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Elsevier Science

Environmental Management
Engineering the Water-Environment and Geo-Environment
1st Edition
D. Sivakumar + 1 more
English
The Second International Conference on Environmental Management (ICEM2) focuses on the engineering management of the water and geo environments and aims to bring together scientists, engineers and other professionals to review as well as to report on the latest developments in the field.This book contains 160 peer reviewed papers covering the following interdisciplinary themes: Sustainable development/environm... management. Water, wastewater and stormwater management. Water quality/sediment transport. Total catchment management. Waste management and industrial waste products. Geotechnology and the environment. Slope stability and landslide management. Natural hazards and management. Mine environmental engineering.
Advances in Molecular and Cellular Endocrinology
1st Edition
Volume 2
D. LeRoith
English
Volume 2 has focused on aspects of the pituitary gland both anterior (growth hormone and prolactin receptors, and GH action) and posterior (vasopressin) pituitary. In addition, thyroid cancer and steroidogenic enzymes and precocious puberty are covered. Finally, the "hot topics" include leptin and growth factor signaling.
Cognitive Reliability and Error Analysis Method (CREAM)
1st Edition
E. Hollnagel
English
The growing dependence of working environments on complex technology has created many challenges and lead to a large number of accidents. Although the quality of organization and management within the work environment plays an important role in these accidents, the significance of individual human action (as a direct cause and as a mitigating factor) is undeniable. This has created a need for new, integrated approaches to accident analysis and risk assessment.This book detailing the use of CREAM is, therefore, both timely and useful. It presents an error taxonomy which integrates individual, technological and organizational factors based on cognitive engineering principles. In addition to the necessary theoretical foundation, it provides a step-by-step description of how the taxonomy can be applied to analyse as well as predict performance using a context-dependent cognitive model.CREAM can be used as a second-generation human reliability analysis (HRA) approach in probabilistic safety assessment (PSA), as a stand-alone method for accident analysis and as part of a larger design method for interactive systems. In particular, the use of CREAM will enable system designers and risk analysts to: • identify tasks that require human cognition and therefore depend on cognitive reliability• determine the conditions where cognitive reliability and ensuing risk may be reduced• provide an appraisal of the consequences of human performance on system safety which can be used in PSA.
Protein Structural Biology in Biomedical Research, Part A
1st Edition
Volume 22
C. Woodward
N.M. Allewell
English
Recent advances in protein structural biology, coupled with new developments in human genetics, have opened the door to understanding the molecular basis of many metabolic, physiological, and developmental processes in human biology. Medical pathologies, and their chemical therapies, are increasingly being described at the molecular level. For single-gene diseases, and some multi-gene conditions, identification of highly correlated genes immediately leads to identification of covalent structures of the actual chemical agents of the disease, namely the protein gene products. Once the primary sequence of a protein is ascertained, structural biologists work to determine its three-dimensional, biologically active structure, or to predict its probable fold and/or function by comparison to the data base of known protein structures. Similarly, three-dimensional structures of proteins produced by microbiological pathogens are the subject of intense study, for example, the proteins necessary for maturation of the human HIV virus. Once the three-dimensional structure of a protein is known or predicted, its function, as well as potential binding sites for drugs that inhibit its function, become tractable questions. The medical ramifications of the burgeoning results of protein structural biology, from gene replacement therapy to "rational" drug design, are well recognized by researchers in biomedical areas, and by a significant proportion of the general population. The purpose of this book is to introduce biomedical scientists to important areas of protein structural biology, and to provide an insightful orientation to the primary literature that shapes the field in each subject. The chapters in this volume cover aspects of protein structural biology which have led to the recognition of fundamental relationships between protein structure and function.
The Aging Brain
1st Edition
Volume 2
J.W. Geddes + 1 more
English
The brain is the most complex organ system in the human, both in the intricacy of its cellular architecture and in the extent of its repertoire of macromolecules. The Aging Brain presents the current state of understanding of molecular, cellular, and functional changes that occur in normal brain aging, and compares and contrasts those changes with events occurring in age-related neurodegenerative disorders. The chapters, written by world leaders in the field of brain aging, provide a timely and comprehensive consideration of key areas of this rapidly growing field of aging research. The topics covered include structural, functional, biochemical and molecular changes that occur during usual aging and in age-related neurological disorders. An emphasis is placed on emerging findings at the cellular and molecular levels. The roles of oxidative stress and perturbed energy metabolism in aging and neurodegenrative disorders are covered in considerable detail. In addition, the impact of aging and disease on specific neurotransmitter, neurotrophic factor and cytokine signaling pathways is reviewed. Finally, recent findings concerning possible approaches to reduce risk for age-related neurodegenerative disorders, such as caloric restriction, are presented. The collective body of information presented in The Aging Brain will provide those stepping into the field of brain aging with an overview of our current understanding of fundamental changes that occur in the aging brain, and their molecular and cellular underpinnings. At the same time, the book delves deeply into critical mechanistic details of brain aging that should prove valuable to experts in the field.
