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Elsevier

Elsevier Science

  • Approaches to Design and Synthesis of Antiparasitic Drugs

    • 1st Edition
    • Volume 25
    • N. Anand + 1 more
    • English
    This book presents a comprehensive and up to date account of the chemotherapy of parasitic diseases, both human and veterinary. The book starts with an overview of parasitic diseases. The body of the book is divided into two parts: antihelminthic drugs, and antiprotozoal drugs. Both parts start with chapters highlighting the 'biochemical targets' available for chemotherapeutic interference. Individual chapters deal with one chemical class of compounds and describe their origin, structure-activity relationship, mode of action, and methods of synthesis and their status both in clinical and veterinary practice. The book will be useful to a wide spectrum of readers: students embarking on a research career in parasitic chemotherapy, clinicians (and veterinarians) and clinical pharmacologists desiring detailed information about the drugs currently in use, and pharmaceutical technologists wanting to update their knowledge of the methods of manufacture.

  • Serotonin Receptors and their Ligands

    • 1st Edition
    • Volume 27
    • B. Olivier + 2 more
    • English
    An international group of authors have produced an overview of the progress made in the medicinal chemistry of compounds (selectively) acting at serotonin receptors or serotonin transporters either as agonists, partial agonists or antagonists.Structur... - affinity relationships and structure - activity relationships of agonists, partial agonists, and antagonists of 5-HT receptors and uptake sites, are discussed. Structure, sequence homology and the effect of site-directed mutations of 5-HT receptors and the reuptake site on the binding of ligands show the tremendous impact of molecular biology on medicinal chemistry research. Also discussed is the pharmacology and (potential) clinical applications of ligands for the 5-HT receptors and the reuptake site. By developing elegant techniques of cloning and expression of serotonin receptor subtypes, their mutants and chimeras, a unique opportunity was offered to study the binding mode of serotoninergic ligands to their receptors and transporters.The distribution, structure and homologies of serotonin receptor subtypes and the structure of the serotonin transporter are also taken into account.The (potential) therapeutic applications of ligands of the different subtypes are described.Altogether an excellent addition to the Pharmacochemical Library series.

  • Heterogeneous Catalysis and Fine Chemicals IV

    • 1st Edition
    • Volume 108
    • H.U. Blaser + 2 more
    • English
    After three meetings in Poitiers, France, the 4th International Symposium on Heterogeneous Catalysis and Fine Chemicals was held under the auspices of the New Swiss Chemical Society in Basel, Switzerland. Fundamental as well as applied contributions on the use of heterogeneous catalysis for the preparation of fine chemicals were presented and discussed.The program consisted of 4 plenary lectures, 28 oral contributions and around 90 posters covering a broad range of reactions and catalytic aspects. 82 of these contributions are collected in the present proceedings, grouped into the following 8 topical areas:- Industrial and engineering problems (7 contributions)- Alkylation and acylation reactions (11 contributions)- Enantio- and diastereoselective hydrogenation reactions (9 contributions)- Chemoselective hydrogenation reactions (12 contributions)- Oxidation reactions (14 contributions)- Immobilized and encapsulated complex catalysts (12 contributions)- Zeolite and clay catalysts (12 contributions)- Miscellaneous topics (5 contributions)

  • New Cosmetic Science

    • 1st Edition
    • T. Mitsui
    • English
    Cosmetic science covers the fields from natural sciences to human and social sciences, and is an important interdisciplinary element in various scientific disciples. New Cosmetic Science is a completely updated comprehensive review of its 35 year old counterpart Cosmetic Science. New Cosmetic Science has been written to give as many people as possible a better understanding of the subject, from scientists and technologists specializing in cosmetic research and manufacturing, to students of cosmetic science, and people with a wide range of interests concerning cosmetics.The relationship between the various disciplines comprising cosmetic science, and cosmetics, is described in Part I. In addition to discussing the safety of cosmetics, the "Usefulness of Cosmetics", rapidly becoming an important theme, is described using research examples. The latest findings on cosmetic stability are presented, as are databases, books and magazines, increasingly used by cosmetic scientists. Part II deals with cosmetics from a usage viewpoint, including skin care cosmetics, makeup cosmetics, hair care cosmetics, fragrances, body cosmetics, and oral care cosmetics. Oral care cosmetics and body cosmetics are presented with product performance, types, main components, prescriptions and manufacturing methods described for each item.This excellent volume enlightens the reader not only on current cosmetics and usage, but indicates future progress enlarging the beneficial effects of cosmetics. Products with better pharmaceutical properties (cosmeceuticals), working both physically and psychologically, are also highlighted.

  • Optical, Electric and Magnetic Properties of Molecules

    A Review of the Work of A.D. Buckingham
    • 1st Edition
    • D.C. Clary + 1 more
    • English
    This book celebrates the career and scientific accomplishments of Professor David Buckingham, who is due to retire from his Chair at Cambridge University in 1997. The adopted format comprises reprints of a number of David Buckingham's key scientific papers, each one or two of these preceded by a review of the corresponding area of David's wide-ranging research interest. Each reviewer is recognised as an expert in that field of interest and has some close association with David Buckingham, as a scientific colleague and/or a former research student. The book should serve as a distinctive reference source, both retrospective and prospective, for the field of chemical physics with which the name A.D. Buckingham is associated.The editors opted to reprint a majority of early classic Buckingham papers, balanced by some of David Buckingham's more recent publications. Reprinted papers have been placed into a general scientific context that covers prior influences on, and later impacts by, the work nominated for review.

