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Books in Life sciences

Elsevier's Life Sciences collection helps researchers get comprehensive coverage and up-to-date information on the study of living organisms, their processes, and interrelationships, spanning disciplines like biology, genetics, and biochemistry, and addressing emerging trends such as genomics, biotechnology, and sustainability, essential for advancing knowledge and driving innovation in the field.

BooksJournals

    • The Lymphatic System in Colorectal Cancer

      • 1st Edition
      • February 11, 2022
      • Wim Ceelen
      • English
      • Paperback
        9 7 8 0 1 2 8 2 4 2 9 7 1
      • eBook
        9 7 8 0 1 2 8 2 4 2 9 8 8
      The Lymphatic System in Colorectal Cancer: Basic Concepts, Pathology, Imaging, and Treatment Perspectives provides an in-depth overview on the role of the lymphatic system in the pathogenesis and treatment of colorectal cancer. This is the first book to provide a comprehensive, multidisciplinary approach to the lymphatic system in colorectal cancer, with topics ranging from cancer biology and mathematical modeling to surgical approaches and novel imaging techniques. This book is valuable for cancer researchers, oncologists and anyone interested in the biology and treatment of colorectal cancer. Bringing together internationally renowned experts, the book's chapters encompass relevant content to help readers understand complex subjects. Lymphatic spread is one of the hallmarks of locally advanced colorectal cancer that adversely affects prognosis. Nevertheless, the molecular pathogenesis, dynamics and prognostic significance of lymphatic spread remain poorly understood. At the same time, novel surgical approaches such as complete mesocolic excision and sentinel node identification are being introduced, but their value remains uncertain.

    • MCB: CAR T Cells: Development, Characterization and Applications

      • 1st Edition
      • Volume 167
      • February 11, 2022
      • Lorenzo Galluzzi + 1 more
      • English
      • Hardback
        9 7 8 0 3 2 3 8 5 5 0 1 3
      • eBook
        9 7 8 0 3 2 3 8 5 5 0 2 0
      MCB: CAR T Cells: Development, Characterization and Applications, Volume 167 in the Methods in Cell Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including High-efficiency of genetic modification using CRISPR/Cpf1 system for engineered CAR T-cell therapy, Determination of the Biodistribution of Chimeric Antigen Receptor-Modified T Cells against CD19 in NSG Mice, Generation of CAR-T cells using lentiviral vectors, Generation of CAR T-cells using γ-retroviral vector, Flow cytometry detection and quantification of CAR T cells into solid tumors, Evaluation of CAR-T Cell Cytotoxicity: Real-Time Impedance-Based Analysis, and much more.

    • Multi-Objective Combinatorial Optimization Problems and Solution Methods

      • 1st Edition
      • February 9, 2022
      • Mehdi Toloo + 2 more
      • English
      • Paperback
        9 7 8 0 1 2 8 2 3 7 9 9 1
      • eBook
        9 7 8 0 1 2 8 2 3 8 0 0 4
      Multi-Objective Combinatorial Optimization Problems and Solution Methods discusses the results of a recent multi-objective combinatorial optimization achievement that considered metaheuristic, mathematical programming, heuristic, hyper heuristic and hybrid approaches. In other words, the book presents various multi-objective combinatorial optimization issues that may benefit from different methods in theory and practice. Combinatorial optimization problems appear in a wide range of applications in operations research, engineering, biological sciences and computer science, hence many optimization approaches have been developed that link the discrete universe to the continuous universe through geometric, analytic and algebraic techniques. This book covers this important topic as computational optimization has become increasingly popular as design optimization and its applications in engineering and industry have become ever more important due to more stringent design requirements in modern engineering practice.

    • Fertility, Pregnancy, and Wellness

      • 1st Edition
      • February 9, 2022
      • Diana Vaamonde + 2 more
      • English
      • Paperback
        9 7 8 0 1 2 8 1 8 3 0 9 0
      • eBook
        9 7 8 0 1 2 8 1 8 3 1 0 6
      Fertility, Pregnancy, and Wellness is designed to bridge science and a more holistic approach to health and wellness, in particular, dealing with female-male fertility and the gestational process. Couples seeking to solve fertility issues for different reasons, whether failed assisted reproductive techniques or the emotional impact they entail, economic or moral reasons, are demanding more natural ways of improving fertility. This book explores the shift in paradigm from just using medications which, in the reproductive field, can be very expensive and not accessible to the entire population, to using lifestyle modifications and emotional support as adjunctive medicine therapies. This must-have reference brings together the current knowledge – highlighting the gaps – and delivers an important resource for various specialists and practitioners.

    • Artificial Intelligence-Based Brain-Computer Interface

      • 1st Edition
      • February 4, 2022
      • Varun Bajaj + 1 more
      • English
      • Paperback
        9 7 8 0 3 2 3 9 1 1 9 7 9
      • eBook
        9 7 8 0 3 2 3 9 1 4 1 2 3
      Artificial Intelligence-Based Brain Computer Interface provides concepts of AI for the modeling of non-invasive modalities of medical signals such as EEG, MRI and FMRI. These modalities and their AI-based analysis are employed in BCI and related applications. The book emphasizes the real challenges in non-invasive input due to the complex nature of the human brain and for a variety of applications for analysis, classification and identification of different mental states. Each chapter starts with a description of a non-invasive input example and the need and motivation of the associated AI methods, along with discussions to connect the technology through BCI. Major topics include different AI methods/techniques such as Deep Neural Networks and Machine Learning algorithms for different non-invasive modalities such as EEG, MRI, FMRI for improving the diagnosis and prognosis of numerous disorders of the nervous system, cardiovascular system, musculoskeletal system, respiratory system and various organs of the body. The book also covers applications of AI in the management of chronic conditions, databases, and in the delivery of health services.