Trends in Drug Research II
1st Edition
Volume 29
H. van der Goot
English
This volume of Pharmacochemistry Library comprises the text of invited lectures presented at the 11th Noordwijkerhout-Came... Symposium Trends in Drug Research, held in Noordwijkerhout, The Netherlands, from 11-15 May 1997. In the programme attention has been given to the generation of new biological target systems and the generation of new lead molecules, with presentations on e.g. combinatorial chemistry, compound libraries, database search, high throughput screening and molecular biology. Other topics discussed were the perspectives for new medicines for the gastro-intestinal tract, the major developments in the search for effective anti-HIV drugs and new aspects in synthetic approaches. In a special session three topics which currently draw much attention were discussed: How to deal with the major problem of resistance against antimirobial agents? Can the apoptosis mechanism be used as a drug target? Is the newly observed phenomenon of inverse agonism a general principle and has it consequences for drug development (and use?)
Geology and hydrogeology of carbonate islands
1st Edition
Volume 54
Leonard H.L. Vacher + 1 more
English
The Geology and Hydrogeology of Carbonate Islands presents a survey of more than 30 selected islands such as Bermuda, the Bahamas, the Florida Keys, coastal Yucatan, Barbados, the Caymans, Isla de Mona, islands of Polynesia, the Cooks, Guam, Niue, Nauru, Rottnest Island, the Houtman Abrolhos, islands of the Great Barrier Reef and many atolls including Enewetak, Tarawa, Diego Garcia, Mururoa, and the Cocos Islands. The book provides a wealth of observational data and a survey of interpretations on the issues within the intersection of carbonate geology (depositional architecture, diagenetic processes and dolomitization, Cenozoic sea-level history, karstification and blue holes) and island hydrology (distribution of fresh and brackish groundwater, dual-aquifer conceptualizations, modeling of island lenses, water budgets and water resources, effects of climatic variations, island karst, endo-upwelling).
Pneumatic Handbook
8th Edition
A. Barber
English
Accepted as the standard reference work on modern pneumatic and compressed air engineering, the new edition of this handbook has been completely revised, extended and updated to provide essential up-to-date reference material for engineers, designers, consultants and users of fluid systems.
Hydrocarbon Seals
Importance for Exploration and Production
1st Edition
Volume 7
P. Møller-Pedersen + 1 more
English
In January 1996 a total of 270 conference participants gathered for 3 days in Trondheim, Norway, to focus on and to discuss the complex topic of hydrocarbon seals particularly related to deformation zones and to caprocks. The conference was the first in Norway and one of the first in Europe to exclusively address this very important subject. The purpose of the conference was to present some of the most recent research results, to establish state-of-the-art with respect to understanding hydrocarbon seals and to discuss where to go from here to find some of the keys to successful future exploration and enhanced oil and gas recovery. Out of the presented papers and posters, 17 are compiled and published in this volume. These provide a good overview of and an introduction to the numerous aspects covered during the fruitful days in Trondheim.
Advanced Materials for Interconnections
1st Edition
Volume 66
Th. Gessner
English
The conference "Advanced Materials for Interconnections" took place in Strasbourg on 4-7 June 1996 hosted by the EMRS Society. Based on the recent trends in microelectronics the main topics of the conference were new materials for interconnects like special aluminum alloys, tungsten and copper as well as low k dielectric materials.64 Papers were presented at the conference and 51 of these are contained as full length papers within this volume of Microelectronic Engineering.The proceedings are divided into 5 chapters. Chapter 1 related to Metallization discusses cluster equipment for IC manufacturing, copper advanced technology, gap filling, mechanical reliability, deposition technology, electroless and electro-plating, copper metallization copper interconnects and patterning of aluminum. Chapter 2, Process Integration, discusses multilevel interconnect, study on thin-film SOI devices, wet cleanings, influence of material characteristics and deposition processes, copper contamination and metallization, plasma behaviour, CMP processes, sub-micron inverse metallisation, interconnect formation and mechanical polishing investigations. Chapter 3 covers Barriers, and chapter 4 studies, evaluates and monitors Dielectrics. The final chapter looks at modelling comparisons.

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