  • Composite Sheet Forming

    • 1st Edition
    • Volume 11
    • D. Bhattacharyya
    • English
    Sheet forming is the most common process used in metal forming and is therefore constantly being adapted or modified to suit the needs of forming composite sheets. Due to the increasing availability of various types of fibre reinforced polymeric sheets, especially with thermoplastic matrices, the scope of use of such materials is rapidly expanding in the automobile, building, sports and other manufacturing industries beyond the traditional areas of aerospace and aircraft applications. This book contains twelve chapters and attempts to cover different aspects of sheet forming including both thermoplastic and thermosetting materials. In view of the expanded role of fibre reinforced composite sheets in the industry, the book also describes some non-traditional applications, processes and analytical techniques involving such materials.The first chapter is a brief introduction to the principles of sheet metal forming. The next two chapters introduce the various forms of materials, manufacturing techniques and the fundamentals of computer simulation. Chapter 4 describes the different aspects of thermoforming of continuous fibre reinforced thermoplastics and the following chapter studies the shear and frictional behaviour of composite sheets during forming. Chapter 6 explores the possibility of applying the grid strain analysis method in continuous fibre reinforced polymeric sheets. The next two chapters address fundamental concepts and recent developments in finite element modelling and rheology. Chapter 9 introduces the theory of bending of thermoplastic composite sheets and shows a novel way of determining both longitudinal and transverse viscosities through vee-bend tests. A significant expansion in the usage of composite materials is taking place in biomedical areas. Chapter 10 discusses the thermoforming of knitted fabric reinforced thermoplastics for load bearing and anisotropic bio-implants. The final chapter introduces roll forming, a commonly used rapid manufacturing process for sheet metals, and discusses the possibility of applying it economically for continuous reinforced thermoplastic sheets.

  • Advanced Methods in Materials Processing Defects

    • 1st Edition
    • Volume 45
    • M. Predeleanu + 1 more
    • English
    This collection of papers focus on advanced methods for predicting and avoiding the occurrence of defects in manufactured products. A new feature is included, namely, the influence of the processing-induced defects on the integrity of structures.The following topics are developed: damage modeling; damage evaluation and rupture; strain localization and instability analysis; formability characterization; prediction of shape inaccuracies; influence of defects on structural integrity. The main manufacturing operations are covered and various materials are examined, such as new and conventional metal alloys, ceramics, polymers and composites.

  • Mercury Cadmium Telluride Imagers

    A Patent-oriented Survey
    • 1st Edition
    • Volume 5
    • A.C. Onshage
    • English
    In two parts, this book describes the evolution of mercury cadmium telluride (HgCdTe) imager structures based upon published patents and patent applications. The first part covers monolithic arrays, and the second part describes hybrid arrays. Each part has 5 chapters, with each document placed in chronological order, with the documents with the earliest priority placed first. Focus has been directed at the steps of manufacturing and structures of imagers.There is an index at the end of the book containing the patent number, the name of the applicant and the date of publication of each cited document.This monograph will serve as a useful summary of the patents and patent applications in the field of mercury cadmium telluride imagers.

  • Miocene Stratigraphy

    An Integrated Approach
    • 1st Edition
    • Volume 15
    • A. Montanari + 2 more
    • English
    Integrated stratigraphy is essential for⧫ detailed paleoecologic studies of critical intervals in Earth history⧫ the calibration of the time scale for global use⧫ the establishment of Global Stratotype Sections and Points (GSSPs) for the definition of chronostratigraphic boundaries.This book constitutes an excellent and probably unique example of how interdisciplinary stratigraphic and geochronologic studies are approached with modern methodologies and techniques.It contains numerous unpublished, accurate radioisotopic dates of volcano-sedimentary layers interbedded in fossiliferous marine and continental Miocene sequences representing Mediterranean and Pacific environments. New, extremely detailed paleontologic data which constitute the basis for an accurate definition of the Miocene biostratigraphy, and the study of the ecologic evolution of Miocene marine environments are also included.The chapters are complimented by black-and-white photographs, graphic figures, and tables.Stratigrapher... paleontologists and sedimentologists plus geologists working in oil companies will certainly find this work of interest.

  • Growth and Properties of Ultrathin Epitaxial Layers

    • 1st Edition
    • Volume 8
    • English
    Although there has been steady progress in understanding aspects of epitaxial growth throughout the last 30 years of modern surface science, work in this area has intensified greatly in the last 5 years. A number of factors have contributed to this expansion. One has been the general trend in surface science to tackle problems of increasing complexity as confidence is gained in the methodology, so for example, the role of oxide/metal interfaces in determining the properties of many practical supported catalysts is now being explored in greater detail. A second factor is the recognition of the potential importance of artificial multilayer materials not only in semiconductor devices but also in metal/metal systems because of their novel magnetic properties. Perhaps even more important than either of these application areas, however, is the newly-discovered power of scanning probe microscopies, and most notably scanning tunneling microscopy (STM), to provide the means to study epitaxial growth phenomena on an atomic scale under a wide range of conditions. These techniques have also contributed to revitalised interest in methods of fabricating and exploiting artificial structures (lateral as well as in layers) on a nanometre scale.This volume, on Growth and Properties of Ultrathin Epitaxial Layers, includes a collection of articles which reflects the present state of activity in this field. The emphasis is on metals and oxides rather than semiconductors.

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