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Elsevier

Academic Press

  • Collaborative Genomics Projects: A Comprehensive Guide

    • 1st Edition
    • Margi Sheth + 2 more
    • English
    Collaborative Genomics Projects: A Comprehensive Guide contains operational procedures, policy considerations, and the many lessons learned by The Cancer Genome Atlas Project. This book guides the reader through methods in patient sample acquisition, the establishment of data generation and analysis pipelines, data storage and dissemination, quality control, auditing, and reporting. This book is essential for those looking to set up or collaborate within a large-scale genomics research project. All authors are contributors to The Cancer Genome Atlas (TCGA) Program, a NIH- funded effort to generate a comprehensive catalog of genomic alterations in more than 35 cancer types. As the cost of genomic sequencing is decreasing, more and more researchers are leveraging genomic data to inform the biology of disease. The amount of genomic data generated is growing exponentially, and protocols need to be established for the long-term storage, dissemination, and regulation of this data for research. The book's authors create a complete handbook on the management of research projects involving genomic data as learned through the evolution of the TCGA program, a project that was primarily carried out in the US, but whose impact and lessons learned can be applied to international audiences.

  • The Innate Immune Response to Noninfectious Stressors

    Human and Animal Models
    • 1st Edition
    • Massimo Amadori
    • English
    The Innate Immune Response to Non-infectious Stressors: Human and Animal Models highlights fundamental mechanisms of stress response and important findings on how the immune system is affected, and in turn affects such a response. In addition, this book covers the crucial link between stress response and energy metabolism, prompts a re-appraisal of some crucial issues, and helps to define research priorities in this fascinating, somehow elusive field of investigation.

  • Basics of Engineering Turbulence

    • 1st Edition
    • David Ting
    • English
    Basics of Engineering Turbulence introduces flow turbulence to engineers and engineering students who have a fluid dynamics background, but do not have advanced knowledge on the subject. It covers the basic characteristics of flow turbulence in terms of its many scales. The author uses a pedagogical approach to help readers better understand the fundamentals of turbulence scales, especially how they are derived through the order of magnitude analysis. This book is intended for those who have an interest in flowing fluids. It provides some background, though of limited scope, on everyday flow turbulence, especially in engineering applications. The book begins with the ‘basics’ of turbulence which is necessary for any reader being introduced to the subject, followed by several examples of turbulence in engineering applications. This overall approach gives readers all they need to grasp both the fundamentals of turbulence and its applications in practical instances.

  • Intracellular Consequences of Amyloid in Alzheimer's Disease

    • 1st Edition
    • Michael R. D'Andrea
    • English
    Consequences of Intracellular Amyloid in Alzheimer’s Disease addresses one of the more currently unresolved aspects confounding Alzheimer’s research, the significance of intraneuronal amyloid. It seeks to explain some of the unresolved questions concerning intracellular amyloid and its origin, entry, and toxicity. Following up on Dr. D’Andrea’s first book, Bursting Neurons and Fading Memories: An Alternative Hypothesis for the Pathogenesis of Alzheimer’s Disease, this book further examines the Inside-Out or Bursting alternative hypothesis of how amyloid escapes the circulatory system to ultimately enter neurons, also examining whether there is a relationship between intracellular amyloid, amyloid plaques, and cognitive impairment. Through a comprehensive explanation of the currently relevant scientific research on intracellular amyloid compiled in this handy reference, readers will better understand the mechanisms that lead to neuron death.

  • Pharmacy Practice in Developing Countries

    Achievements and Challenges
    • 1st Edition
    • Ahmed Fathelrahman + 2 more
    • English
    Pharmacy Practice in Developing Countries: Achievements and Challenges offers a detailed review of the history and development of pharmacy practice in developing countries across Africa, Asia, and South America. Pharmacy practice varies substantially from country to country due to variations in needs and expectations, culture, challenges, policy, regulations, available resources, and other factors. This book focuses on each country’s strengths and achievements, as well as areas of weakness, barriers to improvement and challenges. It sets out to establish a baseline for best practices, taking all of these factors into account and offering solutions and opportunities for the future. This book is a valuable resource for academics, researchers, practicing pharmacists, policy makers, and students involved in pharmacy practice worldwide as it provides lessons learned on a global scale and seeks to advance the pharmacy profession.

