord compression
- Introduction
- Non-metastatic epidural lesions
- Metastatic epidural spinal cord compression
- Magnetic resonance imaging
- Additional imaging modalities
- Future directions in spinal epidural mass imaging
- Chapter 61. Neuroimaging for surgical treatment planning of neoplastic disease of the spine
- Introduction
- Metastatic spinal tumours
- Primary bone tumours
- Extramedullary intradural spinal tumours
- Intramedullary tumours
- Surgical intervention for spinal tumours
- Neuroimaging preoperative planning
- Computed tomography
- Differential diagnosis of spinal tumours
- Dynamic X-rays
- Positron emission tomography scan
- Single-photon emission computed tomography/computed tomography
- Angiography
- Conclusions
- Chapter 62. Imaging of plexopathy in oncologic patients
- Introduction
- Normal anatomy of plexuses
- Radiographic methods of imaging
- Primary plexus neoplasms
- Extrinsic plexus tumours
- Radiation injury
- Future trends
- Summary
- Chapter 63. Imaging of peripheral neurogenic tumours
- Introduction
- Benign peripheral nerve sheath tumours
- Neurilemoma
- Neurofibroma
- Imaging of benign PNSTs
- Neurofibromatosis
- Neural fibrolipoma
- Traumatic neuroma
- Nerve sheath ganglion
- Morton's neuroma
- Glomus tumour
- Malignant PNST
- Metastases to nerves
- Secondary signs
- Summary
- Chapter 64. Neuroimaging of cerebrovascular complications in cancer patients
- Introduction
- Tumour-related cerebrovascular complications
- Therapy-related cerebrovascular complications
- Combined tumour- and therapy-related cerebrovascular complications
- Miscellaneous tumour-related cerebrovascular conditions
- Summary
- Chapter 65. Neuroimaging in paraneoplastic syndromes
- Paraneoplastic cerebellar degeneration
- Paraneoplastic limbic encephalitis
- NMDAR encephalitis
- Paraneoplastic brainstem encephalitis
- Paraneoplastic chorea
- Paraneoplastic myelopathy
- Imaging of Occult malignancy in patients with paraneoplastic disorders
- Summary
- Index
- No. of pages: 1020
- Language: English
- Edition: 3
- Published: August 21, 2022
- Imprint: Academic Press
- Hardback ISBN: 9780128228357
- eBook ISBN: 9780128229958
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