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Books in Life sciences

Elsevier's Life Sciences collection helps researchers get comprehensive coverage and up-to-date information on the study of living organisms, their processes, and interrelationships, spanning disciplines like biology, genetics, and biochemistry, and addressing emerging trends such as genomics, biotechnology, and sustainability, essential for advancing knowledge and driving innovation in the field.

BooksJournals

    • Small Lungs and Obstructed Airways

      • 1st Edition
      • October 21, 2024
      • Peter Burney
      • English
      • Paperback
        9 7 8 0 4 4 3 1 3 9 2 2 2
      • eBook
        9 7 8 0 4 4 3 1 3 9 2 1 5
      Small Lungs and Obstructed Airways: Reassessing Chronic Obstructive Pulmonary Disease proposes an alternative perspective to current explanations for the distribution of chronic lung disease. The book considers the link between chronic respiratory disease and associated mortality with smaller lungs rather than obstructed airways and explores other factors contributing to poor lung health besides the current emphasis on the roles of air pollution, occupational exposures, and cardio-metabolic disease. It presents the findings of the Burden of Obstructive Lung Disease (BOLD) study, sharing new views on the prevalence of obstructive lung disease and risk factors across various global regions. Sections cover decreased lung function, including the prevalent views on the impact of both household and external air pollution, occupational exposure, and the prenatal and postnatal/childhood environment in the etiology of impaired lung function and COPD. The book then moves on to discussions on the impact poverty and nutrition has on lung health, sharing the findings of the BOLD study regarding its effect on lung function and risk of COPD in lower-income countries. The book closes with a chapter outlining the clinical and public health implications of the findings discussed in the book.

    • The multitasking molecular chaperone Hsp60

      • 1st Edition
      • October 19, 2024
      • Francesco Cappello + 2 more
      • English
      • Paperback
        9 7 8 0 4 4 3 2 3 9 9 6 0
      • eBook
        9 7 8 0 4 4 3 2 3 9 9 7 7
      The Multitasking Molecular Chaperone Hsp60: Structure, Function, and Impact on Health and Disease provides an overview of this key component of the Chaperone System (CS). The book covers various areas of medicine in which Hsp60 chaperonopathies have been identified. Various chapters discuss the Hsp60 structure, localization, functions, and participation in disease mechanisms both genetic and acquired, focusing on humans but also presenting data obtained from pro- and eukaryotic experimental models. The main goal is to provide information accessible to all healthcare professionals in a way that can be understood by nonspecialists and that would stimulate clinical and pathological detection of Hsp60 chaperonopathies.Mol... mechanisms are briefly described with the purpose of illuminating roads toward accurate diagnosis, treatment, and patient monitoring. Consequently, the possibility of developing/applying chaperonotherapy centered on Hsp60, as a therapeutic tool or target, is analyzed in many sections of this book, across a variety of medical specialties. Over the last several years, the importance of the CS as a physiological system has been brought to prominence and its roles in health and disease made clear. The molecular chaperones, including Hsp60, are the key components of the CS that are typically cytoprotective, but they can also be etiopathogenic factors, causing diseases named chaperonopathies.

    • γδ T Cell Cancer Immunotherapy

      • 1st Edition
      • October 17, 2024
      • Marta Barisa
      • English
      • Hardback
        9 7 8 0 4 4 3 2 1 7 6 6 1
      • eBook
        9 7 8 0 4 4 3 2 1 7 6 7 8
      γδ T Cell Cancer Immunotherapy: Evidence-Based Perspectives for Clinical Translation sets out and critically discusses the current clinical and relevant preclinical γδ T cell immunotherapy landscape.In five chapters, field experts discuss the challenges facing γδ T cell oncoimmunotherapy, propose solutions, and map next steps.Particular attention is given to summarizing our understanding of the complex, translationally relevant human γδ T cell biology, the evidence basis for designing γδ T cell combination trials and data-driven perspectives on what is known—and what isn’t—about γδ T cell therapeutic persistence. Various perspectives are provided on how issues of cytotoxic effector function, functional exhaustion, and cytokine addiction can be mitigated using gene engineering.A chapter is dedicated to the systematic review of all γδ T cell immunotherapy trials to date, and the cell therapy products that were used in these trials. The final chapter discusses allograft persistence-enhancem... techniques in the context of γδ T cell therapy, covering lymphodepleting chemotherapy and synthetic stealth engineering.γδ T Cell Cancer Immunotherapy: Evidence-Based Perspectives for Clinical Translation gives an updated and comprehensive insight into the current state of γδT cell immunotherapy, which is of interest to existing translational γδ T cell specialists, the proliferating range of academic scientists and commercial scientists entering the field, as well as clinicians who may encounter γδ T cell immunotherapy in the clinic, or are wishing to familiarize themselves with noncanonical lymphocyte immunotherapy.

