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Elsevier Science

A Manual of Adverse Drug Interactions
5th Edition
J.P. Griffin + 1 more
English
For twenty years this book, now in its 5th edition, has provided information on adverse drug interactions that is unrivalled in coverage and scholarship.Adverse drug reactions, many of them ascribable to interactions with other drugs or with chemical substances in food or the environment, are thought to cause or complicate one in twenty of hospital admissions.The book is conveniently divided into two parts: Part 1 comments on drug interactions and their mechanisms, on a pharmacokinetic and pharmacodynamic level, while Part 2 consists of drug interaction tables, divided and subdivided into categories of disorders, and the drugs used in the treatment of these disorders.If safety in drugs is to improve, education of prescribers is vitally important. This book, with its up-to-date and coordinated approach, serves that purpose well. The real threat, as the authors remind us, is the ignorance of practitioners, not the drug itself. The volume is therefore an essential addition to the shelves of those responsible for the prescription of drugs, in order to prevent a potential backlash when used in combination with other drugs or chemical substances.
Hydrodynamic Lubrication
Bearings and Thrust Bearings
1st Edition
Volume 33
J. Frene + 4 more
English
Hydrodynamic Lubrication is the culmination of over 20 years close, collaborative work by the five authors and discusses the practical use of the formalization of low pressure lubrication. The work concentrates on the developments to journal and thrust bearings and includes subjects such as:• the dynamic behaviour of plain and tilting-pads• the thermal aspects• the positive and negative effects of non-cyclindricity and shape defects resulting from manufacturing or operation• the effects of inertia• the appearance of Taylor's vortices and of turbulence and their repercussions.The book contains an abundance of test results objectively compared with theoretical conclusions and a chapter on "technical considerations" to ensure that draft mechanisms will work satisfactorily under the imposed conditions.Hydrodyna... Lubrication is an essential reference book for future and practising engineers who want to put hydrodynamic and hydrostatic journal bearings and thrust bearings into operation under conditions of total safety.
Soil Quality for Crop Production and Ecosystem Health
1st Edition
Volume 25
E.G. Gregorich + 1 more
English
Soil is a complex body that exists as many types, each with diverse properties that may vary widely across time and space as a function of many factors. This complexity makes the evaluation of soil quality much more challenging than that of water or air quality. Evaluation of soil quality now considers environmental implications as well as economic productivity, seeking to be more holistic in its approach.Thus, soil quality research draws from a wide range of disciplines, blending the approaches of biologists, physicists, chemists, ecologists, economists and agronomists, among others.This book presents a broad perspective of soil quality that includes these various perspectives and gives a strong theoretical basis for the assessment of soil quality.A short glossary provides definitions for terms used throughout the book.
Structural and Residual Stress Analysis by Nondestructive Methods
Evaluation - Application - Assessment
1st Edition
V. Hauk
English
The field of stress analysis has gained its momentum from the widespread applications in industry and technology and has now become an important part of materials science. Various destructive as well as nondestructive methods have been developed for the determination of stresses. This timely book provides a comprehensive review of the nondestructive techniques for strain evaluation written by experts in their respective fields.The main part of the book deals with X-ray stress analysis (XSA), focussing on measurement and evaluation methods which can help to solve the problems of today, the numerous applications of metallic, polymeric and ceramic materials as well as of thin-film-substrate composites and of advanced microcomponents. Furthermore it contains data, results, hints and recommendations that are valuable to laboratories for the certification and accreditation of their stress analysis.Stress analysis is an active field in which many questions remain unsettled. Accordingly, unsolved problems and conflicting results are discussed as well. The assessment of the experimentally determined residual and structural stress states on the static and dynamic behavior of materials and components is handled in a separate chapter.Students and engineers of materials science and scientists working in laboratories and industries will find this book invaluable.