  • Electronic Noses and Tongues in Food Science

    • 1st Edition
    • Maria Luz Rodriguez Mendez
    • English
    Electronic Noses and Tongues in Food Science describes the electronic products of advanced chemical and physical sciences combined with intuitive integration of microprocessors, advanced bioinformatics and statistics. These include, for example, voltammetric, bio-electronic, piezoelectric platforms made from a variety of components including, nanoparticles, enzyme biosensors, heavy metals, graphite-epoxy composites, metal oxide semiconductors, microelectrodes, microfluidic channels, pre-manufactured gas sensors, redox enzymes and others and is an ideal resource for understanding and utilizing their power in Food Science settings. Devices used to analyse one particular food item can theoretically be adapted for other food items or components. This does not just mean the re-deploying the physical platforms but also the mode of bioinformatic and statistical analysis. This includes artificial neural networks (ANN), linear discriminant analysis (LDA), partial least squares (PLS), principal component analysis (PCA) etc. In other words, there is cross transference of chemistry, physics, concepts, techniques, findings and approaches from one food to another. Electronic noses and tongues are two of these devices but are advancing in application and importance. This book provides examples of the use of electronic noses and tongues to characterise components that contribute to sensory or compositional profiles, from ripening to harvesting and from storage of raw materials to packaging and consumption. These devises are suitable for high-throughput analysis, quality control or to determine the nature and extent of spoilage and adulteration, and have also been used to ascertain the geographical origins of food and mixtures.

  • The Membranes of Cells

    • 3rd Edition
    • Philip L. Yeagle
    • English
    The Membranes of Cells, Third Edition, provides a basic guide to biomembranes, connecting researchers to the numerous fields of biology. The new edition offers a complete update of content based on new understandings in the field. Foundational content for graduate students, researchers, professors, and undergraduate students across the sciences is provided, succinctly covering all of the basic information needed for lipids and membranes.

  • Alzheimer's Disease

    Life Course Perspectives on Risk Reduction
    • 1st Edition
    • Amy Borenstein + 1 more
    • English
    Alzheimer's Disease: Lifecourse Perspectives on Risk Reduction summarizes the growing body of knowledge on the distribution and causes of Alzheimer’s disease (AD) in human populations, providing the reader with knowledge on how we define the disease and what its risk and protective factors are in the context of a life-course approach. At the conclusion of the book, the reader will understand why Alzheimer’s disease likely begins at conception, then progresses through early-life and adult risk factors that ultimately impact the balance between pathologic insults in the brain and the ability of the brain to modify disease symptoms. In contrast to edited volumes that may have little cohesion, this book focuses on an integrated life-course approach to the epidemiology of dementia, in particular, Alzheimer’s disease.

  • Metabolic Phenotyping in Personalized and Public Healthcare

    • 1st Edition
    • Jeremy Nicholson + 3 more
    • English
    Metabolic Phenotyping in Personalized and Public Healthcare provides information on the widespread recognition that a personalized or stratified approach to patient treatment may offer a more efficient and effective healthcare solution than phenotype-led approaches.In order to achieve that objective, a deep personal description is required at the level of the genome, proteome, metabolome, or preferably a combination of these aided by technology. This book, edited and written by the outstanding luminaries of this evolving field, evaluates metabolic profiling and its uses across personalized and population healthcare, while also covering the advent of new technology fields, such as surgical metabonomics. In addition, the text presents specific examples of where this technology has been used clinically and with efficacy, pointing towards a framework and protocol for usage as it hits the clinical mainstream.

  • Making a Scientific Case for Conscious Agency and Free Will

    • 1st Edition
    • William R. Klemm
    • English
    Making a Scientific Case for Conscious Agency and Free Will makes a series of arguments that certain human behaviors are impossible to explain in the absence of free will, and that free will emerges from materialistic processes of brain function. It outlines future directions for neuroscience studies that can harness emerging technologies and tools for systems-level analysis. All humans have the sensation that they consciously will certain things to happen and that, in the absence of external constraints, they are free to choose from among alternatives. This notion of free will is deemed obvious by the average person based on common experience. Free will is frequently defended with arguments stemming from social, legal, philosophical, and religious perspectives. But these arguments appeal to consequences—not causes—of choices and decisions. In the past 3 decades, debate has raged within the scientific community over whether free will is in fact an illusion. Because free will would require conscious agency, the supporting corollary is that consciousness itself cannot do anything and is merely an observer rather than an actor.

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