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Books in Life sciences

Elsevier's Life Sciences collection helps researchers get comprehensive coverage and up-to-date information on the study of living organisms, their processes, and interrelationships, spanning disciplines like biology, genetics, and biochemistry, and addressing emerging trends such as genomics, biotechnology, and sustainability, essential for advancing knowledge and driving innovation in the field.

BooksJournals

    • Applied Multivariate Statistical Analysis in Medicine

      • 1st Edition
      • August 21, 2024
      • Jingmei Jiang
      • English
      • Paperback
        9 7 8 0 4 4 3 2 3 5 8 7 0
      • eBook
        9 7 8 0 4 4 3 2 3 5 8 8 7
      Applied Multivariate Statistical Analysis in Medicine provides a multivariate conceptual framework that allows readers to understand the interconnectivity and interrelations among variables, which maintains the intrinsic precision of statistical theories. With a strong focus on the fundamental concepts of multivariate statistical analysis, the book also gives insight into the applications of multivariate distribution in biomedical fields. In 14 chapters, Applied Multivariate Statistical Analysis in Medicine covers the main topics of multivariate analysis methods widely used in health science research. The content is organized progressively from fundamental concepts to sophisticated methods. It begins with basic descriptive statistics in multivariate analysis and follows with parameter estimation, in addition to the hypothesis testing of a multivariate normal distribution, which has heavy applications in biomedical fields where the relationships among approximately normal variables are of great interest. Keeping mathematics to a minimum, considerable emphasis is placed on explanations and real-world applications of core principles to maintain a good balance between introducing theory and cultivating problem-solving skills. This book is a very valuable reference text for clinicians, medical researchers, and other researchers across medical and biomedical disciplines, all of whom confront increasingly complex statistical methods during the analysis and presentation of their results.

    • Critical Heart Condition During Pregnancy

      • 1st Edition
      • August 18, 2024
      • Jorge Hidalgo + 2 more
      • English
      • Hardback
        9 7 8 0 4 4 3 2 2 0 0 8 1
      • eBook
        9 7 8 0 4 4 3 2 2 0 0 7 4
      Critical Heart Condition During Pregnancy, a volume in the Critical Care Obstetrics series, provides a novel reference to educate physicians, nurses, and all allied healthcare personnel caring for pregnant women with various health compromises specific to cardiac complications. The book's chapters reflect the growing scope of critical care obstetrics and the increasing importance and recognition of the hospital structure's field. All intensivists, regardless of primary discipline, must possess a core set of critical care skills that allow them to manage critically ill patients. The authors have gathered the best evidence-based material explicitly focused on cardiac scenarios.This volume presents cardiac medical-surgical complications that any patient can present during and post-partem, such as Arrhythmias, Endocarditis, Cardiogenic Shock, heart failure, and more.

    • Management, Body Systems, and Case Studies in COVID-19

      • 1st Edition
      • June 15, 2024
      • Rajkumar Rajendram + 3 more
      • English
      • Hardback
        9 7 8 0 4 4 3 1 8 7 0 3 2
      • eBook
        9 7 8 0 4 4 3 1 8 7 0 4 9
      Management, Body Systems, and Case Studies in COVID-19 describes the assessment and treatment of patients infected with the novel coronavirus that causes the varied symptoms of COVID-19. Detailing this multisystem disease and the organs and tissues affected, this volume features chapters on several body systems. Conditions affecting the respiratory, hematological, hepatobiliary, renal, gastrointestinal, nervous, musculoskeletal, and cardiovascular systems are addressed. The fundamental role of telemedicine during the pandemic is also discussed. This volume is relevant for all clinicians and scientists working to ensure the best outcomes for patients with COVID-19.

    • The multitasking molecular chaperone Hsp60

      • 1st Edition
      • October 19, 2024
      • Francesco Cappello + 2 more
      • English
      • Paperback
        9 7 8 0 4 4 3 2 3 9 9 6 0
      • eBook
        9 7 8 0 4 4 3 2 3 9 9 7 7
      The Multitasking Molecular Chaperone Hsp60: Structure, Function, and Impact on Health and Disease provides an overview of this key component of the Chaperone System (CS). The book covers various areas of medicine in which Hsp60 chaperonopathies have been identified. Various chapters discuss the Hsp60 structure, localization, functions, and participation in disease mechanisms both genetic and acquired, focusing on humans but also presenting data obtained from pro- and eukaryotic experimental models. The main goal is to provide information accessible to all healthcare professionals in a way that can be understood by nonspecialists and that would stimulate clinical and pathological detection of Hsp60 chaperonopathies.Mol... mechanisms are briefly described with the purpose of illuminating roads toward accurate diagnosis, treatment, and patient monitoring. Consequently, the possibility of developing/applying chaperonotherapy centered on Hsp60, as a therapeutic tool or target, is analyzed in many sections of this book, across a variety of medical specialties. Over the last several years, the importance of the CS as a physiological system has been brought to prominence and its roles in health and disease made clear. The molecular chaperones, including Hsp60, are the key components of the CS that are typically cytoprotective, but they can also be etiopathogenic factors, causing diseases named chaperonopathies.

