Skip to main content
Elsevier

Elsevier Science

  • Damage Mechanics in Engineering Materials

    • 1st Edition
    • Volume 46
    • Jiann-Wen Woody Ju + 2 more
    • English
    This book contains thirty peer-reviewed papers that are based on the presentations made at the symposium on "Damage Mechanics in Engineering Materials" on the occasion of the Joint ASME/ASCE/SES Mechanics Conference (McNU97), held in Evanston, Illinois, June 28-July 2, 1997. The key area of discussion was on the constitutive modeling of damage mechanics in engineering materials encompassing the following topics: macromechanics/micro... constitutive modeling, experimental procedures, numerical modeling, inelastic behavior, interfaces, damage, fracture, failure, computational methods. The book is divided into six parts: Study of damage mechanics. Localization and damage. Damage in brittle materials. Damage in metals and metal matrix composites. Computational aspects of damage models. Damage in polymers and elastomers.

  • Recent Advances in Basic and Applied Aspects of Industrial Catalysis

    • 1st Edition
    • Volume 113
    • T.S.R. Prasada Rao + 1 more
    • English
    Since the Catalysis Society of India was formed in 1973, it has grown into a vibrant and active professional body serving the Indian catalysis community and acts as a professional link between them and the rest of the world. The Silver Jubilee Symposium of the CSI, the thirteenth in a successful series of national symposia, brought together all those devoted to various aspects of this fascinating interdisciplinary field of catalysis. More than 400 delegates from around the country attended and there was considerable international participation. The scientific programme of the symposium covered different aspects of catalysis, processes based on catalysis and novel catalysis materials for various applications. This volume comprises two eminent scientist award lectures, six plenary lectures, five invited papers and 111 contributed papers which were critically selected from an impressive response to the call for papers.

  • Risk Assessment and Management in the Context of the Seveso II Directive

    • 1st Edition
    • Volume 6
    • Michalis D Christou + 1 more
    • Christian Kirchsteiger
    • English
    The assessment and management of risk to society from the operation of chemical process plants and other industrial activities in which dangerous substances are produced, used, handled or stored will remain a topic of great importance in the next decade. In order to evaluate this specific risk on a qualitative and/or quantitative basis, the concepts of risk analyses are linked together in this book.The "performance based" and "goal oriented" regulatory requirements of the European Council's new "Seveso II Directive" for the identification of large scale industrial hazards, prevention of sudden and uncontrolled releases of dangerous substances from industrial plants and mitigation of serious consequences of industrial accidents to people and the environment are examined. The fact that risk assessment and management are key elements to such forms of regulation is also demonstrated.While the "Seveso II Directive" defines "what" has to be achieved on the control of major hazards involving dangerous substances within the European Union, the methods of risk assessment and management give guidance on "how" to achieve it. The text provides a practical guide for decision-makers in regulatory bodies and companies with a non-technical background. Scientists and engineers who are not yet familiar with the concepts of risk assessment and who want a survey of some fundamentals of, and principal results from, risk assessment studies and approaches primarily for applications in the context defined by the "Seveso Directives" will also find this book invaluable.

  • Microbiology

    • 1st Edition
    • Volume 9A
    • Edward Bittar
    • English
    There is a need in small group teaching for a readable module that provides a balanced treatment of the four main areas of medical microbiology-bacteri... mycology, virology and parasistology. It need not be encyclopedic in scope nor didactic, but it should emphasise principles and concepts. Any existing gaps in this type of presentation are, of course, left for the student to fill.Some subject material has been excluded. An example is a chapter on laboratory procedures including PCR for rapid bacterial and viral diagnosis. The discussion of bacterial sexually transmitted diseases does not cover goncoccal infections. This is not a serious matter because the tutor can assign the topic to the students. Moreover, we have reluctantly omitted a separate chapter on anaerobic bacteria. The subject of nosocomial pathogens is touched upon but not in sufficient detail (e.g., control). These bacteria (e.g., S. aureus, E. coli and pseudomonas) are found in hospitals and are resistant to disinfectants and antibiotics. A new but serious problem is the emergence of resistance to antiviral agents.Without question, molecular biology owes more to the study of viruses than bacteria. The fact remains, however, that effective therapy against most viral diseases is not yet available. Perhaps one of the most dramatic examples of this situation is the fight against the AIDS virus and the search for a vaccine. The public health challenge of AIDS remains formidable in spite of the recent encouraging results obtained with protease inhibitor therapy. At the moment at least six receptors for HIV are known to be present in human cells. One of them is the CCR5 receptor in the absence of which cells fail to get infected with the virus. Drugs that can interrupt CCR5 binding sites on the virus envelope are being vigorously sought. Thus, Volume 9B gives a large place to HIV disease.The last group of chapters highlight several features of microbiology which are also of clinical importance and heuristic value. The chapter on fever of unknown origin provides fertile soil for problem based learning.

  • Environmental Management

    Engineering the Water-Environment and Geo-Environment
    • 1st Edition
    • D. Sivakumar + 1 more
    • English
    The Second International Conference on Environmental Management (ICEM2) focuses on the engineering management of the water and geo environments and aims to bring together scientists, engineers and other professionals to review as well as to report on the latest developments in the field.This book contains 160 peer reviewed papers covering the following interdisciplinary themes: Sustainable development/environm... management. Water, wastewater and stormwater management. Water quality/sediment transport. Total catchment management. Waste management and industrial waste products. Geotechnology and the environment. Slope stability and landslide management. Natural hazards and management. Mine environmental engineering.