    • Marine Molecules from Algae and Cyanobacteria

      • 1st Edition
      • October 17, 2024
      • Paz Otero Fuertes + 1 more
      • English
      • Paperback
        9 7 8 0 4 4 3 2 1 6 7 4 9
      • eBook
        9 7 8 0 4 4 3 2 1 6 7 5 6
      The marine environment is a rich but underexploited source of commercially interesting natural products with different applications. Several marine organisms, such as seaweeds, microalgae, sponges, cyanobacteria, ascidians, and fungi, are sources of natural valuable molecules. These chemical compounds range from small molecules and enzymes to highly complex secondary metabolites that show bioactivities in physiological systems. It is thus of great importance to collect information concerning the discovery of these molecules and their characterization and relation to human diseases. Gathering data about novel technologies and sources to obtain and isolate such as precious molecules as well as new applications for them is extremely appreciated in the chemical field. It is very useful for chemists to obtain these molecules with high purity to be used as analytical standards to calibrate the chromatography equipment. Many of these compounds are not commercially available, so the isolation methods of these molecules from microalgae, seaweeds, and cyanobacteria is a challenging task. The availability of some marine molecules has been a long-term problem due to the difficulty of their synthesis. Because of the complexity of their structure, the total synthesis has been shown to be difficult. Developing protocols to obtain reference standards from natural sources has shown satisfactory results in the chemical industry. Marine Molecules From Algae and Cyanobacteria addresses these topics, highlighting fundamentals of biomolecules, their roll in living organism, structure elucidation, sources, important characteristics, and the industrial applications of these biomaterials for educational (academic) as well as industrial purposes. This book covers all methodologies used in the search of marine natural products: screening of marine molecules by chemical methods like HPLC, LC-MS/MS, the isolation of high-value compounds with biotechnological potential, discovery of new molecules, and the optimization of green extraction procedures of these molecules, such as supercritical fluid extraction and pressurized solvent extraction, and other alternative chemical techniques applied in the exploration for marine compound.

    • Protocols in Biochemistry and Clinical Biochemistry

      • 2nd Edition
      • October 16, 2024
      • Buddhi Prakash Jain + 2 more
      • English
      • Paperback
        9 7 8 0 4 4 3 1 3 9 4 5 1
      • eBook
        9 7 8 0 4 4 3 1 3 9 4 6 8
      Protocols in Biochemistry and Clinical Biochemistry, second edition, offers clear, applied instruction in fundamental biochemistry methods and protocols, from buffer preparation to nucleic acid purification, protein, lipid, carbohydrate, and enzyme testing, and clinical testing of vitamins, glucose, and cholesterol levels, among other diagnostics. Each protocol is illustrated with step-by-step instructions, labeled diagrams, and color images, as well as a thorough overview of materials and equipment, precursor techniques, safety considerations and standards, analysis and statistics, alternative methods, and troubleshooting, all to support a range of study types and clinical diagnostics. This fully revised edition has been expanded and enriched to feature 100 protocols, as well as chapter key term definitions and worked examples. All-new protocols added to this edition include identification of lipids by TLC, lipid per oxidation measurement by thiobarbituric acid assays, determination of serum amylase, catalase activity assay, superoxide dismutase assay, qualitative analysis of plant secondary metabolites, qualitative analysis of photochemicals, quantitative estimation of secondary metabolites, estimation of chlorophyll contents, and starch determination, among others. Each protocol is written to help researchers and clinicians easily reproduce lab methods and ensure accurate test results.

    • Deciding with Children in Pediatrics

      • 1st Edition
      • October 16, 2024
      • John Massie + 2 more
      • English
      • Paperback
        9 7 8 0 4 4 3 2 2 3 2 3 5
      • eBook
        9 7 8 0 4 4 3 2 2 3 2 2 8
      Deciding with Children in Pediatrics: Children’s Participation in Healthcare Decision-making provides the ethical underpinning and offers practical strategies to foster meaningful participation of children in decisions affecting their healthcare. It will assist clinicians to bring forward the perspectives and values of the child, ensuring their preferences are incorporated into decision-making or appropriately justified when this is not possible. This is to both improve healthcare delivery and serve the best interests of children— now and as decision-makers in the future.This book reviews theories underpinning the concept of deciding with children and explores how pediatric decision-making is standardly managed. It then proposes a model for making healthcare decisions with children. A panel of experienced clinicians and ethicists demonstrate, via a series of case studies, how to promote children’s participation across a variety of clinical areas, child ages, and developmental stages. It concludes with a review of questions, concerns, and challenges. Deciding with Children in Pediatrics: Children’s Participation in Healthcare Decision-making helps bridge the gap between philosophy and practical clinical ethics and creates a frame of reference for children’s healthcare providers.

