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Elsevier

Elsevier Science

  • Advanced Problems in Organic Reaction Mechanisms

    • 1st Edition
    • Volume 16
    • English
    The Elsevier Tetrahedron Organic Chemistry Series is a topical series of monographs by world-renowned scientists in several fields of organic chemistry. The Tetrahedron Organic Chemistry Series has been very successful in providing some of the very best scholarly works in these topical areas that have proven to be of lasting quality as indispensable reference sources. These books have provided the practicing researcher, student and scholar with an invaluable source of comprehensive reviews in organic chemistry, predominantly in the areas of synthesis and structure determination, including:* Reagents* Reaction mechanisms* Molecular Diversity* Asymmetric Synthesis* Multi-dimensional nmr* Enzymatic Synthesis* Organometallic Chemistry* Biologically Important Molecules

  • Methods for Structure Elucidation by High-Resolution NMR

    Applications to Organic Molecules of Moderate Molecular Weight
    • 1st Edition
    • Volume 8
    • G. Batta + 2 more
    • English
    Nuclear Magnetic Resonance Spectroscopy (NMR) is now widely regarded as having evolved into a subscience. The field has become immensely diverse, ranging from medical use through solid state NMR to liquid state applications, with countless books and scientific journals devoted to these topics. Theoretical as well as experimental advance continues to be rapid, and has in fact accelerated by many novel innovations. This multi-authored book focuses on the latest developments in the rapidly evolving field of high resolution NMR, specifically with a view to applications on the structure elucidation of organic molecules of moderate molecular weight. Conceptually it differs from basic educational texts, hard-core scientific papers and regular review articles in that each chapter may be regarded as the authors' personal account of their special insights and results that crystallised after several years of research into a given topic. The book revolves around several themes and offers a handful of scientific "gems" of various colors, reflecting the great diversity of NMR. It contains 16 loosely connected chapters written by some of today's most accomplished NMR scientists in the world. Each chapter is a unique synthesis of the authors' previous research results in the given field, and thus projects special insights. Much emphasis has been given to the latest developments in NMR, in particular to selective pulses and pulsed field gradients. As a part of the series "Analytical Spectroscopy Library", with subsequent editions coming along this book should provide a platform for future research accounts of similar flavor. The material is presented in a mostly non-mathematical fashion, and is intended mainly for chemists, application NMR scientists and students with already some background in NMR. Some of the chapters slightly overlap in the discussed topics, which is particularly exciting in terms of gaining insight into the same area from different angles.

  • Low-temperature Combustion and Autoignition

    • 1st Edition
    • Volume 35
    • M.J. Pilling
    • English
    Combustion has played a central role in the development of our civilization which it maintains today as its predominant source of energy. The aim of this book is to provide an understanding of both fundamental and applied aspects of low-temperature combustion chemistry and autoignition. The topic is rooted in classical observational science and has grown, through an increasing understanding of the linkage of the phenomenology to coupled chemical reactions, to quite profound advances in the chemical kinetics of both complex and elementary reactions. The driving force has been both the intrinsic interest of an old and intriguing phenomenon and the centrality of its applications to our economic prosperity. The volume provides a coherent view of the subject while, at the same time, each chapter is self-contained.

  • Molecular and Cellular Pharmacology

    • 1st Edition
    • Edward Bittar
    • English

  • Waste Materials in Construction

    Putting Theory into Practice
    • 1st Edition
    • Volume 71
    • G.J. Senden + 2 more
    • English
    This book presents the proceedings of the 3rd International Conference on Waste Materials in Construction, held in June 1997. The papers presented give the state of the art on leaching of materials and products, demonstration projects and product development. Results of workshops on immobilisation and quality control are also presented. A good overview of the latest results on the application of various materials in construction, based on both technical and environmental data, is provided. The book provides a unique opportunity for environmental researchers, environmental consultants, policy-makers, and those involved in the construction industry to gain the latest information on the subject.

  • African Basins

    • 1st Edition
    • Volume 3
    • R.C. Selley
    • English
    Following on from the first 2 books in the series, Sedimentary Basins of the World, which covered Chinese Sedimentary Basins (Volume 1) and South Pacific Sedimentary Basins (Volume 2), comes Volume 3, on African Basins.Africa covers a larger land area than the USA, Europe, India and the ASEAN nations put together. It is rich in natural resources, including oil, gas, coal and nearly every metalliferous mineral. Yet Africa is still one of the least explored continents.This book brings together in one volume, concise reviews of basins previously documented in a vast array of diffuse literature. It also contains some of the first detailed accounts of several basins which have never before been described in such depth. These include the onshore Owambo, Iullemmeden, and Sudanese rift basins, and the offshore basins of southern Africa.The contributions are by authors, and teams of authors, with great knowledge and experience of the basins that they describe.The thirteen chapters are arranged in 3 parts covering North Africa, Central Africa and Southern Africa and the book is illustrated by maps, cross-sections, stratigraphic sections and seismic lines. Each chapter includes a comprehensive bibliography and the book concludes with a subject index.For academic geologists researching the geology of Africa, and for industrial geologists seeking natural resources within African sedimentary rocks, this book is an invaluable source of information.