  • Cognitive Reliability and Error Analysis Method (CREAM)

    • 1st Edition
    • E. Hollnagel
    • English
    The growing dependence of working environments on complex technology has created many challenges and lead to a large number of accidents. Although the quality of organization and management within the work environment plays an important role in these accidents, the significance of individual human action (as a direct cause and as a mitigating factor) is undeniable. This has created a need for new, integrated approaches to accident analysis and risk assessment.This book detailing the use of CREAM is, therefore, both timely and useful. It presents an error taxonomy which integrates individual, technological and organizational factors based on cognitive engineering principles. In addition to the necessary theoretical foundation, it provides a step-by-step description of how the taxonomy can be applied to analyse as well as predict performance using a context-dependent cognitive model.CREAM can be used as a second-generation human reliability analysis (HRA) approach in probabilistic safety assessment (PSA), as a stand-alone method for accident analysis and as part of a larger design method for interactive systems. In particular, the use of CREAM will enable system designers and risk analysts to: • identify tasks that require human cognition and therefore depend on cognitive reliability• determine the conditions where cognitive reliability and ensuing risk may be reduced• provide an appraisal of the consequences of human performance on system safety which can be used in PSA.

  • Advances in Molecular and Cellular Endocrinology

    • 1st Edition
    • Volume 2
    • D. LeRoith
    • English
    Volume 2 has focused on aspects of the pituitary gland both anterior (growth hormone and prolactin receptors, and GH action) and posterior (vasopressin) pituitary. In addition, thyroid cancer and steroidogenic enzymes and precocious puberty are covered. Finally, the "hot topics" include leptin and growth factor signaling.

  • Protein Structural Biology in Biomedical Research, Part A

    • 1st Edition
    • Volume 22
    • C. Woodward
    • N.M. Allewell
    • English
    Recent advances in protein structural biology, coupled with new developments in human genetics, have opened the door to understanding the molecular basis of many metabolic, physiological, and developmental processes in human biology. Medical pathologies, and their chemical therapies, are increasingly being described at the molecular level. For single-gene diseases, and some multi-gene conditions, identification of highly correlated genes immediately leads to identification of covalent structures of the actual chemical agents of the disease, namely the protein gene products. Once the primary sequence of a protein is ascertained, structural biologists work to determine its three-dimensional, biologically active structure, or to predict its probable fold and/or function by comparison to the data base of known protein structures. Similarly, three-dimensional structures of proteins produced by microbiological pathogens are the subject of intense study, for example, the proteins necessary for maturation of the human HIV virus. Once the three-dimensional structure of a protein is known or predicted, its function, as well as potential binding sites for drugs that inhibit its function, become tractable questions. The medical ramifications of the burgeoning results of protein structural biology, from gene replacement therapy to "rational" drug design, are well recognized by researchers in biomedical areas, and by a significant proportion of the general population. The purpose of this book is to introduce biomedical scientists to important areas of protein structural biology, and to provide an insightful orientation to the primary literature that shapes the field in each subject. The chapters in this volume cover aspects of protein structural biology which have led to the recognition of fundamental relationships between protein structure and function.

  • The Aging Brain

    • 1st Edition
    • Volume 2
    • J.W. Geddes + 1 more
    • English
    The brain is the most complex organ system in the human, both in the intricacy of its cellular architecture and in the extent of its repertoire of macromolecules. The Aging Brain presents the current state of understanding of molecular, cellular, and functional changes that occur in normal brain aging, and compares and contrasts those changes with events occurring in age-related neurodegenerative disorders. The chapters, written by world leaders in the field of brain aging, provide a timely and comprehensive consideration of key areas of this rapidly growing field of aging research. The topics covered include structural, functional, biochemical and molecular changes that occur during usual aging and in age-related neurological disorders. An emphasis is placed on emerging findings at the cellular and molecular levels. The roles of oxidative stress and perturbed energy metabolism in aging and neurodegenrative disorders are covered in considerable detail. In addition, the impact of aging and disease on specific neurotransmitter, neurotrophic factor and cytokine signaling pathways is reviewed. Finally, recent findings concerning possible approaches to reduce risk for age-related neurodegenerative disorders, such as caloric restriction, are presented. The collective body of information presented in The Aging Brain will provide those stepping into the field of brain aging with an overview of our current understanding of fundamental changes that occur in the aging brain, and their molecular and cellular underpinnings. At the same time, the book delves deeply into critical mechanistic details of brain aging that should prove valuable to experts in the field.

  • Trends in Drug Research II

    • 1st Edition
    • Volume 29
    • H. van der Goot
    • English
    This volume of Pharmacochemistry Library comprises the text of invited lectures presented at the 11th Noordwijkerhout-Came... Symposium Trends in Drug Research, held in Noordwijkerhout, The Netherlands, from 11-15 May 1997. In the programme attention has been given to the generation of new biological target systems and the generation of new lead molecules, with presentations on e.g. combinatorial chemistry, compound libraries, database search, high throughput screening and molecular biology. Other topics discussed were the perspectives for new medicines for the gastro-intestinal tract, the major developments in the search for effective anti-HIV drugs and new aspects in synthetic approaches. In a special session three topics which currently draw much attention were discussed: How to deal with the major problem of resistance against antimirobial agents? Can the apoptosis mechanism be used as a drug target? Is the newly observed phenomenon of inverse agonism a general principle and has it consequences for drug development (and use?)

Browse by Publisher