    • Chemical and Genomic Methods in Nucleic Acid Biology

      • 1st Edition
      • Volume 705
      • October 15, 2024
      • English
      • Hardback
        9 7 8 0 4 4 3 2 9 7 2 4 3
      • eBook
        9 7 8 0 4 4 3 2 9 7 2 5 0
      Chemical and Genomic Methods in Nucleic Acid Biology, Volume 704 highlights new advances in the field of nucleic acids, with this new volume presenting interesting chapters written by an international board of authors. Specific chapters in this new release include A real-time FRET-based biochemical assay for DNA deaminase enzymology and inhibition, DEER spectroscopy to probe DNA wrapping by protein complexes, PAR-dCLIP: Enhancing PhotoActivatable Ribonucleoside analog-enhanced CrossLinking and Immunoprecipitation through capture of bound 5’ terminal RNA fragments, Site-specific targeting of transgene cDNA insertion, Simultaneous Profiling of the RNA Targets of Two RNA-Binding Proteins Using TRIBE-STAMP, and much more.Additional chapters cover Ensemble FRET Approach to Directly and Continuously Monitor Protein? DNA Interactions, Utilizing nuclear extracts to characterize protein-DNA interactions at the single-molecule level, RNA-Guided Protease Activation in CRISPR-Cas, Activity-based profiling of RNA modifying enzymes, Purification of Cas9 and Cas12a for Peptide-Assisted Genome Editing, Studying the intersection of nucleoside modifications and SARS-CoV-2 RNA-dependent RNA transcription using an in vitro reconstituted system, and more.

    • Artificial Intelligence in Urology

      • 1st Edition
      • October 15, 2024
      • Andrew J Hung
      • English
      • Paperback
        9 7 8 0 4 4 3 2 2 1 3 2 3
      • eBook
        9 7 8 0 4 4 3 2 2 1 3 1 6
      Artificial Intelligence in Urology: Present and Future summarizes the cutting-edge development and adoption of Artificial Intelligence (AI) technologies in urology. The book explores barriers that prevent the further adoption of AI technologies, provides ethical considerations, and investigates the future role AI is expected to play. In addition, it includes applications of AI technology in the diagnosis and treatment of cancers (prostate, bladder, and more) and kidney stones, and in both adult and pediatric care. This is the perfect reference for researchers developing AI technologies for clinical applications and for clinicians who aim to effectively adopt AI technologies to solve clinical questions.

    • Moving Towards Everlasting Artificial Intelligent Battery-Powered Implants

      • 1st Edition
      • October 15, 2024
      • Marvellous Moyo + 1 more
      • English
      • Paperback
        9 7 8 0 4 4 3 2 4 8 3 0 6
      • eBook
        9 7 8 0 4 4 3 2 4 8 3 1 3
      Moving Towards Everlasting Artificial Intelligent Battery-Powered Implants presents the development process of new artificial intelligent (AI) charging systems for battery-powered implants that can last for a lifetime after implantation. This book introduces new strategies to address the limitations of technologies that have been employed to improve the lifespan of medical implants. This book also provides guidelines that medical implant manufacturers can adopt during their product development stages—this adds a new dimension of research on medical device implants that can be a game changer for the AI medical implants industry. Researchers, engineers, and graduate students in the elds of biomedical engineering, electrical engineering, and computer science will find this text helpful as they seek to understand the potential of AI systems to help achieve sustainability in healthcare and make current medical implants relevant in the future.

    • Targeting Signaling Pathways in Solid Tumors Part C

      • 1st Edition
      • Volume 389
      • October 11, 2024
      • English
      • Hardback
        9 7 8 0 4 4 3 2 3 5 5 0 4
      • eBook
        9 7 8 0 4 4 3 2 3 5 5 1 1
      Targeting Signaling Pathways in Solid Tumors, Part C, Volume 389 in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Drugging the Undruggable: Advances in Targeting KRAS Signaling in Solid Tumors, Emerging Trends in Gastrointestinal Cancers: Targeting Developmental Pathways in their Carcinogenesis and Tumor Progression, Importance of targeting various cell signaling pathways in solid cancers, Targeting signaling pathways in cancer stem cells: a potential approach for developing novel anticancer therapeutics, Factors affecting heterogeneity in breast cancer microenvironment: A narrative review, and much more.Additional sections cover Exploring TLR Signaling Pathways as Promising Targets in Cervical Cancer: The Road Less Travelled

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