Trends in Drug Research II

Preface. Insights into the structure and function of genetic disease genes from genome research and clues for drug therapy (P.L. Pearson). Structure-based design: fact or fiction? (P.D.J. Grootenhuis et al.). New developments in synthetic medicinal chemistry (F. Gualtieri) . New biocatalytic approaches for the synthesis of chiral drugs, intermediates, and substrates (K. Laumen et al.). ∝ -Diazorcarbonyl chemistry- target driven applications (R. Pellicciari et al.) Ligands for the 5-HT 2C receptor as potential antidepressents and anxiolytics (D.Leysen, J. Kelder). 5-HT 1A-affinity, activity and selectivity versus D2-receptors of flesinoxan and analogues N-Arylpiperazines (W. Kuipers). Serotonin transmission in depression and anxiety disorders - new insights and potential new drugs (M. Briley, C. Moret). Pharmacokinetics and metabolism in drug development: current and future strategies (D.D. Breimer). Novel approaches towards anti-HIV chemotherapy (E. de Clercq). PMEA and PMPA: acyclic nucleoside phosphonates with potent anti-HIV activity (T. Cihlar, N. Bischofberger). HBY 097 - a second-generation nonnucleoside inhibitor of the HIV-1 reverse transcriptase (J-P. Kleim). The HIV tat-TAR interaction, a novel target for drug discovery (J. Karn et al.). Diverse approaches to combinatorial library design (E.J. Martin et al.). Heterocyclic mixture- based combinatorial libraries: synthesis and analysis of composition (J.S. Kiely, Y. Pei). The quest of new chemical entities to treat the gastric pathogen Helicobacter pylori (T.C. Kühler). Chemistry and SAR of prokinetic motilides: non peptidic motilin receptor agonists (P.A. Lartey). Modulators of 5-HT functions in the treatment of gastrointestinal disorders (F.D. King et al.). The impact of robotics and novel assay technologies on lead discovery processes (J.G. Houston). New animal models in target discovery (R.S. Oosting et al.). Hot topics (P. Angeli). Inverse agonism at G protein-coupled receptors. Studies with wild type and mutated adrenergic and opioid receptors (G. Milligan). Life and death decisions: medicinal chemistry approaches to apoptosis (A.P. Kozikowski). Antibiotic resistance - a view from the pharmaceutical industry (R. Bax).