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Elsevier

Academic Press

  • The Diverse Faces of Bacillus Cereus

    • 1st Edition
    • Vincenzo Savini
    • English
    The Diverse Faces of Bacillus cereus elucidates all characteristics of this microorganism, from its environmental and ecologic relevance, to its veterinary involvement, its clinical settings, most common B. cereus associated food poisoning episodes, and the newest airway disease pictures mimicking the inhalation of anthrax. Due to its environmental distribution, B. cereus may cause serious, even fatal human diseases. The organism shows many diverse faces, as it is not only a veterinary pathogen, but also used as a biocontrol agent to control vegetable decay due to its natural antimicrobial properties. Once considered as a mere colonizer or contaminant, Bacillus cereus is nowadays acquiring increasing importance as an agent of nosocomial infections. The book's target audience is familiar with this opportunistic pathogen and will benefit from this clear compendium on the classical and molecular techniques and procedures that may be adopted or followed to correctly identify this intriguing multi-faceted microorganism.

  • Ion Channels as Therapeutic Targets, Part A

    • 1st Edition
    • Volume 103
    • English
    Ion Channels as Therapeutic Targets is the latest volume in the popular Advances in Protein Chemistry and Structural Biology series, an essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics.

  • Advances in Computers

    • 1st Edition
    • Volume 101
    • English
    Advances in Computers carries on a tradition of excellence, presenting detailed coverage of innovations in computer hardware, software, theory, design, and applications. The book provides contributors with a medium in which they can explore their subjects in greater depth and breadth than journal articles typically allow. The articles included in this book will become standard references, with lasting value in this rapidly expanding field.

  • Advances in Genetics

    • 1st Edition
    • Volume 93
    • English
    Advances in Genetics provides the latest information on the rapidly evolving field of genetics, presenting new medical breakthroughs that are occurring as a result of advances in our knowledge of the topic. The book continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines, critically analyzing future directions.

  • e-Design

    Computer-Aided Engineering Design
    • 1st Edition
    • Kuang-Hua Chang
    • English
    e-Design: Computer-Aided Engineering Design, Revised First Edition is the first book to integrate a discussion of computer design tools throughout the design process. Through the use of this book, the reader will understand basic design principles and all-digital design paradigms, the CAD/CAE/CAM tools available for various design related tasks, how to put an integrated system together to conduct All-Digital Design (ADD), industrial practices in employing ADD, and tools for product development.

  • Hsp90 in Cancer: Beyond the Usual Suspects

    • 1st Edition
    • Volume 129
    • English
    Hsp90 in Cancer: Beyond the Usual Suspects, the latest volume in the Advances in Cancer Research series, focuses on the multifunctional molecular chaperone Hsp90 which regulates the post-translational stability and function of a broad repertoire of client proteins and discusses some of the lesser-known aspects of how Hsp90 and its related family members enable oncogenic transformation and malignant progression.

  • Molecules to Medicine with mTOR

    Translating Critical Pathways into Novel Therapeutic Strategies
    • 1st Edition
    • Kenneth Maiese
    • English
    Molecules to Medicine with mTOR: Translating Critical Pathways into Novel Therapeutic Strategies is a one-stop reference that thoroughly covers the mechanistic target of rapamycin (mTOR). mTOR, also known as the mammalian target of rapamycin, is a 289-kDa serine/threonine protein kinase that is ubiquitous throughout the body and has a critical role in gene transcription and protein formation, stem cell development, cell survival and senescence, aging, immunity, tissue regeneration and repair, metabolism, tumorigenesis, oxidative stress, and pathways of programmed cell death that include apoptosis and autophagy. Incorporating a translational medicine approach, this important reference highlights the basic cellular biology of mTOR pathways, presents the role of mTOR during normal physiologic function and disease, and illustrates how the mechanisms of mTOR can be targeted for current and future therapeutic treatment strategies. Coverage of mTOR signaling includes the entire life cycle of cells that impacts multiple systems of the body including those of nervous, cardiovascular, immune, musculoskeletal, endocrine, reproductive, renal, and respiratory origin.

  • Clinical Trials

    Study Design, Endpoints and Biomarkers, Drug Safety, and FDA and ICH Guidelines
    • 2nd Edition
    • Tom Brody
    • English
    Clinical Trials, Second Edition, offers those engaged in clinical trial design a valuable and practical guide. This book takes an integrated approach to incorporate biomedical science, laboratory data of human study, endpoint specification, legal and regulatory aspects and much more with the fundamentals of clinical trial design. It provides an overview of the design options along with the specific details of trial design and offers guidance on how to make appropriate choices. Full of numerous examples and now containing actual decisions from FDA reviewers to better inform trial design, the 2nd edition of Clinical Trials is a must-have resource for early and mid-career researchers and clinicians who design and conduct clinical trials.

  • Energy, Resources and Welfare

    Exploration of Social Frameworks for Sustainable Development
    • 1st Edition
    • Bent Sorensen
    • English
    Bent Sørensen, one of the world’s leading experts in the field of renewable energy systems, explores the current hurdles to the universal adoption of renewable energy sources and proposes solutions to the current situation in this new inspiring work. He discusses the social, political and economic issues that make sustainability seem like such an attainable goal, and explores the ways through which change can be achieved without loss of welfare. Even though the author has written several scientific monographs covering the technical issues behind the energy and social transitions mentioned in this book, and bases his conclusions on solid facts and analysis, Sørensen avoids specialist jargon in this text. He therefore addresses scientists and engineers directly involved in sustainable technologies, as well as energy planners and decision makers in industry and government, and also those interested in the direction in which our societies are moving. This book can be a good basis for discussions and debate, whether in academic or in political circles, and may even be used as complementary reading for students in the field of energy generation, implementation, planning, management, markets and policy.

  • Chemosensory Transduction

    The Detection of Odors, Tastes, and Other Chemostimuli
    • 1st Edition
    • Frank Zufall + 1 more
    • English
    Written by leaders in the field of chemosensation, Chemosensory Transduction provides a comprehensive resource for understanding the molecular mechanisms that allow animals to detect their chemical world. The text focuses on mammals, but also includes several chapters on chemosensory transduction mechanisms in lower vertebrates and insects. This book examines transduction mechanisms in the olfactory, taste, and somatosensory (chemesthetic) systems as well as in a variety of internal sensors that are responsible for homeostatic regulation of the body. Chapters cover such topics as social odors in mammals, vertebrate and invertebrate olfactory receptors, peptide signaling in taste and gut nutrient sensing. Includes a foreword by preeminent olfactory scientist Stuart Firestein, Chair of Columbia University’s Department of Biological Sciences in New York, NY. Chemosensory Transduction describes state-of-the-art approaches and key findings related to the study of the chemical senses. Thus, it serves as the go-to reference for this subject for practicing scientists and students with backgrounds in sensory biology and/or neurobiology. The volume will also be valuable for industry researchers engaged in the design or testing of flavors, fragrances, foods and/or pharmaceuticals.

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