    • Fundamentals of Recombinant Protein Production, Purification and Characterization

      • 1st Edition
      • September 10, 2024
      • Deepti Yadav + 2 more
      • English
      • Paperback
        9 7 8 0 3 2 3 9 8 3 8 8 4
      • eBook
        9 7 8 0 3 2 3 9 8 5 8 4 0
      Fundamentals of Recombinant Protein Production, Purification and Characterization is organized into nine chapters in a logical fashion that cover an introduction to recombinant proteins and expression in different host expression systems, extraction, purification and analysis of proteins. This important reference features protocols, along with the advantages and disadvantage of each expression hosts and characterization technique (presented in tabular format) and offers detailed coverage of all aspects of protein production and processing (upstream and downstream processing) in one place. Finally, the book ends with different characterization techniques. Production of recombinant proteins for biotechnological and therapeutic applications at a large scale is an essential need of mankind. With the huge application potential of therapeutic and industrial proteins, there has been increasing demand for effective and efficient bioprocessing strategies. Recent progress around recombinant DNA technologies and bioprocessing strategies has paved the way for efficient production of recombinant proteins. Important factors such as insolubility and cost of production need to be considered for large scale production of these recombinant proteins.

    • Implementation of Personalized Precision Medicine

      • 1st Edition
      • November 22, 2024
      • William P. Stanford + 1 more
      • English
      • Paperback
        9 7 8 0 3 2 3 9 8 8 0 8 7
      • eBook
        9 7 8 0 3 2 3 9 7 2 7 6 5
      At the heart of precision medicine lies one concept missing from modern medicine – the unique genetic and biochemical make-up of each individual patient. Implementation of Personalized Precision Medicine: Expanding the Clinical Vision towards Prevention, Early Detection, and Precision Treatment of Disease to Drive Extended Healthspan establishes a landscape of precision medicine geared towards implementation of fully personalized approaches within precision medicine to facilitate prevention and early detection of age-related disease in each individual. This reference details how these lofty goals are now achievable with the science of today and tomorrow and provides the context, thought process and beginning blueprint to guide researchers and clinicians in more effectively considering the prevention and treatment of complex chronic disease. Uniquely organized, this reference provides insight into creating fully personalized precision medical treatments. Chapters include conventionally considered data such as genetic inherited risk, current epigenetic modifications, and current biochemical markers but also include less conventional food for thought such as microbiome, mitochondrial function, and dna repair. This provocative landscape makes this reference a valuable addition to the literature expanding precision medicine towards personalized chronic disease prevention and treatment.

    • Revealing Uncharted Biology with Single Cell Multiplex Proteomic Technologies

      • 1st Edition
      • June 25, 2024
      • Wendy Fantl
      • English
      • Paperback
        9 7 8 0 1 2 8 2 2 2 1 3 3
      • eBook
        9 7 8 0 1 2 8 2 2 2 1 4 0
      Revealing Uncharted Biology with Single Cell Multiplex Proteomic Technologies: ApplicationsHealthy tissues and organs rely on the precise coordination of diverse cell types, each responding to external and internal signals. Disease disrupts this coordination. Since proteins drive cellular function, analyzing their abundance and activation states in single cells helps identify key cell populations in health and disease. Bulk protein analyses mask critical differences between individual cells. Additionally, the arrangement of cells into neighborhoods through cell-cell interactions is essential for tissue function. Over the last decade, single-cell proteomic phenotyping combined with positional information has become crucial for understanding biology in health and disease. This has led to the development of multiple technology platforms, profoundly impacting fields including developmental biology, cancer biology, immunology, neuroscience, and drug discovery. This book focuses on the application of single-cell multiplex proteomic platforms to various biological systems. These platforms have proved to be essential in biomedical research, advancing our understanding of complex biological systems at the cellular level. Compelling studies where authors use these technologies to answer previously unanswerable questions are featured. Exploring this "Uncharted Biology" opens new avenues for scientific inquiry and clinical translation, covering areas including oncology, immunology, metabolomics, stem cell research, preclinical models, and translational research. The initial chapters discuss incorporating these technologies into core facilities and consortia, providing access for multiple users and integrating datasets from other omics technologies. The following chapters cover applications in diverse areas such as muscle stem cell function in skeletal muscle regeneration, metabolic regulome profiling, translational studies, developing predictive biomarkers for patients receiving immune checkpoint inhibitors, and pre-clinical studies of lung cancer. These applications demonstrate how advanced single cell proteomic technologies are reshaping our understanding of complex biological systems and enhancing clinical translation. Revealing Uncharted Biology with Single Cell Multiplex Proteomic Technologies: Applications highlights the transformative benefits of single-cell proteomics, offering insights into cellular mechanisms underlying health and disease and inspiring further exploration into "Uncharted Biology." It is an essential resource for researchers, clinicians, and students aiming to advance biomedical science and improve therapeutic outcomes.