  • Ion Pumps, Part A

    • 1st Edition
    • Volume 23
    • J.P. Andersen
    • English
    Both eukaryotic and prokaryotic cells depend strongly on the function of ion pumps present in their membranes. The term ion pump, synonymous with active ion-transport system, refers to a membrane-associated protein that translocates ions uphill against an electrochemical potential gradient. Primary ion pumps utilize energy derived from chemical reactions or from the absorption of light, while secondary ion pumps derive the energy for uphill movement of one ionic species from the downhill movement of another species. In the present volume, various aspects of ion pump structure, mechanism, and regulation are treated using mostly the ion-transporting ATPases as examples. One chapter has been devoted to a secondary ion pump, the Na+-Ca2+ exchanger, not only because of the vital role played by this transport system in regulation of cardiac contractility, but also because it exemplifies the interesting mechanistic and structural similarities between primary and secondary pumps.

  • Idiotypes in Medicine: Autoimmunity, Infection and Cancer

    • 1st Edition
    • R.C. Kennedy + 2 more
    • English
    This is the most comprehensive review of the idiotypic network available. All the current knowledge of idiotypes of the various antibodies is incorporated in this volume. The pathogenic role of idiotypes in autoimmunity and cancer is reviewed in depth. The therapeutic part focusses on harnessing anti-idiotypes for treating autoimmunological disorders, and on the employment of idiotypes for vaccines in cancer and infectious diseases, as well as explaining the manipulation of the idiotypic network in autoimmunity and cancer idiotypes and vaccines.

  • Advances in DNA Sequence-specific Agents

    • 1st Edition
    • Volume 3
    • M. Palumbo
    • English
    In this volume the entire focus is devoted to the macromolecule target specificity of DNA interactive developmental therapeutic agents of current interest. A brief introduction to DNA interactive anticancer agents is included for readers who may benefit from an overview surrounding the developments that have contributed to our general understanding of this field. The following nine chapters have been carefully chosen so that they describe topics which are at the forefront of development in DNA-targeted cancer chemotherapy. Issues that have been addressed include the mechanisms of selective DNA topoisomerase I and II poisoning by antitumor agents (Chapters 1 and 2), sequence-specific recognition of DNA by groove-binding drugs and drug-conjugates (Chapters 3 and 4), recent developments in nitrogen mustard alkylating agents and their potential use for antibody-directed enzyme-prodrug therapy (Chapter 5), nonclassical platinum anticancer complexes, including dinuclear and trans-platinum derivatives (Chapter 6), DNA cleaving antitumor chromoproteins containing reactive enediyne moieties, which exhibit interesting free-radical chemistry along with selective targeting (Chapter 7), the potential of new sequence-specific antisense and antigene therapy in oncology (Chapter 8), and finally the conceivable chemotherapeutic use of mimetics of the DNA structure, obtained by substitution of the sugar-phosphate natural chain with a peptide backbone, the so-called peptide nucleic acids (Chapter 9). Important approaches being currently investigated for selective cancer treatment, such as gene therapy and immunochemotherapy, are not discussed in this volume since they fall beyond its scope.

  • Cell Structure and Signaling

    • 1st Edition
    • Volume 24
    • R.H. Getzenberg
    • English
    In the past approximately quarter of a century, science has made significant progress in elucidating the skeletal elements of the cell, the extracellular matrix, cytoskeleton and nuclear matrix (i.e. the tissue matrix). While we currently know a great deal about some of the elements that comprise these structural systems, we still do not fully understand cellular structures and their relationship to cellular function. The cell is a highly ordered machine in which the skeleton provides the framework on which cellular functions take place. It is now becoming apparent that what were typically considered "soluble reactions" are rare, if existent at all. The structural systems contribute more to the cell than a framework for shape, although this is an important function. Cellular shape is reflecting what a cell is, does and will be. One can not inextricably separate cell structure and function, they go hand-in-hand.Numerou... laboratories have contributed to our current understanding of the role of cell structure in cell signaling and we are now at an exciting time in this field. This volume summerizes where investigations into the role of the tissue matrix system in cellular signaling have come and to propose new directions that this research will take in the next several years. This is not meant to be complete, but hopefully will provide the reader with an overview on our current understanding of this field.

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