Retinoids: Their Physiological Function and Therapeutic Potential
1st Edition
Volume 3
G.V. Sherbet
English
Retinoids have received considerable attention in recent years and due cognizance has been given to their versatility as biological response modifiers, as evidenced by the virtually explosive growth of literature in this field in the past few years. This volume has been designed to give a current state-of-the-art picture of retinoids. The perceived potential of retinoids in the treatment of certain disease stated has initiated attempts at identifying and synthesizing new retinoid derivatives with definable and selective effects on aberrant biological phenomena. Appropriately, therefore, we begin with the chemistry of retinoids and their derivatives together with discussions of their biological activity. Major advances have been made in understanding the mechanisms by which retinoids modulate physiological and phenotypic traits of cells. The transduction of retinoid signaling by the mediation of nuclear receptors of the steroid/thyroid receptor superfamily has now been studied extensively and the cloning and defining the characteristics of these receptors has been a focus of discussion in this volume. Retinoids also markedly modulate the transduction of extracellular signals such as those imparted by growth factors and hormones, and thus actively influence and control cellular proliferative patterns. Retinoids can alter epidermal growth factor receptor expression (Kawaguchi et al., 1994), responsiveness to thyroid hormone (Esfandiari et al., 1994; Pallet et al., 1994), inhibit the proliferative responses of hematopoietic progenitor cells to granulocyte colony stimulating factor (Smeland et al., 1994), and modulate secretion on interleukins by leukaemic cells (Balitrand et al., 1994), among other things. This has obvious implications for pharmacological manipulation of deregulated growth (Dickens and Colletta, 1993; Mulshine et al., 1993). Apoptosis is another component in the regulation of growth control. Apoptotic cell death is influenced by several agents and retinoids may function by interfering with apoptotic pathways of regulation of growth control and quite legitimately, therefore, the importance of this aspect of retinoid function has been duly recognized here.
Advances in Developmental Biology
1st Edition
Volume 5a
Paul Wassarman
English
Volume 5 of Advances in Developmental Biology and Biochemistry consists of seven chapters that review specific aspects of development in several different organisms, including sea urchins, flies, worms, frogs, and mice. In Chapter 1, Wassarman and Therrier provide a detailed analysis of RAS1-mediated photoreceptor development in Drosophila as determined by genetic and biochemical approaches. Much of the information in this area has come from studies of the role of RAS1 in the Sevenless (SEV) signal transduction pathway that specifies the R7 photoreceptor cell fate. In Chapter 2, Westlund, Berry, and Schedl describe the regulation of germline proliferation in the nematode, C. elegans. In large part, the authors discuss components of signaling pathways, including glp-1 and other members of the Notch protein family that are crucial for a germ cell's decision of whether to remain mitotic or to enter meiotic prophase. In Chapter 3, Richards details the current status of the ecdysone regulatory cascade in Drosophila. In a comprehensive presentation, he describes ecdysone-regulated chromosomal puffs, their corresponding genes, and the receptors and transcription factors involved in the ecdysone regulatory cascade. In Chapter 4, Tam, Quinlan, and Trainor describe the patterning of progenitor tissues for the cranial region of the mouse embryo during gastrulation and early organogenesis. In particular, the authors review the sequence of developmental processes that delineate major tissue domains and the finer segmental organization of the progenitor tissues for the formation of craniofacial structures. In Chapter 5, Bodmer and his colleagues detail the genetic basis of heart development in Drosophila. Here, the authors discuss various gene functions that are required for the initial specification and later differentiation of the heart and compare molecular mechanisms that lead to heart formation in Drosophila with those that may be involved in heart formation in vertebrates. In Chapter 6, Tata Discusses hormonal signaling and amphibian metamorphosis. Following a review of amphibian metamorphosis, the author describes thyroid hormone receptors, the genes encoding them, and their target genes, as well as how their activities are coordinated by signaling molecules. Finally, in Chapter 7, Kaldis and colleagues discuss the functions of creatine kinase (CK) isozymes in spermatozoa from a variety of mammalian and nonmammalian species.
Advances in Lipobiology, Volume 2
1st Edition
R.W. Gross
English
Frontiers in Electronics: High Temperature and Large Area Applications
1st Edition
Volume 59
Bozzano G Luisa
English
Soft Scale Insects
1st Edition
Volume 7A
English
This text presents an up-to-date account of the soft-scale insects, "Coccidae", and covers almost the entire spectrum of the knowledge of this insect family. It is divided into three sections, covering: soft scale insects; their natural enemies; and damage and control.
Wear of Materials
1st Edition
R.G. Bayer + 1 more
English
This volume contains the proceedings from the Eleventh Wear of Materials conference held in San Diego in April 1997. As 1997 marked the 20th anniversary of the conference a review of the conference history has been published including personal recollections from past Chairmen. In addition 67 full papers have been published together with 14 communications and case studies, providing an important information resouce for engineers and researchers worldwide.

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