    • Responsible and Explainable Artificial Intelligence in Healthcare

      • 1st Edition
      • November 14, 2024
      • Akansha Singh + 2 more
      • English
      • Paperback
        9 7 8 0 4 4 3 2 4 7 8 8 0
      • eBook
        9 7 8 0 4 4 3 2 4 7 8 9 7
      Responsible and Explainable Artificial Intelligence in Healthcare: Ethics and Transparency at the Intersection provides clear guidance on building trustworthy Artificial Intelligence systems for healthcare. The book focuses on using Artificial Intelligence to improve diagnosis, prevent diseases, and personalize patient care. It addresses potential drawbacks, like reduced human interaction and ethical concerns, offering solutions for ethical and transparent Artificial Intelligence use in medicine. Across eight chapters, the book explores Artificial Intelligence's current status, its importance, and associated risks in healthcare. It explains designing reliable Artificial Intelligence for healthcare, tackling biases, and safeguarding patient privacy in the age of big data. The legal and regulatory landscape is also covered. One chapter is dedicated to showcasing real-world examples of responsible Artificial Intelligence in healthcare, highlighting best practices. The book concludes by summarizing key takeaways and discussing future challenges. "Responsible and Explainable Artificial Intelligence in Healthcare: Ethics and Transparency at the Intersection" is a valuable resource for healthcare professionals, policymakers, computer scientists, and ethicists concerned about Artificial Intelligence's ethical and societal impact on medicine.

    • Gallstone Formation, Diagnosis, Treatment and Prevention

      • 1st Edition
      • March 11, 2024
      • Rajani Sharma + 2 more
      • English
      • Paperback
        9 7 8 0 4 4 3 1 6 0 9 8 1
      • eBook
        9 7 8 0 4 4 3 1 6 0 9 9 8
      Gallstone Formation, Diagnosis, Treatment, and Prevention describes the current scenario of gallstones and adopted treatment methods. It is a complete reference for researchers introducing new techniques to help prevent extreme treatments such as a cholecystectomy. This reference provides current knowledge and basic challenges of understanding gallstone formation, with all variations of composition, including complications of the treatment process. This content directs researchers to focus on gallstone mechanisms to design and develop new treatment methods. The book provides all possible factors for gallstone formation as well as preventative measures.

    • Small Lungs and Obstructed Airways

      • 1st Edition
      • October 21, 2024
      • Peter Burney
      • English
      • Paperback
        9 7 8 0 4 4 3 1 3 9 2 2 2
      • eBook
        9 7 8 0 4 4 3 1 3 9 2 1 5
      Small Lungs and Obstructed Airways: Reassessing Chronic Obstructive Pulmonary Disease proposes an alternative perspective to current explanations for the distribution of chronic lung disease. The book considers the link between chronic respiratory disease and associated mortality with smaller lungs rather than obstructed airways and explores other factors contributing to poor lung health besides the current emphasis on the roles of air pollution, occupational exposures, and cardio-metabolic disease. It presents the findings of the Burden of Obstructive Lung Disease (BOLD) study, sharing new views on the prevalence of obstructive lung disease and risk factors across various global regions. Sections cover decreased lung function, including the prevalent views on the impact of both household and external air pollution, occupational exposure, and the prenatal and postnatal/childhood environment in the etiology of impaired lung function and COPD. The book then moves on to discussions on the impact poverty and nutrition has on lung health, sharing the findings of the BOLD study regarding its effect on lung function and risk of COPD in lower-income countries. The book closes with a chapter outlining the clinical and public health implications of the findings discussed in the book.

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