Epilepsy and Brain Tumors

1st Edition - March 4, 2015
Editors: Herbert B. Newton, Marta Maschio
Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 4 1 7 0 4 3 - 8
eBook ISBN:
9 7 8 - 0 - 1 2 - 4 1 7 1 2 6 - 8

Patients with brain tumor-related epilepsy (BTRE) suffer from two serious pathologies simultaneously – a brain tumor and a secondary form of epilepsy. Although there has been re… Read more

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Patients with brain tumor-related epilepsy (BTRE) suffer from two serious pathologies simultaneously – a brain tumor and a secondary form of epilepsy. Although there has been remarkable progress in BTRE research in recent years, it remains an on-going challenge for clinicians and continues to stimulate much debate in the scientific community. This volume is the first to be completely dedicated to BTRE, and in doing so it explores issues faced by the health care team as well as some of the novel and promising directions that future research may take. Epilepsy and Brain Tumors is not only a complete reference on BTRE but also a practical guide based on clinical experiences, with a comprehensive collection of presentations from international experts who share some of the latest discoveries and their approaches to tackling a wide range of difficult and complex issues.

Dedication
Foreword
Preface
Chapter 1: Brain Tumor-Related Epilepsy: Introduction and Overview
- Abstract
- Introduction
- Epilepsy: Definition, Incidence, Social Context and Treatment Options
Chapter 2: Overview of Epidemiology, Pathology, and Treatment of Primary Brain Tumors
- Abstract
- Acknowledgments
- Epidemiology of PBT
- Pathology of Selected PBT
- Surgical Therapy of PBT
- Radiation Therapy of PBT
- Chemotherapy of PBT
- Molecular or “Targeted” Treatment
Chapter 3: Overview of Epidemiology, Pathology, and Treatment of Metastatic Brain Tumors
- Abstract
- Acknowledgments
- Epidemiology of MBTs
- Pathology of MBTs
- Surgical Therapy of MBTs
- Radiation Therapy of MBTs
- Chemotherapy of MBTs
Chapter 4: Supportive Care of Brain Tumor Patients
- Abstract
- Introduction
- Seizures and Anticonvulsant Therapy
- Corticosteroids
- Gastric Acid Inhibitors
- Thromboembolic Complications and Anticoagulation
- Dysphagia and Swallowing Disorders
- Psychiatric Issues
- Pain Control Issues
- Palliative Care
- Ethical Issues
- Conclusion
Chapter 5: Brain-Tumor-Related Epilepsy in Children
- Abstract
- Acknowledgment
- The Pediatric Perspective
- Epilepsy-Associated Brain Tumors
- Pathophysiology
- Epidemiology
- Presentation
- General Principles of Management
- History and Physical Exam
- Diagnostic Evaluation
- Medical Management
- Surgical Management
- Outcome
- Future Directions
Chapter 6: Mechanisms of Focal Epileptogenesis
- Abstract
- Time Course and Specificity of Acquired Epileptogenesis
Chapter 7: Pathophysiology of Brain Tumor-Related Epilepsy
- Abstract
- Introduction
- Epidemiology of BTRE
- Pathophysiology of BTRE
- Treatment of BTRE
Chapter 8: The Neurophysiology of Central Nervous System Tumors
- Abstract
- Introduction
- EEG Modalities and Applications
- EEG Background Changes
- Epileptiform Activity
- Meningiomas
- Generation of Abnormal Cerebral Activity
Chapter 9: Surgical Treatment for Epilepsy
- Abstract
- Introduction
- Evaluation and Selection of the Surgical Candidate
- Resection Procedures
- Nonresective Techniques
- Disconnection Surgeries
Chapter 10: Clinical Evaluation of Epilepsy in the Brain-Tumor Patient
- Abstract
- Acknowledgments
- Differential Diagnosis
- Clinical History and Physical Examination
- Neuroimaging Evaluation
- Clinical and Electrophysiological Work-Up
- Effects of Oncological Therapy on Brain Tumor-Related Epilepsy
Chapter 11: Antiepileptic Drugs: First Generation
- Abstract
- Carbamazepine
- Ethosuximide
- Phenobarbital
- Phenytoin
- Primidone
- Valproate
Chapter 12: Antiepileptic Drugs: Second and Third Generation
- Abstract
- Introduction
- Clobazam
- Eslicarbazepine Acetate
- Ezogabine/Retigabine
- Felbamate
- Gabapentin
- Lacosamide
- Lamotrigine
- Levetiracetam
- Oxcarbazepine
- Perampanel
- Pregabalin
- Rufinamide
- Tiagabine Hydrochloride
- Topiramate
- Vigabatrin
- Zonisamide
Chapter 13: Antiepileptic Drugs and Brain Tumor Patients
- Abstract
- Introduction
- Pathophysiology
- Type of Seizure
- Treatment of Seizures
- Levetiracetam
- Oxcarbazepine
- Lacosamide
- Pregabalin
- Topiramate
- Zonisamide
- Lamotrigine
- Conclusion
Chapter 14: Clinical Approach to Brain Tumor-Related Epilepsy
- Abstract
- Seizure Prophylaxis in Patients with BTRE
- Is There a Best Practice for Seizure Treatment?
- Clinical Approach to BTRE
- Driving and BTRE
Chapter 15: Neuropsychology of BTRE
- Abstract
- Introduction
- Overview of Neurocognitive Impairment in BT, Epilepsy, and BTRE
- Neurocognitive Impairment in BTRE
- Specific Cognitive Deficits in BT, Epilepsy, and BTRE
- Overview of Neuropsychological Assessment Techniques for BT, Epilepsy, and BTRE
- Psychological Issues in BT, Epilepsy, and BTRE
- Sexual Disturbances in Patients with BT, Epilepsy and BTRE
- QoL Assessment and Monitoring in BT, Epilepsy and BTRE
- Conclusions
Chapter 16: Cognitive Rehabilitation in Patients with BTRE
- Abstract
- Introduction
- Goals of Cognitive Rehabilitation
- Treatment Modalities in BT
- Treatment Modalities in Epilepsy
- Treatment Modalities in BTRE
- Pharmacological Approaches for Treatment of Cognitive Deficits
- Caregivers Issues
- Implications for Future Research in BTRE
Chapter 17: Social Cost of Brain Tumor-Related Epilepsy
- Abstract
- Introduction
- Health Economic Reporting: Terminology and Aims
- Health Economics: Funding Priorities
- Epilepsy
- Brain Tumor
- Conclusion
Appendix: The Prospects of Brain Research within Horizon 2020: Responding Efficiently to Europe’s Societal Needs European Parliament, Brussels May 30^th, 2013
- Summary
Index