    • Liquid Biopsy in Urogenital Cancers and its Clinical Utility

      • 1st Edition
      • January 30, 2022
      • Seyed Mohammad Kazem Aghamir
      • English
      • Paperback
        9 7 8 0 3 2 3 9 9 8 8 4 0
      • eBook
        9 7 8 0 3 2 3 9 8 3 9 7 6
      Liquid Biopsy in Urogenital Cancers and Their Clinical Utility presents updated information on liquid biopsy techniques and their utility for diagnosing urological cancers. As a promising and recent diagnostic method, these techniques can be used for identifying tumors at initial stage, thus greatly improving treatment outcomes and survivorship. Chapters provide an overview of liquid biopsy as a new tool for diagnosis, monitoring and personalized medicine in urogenital cancers and explain its applicability in different cancer types, including bladder, prostate, kidney and testis tumors, female genital tract and pediatric urogenital tumors. This is a valuable resource for cancer researchers, oncologists, graduate students, urologists and biomedical researchers who need to understand more about liquid biopsy and its use for urogenital cancers.

    • Lipids in Plants and Algae: From Fundamental Science to Industrial Applications

      • 1st Edition
      • Volume 101
      • January 29, 2022
      • English
      • Hardback
        9 7 8 0 1 2 8 2 0 8 0 3 8
      • eBook
        9 7 8 0 1 2 8 2 0 8 0 4 5
      Lipids in Plants and Algae: From Fundamental Science to Industrial Applications, Volume 101 provides in-depth reviews on the most important aspects of the field. Topics in this volume encompass the most recent data about the physical properties of membrane lipids, lipid biosynthesis and metabolism (including glycerolipids, fatty acids, sterols, N-acylethanolamines, prostaglandins, phytoprostane), lipid storage, acyl flux, the dynamic and transport of glycerolipids, and the conversion of fatty acids into hydrocarbons. Lipid metabolism and lipidomics in plants and algae are one of the most challenging areas in biology, not only for fundamental research but also for the sustainable production of valuable molecules for green chemistry, including biofuel and health.

    • RAS: Past, Present, and Future

      • 1st Edition
      • Volume 153
      • January 29, 2022
      • English
      • Hardback
        9 7 8 0 1 2 8 2 4 4 8 5 2
      • eBook
        9 7 8 0 1 2 8 2 4 4 8 6 9
      Advances in Cancer Research, volume 153 provides a timely review of the biology, biochemistry, and current approaches to therapeutically target the RAS oncoprotein, the most frequently mutated oncogene family in human cancers. 2021 saw the approval of the first direct RAS inhibitor (sotorasib) for use in treating non-small cell lung cancers harboring KRAS(G12C) mutations. The successful approval and use of this drug highlights that the once “undruggable” RAS is indeed pharmacologically tractable. This volume provides an overview of efforts to develop additional approaches to therapeutically target oncogenic RAS. In addition, the reader will find excellent reviews on the history and research efforts to understand the biochemistry and oncogenic activity of RAS in human cancers.

    • Handbook on Opium

      • 1st Edition
      • January 29, 2022
      • Vasanth Kumar
      • English
      • Paperback
        9 7 8 0 3 2 3 9 0 9 0 3 7
      • eBook
        9 7 8 0 3 2 3 9 0 9 0 4 4
      Handbook of Opium: History and Basis of Opioids in Therapeutics traces the history of poppy from its prehistory, its use in Greek and Egyptian medicine through the European Renaissance, and the opioid epidemic of the present day. The book explores the discovery of morphine and its alkaloids, reviews its biosynthetic process, and covers the evolution of synthetic opioids. Further, it reviews the biological effects of opium and the molecular basis of its actions, including future perspectives in clinical applications with therapeutic targets. The book is interspersed with numerous notes on the events and great minds in history and medicine who advocated, analyzed and advanced opium through history. The book is a comprehensive review on opium, covering a breadth of topics, including its history, botany, chemistry, trade, physiology, clinical use and molecular biology, with numerous references, tables, vignettes and illustrations included for additional understanding.

    • Selenoprotein Structure and Function

      • 1st Edition
      • Volume 662
      • January 28, 2022
      • English
      • Hardback
        9 7 8 0 3 2 3 9 0 7 3 5 4
      • eBook
        9 7 8 0 3 2 3 9 0 7 3 6 1
      Selenoprotein Structure and Function, Volume 662 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Chapters in this new release include Identification of Selenoprotein O substrates using a biotinylated ATP analog, Selenium-encoded isotopic signature targeted profiling, Designing tRNASec variants for efficient selenocysteine incorporation using Sec-specific reporters, Preparation of selenoprotein S by chemical ligation, Examining xCT-mediated selenium uptake and selenoprotein production capacity in cells, SecMS analysis of selenoprotein with selenocysteine insertion sequence and beyond, Selenocysteine substitutions in thiyl radical enzymes, and much more. Additional chapters cover Recombinant selenoprotein expression in E. coli based upon the redefinition of a UAG codon in an RF1-depleted host strain, Metabolic labeling with radioactive selenium in zebrafish, Low pH isoTOP-ABPP to identify selenocysteines, Expression of selenoproteins via genetic code expansion in mammalian cells, Alpha-methyl selenocysteine as a tool for the study of selenoproteins, Selective selenol fluorescent probes: design, synthesis, structural determinants, and biological applications, and much more.

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