Herbert B. Newton

Dr. Newton is currently the Director of the Neuro-Oncology Center and CNS Oncology Program at the Advent Health Cancer Institute and Advent Health Orlando Campus. He recently retired as Professor of Neurology and Neurosurgery at the Ohio State University Medical Center and the James Cancer Hospital, and was the holder of the Esther Dardinger Endowed Chair in Neuro-Oncology. He trained in Neuro-Oncology with Drs. Jerome Posner and William Shapiro at Memorial Sloan-Kettering Cancer Center in New York, and since then had been in academic Neuro-Oncology for over 25 years. He has published more than 220 peer-reviewed articles and book chapters, and is the Chief Editor or Co-Editor of ten textbooks in the field of Neurology and Neuro-Oncology. In addition, he has been listed as a Best Doctor (Neurology) and Top Doctor for Cancer (Neuro-Oncology) for the past 18 years.

Affiliations and expertise

Advent Health Cancer Institute, FL, USA

Marta Maschio

Dr. Marta Maschio is Neurologist, Epileptologist, and Director of The Center for Brain Tumor-related Epilepsy, Regina Elena National Cancer Institute in Rome, Italy. Since 2005, she has been Director of this unique center, one of the few in Europe dedicated entirely to patients with Brain tumor-related Epilepsy. Known for her ability to think outside the box, Dr. Maschio is constantly searching for innovative approaches to improving patient care for this complex pathology, where epileptologists are rarely part of the patient’s primary care team. She is dedicated to changing that through educational initiatives, membership in the leading international organizations in the field of epilepsy, and by publishing her research in leading scientific journals.

In addition to her clinical work, Dr. Maschio is an active researcher and has published over 100 articles on BTRE and numerous book chapters. She also contributed to the development of BTRE Treatment Recommendations published in 2008, as member of the Italian Scientific Committee, designated by the Italian Association for Neuro-oncology. Since 2011, she has been Co-Director of the Neuro-oncological Section, International School of Neurological Science S. Servolo, Venice International University, and since 2012, is National Coordinator of the BTRE Study Group, Italian Society against Epilepsy.

In 2010, she created her Centers’ web portal, the first in the world exclusively for BTRE patients, of which she is very proud.

On a personal note, she has also won several national poetry awards.

Affiliations and expertise

Center for Tumor-related Epilepsy, UOSD Psychiatry, Health Direction, National Institute for Cancer "Regina Elena", Rome, Italy

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health